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    Method for the calibration of a pair of sensors placed in a dialysis circuit
    1.
    发明授权
    Method for the calibration of a pair of sensors placed in a dialysis circuit 失效
    用于校准放置在透析电路中的一对传感器的方法

    公开(公告)号：US5342527A

    公开(公告)日：1994-08-30

    申请号：US82928

    申请日：1993-06-29

    申请人： Jacques Chevallet ,  Bernard Bene

    发明人： Jacques Chevallet ,  Bernard Bene

    IPC分类号： A61M1/14 ,  A61M1/16 ,  G01F25/00 ,  B01D61/32

    CPC分类号： A61M1/16 ,  A61M1/1607 ,  A61M1/1609 ,  A61M1/165 ,  G01F25/0007

    摘要： Disclosed is a method for the calibration of a pair of sensors placed in a dialysis circuit. The method includes performing at least one step for determining an auxiliary calibration coefficient for the intake sensor, performing at least one step for determining an auxiliary calibration coefficient for the outlet sensor, and in determining on the basis of at least one auxiliary calibration coefficient, a new calibration coefficient for the two sensors.

    摘要翻译： 公开了一种用于校准放置在透析电路中的一对传感器的方法。 该方法包括执行用于确定进气传感器的辅助校准系数的至少一个步骤，执行用于确定出口传感器的辅助校准系数的至少一个步骤，以及基于至少一个辅助校准系数， 两个传感器的新校准系数。

    Artificial kidney dosing method
    2.
    发明授权
    Artificial kidney dosing method 失效
    人造肾给药方法

    公开(公告)号：US5725775A

    公开(公告)日：1998-03-10

    申请号：US493969

    申请日：1995-06-23

    申请人： Bernard Bene ,  Jacques Chevallet

    发明人： Bernard Bene ,  Jacques Chevallet

    IPC分类号： A61M1/14 ,  A61M1/16 ,  A61M1/34 ,  B01D61/22 ,  B01D61/32

    CPC分类号： A61M1/3441 ,  A61M1/16 ,  A61M1/1643 ,  A61M1/3437 ,  A61M1/3451 ,  A61M1/3458 ,  A61M1/3465 ,  A61M1/3413 ,  Y10S210/929

    摘要： An artificial kidney dosing method includes the steps of connecting a patient to an exchanger having first and second compartments separated by a semipermeable membrane. The first compartment is connected to a circuit for extracorporeal blood circulation, and the second compartment has an outlet for draining a waste liquid. After the patient is connected to the exchanger, a perfusion liquid containing a substance (A) is perfused to the patient. The concentration of substance (A) in the blood of the patient is adjusted to a desired concentration {A}.sub.DES, by controlling a flow rate (Q.sub.A) of the perfusion liquid as a function of (1) a flow rate (Q.sub.OUT) of the waste liquid; (2) the desired concentration {A}.sub.DES ; and (3) a concentration {A}.sub.SOL of substance (A) in the perfusion liquid, whereby during this adjustment, a transfer of substance {A} through the semipermeable membrane is taken into account.

    摘要翻译： 人造肾剂量方法包括将患者连接到具有由半透膜隔开的第一和第二隔室的交换器的步骤。 第一隔室连接到用于体外血液循环的回路，第二隔室具有用于排出废液的出口。 患者连接到交换器后，将含有物质（A）的灌注液灌注到患者身上。 通过控制灌注液的流量（QA）作为（1）的流量（QOUT）的函数，将患者血液中物质（A）的浓度调节至所需浓度{A} DES 废液; （2）所需浓度{A} DES; 和（3）灌注液中物质（A）的浓度{A} SOL，由此在该调整期间，考虑到物质{A}通过半透膜的转移。

    Artificial kidney for adjusting a concentration of substance in blood
    3.
    发明授权
    Artificial kidney for adjusting a concentration of substance in blood 失效
    用于调节血液中物质浓度的人造肾

    公开(公告)号：US5698090A

    公开(公告)日：1997-12-16

    申请号：US738829

    申请日：1996-10-28

    申请人： Bernard Bene ,  Jacques Chevallet

    发明人： Bernard Bene ,  Jacques Chevallet

    IPC分类号： A61M1/16 ,  A61M1/34 ,  B01D61/00 ,  A61M1/14 ,  B01D61/22 ,  B01D61/32

    CPC分类号： A61M1/3441 ,  A61M1/16 ,  A61M1/1643 ,  A61M1/3437 ,  A61M1/3451 ,  A61M1/3458 ,  A61M1/3465 ,  A61M1/3413 ,  Y10S210/929

    摘要： An artificial kidney comprises an exchanger (1) having two compartments (2, 3) separated by a semipermeable membrane (4), a first compartment (2) being connected to a circuit (5, 7) for extracorporeal blood circulation, the second compartment (3) having an outlet for draining waste liquid. Means (22, 25) are provided for controlling the flow rate (Q.sub.A) of a sterile solution containing a substance (A) to be perfused into the circuit (5, 7) for conveying a flow of blood outside the body, which flow rate is controlled as a function of the flow rate (Q.sub.OUT) of waste liquid. This kidney makes it possible to dose a substance such as a medicine, glucose or bicarbonate, accurately into the blood of a patient undergoing treatment by hemofiltration, hemodialysis, or hemodiafiltration.

    摘要翻译： 人造肾包括具有由半透膜隔开的两个隔室（2,3）的交换器（1），与用于体外血液循环的回路（5,7）连接的第一隔室（2），第二隔室 （3）具有用于排出废液的出口。 提供装置（22,25），用于控制含有要灌注到用于输送身体外部的血液的电路（5,7）中的物质（A）的无菌溶液的流量（QA），该流量 作为废液流量（QOUT）的函数进行控制。 该肾使得可以将药物，葡萄糖或碳酸氢盐等物质准确地注入通过血液透析，血液透析或血液透析滤过治疗的患者的血液中。

    Artificial kidney and method for adjusting a concentration of substance in blood using thereof
    4.
    发明授权
    Artificial kidney and method for adjusting a concentration of substance in blood using thereof 失效
    人造肾及其调节血液中物质浓度的方法

    公开(公告)号：US5578223A

    公开(公告)日：1996-11-26

    申请号：US383208

    申请日：1995-02-03

    申请人： Bernard Bene ,  Jacques Chevallet

    发明人： Bernard Bene ,  Jacques Chevallet

    IPC分类号： A61M1/14 ,  A61M1/16 ,  A61M1/34 ,  B01D61/00 ,  B01D61/22 ,  B01D61/32 ,  B01D61/34

    CPC分类号： A61M1/3441 ,  A61M1/16 ,  A61M1/1643 ,  A61M1/3437 ,  A61M1/3451 ,  A61M1/3458 ,  A61M1/3465 ,  A61M1/3413 ,  Y10S210/929

    摘要： An artificial kidney comprises an exchanger (1) having two compartments (2, 3) separated by a semipermeable membrane (4), a first compartment (2) being connected to a circuit (5, 7) for extracorporeal blood circulation, the second compartment (3) having an outlet for draining waste liquid. Means (22, 25) are provided for controlling the flow rate (Q.sub.A) of a sterile solution containing a substance (A) to be perfused into the circuit (5, 7) for conveying a flow of blood outside the body, which flow rate is controlled as a function of the flow rate (Q.sub.OUT) of waste liquid. This kidney makes it possible to dose a substance such as a medicine, glucose or bicarbonate, accurately into the blood of a patient undergoing treatment by hemofiltration, hemodialysis, or hemodiafiltration.

    摘要翻译： 人造肾包括具有由半透膜隔开的两个隔室（2,3）的交换器（1），与用于体外血液循环的回路（5,7）连接的第一隔室（2），第二隔室 （3）具有用于排出废液的出口。 提供装置（22,25），用于控制含有要灌注到用于输送身体外部的血液的电路（5,7）中的物质（A）的无菌溶液的流量（QA），该流量 作为废液流量（QOUT）的函数进行控制。 该肾使得可以将药物，葡萄糖或碳酸氢盐等物质准确地注入通过血液透析，血液透析或血液透析滤过治疗的患者的血液中。

    Device for controlling blood circulation for a single needle circuit
    6.
    发明授权
    Device for controlling blood circulation for a single needle circuit 失效
    用于控制单针电路血液循环的装置

    公开(公告)号：US07540958B2

    公开(公告)日：2009-06-02

    申请号：US11074067

    申请日：2005-03-08

    申请人： Jacques Chevallet ,  Jean-Louis Romarie ,  Alain Frugier

    发明人： Jacques Chevallet ,  Jean-Louis Romarie ,  Alain Frugier

    IPC分类号： B01D61/28 ,  B01D61/18

    CPC分类号： A61M1/30 ,  A61M1/1006 ,  A61M1/1039 ,  A61M1/1081 ,  A61M1/302 ,  A61M1/303 ,  A61M1/308

    摘要： Device for extracorporeal treatment of blood 1 intended to operate in a mode with a single needle 2, comprising: a treatment unit 3 having a first compartment 4 and a second compartment 5, which are separated by a semipermeable membrane 6, an extracorporeal blood circuit comprising a single needle 2, an intake line 7 in fluid communication with the first compartment 4 of the treatment unit 3, the first compartment 4, and a return line 8 in fluid communication with the first compartment 4 of the treatment unit 3, a purge line 9 at the outlet of the second compartment 5, a closure means (10, 11) acting on at least the intake line 7 and the return line 8 in order to generate the alternate sequence of blood intake and return, at least a first chamber 12 which is in fluid communication with the extracorporeal blood circuit and defines a first additional blood volume, the first chamber 12 having a variable total content; the first chamber 4 being rigid and including at least one wall capable of being moved, the device including a means 19 acting on the chamber 12 in order to modify the volume of the chamber 12, making it possible to store blood during the arterial phase and release blood during the venous phase.

    摘要翻译： 用于体外处理用于以单针2模式操作的血液1的装置，包括：具有由半透膜6分离的第一隔室4和第二隔室5的治疗单元3，体外血液回路包括 单个针2，与处理单元3的第一隔室4流体连通的进入管线7，第一隔室4和与处理单元3的第一隔室4流体连通的返回管线8，净化管线 9，在第二隔室5的出口处，至少作用在进气管线7和返回管线8上的闭合装置（10,11），以产生血液进入和返回的交替序列，至少第一室12 其与体外血液回路流体连通并限定第一附加血液体积，第一腔室12具有可变的总含量; 第一腔室4是刚性的并且包括能够被移动的至少一个壁，该装置包括作用在腔室12上的装置19，以便改变腔室12的体积，使得可以在动脉期期间储存血液， 在静脉期释放血液。

    Fluid Distribution Module and Extracorporeal Blood Circuit Including Such a Module
    8.
    发明申请
    Fluid Distribution Module and Extracorporeal Blood Circuit Including Such a Module 有权
    流体分布模块和体外血液循环包括这样一个模块

    公开(公告)号：US20070269340A1

    公开(公告)日：2007-11-22

    申请号：US10595705

    申请日：2004-10-29

    申请人： Jurgen Dannenmaier ,  Hermann Goehl ,  Thomas Ertl ,  Jacques Chevallet

    发明人： Jurgen Dannenmaier ,  Hermann Goehl ,  Thomas Ertl ,  Jacques Chevallet

    IPC分类号： B01D61/00

    CPC分类号： A61M1/3627 ,  A61M1/1008 ,  A61M1/1039 ,  A61M1/1086 ,  A61M1/16 ,  A61M1/3639 ,  A61M1/3641 ,  A61M2205/12 ,  B01D61/30 ,  B01D63/02

    摘要： A fluid distribution module (1) for causing and monitoring the circulation of fluids from and to a patient through an extracorporeal blood treatment device, comprises a degassing device (11) connected to a connecting structure (10). The degassing device (11) comprises a first chamber (12) having a lower inlet (13) for a liquid and a second chamber (14) having an upper opening (79) closed by a hydrophobic membrane (78) and an outlet (15) for discharging the liquid. The connecting structure (10) has at least a first and a second conduits (20, 21) defined therein, wherein the first conduit (20) comprises a first end for connection to a discharge tube (7) from the treatment device and a second end connected to the inlet (13) of the first chamber (12) of the degassing device (11), and the second conduit (21) comprises a first end connected to the outlet (15) of the second chamber (14) of the degassing device (11) and a second end for connection to a blood return tube (6) to a patient.

    摘要翻译： 一种用于通过体外血液处理装置引导和监测来自和来自患者的流体循环的流体分配模块（1），包括连接到连接结构（10）的脱气装置（11）。 脱气装置（11）包括具有用于液体的下入口（13）的第一室（12）和具有由疏水膜（78）和出口（15）封闭的上开口（79）的第二室（14） ）用于排出液体。 连接结构（10）具有至少限定在其中的第一和第二导管（20,21），其中第一导管（20）包括用于从治疗装置连接到放电管（7）的第一端和第二导管 端部连接到脱气装置（11）的第一室（12）的入口（13），并且第二导管（21）包括连接到第二室（14）的出口（15）的第一端 脱气装置（11）和用于连接到患者的血液回流管（6）的第二端。

    Method and device for in-line preparation of liquid for an extracorporeal blood treatment apparatus
    10.
    发明申请
    Method and device for in-line preparation of liquid for an extracorporeal blood treatment apparatus 失效
    用于体外血液处理装置的液体的在线制备方法和装置

    公开(公告)号：US20060283801A1

    公开(公告)日：2006-12-21

    申请号：US11507614

    申请日：2006-08-22

    申请人： Jacques Chevallet ,  Guy Mercier ,  Laurent Simard

    发明人： Jacques Chevallet ,  Guy Mercier ,  Laurent Simard

    IPC分类号： B01D61/00

    CPC分类号： C02F1/444 ,  A61M1/1656 ,  A61M1/1668 ,  A61M2205/14 ,  A61M2205/60 ,  A61M2205/7518 ,  A61M2205/7581 ,  B01D61/142 ,  B01D61/20 ,  B01D61/22

    摘要： A method for in-line preparation of liquid for an extracorporeal blood treatment apparatus that makes provision for placing a filter in correspondence with each of two successive filtration stations, for carrying out a liquid preparation cycle, for removing the filter, which operates in correspondence with a first filtration station, for placing in correspondence with the first filtration station the filter that operated in correspondence with the second filtration station, for placing a new filter in correspondence with a second filtration station and for launching a new sterile liquid preparation cycle. The invention also provides a device for implementing the described method and an apparatus for extracorporeal blood treatment, which incorporates this device.

    摘要翻译： 一种用于体外血液处理装置的液体的在线制备方法，其用于设置与两个连续的过滤站中的每一个相对应的过滤器，用于进行液体制备循环，用于除去与 第一过滤站，用于与第一过滤站相对应地放置与第二过滤站相对应地操作的过滤器，用于与第二过滤站相对放置新的过滤器，以及发射新的无菌液体制备循环。 本发明还提供了一种用于实现所述方法的装置和用于体外血液处理的装置，其包括该装置。