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7 条记录 (耗时 0.02 秒)

    Pyrrolopyrimidinones and pyrroloimidazolones and their compositions and therapeutic methods
    1.
    发明授权
    Pyrrolopyrimidinones and pyrroloimidazolones and their compositions and therapeutic methods 失效
    吡咯并嘧啶酮和吡咯并咪唑酮及其组成和治疗方法

    公开(公告)号：US4325954A

    公开(公告)日：1982-04-20

    申请号：US117482

    申请日：1980-02-01

    申请人： Jacques G. Maillard ,  Tri Vovan ,  Jacky M. Legeai

    发明人： Jacques G. Maillard ,  Tri Vovan ,  Jacky M. Legeai

    IPC分类号： A61K31/415 ,  A61K31/435 ,  A61K31/505 ,  A61K31/55 ,  A61P25/24 ,  A61P25/26 ,  C07D207/22 ,  C07D211/72 ,  C07D471/04 ,  C07D487/04

    CPC分类号： C07D471/04 ,  C07D207/22 ,  C07D211/72 ,  C07D487/04

    摘要： The present invention relates to compounds having the formula: ##STR1## in which: n is equal to 1 or 2,R.sub.1 represents a hydrogen atom and R.sub.2 represents a phenyl group or a benzofuryl group; or R.sub.2 represents a hydrogen atom and R.sub.1 represents a phenyl group or a benzyl group; andgrouping -A-B- represents a group of the formula: ##STR2## or --CO--(CH.sub.2).sub.3 --in which R represents a hydrogen atom, a C.sub.1-6 alkyl radical, a phenyl group, a benzyl group, a methylthioethyl group, or a group having the formula --(CH.sub.2).sub.m --COOR' in which m is equal to 0, 1 or 2 and R' is a C.sub.1-6 alkyl radical,and their pharmacologically acceptable acid addition salts.These compounds are useful in the treatment of depressions.

    摘要翻译： 本发明涉及具有下式的化合物：其中n等于1或2，R1代表氢原子，R2代表苯基或苯并呋喃基; 或R 2表示氢原子，R 1表示苯基或苄基; 并且分组-AB-表示下式的基团：其中R表示氢原子，C 1-6烷基，苯基，苄基，甲硫基乙基，或者-CO-（CH 2）3） 或具有式 - （CH 2）m -COOR'的基团，其中m等于0,1或2，R'为C 1-6烷基，以及它们的药理学上可接受的酸加成盐。 这些化合物可用于治疗凹陷。

    Benzofuran derivatives and their therapeutic applications
    6.
    发明授权
    Benzofuran derivatives and their therapeutic applications 失效
    苯并呋喃衍生物及其治疗应用

    公开(公告)号：US4339384A

    公开(公告)日：1982-07-13

    申请号：US54626

    申请日：1979-07-03

    申请人： Jacques G. Maillard ,  Jacky Legeai

    发明人： Jacques G. Maillard ,  Jacky Legeai

    IPC分类号： C07D405/12 ,  A61K31/40 ,  A61K31/4025 ,  A61K31/443 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61K31/55 ,  A61P9/00 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P25/00 ,  C07D307/79 ,  C07D405/04

    CPC分类号： C07D307/79 ,  Y10S514/821

    摘要： This invention relates to compounds having the general formula: ##STR1## in which ##STR2## is selected from: a radical ##STR3## in which R'.sub.1 is hydrogen and R'.sub.2 is selected from hydrogen; C.sub.1-6 alkyl; C.sub.2-6 alkenyl; C.sub.2-6 alkynyl; phenyl; phenyl C.sub.1-6 alkyl; mono-, di- and trimethoxyphenyl C.sub.1-6 alkyl; C.sub.1-6 alkoxy; benzyloxy; di-C.sub.1-6 alkylamino-C.sub.1-6 alkyl; C.sub.1-6 hydroxyalkyl; C.sub.1-6 alkyloxycarbonyl-C.sub.1-6 alkyl;a radical ##STR4## in which R".sub.1 and R".sub.2 are C.sub.1-6 alkyl; a radical ##STR5## in which n is selected from 4, 5 and 6; the radical ##STR6## and the radical ##STR7## and their pharmacologically acceptable inorganic and organic acid addition salts.Said compounds are therapeutically useful for the treatment of dysrhythmia.

    摘要翻译： 本发明涉及具有以下通式的化合物：其中选自：其中R 1是氢并且R 2选自氢的基团 C 1-6烷基; C 2-6烯基; C 2-6炔基; 苯基; 苯基C 1-6烷基; 单，二和三甲氧基苯基C 1-6烷基; C 1-6烷氧基 苄氧基; 二-C 1-6烷基氨基-C 1-6烷基; C 1-6羟基烷基; C 1-6烷氧基羰基-C 1-6烷基; 其中R“1和R”2为C 1-6烷基的基团“IMAGE” 其中n选自4,5和6的激进的 激进的“IMAGE”和激进的“IMAGE”及其药理学上可接受的无机和有机酸加成盐。 所述化合物对于治疗心律失常是治疗上有用的。

    Phenylacetic acid derivatives and therapeutic composition containing same
    7.
    发明授权
    Phenylacetic acid derivatives and therapeutic composition containing same 失效
    苯乙酸衍生物和含有它们的治疗组合物

    公开(公告)号：US4181736A

    公开(公告)日：1980-01-01

    申请号：US962653

    申请日：1978-11-21

    申请人： Jacques G. Maillard

    发明人： Jacques G. Maillard

    IPC分类号： C07C59/54 ,  A61K31/19 ,  C07C65/20 ,  C07C69/95

    CPC分类号： C07C59/54

    摘要： This invention relates to phenylacetic acid derivatives having the formula: ##STR1## in which A represents a grouping ##STR2## R, R.sub.2, R.sub.3 and R.sub.4, which may be the same or different, represent each hydrogen or an alkyl group, and represents a single or double carbon-carbon bond; and their salts with inorganic and organic bases. Said compounds possess anti-inflammatory and analgesic activities that make them therapeutically useful, in particular for the treatment of rheumatic diseases and of local inflammations.

    摘要翻译： 本发明涉及具有下式的苯乙酸衍生物：其中A代表分子式，R，R 2，R 3和R 4可以相同或不同，表示每个氢或烷基，代表 单或双碳 - 碳键; 和它们与无机和有机碱的盐。 所述化合物具有使其具有治疗用途，特别是用于治疗风湿性疾病和局部炎症的抗炎和止痛活性。