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    OPTIMIZED METHOD FOR LID BIOSENSOR RESONANCE DETECTION
    1.
    发明申请
    OPTIMIZED METHOD FOR LID BIOSENSOR RESONANCE DETECTION 有权
    用于生物传感器谐振检测的优化方法

    公开(公告)号：US20090138205A1

    公开(公告)日：2009-05-28

    申请号：US12266060

    申请日：2008-11-06

    申请人： Jacques Gollier ,  Garrett A. Piech ,  Michael B. Webb ,  Qi Wu

    发明人： Jacques Gollier ,  Garrett A. Piech ,  Michael B. Webb ,  Qi Wu

    IPC分类号： G06F19/00 ,  G06F15/00

    CPC分类号： G01J3/28 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/1895 ,  G01J3/2803 ,  G01N21/7743

    摘要： An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.

    摘要翻译： 本文描述了一种光询问系统，其可以询问标签无关检测（LID）生物传感器并在生物传感器顶部监测生物事件，而不会遇到有问题的寄生反射和/或有问题的像素化效应。 在一个实施例中，光询问系统能够询问生物传感器并使用低通滤波器算法来数字地去除包含在光学共振的光谱中的有问题的寄生反射，这使得更容易确定生物事件是否发生在 生物传感器 在另一个实施例中，光询问系统能够询问生物传感器并使用过采样/平滑算法来减少由问题像素化效应引起的光学共振的估计位置中的振荡，这使得更容易确定生物事件 发生在生物传感器上。

    Optimized method for LID biosensor resonance detection
    2.
    发明授权
    Optimized method for LID biosensor resonance detection 失效
    LID生物传感器共振检测的优化方法

    公开(公告)号：US07509239B2

    公开(公告)日：2009-03-24

    申请号：US11716425

    申请日：2007-03-09

    申请人： Jacques Gollier ,  Garrett A. Piech ,  Michael B. Webb ,  Qi Wu

    发明人： Jacques Gollier ,  Garrett A. Piech ,  Michael B. Webb ,  Qi Wu

    IPC分类号： G03F1/26

    CPC分类号： G01J3/28 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/1895 ,  G01J3/2803 ,  G01N21/7743

    摘要： An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.

    摘要翻译： 本文描述了一种光询问系统，其可以询问标签无关检测（LID）生物传感器并在生物传感器顶部监测生物事件，而不会遇到有问题的寄生反射和/或有问题的像素化效应。 在一个实施例中，光询问系统能够询问生物传感器并使用低通滤波器算法来数字地去除包含在光学共振的光谱中的有问题的寄生反射，这使得更容易确定生物事件是否发生在 生物传感器 在另一个实施例中，光询问系统能够询问生物传感器并使用过采样/平滑算法来减少由问题像素化效应引起的光学共振的估计位置中的振荡，这使得更容易确定生物事件 发生在生物传感器上。

    Spatially scanned optical reader system and method for using same
    3.
    发明授权
    Spatially scanned optical reader system and method for using same 失效
    空间扫描光学阅读器系统及其使用方法

    公开(公告)号：US07604984B2

    公开(公告)日：2009-10-20

    申请号：US11027547

    申请日：2004-12-29

    申请人： Anthony G. Frutos ,  Jacques Gollier ,  Jinlin Peng ,  Garrett A. Piech ,  Michael B. Webb

    发明人： Anthony G. Frutos ,  Jacques Gollier ,  Jinlin Peng ,  Garrett A. Piech ,  Michael B. Webb

    IPC分类号： C12M1/34 ,  G01N21/00 ,  G01N21/01 ,  G01J3/00 ,  G01J3/28 ,  G02B6/00 ,  G02B6/34 ,  G02B26/08 ,  G02F1/07

    CPC分类号： G01N21/253 ,  G01N21/554 ,  G01N21/7743

    摘要： An optical reader system is described herein that uses a scanned optical beam to interrogate a biosensor to determine if a biomolecular binding event occurred on a surface of the biosensor. In one embodiment, the optical reader system includes a light source, a detector and a processor (e.g., computer, DSP). The light source outputs an optical beam which is scanned across a moving biosensor and while this is happening the detector collects the optical beam which is reflected from the biosensor. The computer processes the collected optical beam and records the resulting raw spectral or angle data which is a function of a position (and possibly time) on the biosensor. The processor can then analyze the raw data to create a spatial map of resonant wavelength (peak position) or resonant angle which indicates whether or not a biomolecular binding event occurred on the biosensor. Several other uses of the raw data are also described herein.

    摘要翻译： 本文描述了一种光学阅读器系统，其使用扫描的光束来询问生物传感器以确定生物分子结合事件是否在生物传感器的表面上发生。 在一个实施例中，光学读取器系统包括光源，检测器和处理器（例如，计算机，DSP）。 光源输出沿着移动的生物传感器扫描的光束，并且当发生这种情况时，检测器收集从生物传感器反射的光束。 计算机处理所收集的光束并记录所生成的原始光谱或角度数据，该数据是生物传感器上的位置（可能是时间）的函数。 然后，处理器可以分析原始数据以创建谐振波长（峰值位置）或共振角的空间图，其指示生物传感器上是否发生生物分子结合事件。 这里还描述了原始数据的几种其他用途。

    Optimized method for LID biosensor resonance detection
    8.
    发明授权
    Optimized method for LID biosensor resonance detection 失效
    LID生物传感器共振检测的优化方法

    公开(公告)号：US08510082B2

    公开(公告)日：2013-08-13

    申请号：US13151605

    申请日：2011-06-02

    申请人： Jacques Gollier ,  Garrett A. Piech ,  Michael B. Webb ,  Qi Wu

    发明人： Jacques Gollier ,  Garrett A. Piech ,  Michael B. Webb ,  Qi Wu

    IPC分类号： H03F1/26

    CPC分类号： G01J3/28 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/1895 ,  G01J3/2803 ,  G01N21/7743

    摘要： An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.

    摘要翻译： 本文描述了一种光询问系统，其可以询问标签无关检测（LID）生物传感器并在生物传感器顶部监测生物事件，而不会遇到有问题的寄生反射和/或有问题的像素化效应。 在一个实施例中，光学询问系统能够询问生物传感器并使用过采样/平滑算法来减少由有问题的像素化效应引起的光学共振的估计位置中的振荡，这使得更容易确定生物事件 发生在生物传感器上。

    Optimized method for LID biosensor resonance detection
    9.
    发明授权
    Optimized method for LID biosensor resonance detection 有权
    LID生物传感器共振检测的优化方法

    公开(公告)号：US07979241B2

    公开(公告)日：2011-07-12

    申请号：US12266060

    申请日：2008-11-06

    申请人： Jacques Gollier ,  Garrett A. Piech ,  Michael B. Webb ,  Qi Wu

    发明人： Jacques Gollier ,  Garrett A. Piech ,  Michael B. Webb ,  Qi Wu

    IPC分类号： H03F1/26

    CPC分类号： G01J3/28 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/1895 ,  G01J3/2803 ,  G01N21/7743

    摘要： An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.

    摘要翻译： 本文描述了一种光询问系统，其可以询问标签无关检测（LID）生物传感器并在生物传感器顶部监测生物事件，而不会遇到有问题的寄生反射和/或有问题的像素化效应。 在一个实施例中，光询问系统能够询问生物传感器并使用低通滤波器算法来数字地去除包含在光学共振的光谱中的有问题的寄生反射，这使得更容易确定生物事件是否发生在 生物传感器 在另一个实施例中，光询问系统能够询问生物传感器并使用过采样/平滑算法来减少由问题像素化效应引起的光学共振的估计位置中的振荡，这使得更容易确定生物事件 发生在生物传感器上。

    Optical interrogation system and method for increasing a read-out speed of a spectrometer
    10.
    发明授权
    Optical interrogation system and method for increasing a read-out speed of a spectrometer 失效
    光学询问系统和增加光谱仪读出速度的方法

    公开(公告)号：US07705336B2

    公开(公告)日：2010-04-27

    申请号：US11500048

    申请日：2006-08-07

    申请人： Garrett A. Piech ,  Michael B. Webb

    发明人： Garrett A. Piech ,  Michael B. Webb

    IPC分类号： G01N21/00

    CPC分类号： G01N21/7743 ,  G01J3/2803

    摘要： A typical use of linear or two dimensional spectrometers is to expose the detector area, and then shift the photo-electric charges out of the device in a serial fashion. If the illuminating signal is spatially narrow relative to the size of the array, this will drive down the percent of the detector that is utilized, as only a relatively small number of pixels are used to detect the beam. The present invention proposes a method which capitalizes on this spatial under-utilization, and alters the clocking scheme to maximize the read-out speed of the pixels containing signal information. This type of clocking scheme raises the optical power saturation level of the spectrometer. Such an improvement in optical power handling is beneficial for spectrometer based detection of resonant waveguide grating biochemical binding, since in such systems the performance is frequently limited by spectrometer saturation.

    摘要翻译： 线性或二维光谱仪的典型用途是暴露检测器区域，然后将光电荷以串联方式移出设备。 如果照明信号相对于阵列的尺寸在空间上窄，则这将驱动所使用的检测器的百分比，因为仅使用相对较少数量的像素来检测光束。 本发明提出了一种利用该空间利用不足的方法，并且改变了时钟方案以使包含信号信息的像素的读出速度最大化。 这种类型的时钟方案提高了光谱仪的光功率饱和水平。 光功率处理的这种改进对于谐振波导光栅生化结合的基于光谱仪的检测是有利的，因为在这样的系统中，性能常常受到光谱仪饱和度的限制。