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公开(公告)号：US07604984B2
公开(公告)日：2009-10-20
申请号：US11027547
申请日：2004-12-29
IPC分类号： C12M1/34 , G01N21/00 , G01N21/01 , G01J3/00 , G01J3/28 , G02B6/00 , G02B6/34 , G02B26/08 , G02F1/07
CPC分类号： G01N21/253 , G01N21/554 , G01N21/7743
摘要： An optical reader system is described herein that uses a scanned optical beam to interrogate a biosensor to determine if a biomolecular binding event occurred on a surface of the biosensor. In one embodiment, the optical reader system includes a light source, a detector and a processor (e.g., computer, DSP). The light source outputs an optical beam which is scanned across a moving biosensor and while this is happening the detector collects the optical beam which is reflected from the biosensor. The computer processes the collected optical beam and records the resulting raw spectral or angle data which is a function of a position (and possibly time) on the biosensor. The processor can then analyze the raw data to create a spatial map of resonant wavelength (peak position) or resonant angle which indicates whether or not a biomolecular binding event occurred on the biosensor. Several other uses of the raw data are also described herein.
摘要翻译： 本文描述了一种光学阅读器系统，其使用扫描的光束来询问生物传感器以确定生物分子结合事件是否在生物传感器的表面上发生。 在一个实施例中，光学读取器系统包括光源，检测器和处理器（例如，计算机，DSP）。 光源输出沿着移动的生物传感器扫描的光束，并且当发生这种情况时，检测器收集从生物传感器反射的光束。 计算机处理所收集的光束并记录所生成的原始光谱或角度数据，该数据是生物传感器上的位置（可能是时间）的函数。 然后，处理器可以分析原始数据以创建谐振波长（峰值位置）或共振角的空间图，其指示生物传感器上是否发生生物分子结合事件。 这里还描述了原始数据的几种其他用途。
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2.发明申请OPTICAL READER SYSTEM AND METHOD FOR MONITORING AND CORRECTING LATERAL AND ANGULAR MISALIGNMENTS OF LABEL INDEPENDENT BIOSENSORS 审中-公开用于监测和校正标签独立生物传感器的横向和角度误差的光学读取器系统和方法公开(公告)号：US20110043828A1
公开(公告)日：2011-02-24
申请号：US12938740
申请日：2010-11-03
CPC分类号： G01N21/553 , G01N21/7743
摘要： An optical reader system and method are described herein that can detect a lateral and/or angular misalignment of one or more biosensors so that the biosensors can be properly re-located after being removed from and then reinserted into the optical reader system. In one embodiment, the biosensors are incorporated within the wells of a microplate.
摘要翻译： 本文描述了可以检测一个或多个生物传感器的侧向和/或角度偏移的光学读取器系统和方法，使得生物传感器可以在从光学读取器系统中移除并重新插入到光学读取器系统之后被适当地重新定位。 在一个实施方案中，将生物传感器并入微板的孔内。
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3.发明申请Method for creating a reference region and a sample region on a biosensor 审中-公开用于在生物传感器上产生参考区域和样品区域的方法公开(公告)号：US20080213481A1
公开(公告)日：2008-09-04
申请号：US12151510
申请日：2008-05-07
CPC分类号： B01L3/5085 , B01J19/0046 , B01J2219/00315 , B01J2219/00367 , B01J2219/00378 , B01J2219/00382 , B01J2219/00385 , B01J2219/00387 , B01J2219/00576 , B01J2219/00585 , B01J2219/00596 , B01J2219/00605 , B01J2219/0061 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00662 , B01J2219/00677 , B01J2219/00693 , B01J2219/00722 , B01J2219/00725 , B01L2200/12 , B01L2200/148 , B01L2300/0636 , B01L2300/0829 , G01N21/553 , G01N21/7743 , G01N2035/00158
摘要： A method is described herein that can use any one of a number of deposition techniques to create a reference region and a sample region on a single biosensor which in the preferred embodiment is located within a single well of a microplate. The deposition techniques that can be used to help create the reference region and the sample region on a surface of the biosensor include: (1) the printing/stamping of a deactivating agent on a reactive surface of the biosensor; (2) the printing/stamping of a target molecule (target protein) on a reactive surface of the biosensor; or (3) the printing/stamping of a reactive agent on an otherwise unreactive surface of the biosensor.
摘要翻译： 本文描述的方法可以使用多个沉积技术中的任何一种来在单个生物传感器上产生参考区域和样品区域，其在优选实施例中位于微板的单个孔内。 可用于帮助创建生物传感器表面上的参考区域和样品区域的沉积技术包括：（1）在生物传感器的反应性表面上印刷/冲压钝化剂; （2）生物传感器的反应性表面上的靶分子（靶蛋白）的印刷/印模; 或（3）在生物传感器的其它非反应性表面上印刷/冲压反应剂。
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公开(公告)号：US20090138205A1
公开(公告)日：2009-05-28
申请号：US12266060
申请日：2008-11-06
申请人： Jacques Gollier , Garrett A. Piech , Michael B. Webb , Qi Wu
发明人： Jacques Gollier , Garrett A. Piech , Michael B. Webb , Qi Wu
CPC分类号： G01J3/28 , G01J3/02 , G01J3/0218 , G01J3/1895 , G01J3/2803 , G01N21/7743
摘要： An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.
摘要翻译： 本文描述了一种光询问系统，其可以询问标签无关检测（LID）生物传感器并在生物传感器顶部监测生物事件，而不会遇到有问题的寄生反射和/或有问题的像素化效应。 在一个实施例中，光询问系统能够询问生物传感器并使用低通滤波器算法来数字地去除包含在光学共振的光谱中的有问题的寄生反射，这使得更容易确定生物事件是否发生在 生物传感器 在另一个实施例中，光询问系统能够询问生物传感器并使用过采样/平滑算法来减少由问题像素化效应引起的光学共振的估计位置中的振荡，这使得更容易确定生物事件 发生在生物传感器上。
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公开(公告)号：US07509239B2
公开(公告)日：2009-03-24
申请号：US11716425
申请日：2007-03-09
申请人： Jacques Gollier , Garrett A. Piech , Michael B. Webb , Qi Wu
发明人： Jacques Gollier , Garrett A. Piech , Michael B. Webb , Qi Wu
IPC分类号： G03F1/26
CPC分类号： G01J3/28 , G01J3/02 , G01J3/0218 , G01J3/1895 , G01J3/2803 , G01N21/7743
摘要： An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.
摘要翻译： 本文描述了一种光询问系统，其可以询问标签无关检测（LID）生物传感器并在生物传感器顶部监测生物事件，而不会遇到有问题的寄生反射和/或有问题的像素化效应。 在一个实施例中，光询问系统能够询问生物传感器并使用低通滤波器算法来数字地去除包含在光学共振的光谱中的有问题的寄生反射，这使得更容易确定生物事件是否发生在 生物传感器 在另一个实施例中，光询问系统能够询问生物传感器并使用过采样/平滑算法来减少由问题像素化效应引起的光学共振的估计位置中的振荡，这使得更容易确定生物事件 发生在生物传感器上。
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6.发明授权Optical reader system and method for monitoring and correcting lateral and angular misalignments of label independent biosensors 失效用于监测和校正标签独立生物传感器的侧向和角度不对准的光学读取器系统和方法公开(公告)号：US07629173B2
公开(公告)日：2009-12-08
申请号：US11210920
申请日：2005-08-23
IPC分类号： G01N21/00 , G01N21/03 , G01N33/53 , G01N33/543 , G01N33/551 , G01N33/553 , C12M1/36 , C12M1/34 , C12M3/00 , C12Q1/00
CPC分类号： G01N21/553 , G01N21/7743
摘要： An optical reader system and method are described herein that can detect a lateral and/or angular misalignment of one or more biosensors so that the biosensors can be properly re-located after being removed from and then reinserted into the optical reader system. In one embodiment, the biosensors are incorporated within the wells of a microplate.
摘要翻译： 本文描述了可以检测一个或多个生物传感器的侧向和/或角度偏移的光学读取器系统和方法，使得生物传感器可以在从光学读取器系统中移除并重新插入到光学读取器系统之后被适当地重新定位。 在一个实施方案中，将生物传感器并入微板的孔内。
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公开(公告)号：US20110238382A1
公开(公告)日：2011-09-29
申请号：US13151605
申请日：2011-06-02
申请人： Jacques Gollier , Garrett A. Piech , Michael B. Webb , Qi Wu
发明人： Jacques Gollier , Garrett A. Piech , Michael B. Webb , Qi Wu
CPC分类号： G01J3/28 , G01J3/02 , G01J3/0218 , G01J3/1895 , G01J3/2803 , G01N21/7743
摘要： An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects.
摘要翻译： 本文描述了一种光询问系统，其可以询问标签无关检测（LID）生物传感器并在生物传感器顶部监测生物事件，而不会遇到有问题的寄生反射和/或有问题的像素化效应。
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8.发明授权Optical reader system and method for monitoring and correcting lateral and angular misaligments of label independent biosensors 有权用于监测和校正标签独立生物传感器的侧向和角度偏移的光学读取器系统和方法公开(公告)号：US07851208B2
公开(公告)日：2010-12-14
申请号：US11789900
申请日：2007-04-26
IPC分类号： C12M3/0025
CPC分类号： G01N21/553 , G01N21/7743
摘要： An optical reader system and method are described herein that can detect a lateral and/or angular misalignment of one or more biosensors so that the biosensors can be properly re-located after being removed from and then reinserted into the optical reader system. In one embodiment, the biosensors are incorporated within the wells of a microplate.
摘要翻译： 本文描述了可以检测一个或多个生物传感器的侧向和/或角度偏移的光学读取器系统和方法，使得生物传感器可以在从光学读取器系统中移除并重新插入到光学读取器系统之后被适当地重新定位。 在一个实施方案中，将生物传感器并入微板的孔内。
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公开(公告)号：US08510082B2
公开(公告)日：2013-08-13
申请号：US13151605
申请日：2011-06-02
申请人： Jacques Gollier , Garrett A. Piech , Michael B. Webb , Qi Wu
发明人： Jacques Gollier , Garrett A. Piech , Michael B. Webb , Qi Wu
IPC分类号： H03F1/26
CPC分类号： G01J3/28 , G01J3/02 , G01J3/0218 , G01J3/1895 , G01J3/2803 , G01N21/7743
摘要： An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.
摘要翻译： 本文描述了一种光询问系统，其可以询问标签无关检测（LID）生物传感器并在生物传感器顶部监测生物事件，而不会遇到有问题的寄生反射和/或有问题的像素化效应。 在一个实施例中，光学询问系统能够询问生物传感器并使用过采样/平滑算法来减少由有问题的像素化效应引起的光学共振的估计位置中的振荡，这使得更容易确定生物事件 发生在生物传感器上。
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公开(公告)号：US07979241B2
公开(公告)日：2011-07-12
申请号：US12266060
申请日：2008-11-06
申请人： Jacques Gollier , Garrett A. Piech , Michael B. Webb , Qi Wu
发明人： Jacques Gollier , Garrett A. Piech , Michael B. Webb , Qi Wu
IPC分类号： H03F1/26
CPC分类号： G01J3/28 , G01J3/02 , G01J3/0218 , G01J3/1895 , G01J3/2803 , G01N21/7743
摘要： An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.
摘要翻译： 本文描述了一种光询问系统，其可以询问标签无关检测（LID）生物传感器并在生物传感器顶部监测生物事件，而不会遇到有问题的寄生反射和/或有问题的像素化效应。 在一个实施例中，光询问系统能够询问生物传感器并使用低通滤波器算法来数字地去除包含在光学共振的光谱中的有问题的寄生反射，这使得更容易确定生物事件是否发生在 生物传感器 在另一个实施例中，光询问系统能够询问生物传感器并使用过采样/平滑算法来减少由问题像素化效应引起的光学共振的估计位置中的振荡，这使得更容易确定生物事件 发生在生物传感器上。
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