公开(公告)号：US4650811A

公开(公告)日：1987-03-17

申请号：US691163

申请日：1985-01-14

申请人： Jacques Guillaume ,  Francois Clemence ,  Neil L. Brown

发明人： Jacques Guillaume ,  Francois Clemence ,  Neil L. Brown

IPC分类号： A61K31/40 ,  A61K31/403 ,  A61K31/404 ,  A61P3/00 ,  A61P3/04 ,  A61P3/08 ,  A61P3/10 ,  A61P7/00 ,  A61P9/06 ,  A61P9/12 ,  A61P13/02 ,  A61P15/00 ,  A61P25/02 ,  A61P43/00 ,  C07D209/08 ,  C07D209/30 ,  C07D209/34 ,  C07D407/12 ,  C07D209/12

CPC分类号： C07D407/12 ,  C07D209/08 ,  C07D209/30 ,  C07D209/34

摘要： Novel ethenylphenol indoles of the formula ##STR1## wherein R and R.sub.1 are individually selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms, cycloalkyl of 3 to 7 carbon atoms, cycloalkylalkyl of 4 to 7 carbon atoms and aralkyl of 7 to 12 carbon atoms optionally substituted with 1 to 3 members of the group consisting of halogen, methyl, ethyl, methoxy, ethoxy, methylthio, --CF.sub.3, --NH.sub.2 and --NO.sub.2 or R and R.sub.1 together with the nitrogen atom form an optionally unsaturated heterocycle optionally containing a second heteroatom selected from the group consisting of --O--, --S-- and ##STR2## R' is hydrogen or alkyl of 1 to 5 carbon atoms, a together with X is .dbd.0 and b is hydrogen or a together with b is a carbon-carbon bond and X is hydrogen, the dotted line indicates the possibility of a double bond with the compounds having the trans configuration if a double bond, A is selected from the group consisting of ##STR3## and --(CH.sub.2).sub.n --, n is 2,3,4 or 5, R.sub.2 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms with the proviso that R and R.sub.1 are not both hydrogen when A is ##STR4## and their non-toxic, pharmaceutically acceptable acid addition salts having anti-arrhythmic and anti hypertensive properties and the property of blocking slow calcium-sodium channels and novel intermediates.

摘要翻译： 式Ⅰ的新型乙烯基苯酚吲哚，其中R和R 1分别选自氢，1至5个碳原子的烷基，3至7个碳原子的环烷基，4至7个碳原子的环烷基烷基和芳烷基 任选被1至3个由卤素，甲基，乙基，甲氧基，乙氧基，甲硫基，-CF 3，-NH 2和-NO 2组成的组中任意取代的7至12个碳原子，或者R和R 1与氮原子一起形成任选不饱和的 任选地含有选自-O - ， - S-和R'的第二杂原子的杂环是氢或1至5个碳原子的烷基，以及X是= 0，b是氢或一起 其中b是碳 - 碳键，X是氢，虚线表示与具有反式构型的化合物具有双键的可能性，如果双键，A选自和 - （CH2 ）n-，n为2,3,4或5，R2选自c 存在氢和1至5个碳原子的烷基，条件是当A为A时，R和R1不同时为氢，并且它们具有抗心律失常和抗高血压性质的无毒的药学上可接受的酸加成盐和其特性 阻断缓慢的钙钠通道和新型中间体。

公开(公告)号：US4530932A

公开(公告)日：1985-07-23

申请号：US536889

申请日：1983-09-28

申请人： Francois Clemence ,  Neil L. Brown

发明人： Francois Clemence ,  Neil L. Brown

IPC分类号： C07D409/14 ,  A61K31/435 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/4433 ,  A61K31/445 ,  A61P3/00 ,  A61P9/06 ,  A61P9/12 ,  A61P25/02 ,  A61P43/00 ,  C07D401/04

CPC分类号： C07D401/04

摘要： Novel 4-(1H-indol-3-yl)-.alpha.-methyl-piperidine-1-ethanol derivatives of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, halogen, alkyl and alkoxy of 1 to 5 carbon atoms, --NO.sub.2, --NH.sub.2, CF.sub.3 -- and CH.sub.3 S--, R.sub.1 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and --OH, Ar is selected from the group consisting of optionally substituted aryl and heteroaryl, the dotted line indicates the optional presence of a double bond and their non-toxic, pharmaceutically acceptable acid addition salts having remarkable antagonistic properties toward calcium ion and antihypertensive activity and certain compounds possess .alpha. and/or .beta.-blocking properties.

摘要翻译： 新颖的4-（1H-吲哚-3-基）-α-甲基 - 哌啶-1-乙醇衍生物，其中R选自氢，卤素，烷基和烷氧基，其为1至5个 碳原子，-NO 2，-NH 2，CF 3 - 和CH 3 S - ，R 1选自氢和1至5个碳原子的烷基，R 2选自氢，1至5个碳原子的烷基 和-OH，Ar选自任选取代的芳基和杂芳基，虚线表示任选存在双键及其对钙离子和抗高血压活性具有显着拮抗性的无毒的药学上可接受的酸加成盐 并且某些化合物具有α和/或β-阻断性质。

公开(公告)号：US5786997A

公开(公告)日：1998-07-28

申请号：US666619

申请日：1996-06-18

申请人： Joshua K. Hoyt ,  Neil L. Brown ,  William D. Leppo

发明人： Joshua K. Hoyt ,  Neil L. Brown ,  William D. Leppo

IPC分类号： G05G9/047 ,  G06F3/038 ,  G05B9/02

CPC分类号： G06F3/0383 ,  G05G9/047 ,  G05G2009/0474 ,  G05G2009/04755 ,  G05G2009/04777 ,  G05G2009/04781 ,  G05G9/04737 ,  Y10T74/20201

摘要： A capacitively coupled, six axis joystick (320) employs a sensor electrode (310) having a perpendicular pair of slots (312, 314) and a fixed electrode assembly (300) having capacitor electrodes (C.sub.S) formed on three mutually orthogonal surfaces of planar circuit boards (302, 304, 306) that are complementarily nested within the slots of the sensor electrode. When nested together, the capacitor electrodes are separated from faces of the sensor electrode by spacings that depend on the rotational and translational movements of the sensor electrode relative to the electrode assembly. A signal generator (352) and address decoder (354) sequentially apply an alternating signal to the capacitor electrodes. The alternating signal is coupled to the closest associated faces of the sensor electrode to a degree dependent on the rotation- and translation-induced spacings. A controller (350) detects and processes each coupled signal voltage to determine a degree of deflection of the sensor electrode in the X-, Y-, Z-, roll-, pitch-, and yaw-axis directions.

摘要翻译： 电容耦合的六轴操纵杆（320）采用具有垂直成对的槽（312,314）的传感器电极（310）和固定电极组件（300），该固定电极组件（300）具有形成在平面的三个相互正交的表面上的电容器电极 互补地嵌套在传感器电极的槽内的电路板（302,304,306）。 当嵌套在一起时，电容器电极通过取决于传感器电极相对于电极组件的旋转和平移运动的间隔与传感器电极的表面分离。 信号发生器（352）和地址解码器（354）顺序地向电容器电极施加交变信号。 交变信号被耦合到传感器电极的最靠近的相关表面，其程度取决于旋转和平移引起的间隔。 控制器（350）检测和处理每个耦合信号电压以确定传感器电极在X，Y，Z，滚动，俯仰和偏航轴方向上的偏转程度。

公开(公告)号：US4866988A

公开(公告)日：1989-09-19

申请号：US251894

申请日：1988-09-30

申请人： Neil L. Brown

发明人： Neil L. Brown

IPC分类号： G01L9/00 ,  G01L9/12

CPC分类号： G01L9/0072 ,  G01L9/0005 ,  G01L9/125

摘要： A pressure transducer capable of measuring very high pressures with great accuracy. The transducer includes a metal structure enclosing a volume which forms a resonant cavity to provide the tuning element in a UHF oscillator. The resonant cavity provides an inductance and a variable capacitance, the capacitance being variable as a function of the pressure to be measured. A transistor oscillator is very loosely coupled to the tuned circuit and provides positive feedback to maintain the oscillation. Due to the loose coupling between the transistor and the tune circuit, changes in the input reactance of the oscillator circuit have very little affect on the frequency of the tuned circuit. The frequency varies as a function of the pressure and provides an indication thereof. Two embodiments of the transducer are described. A first embodiment includes two concentric tubes, a section at the center of the outer tube being reduced in diameter to form an annular gap to provide the variable capacitance. A second embodiment includes a flat diaphragm-like member in close proximity to an opposing flat section. The capacitance between the diaphragm and the section is variable in response to an external pressure.

摘要翻译： 压力传感器能够以很高的精度测量非常高的压力。 换能器包括一个包围体积的金属结构，该体积形成谐振腔以在UHF振荡器中提供调谐元件。 谐振腔提供电感和可变电容，电容根据要测量的压力而变化。 晶体管振荡器非常松耦合到调谐电路，并提供正反馈以保持振荡。 由于晶体管和调谐电路之间的松动耦合，振荡器电路的输入电抗的变化对调谐电路的频率影响很小。 频率随着压力而变化并提供其指示。 描述了换能器的两个实施例。 第一实施例包括两个同心管，外管中心的部分直径减小以形成环形间隙以提供可变电容。 第二实施例包括紧邻相对的平坦部分的平坦的膜状构件。 隔膜与断面之间的电容随外部压力而变化。

公开(公告)号：US20110260566A1

公开(公告)日：2011-10-27

申请号：US13131826

申请日：2009-11-26

申请人： Erik Odvarka ,  Peethamparam Anpalahan ,  Neil L. Brown ,  Richard J. Gray ,  Andy Hutchinson ,  Abdeslam Mebarki ,  Gurpreet Saini ,  Krzysztof Wejrzanowski

发明人： Erik Odvarka ,  Peethamparam Anpalahan ,  Neil L. Brown ,  Richard J. Gray ,  Andy Hutchinson ,  Abdeslam Mebarki ,  Gurpreet Saini ,  Krzysztof Wejrzanowski

IPC分类号： H02K21/24 ,  H02K15/02

CPC分类号： H02K21/24 ,  H02K1/16 ,  H02K1/20 ,  H02K1/2793 ,  H02K15/03 ,  Y10T29/49012

摘要： A rotor disc is disclosed for an axial flux permanent magnet rotating electrical machine. The rotor disc (12) comprises a plurality of laminations in a radial direction through the rotor disc, and a plurality of slots which pass radially through successive laminations for accommodating permanent magnets (14). The rotor disc may be formed from a spirally wound strip of material, or from groups of laminations.

摘要翻译： 公开了用于轴向通量永磁旋转电机的转子盘。 转子盘（12）包括通过转子盘沿径向方向的多个叠片以及径向通过连续叠片以容纳永磁体（14）的多个槽。 转子盘可以由螺旋缠绕的材料条形成，或者由一组叠片形成。

公开(公告)号：US5455513A

公开(公告)日：1995-10-03

申请号：US163356

申请日：1993-12-07

申请人： Neil L. Brown ,  Alan J. Fougere

发明人： Neil L. Brown ,  Alan J. Fougere

IPC分类号： G01N27/02 ,  G01N27/06 ,  G01R27/22

CPC分类号： G01N27/023 ,  G01R27/22

摘要： A system for determining a property, such as conductivity, of a material in which a sensor provides a square wave sensor output signal the value if which is selected to the proper in response to a square wave driver signal. The sensor output signal is compared with a feedback signal to produce an error signal. A forward circuit responds to the error signal and provides an in-phase component thereof which is integrated to provide an integrated DC output signal. A feedback signal provides an in-phase square wave feedback signal the peak-to-peak amplitude of which has a precisely selected relationship with the integrated DC output signal for comparison with the square wave sensor output signal to reduce the error signal to zero. The integrated DC output signal can be digitized and suitably processed to provide a signal which represents the property of the material to a high degree of accuracy.

摘要翻译： 用于确定传感器提供方波传感器输出的材料的性质（例如导电性）的系统用于响应于方波驱动器信号而输出信号，该值被选择为适当的值。 传感器输出信号与反馈信号进行比较，产生误差信号。 正向电路响应于误差信号并提供其集成的同相分量以提供集成的DC输出信号。 反馈信号提供同相方波反馈信号，其峰 - 峰幅度与集成DC输出信号具有精确选择的关系，以与方波传感器输出信号进行比较，以将误差信号减小到零。 集成的DC输出信号可以被数字化并被适当地处理以提供表示材料的性质的信号以高精度。

公开(公告)号：US06720773B2

公开(公告)日：2004-04-13

申请号：US10229260

申请日：2002-08-26

申请人： Neil L. Brown

发明人： Neil L. Brown

IPC分类号： G01N2702

CPC分类号： G01N27/07

摘要： A conductivity sensor configuration which has essentially no external electrical field so that the calibration of the sensor is not affected by the existence of nearby external objects or fouling on the exterior parts of the sensor. Additionally, the sensor is relatively insensitive to electrode fouling or electrode polarization. The sensor includes a tube through which the liquid to be measured flows. An inner electrode plate extends partially along the length of the tube dividing the central portion of the tube into two sections. Two inner electrodes are located on the inner wall, one on each side, and two outer electrodes are located on the inside of the tube opposite the inner electrodes.

摘要翻译： 一种电导率传感器结构，其基本上没有外部电场，使得传感器的校准不受附近外部物体的存在或传感器外部部分污染的影响。 此外，传感器对电极结垢或电极极化相对不敏感。 该传感器包括待测液体流过的管。 内部电极板沿着将管的中心部分分成两部分的管的长度部分地延伸。 两个内电极位于内壁上，每侧一个，两个外电极位于与内电极相对的管内侧。

公开(公告)号：US5959455A

公开(公告)日：1999-09-28

申请号：US944263

申请日：1997-10-06

申请人： Neil L. Brown

发明人： Neil L. Brown

IPC分类号： G01N27/02 ,  G01N27/07 ,  G01N27/74 ,  G01R27/22

CPC分类号： G01R27/22 ,  G01N27/023

摘要： The fluid conductivity sensor disclosed herein is adapted for the non-contacting measurement of fluid conductivity and utilizes first and second insulating tubes, each of which is provided with both the driving transformer and the sensing transformer. The sensor is immersed in the fluid to be tested so that the tubes fill with the fluid. The driving transformer's are oppositely poled so that the current induced in one tube tends to return through the other tube. Shrouds are provided which link the corresponding ends of the tubes and operate to obstruct in-fluid current flow not linking both of the tubes. Accordingly the influence of objects nearby in the fluid is substantially eliminated.

摘要翻译： 本文公开的流体传导率传感器适用于流体传导性的非接触式测量，并且利用第一和第二绝缘管，每个绝缘管均设置有驱动变压器和感测变压器两者。 将传感器浸入要测试的流体中，以使管填充流体。 驱动变压器相反极化，使得在一个管中感应的电流趋于通过另一个管返回。 提供了连接管的相应端部并且操作以阻塞不连接两个管的流体流动流动的护罩。 因此，基本上消除了在液体附近的物体的影响。

公开(公告)号：US5373736A

公开(公告)日：1994-12-20

申请号：US850381

申请日：1992-03-11

申请人： Neil L. Brown

发明人： Neil L. Brown

IPC分类号： G01P5/24 ,  G01F1/00

CPC分类号： G01P5/248

摘要： An acoustic current meter in which a CW burst is transmitted first in one direction along each acoustic path and then in the reverse direction along such path so that a single receiver system may be used and phase shift and/or d.c. offsets canceled. Four orthogonal components of current are measured so that the axis contaminated by the center support strut may be eliminated from further computation. A direction sensor includes a 3 axis magnetometer using feedback to minimize current requirements and a two axis accelerometer aligned therewith as a tilt sensor.

摘要翻译： 一种声流计，其中沿着每个声道首先在一个方向上发送CW脉冲串，然后沿着这样的路径沿相反方向发送CW脉冲串，使得可以使用单个接收机系统，并且进行相移和/或直流。 抵消已取消。 测量电流的四个正交分量，使得被中心支撑支柱污染的轴可以从进一步的计算中消除。 方向传感器包括使用反馈以最小化电流要求的3轴磁力计和与之对准的双轴加速度计作为倾斜传感器。

公开(公告)号：US4246497A

公开(公告)日：1981-01-20

申请号：US947255

申请日：1978-09-29

申请人： Kenneth D. Lawson ,  Neil L. Brown

发明人： Kenneth D. Lawson ,  Neil L. Brown

IPC分类号： G01R25/00 ,  H03K5/22

CPC分类号： G01R25/005

摘要： A circuit for measuring the relative phase of two periodic signals. Two analog waveforms are applied to limiting amplifiers which provide digital output signals. The output signals therefrom are applied to digital circuitry which provides an analog voltage representative of the phase difference between the two input signals over a 360 degree range. The digital circuitry compensates for any offset errors which may be introduced by the limiting amplifiers.

摘要翻译： 用于测量两个周期信号的相对相位的电路。 两个模拟波形应用于提供数字输出信号的限幅放大器。 其输出信号被施加到数字电路，其提供表示360度范围上的两个输入信号之间的相位差的模拟电压。 数字电路补偿由限幅放大器引入的任何偏移误差。