公开(公告)号：US20070154899A1

公开(公告)日：2007-07-05

申请号：US11441804

申请日：2006-05-26

申请人： James Coull ,  Andrew Stern ,  Lawrence Haff ,  Barbara Fox ,  Yumei Huang

发明人： James Coull ,  Andrew Stern ,  Lawrence Haff ,  Barbara Fox ,  Yumei Huang

IPC分类号： C12Q1/68 ,  G01N33/53

CPC分类号： G01N21/6486 ,  C12Q1/6818 ,  C12Q1/6823 ,  G01N33/532 ,  G01N33/58 ,  C12Q2565/501 ,  C12Q2523/101

摘要： The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid templated chemistry, for example, by generating fluorescent, chemiluminescent and/or chromophoric signals.

摘要翻译： 本发明提供了通过核酸模板化学，例如通过产生荧光，化学发光和/或发色信号来检测生物学靶标（例如核酸和蛋白质）的组合物和方法。

公开(公告)号：US09168625B2

公开(公告)日：2015-10-27

申请号：US13820975

申请日：2011-09-08

申请人： Yumei Huang ,  Wen Yan ,  Feng Gao ,  Hao Jiang

发明人： Yumei Huang ,  Wen Yan ,  Feng Gao ,  Hao Jiang

IPC分类号： B24B1/04 ,  B24B37/08 ,  B24B7/17 ,  B24B41/06

CPC分类号： B24B1/04 ,  B24B7/17 ,  B24B37/08 ,  B24B41/067

摘要： A computer numerical control machine tool for grinding two sides of a plane by shifting self-rotation ultrasonic vibration, wherein a pillar (3) is provided on the tool body (1) of the machine tool, a Y axis movement assembly (12) is provided on the platform of the tool body (1), with a lower revolving movement assembly (11), which revolves about a Z coordinate axis, being mounted on the upper surface of the Y axis movement assembly (12), and a lower grinding plate (10) being mounted coaxially above the lower revolving movement assembly (11); an ultrasonic vibration assembly (2) is mounted fixedly on the pillar (3), with a separation plate (8) for clamping a workpiece assembly (9) being provided on the ultrasonic vibration assembly (2); an X axis movement assembly (4) is mounted on the upper part of the pillar (3), a Z axis movement assembly (5) is mounted on the upright face of the X axis movement assembly (4), with an upper revolving movement assembly (6), which revolves about the Z coordinate axis, being provided on the Z axis movement assembly (5), and an upper grinding plate (7) being mounted coaxially on the revolving axis of the upper revolving movement assembly (6). The present invention enhances the time variation of grinding movement tracks, the uniformity of grinding speed distribution, machining efficiency and machining precision.

摘要翻译： 一种用于通过移动自旋超声波振动来研磨平面的两侧的计算机数字控制机床，其中在机床的工具主体（1）上设置有支柱（3），Y轴运动组件（12）是 设置在工具主体（1）的平台上，具有安装在Y轴运动组件（12）的上表面上的围绕Z坐标轴转动的下旋转运动组件（11），以及下磨 板（10）同轴地安装在下旋转运动组件（11）的上方; 超声波振动组件（2）固定地安装在支柱（3）上，具有用于夹紧设置在超声波振动组件（2）上的工件组件（9）的分隔板（8）。 X轴运动组件（4）安装在支柱（3）的上部，Z轴运动组件（5）安装在X轴运动组件（4）的直立面上，上运动组件 围绕Z坐标轴旋转的组件（6）设置在Z轴移动组件（5）上，以及同轴地安装在上部旋转运动组件（6）的旋转轴上的上部研磨板（7）。 本发明增加了研磨运动轨迹的时间变化，磨削速度分布的均匀性，加工效率和加工精度。

公开(公告)号：US09121799B2

公开(公告)日：2015-09-01

申请号：US13811257

申请日：2011-08-04

申请人： Yumei Huang ,  Xingang Yang ,  Ye Hui ,  Rui Zhao

发明人： Yumei Huang ,  Xingang Yang ,  Ye Hui ,  Rui Zhao

IPC分类号： G01N3/40 ,  G01M99/00 ,  B23Q17/00

CPC分类号： G01N3/40 ,  B23Q17/00 ,  B23Q2230/002 ,  G01M99/007

摘要： Disclosed is an operating position changeable loading apparatus with multi-axis joint movement used on machining center. The apparatus consists of a load-receiving test piece and a load-exerting component. Moving the load-exerting component and the load-receiving test piece to a preset loading position according to a multi-axis joint movement, with the displacement value measured by displacement sensors and the amount of simulated load measured by a force sensor of the loaded-exerting component, a stiffness of the load-exertion position under a simulated load can be derived. Changing the load-exertion position, repeating in sequence the previous steps, a stiffness distribution under the simulated load can be derived.

摘要翻译： 公开了一种在加工中心上使用的具有多轴关节运动的操作位置可变装载装置。 该装置由负载接收试验片和负载施加部件组成。 根据多轴关节运动将负载施加部件和承载试验片移动到预设加载位置，通过位移传感器测量的位移值和由负载传感器的力传感器测量的模拟负载量， 可以得出在模拟载荷下载荷运动位置的刚度。 改变载荷消耗位置，依次重复前述步骤，可以得出模拟载荷下的刚度分布。

公开(公告)号：US20130111981A1

公开(公告)日：2013-05-09

申请号：US13811257

申请日：2011-08-04

申请人： Yumei Huang ,  Xingang Yang ,  Ye Hui ,  Rui Zhao

发明人： Yumei Huang ,  Xingang Yang ,  Ye Hui ,  Rui Zhao

IPC分类号： G01N3/40

CPC分类号： G01N3/40 ,  B23Q17/00 ,  B23Q2230/002 ,  G01M99/007

摘要： Disclosed is a processing center multi-axis joint deflection loading apparatus comprising a load-receiving test piece and a load-exerting component. The load-exerting component is constituted by a steel ball, a cap, a ball socket, a bent board, a force sensor, a connection component A, and a connection component B. The connection component A is fixedly connected to a blade handle of the processing center; the blade handle is pulled tight within a bored hole on a main axle; and the connection component A is connected to a main housing via the connection component B. In a method using the apparatus for an inspection of static stiffness distribution, by means of a multi-axle joint movement, moving the load-exerting component and the load-receiving test piece to a preset loading position, allowing the normal at a load-receiving point on a load-receiving face of the load-receiving piece to be aligned with the axis of the ball socket; with the amount of shift measured by position-shift sensors fitted on the main axle, the main axle housing, and a working platform, and the amount of simulated load measured by the force sensor of the loaded-exerting component, deriving a stiffness measurement of the load-exertion position under a simulated load; changing the load-exertion position by means of a multi-axle joint movement, repeating in sequence the previous steps, thus deriving a stiffness distribution under the simulated load.

摘要翻译： 公开了一种加工中心多轴接合偏转加载装置，其包括承载试验片和载荷施加部件。 负载施加部件由钢球，盖，球窝，弯曲板，力传感器，连接部件A和连接部件B构成。连接部件A固定地连接到 加工中心; 刀柄在主轴上的钻孔内被拉紧; 并且连接部件A经由连接部件B连接到主壳体。在使用用于检查静刚度分布的装置的方法中，通过多轴关节运动，使负载施加部件和负载 接收试件到预设加载位置，允许负载接收件的承载面上的载荷接收点处的法线与球窝的轴线对齐; 通过安装在主轴，主轴壳体和工作平台上的位置换档传感器测量的换档量以及由负载运动部件的力传感器测量的模拟负载量，导出刚度测量值 模拟载荷下的载荷作用位置; 通过多轴关节运动改变载荷消耗位置，依次重复先前的步骤，从而导出模拟载荷下的刚度分布。

公开(公告)号：US09366327B2

公开(公告)日：2016-06-14

申请号：US14001896

申请日：2011-10-26

申请人： Yumei Huang ,  Hongyan Liu ,  Xingang Yang ,  Yong Yang

发明人： Yumei Huang ,  Hongyan Liu ,  Xingang Yang ,  Yong Yang

IPC分类号： F16H25/22 ,  B23Q1/30 ,  B23Q5/40

CPC分类号： F16H25/2204 ,  B23Q1/30 ,  B23Q5/40 ,  Y10T74/18656

摘要： A serially-connected ball screw pair and piezoelectric actuator macro-micro driving and guiding device includes, from the bottom to the top, a sliding seat (1), a ball screw pair, a sliding table guide rail pairs, a nut seat (6), a piezoelectric actuator (7), a micro-moving table, a nut seat guide rail pairs and a sliding table (1). The axis of a ball screw is symmetric with respect to two sliding table rail pairs, a nut (3) of the ball screw pair is fixedly mounted into the nut seat (6), one end of the piezoelectric actuator (7) is fixedly connected with the nut seat (6) and the other end thereof is fixedly connected with the micro-moving table (8), the axis of the piezoelectric actuator is symmetric relative to two sliding table rail pairs, an upper surface of the micro-moving table is fixedly mounted to a lower surface of the sliding table, and two nut rail pairs are symmetric relative to the axis of the ball screw. The ultra precision feeding in a long stroke within a full journey can be achieved; and the piezoelectric actuator only endures the driving force without enduring the driving torque generated by the driving force of the ball screw pair, thus, so that the piezoelectric actuator is in a good stressed status, which is applicable to a large-load ultra-precision feed system.

摘要翻译： 一个串联连接的滚珠丝杠对和压电执行器宏观微型驱动和引导装置，包括从底部到顶部的滑动座（1），滚珠丝杠对，滑动台导轨对，螺母座（6 ），压电致动器（7），微移动台，螺母座导轨对和滑动台（1）。 滚珠丝杠的轴线相对于两个滑动台轨对对称，滚珠丝杠对的螺母（3）固定地安装在螺母座（6）中，压电致动器（7）的一端固定连接 与螺母座（6）的另一端与微动台（8）固定连接，压电致动器的轴线相对于两个滑台轨对，微动台的上表面对称 固定地安装在滑动台的下表面，两个螺母导轨对相对于滚珠丝杠的轴线对称。 可以在全程内实现长时间的超精密进给; 并且压电致动器仅承受驱动力而不会承受由滚珠丝杠对的驱动力产生的驱动力矩，使得压电致动器处于良好的应力状态，这适用于大负载超精度 饲料系统

公开(公告)号：US20150300910A1

公开(公告)日：2015-10-22

申请号：US14237336

申请日：2011-10-27

申请人： Yumei Huang ,  Yao Liu ,  Ye Hui ,  Guangpeng Zhang ,  Chuang Gao

发明人： Yumei Huang ,  Yao Liu ,  Ye Hui ,  Guangpeng Zhang ,  Chuang Gao

IPC分类号： G01M5/00

CPC分类号： G01M5/0075

摘要： A device and a method for testing the rigidity and non-linear relationship of the coupling interface for cylindrical fitting including an axial loading assembly which is provided along a horizontal central line within a side wall of a frame test bench and contacting with the test-piece shaft via a steel ball, a radial loading assembly downward provided along a vertical central line of top board of the frame test bench, a tip of a perpendicular loading part of the radial loading assembly extending into the outer housing of the test-piece housing fixed on an upper plane of a bottom wall of the frame test bench, with the test-piece shaft and the test-piece housing fitted and connected to each other via a coupling interface for cylindrical fitting; a plurality of displacement sensors fixed on the test-piece housing, and test heads of respective displacement sensor assembly aiming at the test-piece shaft.

摘要翻译： 一种用于测试用于圆柱形接头的联接接口的刚度和非线性关系的装置和方法，包括沿着框架试验台的侧壁内的水平中心线设置的轴向加载组件，并与试验片 轴，其沿着框架测试台的顶板的垂直中心线向下设置的径向加载组件，所述径向加载组件的垂直装载部分的尖端延伸到所述试件壳体固定的外壳体中 在框架试验台的底壁的上平面上，试件轴和试件壳体通过用于圆柱形配合的联接接口彼此配合和连接; 固定在试件壳体上的多个位移传感器和针对试验轴的各个位移传感器组件的测试头。

公开(公告)号：US20150040703A1

公开(公告)日：2015-02-12

申请号：US14001896

申请日：2011-10-26

申请人： Yumei Huang

发明人： Yumei Huang

IPC分类号： F16H25/22

CPC分类号： F16H25/2204 ,  B23Q1/30 ,  B23Q5/40 ,  Y10T74/18656

摘要： A serially-connected ball screw pair and piezoelectric actuator macro-micro driving and guiding device includes, from the bottom to the top, a sliding seat (1), a ball screw pair, a sliding table guide rail pairs, a nut seat (6), a piezoelectric actuator (7), a micro-moving table, a nut seat guide rail pairs and a sliding table (1). The axis of a ball screw is symmetric with respect to two sliding table rail pairs, a nut (3) of the ball screw pair is fixedly mounted into the nut seat (6), one end of the piezoelectric actuator (7) is fixedly connected with the nut seat (6) and the other end thereof is fixedly connected with the micro-moving table (8), the axis of the piezoelectric actuator is symmetric relative to two sliding table rail pairs, an upper surface of the micro-moving table is fixedly mounted to a lower surface of the sliding table, and two nut rail pairs are symmetric relative to the axis of the ball screw. The ultra precision feeding in a long stroke within a full journey can be achieved; and the piezoelectric actuator only endures the driving force without enduring the driving torque generated by the driving force of the ball screw pair, thus, so that the piezoelectric actuator is in a good stressed status, which is applicable to a large-load ultra-precision feed system.

摘要翻译： 一个串联连接的滚珠丝杠对和压电执行器宏观微型驱动和引导装置，包括从底部到顶部的滑动座（1），滚珠丝杠对，滑动台导轨对，螺母座（6 ），压电致动器（7），微移动台，螺母座导轨对和滑动台（1）。 滚珠丝杠的轴线相对于两个滑动台轨对对称，滚珠丝杠对的螺母（3）固定地安装在螺母座（6）中，压电致动器（7）的一端固定连接 与螺母座（6）的另一端与微动台（8）固定连接，压电致动器的轴线相对于两个滑台轨对，微动台的上表面对称 固定地安装在滑动台的下表面，两个螺母导轨对相对于滚珠丝杠的轴线对称。 可以在全程内实现长时间的超精密进给; 并且压电致动器仅承受驱动力而不会承受由滚珠丝杠对的驱动力产生的驱动力矩，使得压电致动器处于良好的应力状态，这适用于大负载超精度 饲料系统

公开(公告)号：US08071388B2

公开(公告)日：2011-12-06

申请号：US12391898

申请日：2009-02-24

申请人： Yumei Huang ,  James M. Coull

发明人： Yumei Huang ,  James M. Coull

IPC分类号： G01N33/68 ,  G01N33/00 ,  C07D209/04 ,  C07D207/46 ,  C07D209/56 ,  C07H21/04 ,  C07C229/40

CPC分类号： C07H21/04 ,  C07D209/08 ,  C07D209/14 ,  C07D209/56 ,  C07D209/58 ,  C09B23/0091 ,  C09B23/105 ,  G01N33/5308 ,  G01N33/533 ,  Y10T436/143333 ,  Y10T436/145555

摘要： The invention provides compositions and methods for the detection of biological targets, (e.g. nucleic acids and proteins) by nucleic acid-templated chemistry, for example, by generating fluorescent polymethine dyes.

摘要翻译： 本发明提供了通过核酸模板化学，例如通过产生荧光聚甲炔染料来检测生物学靶标（例如核酸和蛋白质）的组合物和方法。

公开(公告)号：US09212906B2

公开(公告)日：2015-12-15

申请号：US14352580

申请日：2012-06-28

申请人： Yumei Huang ,  Xingang Yang ,  Weigang Lv ,  Longfei Zhang ,  Tongqing Liu

发明人： Yumei Huang ,  Xingang Yang ,  Weigang Lv ,  Longfei Zhang ,  Tongqing Liu

IPC分类号： G01B21/24 ,  G01B5/012

CPC分类号： G01B21/24 ,  G01B5/012

摘要： The present invention discloses a device for detecting axis coplanarity of orthogonal rotary shafts having a built-in intersection, wherein a front assembly rotary body is coaxially connected on a front assembly housing, the front assembly rotary body and a rear assembly housing are fixedly connected with each other, the rear assembly rotary body is mounted in the rear assembly housing, a first three dimension movement fine tuning mechanism is mounted at an end of the rear assembly rotary body, the first three dimension movement fine tuning mechanism is connected with a standard sphere through a connecting rod, the three dimension movement fine tuning mechanisms are provided in the horizontal direction of the standard sphere and below the standard sphere in vertical direction, and two non-contact displacement sensors are mounted on said two three dimension movement fine tuning mechanisms respectively. The present invention also discloses a precision measurement method for measuring axis coplanarity of the orthogonal rotary shafts having a built-in intersection by using the above device, having a feature of high measurement precision, which is adaptive to coplanarity detections for the cantilever-type orthogonal shafts having a built-in intersection and the clamp-type orthogonal shafts having a built-in intersection.

摘要翻译： 本发明公开了一种用于检测具有内置交点的正交旋转轴的轴共面性的装置，其中前组件旋转体同轴地连接在前组件壳体上，前组件旋转体和后组件壳体与 彼此相反，后组件旋转体安装在后组件壳体中，第一三维运动微调机构安装在后组件旋转体的一端，第一三维运动微调机构与标准球体 通过连杆，三维运动微调机构在标准球体的水平方向和标准球体的垂直方向下方设置，两个非接触位移传感器分别安装在所述两个三维运动微调机构上 。 本发明还公开了一种通过使用上述装置测量具有内置交点的正交旋转轴的轴线共面性的精密测量方法，具有高测量精度的特征，其适用于悬臂式正交的共平面检测 具有内置交叉的轴和具有内置交点的夹紧型正交轴。

公开(公告)号：US09168623B2

公开(公告)日：2015-10-27

申请号：US13989850

申请日：2011-10-13

申请人： Yumei Huang ,  Hongyan Liu ,  Xingang Yang ,  Yong Yang

发明人： Yumei Huang ,  Hongyan Liu ,  Xingang Yang ,  Yong Yang

IPC分类号： G05G11/00 ,  B23Q5/22 ,  B23Q5/28

CPC分类号： B23Q5/22 ,  B23Q5/28 ,  B23Q2210/002 ,  Y10T74/18992

摘要： A biaxial linear-motion micro drive apparatus includes: a mounting base A on an upper surface of a Z-direction sliding base; a Z-direction micro actuator fixed within the mounting base A and connected with a Z-direction micro-motion platform connected with an X-direction sliding base; Z-direction guide rail strips arranged on the Z-direction sliding; two Z-direction guide rail blocks provided on one Z-direction guide rail strip fixedly mounted on a lower surface of the X-direction sliding base; a mounting base B provided on an upper surface of the X-direction sliding base; an X-direction micro actuator in the mounting base B and connected with an X-direction micro-motion platform connected with an XZ biaxial motion platform; two X-direction guide rail strips arranged on the upper surface of the X-direction sliding base; two X-direction guide rail blocks provided on each X-direction guide rail strip mounted on a lower surface of the XZ biaxial motion platform.

摘要翻译： 双轴直线运动微驱动装置包括：在Z方向滑动基座的上表面上的安装基座A; 固定在安装基座A内并与与X方向滑动基座连接的Z方向微动平台连接的Z方向微致动器; Z方向导轨条布置在Z方向滑动; 设置在固定安装在X方向滑动基座的下表面上的一个Z方向导轨条上的两个Z方向导轨块; 设置在X方向滑动基座的上表面上的安装基座B; 安装基座B上的X方向微型致动器，与XZ双轴运动平台连接的X方向微动平台连接; 两个X方向导轨条布置在X方向滑动底座的上表面上; 设置在安装在XZ双轴运动平台的下表面上的每个X方向导轨条上的两个X方向导轨块。