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1.发明授权1-(3-aminoindazol-5-yl)-3-phenylmethyl-cyclic ureas useful as HIV protease inhibitors 失效可用作HIV蛋白酶抑制剂的1-（3-氨基吲唑-5-基）-3-苯基甲基 - 环脲
公开(公告)号：US5932570A
公开(公告)日：1999-08-03
申请号：US966491
申请日：1997-11-07
IPC分类号： C07D403/06 , A01N43/62 , C07D243/00 , C07D273/02
CPC分类号： C07D403/06
摘要： The present invention relates to compounds of formulae I and II: ##STR1## or pharmaceutically acceptable salt forms or prodrugs thereof, which are useful as inhibitors of HIV protease, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
摘要翻译： 本发明涉及可用作HIV蛋白酶抑制剂的式I和II化合物或其药学上可接受的盐形式或前药，以及含有该蛋白酶的药物组合物和诊断试剂盒及其用于治疗病毒的方法 感染或作为测定标准或试剂。
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2.发明授权Substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors 失效取代的环状羰基及其衍生物可用作逆转录病毒蛋白酶抑制剂
公开(公告)号：US5811422A
公开(公告)日：1998-09-22
申请号：US770546
申请日：1996-11-22
申请人： Patrick Yuk-Sun Lam , Prabhakar Kondaji Jadhav , Charles Joseph Eyermann , Carl Nicholas Hodge , George Vincent De Lucca , James David Rodgers
发明人： Patrick Yuk-Sun Lam , Prabhakar Kondaji Jadhav , Charles Joseph Eyermann , Carl Nicholas Hodge , George Vincent De Lucca , James David Rodgers
IPC分类号： C12N9/99 , A61K31/12 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/451 , A61K31/505 , A61K31/55 , A61K31/554 , A61P31/12 , A61P43/00 , C07C49/723 , C07C49/737 , C07C49/747 , C07D211/74 , C07D211/76 , C07D223/10 , C07D223/12 , C07D239/10 , C07D243/04 , C07D245/02 , C07D247/02 , C07D267/06 , C07D279/02 , C07D281/02 , C07D285/16 , C07D285/36 , C07D313/04 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/04 , C07D417/14 , C07D487/04 , C07D521/00 , C07F9/6584
CPC分类号： C07D239/10 , C07C49/723 , C07C49/747 , C07D211/76 , C07D223/10 , C07D223/12 , C07D231/12 , C07D233/56 , C07D243/04 , C07D245/02 , C07D249/08 , C07D267/06 , C07D279/02 , C07D281/02 , C07D285/16 , C07D285/36 , C07D313/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/14 , C07D487/04 , C07F9/65848
摘要： This invention relates to substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral infection. A representative compound of the invention is the compound of formula: ##STR1## wherein R.sup.22 and R.sup.23 are allyl.
摘要翻译： 本发明涉及用作逆转录病毒蛋白酶抑制剂的取代的环状羰基及其衍生物，包含这些化合物的药物组合物，以及使用这些化合物治疗病毒感染的方法。 本发明的代表性化合物是下式的化合物：其中R 22和R 23是烯丙基。
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3.发明授权公开(公告)号：US06503898B1
公开(公告)日：2003-01-07
申请号：US09113905
申请日：1998-07-10
申请人： Patrick Yuk-Sun Lam , Prabhakar Kondaji Jadhav , Charles Joseph Eyermann , Carl Nicholas Hodge , George Vincent De Lucca , James David Rodgers
发明人： Patrick Yuk-Sun Lam , Prabhakar Kondaji Jadhav , Charles Joseph Eyermann , Carl Nicholas Hodge , George Vincent De Lucca , James David Rodgers
IPC分类号： A61K3155
CPC分类号： C07D239/10 , C07C49/723 , C07C49/747 , C07D211/76 , C07D223/10 , C07D223/12 , C07D231/12 , C07D233/56 , C07D243/04 , C07D245/02 , C07D249/08 , C07D267/06 , C07D279/02 , C07D281/02 , C07D285/16 , C07D285/36 , C07D313/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/10 , C07D403/12 , C07D403/14 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/10 , C07D409/14 , C07D413/10 , C07D413/14 , C07D417/14 , C07D487/04 , C07F9/65848
摘要： This invention relates to substituted cyclic carbonyls and derivatives thereof useful as retroviral protease inhibitors, to pharmaceutical compositions comprising such compounds, and to methods of using these compounds for treating viral infection. A representative compound of the invention is the compound of formula: wherein R22 and R23 are allyl.
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4.发明授权A1-(3-aminoindazol-5-yl)-3 butyl-cyclic urea useful as a HIV protease inhibitor 失效可用作HIV蛋白酶抑制剂的A1-（3-氨基吲唑-5-基）-3-丁基 - 环脲公开(公告)号：US06218386B1
公开(公告)日：2001-04-17
申请号：US08966426
申请日：1997-11-07
IPC分类号： A61K31551
CPC分类号： C07D403/06
摘要： The present invention relates to compounds of formula I: or pharmaceutically acceptable salt forms or prodrugs thereof, which are useful as inhibitors of HIV protease, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
摘要翻译： 本发明涉及可用作HIV蛋白酶抑制剂的式I化合物或其药学上可接受的盐形式或前药，以及包含其的药物组合物和诊断试剂盒及其用途，用于治疗病毒感染或 作为测定标准品或试剂。
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5.发明授权Cyanamide, alkoxyamino, and urea derivatives of 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones as HIV reverse transcriptase inhibitors 有权作为HIV逆转录酶抑制剂的4,4-二取代-3,4-二氢-2（1H） - 喹唑啉酮的氰胺，烷氧基氨基和脲衍生物公开(公告)号：US06946469B2
公开(公告)日：2005-09-20
申请号：US10108843
申请日：2002-03-27
IPC分类号： A61K31/517 , A61P31/18 , C07D239/84 , A61K31/519 , C07D491/048 , A51K31/517
CPC分类号： C07D239/84 , A61K31/517 , Y10S206/828
摘要： The present invention relates to 4,4-disubstituted-3,4-dihydro-2(1H)-quinazolinones of formula I: or stereoisomeric forms, stereoisomeric mixtures, or pharmaceutically acceptable salt forms thereof, wherein A is selected from NCN, NCONH2, and NOR9. The present invention relates to compounds which are useful as inhibitors of HIV reverse transcriptase, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
摘要翻译： 本发明涉及式I的4,4-二取代-3,4-二氢-2（1H） - 喹唑啉酮或其立体异构形式，立体异构混合物或其药学上可接受的盐形式，其中A选自NCN， SUB> 2 和NOR 9。 本发明涉及可用作HIV逆转录酶抑制剂的化合物，以及包含其的药物组合物和诊断试剂，以及使用该化合物治疗病毒感染的方法或作为测定标准或试剂。
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6.发明授权1-(3-aminoindazol-5-yl)-3-butyl-cyclic urea useful as a HIV protease inhibitor 有权可用作HIV蛋白酶抑制剂的1-（3-氨基吲唑-5-基）-3-丁基 - 环脲公开(公告)号：US06451999B2
公开(公告)日：2002-09-17
申请号：US09795932
申请日：2001-02-28
IPC分类号： C07D40306
CPC分类号： C07D403/06
摘要： The present invention relates to compounds of formula I: or pharmaceutically acceptable salt forms or prodrugs thereof, which are useful as inhibitors of HIV protease, and to pharmaceutical compositions and diagnostic kits comprising the same, and methods of using the same for treating viral infection or as an assay standard or reagent.
摘要翻译： 本发明涉及可用作HIV蛋白酶抑制剂的式I化合物或其药学上可接受的盐形式或前药，以及包含其的药物组合物和诊断试剂盒及其用途，用于治疗病毒感染或 作为测定标准品或试剂。
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