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16 条记录 (耗时 0.02 秒)

    Focussing of therapeutic radiation on internal structures of living bodies
    1.
    发明授权
    Focussing of therapeutic radiation on internal structures of living bodies 有权
    聚焦治疗辐射对活体内部结构的影响

    公开(公告)号：US06179767B2

    公开(公告)日：2001-01-30

    申请号：US09241503

    申请日：1999-02-01

    申请人： James Francis Ziegler ,  Robert Jacob von Gutfeld

    发明人： James Francis Ziegler ,  Robert Jacob von Gutfeld

    IPC分类号： A61B500

    CPC分类号： A61B6/12 ,  A61N5/1049 ,  A61N2005/1051 ,  A61N2005/1091

    摘要： This invention helps achieve accurate focussing of therapeutic radiation at an internal structure (e.g. cancerous organ), which is often substantially movable within a living body. For this purpose, suitable sensors are laproscopically or surgically implanted at the location of the organ. These sensors may include semiconductor materials, scintillation materials, piezo-acoustic materials, x-ray emitters, or other materials which emit a signal when they are scanned by a beam of harmless investigative radiation, such as low intensity therapeutic radiation. The emitted signal is then monitored via implanted wires or light fibers or via external detectors during scanning to determine the targetted location at which a signal maximum occurs, whereupon the desired intensity of therapeutic radiation is focussed on this targetted location.

    摘要翻译： 本发明有助于在内部结构（例如癌性器官）处实现治疗辐射的精确聚焦，其通常在活体内基本上可移动。 为此，将合适的传感器在器官的位置进行轮廓扫描或手术植入。 这些传感器可以包括半导体材料，闪烁材料，压电声学材料，x射线发射器或当它们被无害调查辐射束（例如低强度治疗辐射）扫描时发出信号的其它材料。 然后在扫描期间通过植入的线或光纤或经由外部检测器监测发射的信号，以确定出现信号最大值的目标位置，由此将所需的治疗辐射强度集中在该目标位置上。

    Method and apparatus for facilitating radiation treatment of deep tumors
    2.
    发明授权
    Method and apparatus for facilitating radiation treatment of deep tumors 失效
    促进深部肿瘤放射治疗的方法和装置

    公开(公告)号：US06245005B1

    公开(公告)日：2001-06-12

    申请号：US09356179

    申请日：1999-07-16

    申请人： Robert Jacob von Gutfeld ,  James Francis Ziegler

    发明人： Robert Jacob von Gutfeld ,  James Francis Ziegler

    IPC分类号： A16N500

    CPC分类号： A61N5/1048

    摘要： The invention allows more accurate localization of radiation volumes during radiation treatment of tumors. The equipment includes radiation detector elements placed behind the patient during radiation, for treatment of a tumor condition. Such a detector may be constructed of semiconductor or a scintillating material. The radiation treatment plan for the patient includes an additional calculation of the treatment beam energy required for to enable the treatment beam to transit the patient. The energy required for patient transit is then measured, using a treatment beam with a beam current below that which will induce significant tissue damage. The experimental transit flux is then compared to the calculated transit flux, and the difference is used to correct the beam transport parameters in the original radiation treatment plan. Hence lower radiation doses and smaller radiation volumes can be achieved, reducing deleterious radiation side effects.

    摘要翻译： 本发明允许在肿瘤放射治疗期间更准确地定位辐射体积。 该设备包括在辐射期间放置在患者身后的放射线检测器元件，用于治疗肿瘤状况。 这种检测器可以由半导体或闪烁材料构成。 患者的放射治疗计划包括对治疗束使患者转运所需的治疗束能量的额外计算。 然后测量患者转运所需的能量，使用光束电流低于会导致显着组织损伤的束流的治疗束。 然后将实验过渡通量与计算的过渡通量进行比较，并且差异用于校正原始辐射治疗计划中的束传输参数。 因此，可以实现更低的辐射剂量和更小的辐射体积，减少有害的辐射副作用。

    Imaging of internal structures of living bodies by sensing implanted magnetic devices
    3.
    发明授权
    Imaging of internal structures of living bodies by sensing implanted magnetic devices 有权
    通过感应植入磁性装置成像生物体的内部结构

    公开(公告)号：US06230038B1

    公开(公告)日：2001-05-08

    申请号：US09241506

    申请日：1999-02-01

    申请人： Robert Jacob von Gutfeld ,  James Francis Ziegler

    发明人： Robert Jacob von Gutfeld ,  James Francis Ziegler

    IPC分类号： A61B1900

    CPC分类号： A61N5/1049 ,  A61B2090/3954 ,  A61N2005/1051

    摘要： The invention provides a system for therapeutic treatment of an organ, tumor, or other internal structure of a living body with therapeutic radiation after implantation, at the organ, of a magnetic element to identify the location of the organ, the element being capable of emitting a magnetic signal in response to an applied magnetic field. The system comprises a magnetic field generator for irradiating the magnetic element with an applied magnetic field, a movable magnetic field sensor for detecting the magnetic signal from a plurality of selected mutually displaced positions to produce a corresponding plurality of element-locating signals, a computing apparatus for converting the signals to a location image of the internal structure, and a controlled source of therapeutic radiation for focussing a selected degree and duration of therapeutic radiation at a target determined from the location image of the magnetic element. Preferably, the magnetic element is a length of wire of an amorphous magnetic material which produces a magnetic signal that exhibits non-linear Bark+hausen jumps in response to an applied ac magnetic field.

    摘要翻译： 本发明提供了一种用于在植入后在器官处的磁性元件的治疗性放射治疗处理器官，肿瘤或其他内部结构的系统，以识别器官的位置，该元件能够发射 响应于施加的磁场的磁信号。 该系统包括用于用施加的磁场照射磁性元件的磁场发生器，用于从多个选定的相互移位的位置检测磁信号以产生相应的多个元件定位信号的可移动磁场传感器，计算装置 用于将信号转换为内部结构的位置图像，以及受控的治疗辐射源，用于聚焦在从磁性元件的位置图像确定的目标处的治疗辐射的选定程度和持续时间。 优选地，磁性元件是非晶磁性材料的线的长度，其产生响应于所施加的交流磁场而呈现非线性的巴克+ ha en跳跃的磁信号。

    Low temperature Bi-CMOS compatible process for MEMS RF resonators and filters
    5.
    发明授权
    Low temperature Bi-CMOS compatible process for MEMS RF resonators and filters 失效
    用于MEMS RF谐振器和滤波器的低温Bi-CMOS兼容工艺

    公开(公告)号：US07943412B2

    公开(公告)日：2011-05-17

    申请号：US10316254

    申请日：2002-12-10

    申请人： Leena Paivikki Buchwalter ,  Kevin Kok Chan ,  Timothy Joseph Dalton ,  Christopher Vincent Jahnes ,  Jennifer Louise Lund ,  Kevin Shawn Petrarca ,  James Louis Speidell ,  James Francis Ziegler

    发明人： Leena Paivikki Buchwalter ,  Kevin Kok Chan ,  Timothy Joseph Dalton ,  Christopher Vincent Jahnes ,  Jennifer Louise Lund ,  Kevin Shawn Petrarca ,  James Louis Speidell ,  James Francis Ziegler

    IPC分类号： H01L21/00

    CPC分类号： B81C1/00246 ,  B81B2201/0271 ,  B81C1/0023 ,  B81C2203/0735 ,  H03H3/0072 ,  H03H9/2405

    摘要： A method of formation of a microelectromechanical system (MEMS) resonator or filter which is compatible with integration with any analog, digital, or mixed-signal integrated circuit (IC) process, after or concurrently with the formation of the metal interconnect layers in those processes, by virtue of its materials of composition, processing steps, and temperature of fabrication is presented. The MEMS resonator or filter incorporates a lower metal level, which forms the electrodes of the MEMS resonator or filter, that may be shared with any or none of the existing metal interconnect levels on the IC. It further incorporates a resonating member that is comprised of at least one metal layer for electrical connection and electrostatic actuation, and at least one dielectric layer for structural purposes. The gap between the electrodes and the resonating member is created by the deposition and subsequent removal of a sacrificial layer comprised of a carbon-based material. The method of removal of the sacrificial material is by an oxygen plasma or an anneal in an oxygen containing ambient. A method of vacuum encapsulation of the MEMS resonator or filter is provided through means of a cavity containing the MEMS device, filled with additional sacrificial material, and sealed. Access vias are created through the membrane sealing the cavity; the sacrificial material is removed as stated previously, and the vias are re-sealed in a vacuum coating process.

    摘要翻译： 一种形成微机电系统（MEMS）谐振器或滤波器的方法，其与在任何模拟，数字或混合信号集成电路（IC）工艺中的集成兼容，或者与这些工艺中的金属互连层的形成同时 ，由于其组成材料，加工步骤和制造温度。 MEMS谐振器或滤波器包含形成MEMS谐振器或滤波器的电极的较低金属电平，其可与IC上的现有金属互连电平中的任何一个或任何一个共享。 它还包括谐振元件，该谐振元件由用于电连接和静电驱动的至少一个金属层和至少一个用于结构目的的电介质层组成。 通过沉积并随后去除由碳基材料构成的牺牲层来产生电极和谐振构件之间的间隙。 去除牺牲材料的方法是通过氧等离子体或在含氧环境中的退火。 MEMS谐振器或滤波器的真空封装方法是通过一个包含MEMS器件的空腔的装置提供的，其中填充有额外的牺牲材料并被密封。 通过隔膜密封腔形成通孔; 如先前所述去除牺牲材料，并且在真空涂覆工艺中重新密封通孔。

    Radiation microdosimeters correlated with biological cells and cell components
    7.
    发明授权
    Radiation microdosimeters correlated with biological cells and cell components 有权
    辐射微量计与生物细胞和细胞成分相关

    公开(公告)号：US08858888B2

    公开(公告)日：2014-10-14

    申请号：US13959616

    申请日：2013-08-05

    申请人： James Francis Ziegler ,  Chao-tuan Liu ,  Razmig Hagop Messerian ,  Wayne Newhauser

    发明人： James Francis Ziegler ,  Chao-tuan Liu ,  Razmig Hagop Messerian ,  Wayne Newhauser

    IPC分类号： G01N27/00 ,  G01N23/00

    CPC分类号： H01L31/18 ,  A61B6/42 ,  A61B6/542 ,  G01N23/00 ,  G01N23/10 ,  G01N33/48728 ,  G01T1/026 ,  H01L27/14683

    摘要： One feature pertains to a radiation dosimeter comprising a microdosimeter cell array that includes a first microdosimeter cell having a first semiconductor volume configured to generate a first current in response to incident radiation. The first semiconductor volume may have at least one of a first size, a first shape, a first semiconductor type, and/or a first semiconductor doping type and concentration that is associated with a first biological cell type or a first biological cell component type. The dosimeter may further comprise a processing circuit communicatively coupled to the microdosimeter cell array and configured to generate a signal based on the first current. The signal generated may be indicative of an amount of radiation absorbed by the microdosimeter cell array. A display may be utilized by the dosimeter to show a radiation level reading based on the signal generated.

    摘要翻译： 一个特征涉及包括微量测仪单元阵列的放射剂量计，该微量计单元阵列包括具有第一半导体体积的第一微量测单元，第一半容量体积被配置为响应于入射辐射而产生第一电流。 第一半导体体积可以具有与第一生物细胞类型或第一生物细胞组分类型相关联的第一尺寸，第一形状，第一半导体类型和/或第一半导体掺杂类型和浓度中的至少一种。 剂量计还可以包括通信地耦合到微测量计单元阵列并被配置为基于第一电流产生信号的处理电路。 产生的信号可以指示由微量计单元阵列吸收的辐射量。 剂量计可以利用显示器来基于产生的信号来显示辐射水平读数。

    RADIATION DETECTING WEARABLE DEVICES
    9.
    发明申请
    RADIATION DETECTING WEARABLE DEVICES 审中-公开
    辐射检测易损设备

    公开(公告)号：US20150346350A1

    公开(公告)日：2015-12-03

    申请号：US14821681

    申请日：2015-08-07

    申请人： James Francis Ziegler ,  Razmig Hagop Messerian ,  Wayne Newhauser

    发明人： James Francis Ziegler ,  Razmig Hagop Messerian ,  Wayne Newhauser

    IPC分类号： G01T1/02 ,  H01L31/08

    CPC分类号： G01N23/10 ,  G01N2223/501 ,  G01N2223/6126 ,  G01T1/026 ,  H01L31/085

    摘要： One feature pertains to a microdosimeter cell array that includes a plurality of microdosimeter cells each having a semiconductor volume adapted to generate a current in response to incident radiation. The semiconductor volumes of each of the plurality of microdosimeter cells have at least one of a size, a shape, a semiconductor type, and/or a semiconductor doping type and concentration that is associated with one or more cells or cell components of a human eye. A processing circuit is also communicatively coupled to the microdosimeter cell array and generates a signal based on the currents generated by the semiconductor volumes of the plurality of microdosimeter cells. The signal generated by the processing circuit is indicative of an amount of radiation absorbed by the microdosimeter cell array.

    摘要翻译： 一个特征涉及包含多个微量度计单元的微量测单元阵列，每个微量计单元具有适于响应入射辐射产生电流的半导体体积。 多个微量计单元中的每一个的半导体体积具有与人眼的一个或多个细胞或细胞组分相关联的尺寸，形状，半导体类型和/或半导体掺杂类型和浓度中的至少一种 。 处理电路还通信地耦合到微量测单元阵列，并且基于由多个微量测单元的半导体体积产生的电流产生信号。 由处理电路产生的信号指示由微量计单元阵列吸收的辐射量。