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公开(公告)号:US06331609B1
公开(公告)日:2001-12-18
申请号:US08464361
申请日:1995-06-05
申请人: James M. Lee , Axel Ullrich , Arjun Singh
发明人: James M. Lee , Axel Ullrich , Arjun Singh
IPC分类号: C07K1465
CPC分类号: C12N9/2408 , A61K38/00 , C07K14/485 , C07K14/65 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/81
摘要: Human insulin-like growth factor is synthesized in recombinant cell culture by host cells transformed with expression vectors bearing DNA encoding human insulin-like growth factor.
摘要翻译: 通过用编码人类胰岛素样生长因子的DNA的表达载体转化的宿主细胞在重组细胞培养物中合成人胰岛素样生长因子。
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公开(公告)号:USRE39355E1
公开(公告)日:2006-10-17
申请号:US10461712
申请日:2003-06-13
申请人: James M. Lee , Axel Ullrich
发明人: James M. Lee , Axel Ullrich
IPC分类号: C07K14/65
CPC分类号: C12N9/2408 , A61K38/00 , C07K14/485 , C07K14/65 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/81
摘要: Human insulin-like growth factor is synthesized in recombinant cell culture by host cells transformed with expression vectors bearing DNA encoding human insulin-like growth factor.
摘要翻译: 通过用编码人类胰岛素样生长因子的DNA的表达载体转化的宿主细胞在重组细胞培养物中合成人胰岛素样生长因子。
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公开(公告)号:US06331414B1
公开(公告)日:2001-12-18
申请号:US08464255
申请日:1995-06-05
申请人: James M. Lee , Axel Ullrich
发明人: James M. Lee , Axel Ullrich
IPC分类号: C12N1509
CPC分类号: C12N9/2408 , A61K38/00 , C07K14/485 , C07K14/65 , C07K2319/00 , C07K2319/02 , C07K2319/036 , C07K2319/75 , C12N15/81
摘要: Human insulin-like growth factors is synthesized in recombinant cell culture by host cells transformed with expression vectors bearing DNA encoding human insulin-like growth factors.
摘要翻译: 人类胰岛素样生长因子在重组细胞培养中通过宿主细胞合成,所述宿主细胞用含有编码人胰岛素样生长因子的DNA的表达载体转化。
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公开(公告)号:US09008995B2
公开(公告)日:2015-04-14
申请号:US13489784
申请日:2012-06-06
申请人: James M. Lee , John Memishian
发明人: James M. Lee , John Memishian
CPC分类号: G01P15/18 , G01P1/127 , G01P15/0891
摘要: A method of detecting activity with a MEMS accelerometer stores a value of acceleration, then measures acceleration at a later time, calculates a change in acceleration using the measured acceleration and the stored acceleration, and compares the change in acceleration to an activity threshold to detect activity. A method of detecting inactivity uses a similar technique along with a timer. The method of detecting inactivity with a MEMS accelerometer stores an acceleration value, then measures acceleration at a later time, calculates a change in acceleration using the measured acceleration and the stored acceleration, and compares the change in acceleration to an inactivity threshold. If the change in acceleration is less than the inactivity threshold and, if a predetermined period of time has elapsed, then inactivity is detected.
摘要翻译: 使用MEMS加速度计检测活动的方法存储加速度值,然后在以后测量加速度,使用所测量的加速度和存储的加速度来计算加速度的变化,并将加速度变化与活动阈值进行比较以检测活动 。 检测不活动的方法与定时器一起使用类似的技术。 使用MEMS加速度计检测不活动的方法存储加速度值,然后在随后的时间内测量加速度,使用所测量的加速度和存储的加速度来计算加速度的变化,并将加速度的变化与不活动阈值进行比较。 如果加速度的变化小于不活动阈值,并且如果经过了预定时间段,则检测到不活动。
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公开(公告)号:US07240795B2
公开(公告)日:2007-07-10
申请号:US11010427
申请日:2004-12-14
申请人: James M. Lee
发明人: James M. Lee
CPC分类号: B65D25/04 , B65D83/0481
摘要: The multiple compartment pill dispenser has a rotatable cap mechanism having two holes associated with the cap which are displaceable to be aligned with each of the compartments of the dispenser. There are two standard sized holes, one for small pills and one for large pills. The dial cap mechanism is used to rotate one of the two holes into alignment with a particular pill compartment and allow a pill to be dispensed therefrom. As a closure device, an alignment plate is rotatably mounted in the cap mechanism. The alignment plate also includes two different sized holes, identical in diameter, respectively, to the two holes in the cap mechanism.
摘要翻译: 多隔室药丸分配器具有可转动的帽机构,其具有与帽相关联的两个孔,其可移位以与分配器的每个隔室对齐。 有两个标准尺寸的孔,一个用于小丸,一个用于大丸。 拨号盖机构用于将两个孔中的一个旋转成与特定药丸隔间对齐,并允许从其中分配药丸。 作为闭合装置,对准板可旋转地安装在盖机构中。 对准板还包括分别与盖机构中的两个孔相同直径的两个不同尺寸的孔。
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公开(公告)号:UST954006I4
公开(公告)日:1977-01-04
申请号:US672898
申请日:1976-04-02
申请人: James M. Lee , George Sonoda
发明人: James M. Lee , George Sonoda
CPC分类号: H03L1/00 , G05F3/205 , H03K3/011 , H03K17/145
摘要: disclosed is an apparatus for generating and controlling a desired substrate potential level or a semiconductor chip. A pulse source, such as an oscillator, provides a pulse train which, in combination with a control signal from the substrate voltage detector, selectively discharges a capacitor in a voltage level converter for obtaining a desired level of substrate potential. A feedback path through the substrate regulates the conductivity of a reference transistor in the substrate voltage detector providing the required control signal.
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公开(公告)号:US08220329B2
公开(公告)日:2012-07-17
申请号:US12408536
申请日:2009-03-20
申请人: James M. Lee
发明人: James M. Lee
IPC分类号: G01P15/00
CPC分类号: G01P15/18 , G01P1/127 , G01P15/0891 , G11B19/043
摘要: A MEMS system includes an inertial sensor having sensor circuitry and management circuitry implemented with the sensor circuitry. The management circuitry includes a detection module that detects a condition of the system and a management module that coordinates the functionality of the inertial sensor and the detection module based on the detected condition.
摘要翻译: MEMS系统包括具有传感器电路和用传感器电路实现的管理电路的惯性传感器。 管理电路包括检测系统的状态的检测模块和基于检测到的条件来协调惯性传感器和检测模块的功能的管理模块。
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8.
公开(公告)号:US20110256126A1
公开(公告)日:2011-10-20
申请号:US13039201
申请日:2011-03-02
申请人: David P. Arnott , Mercedes Z. Balazs , Nico Ghilardi , Austin L. Gurney , Philip E. Haas , Sarah Hymowitz , James M. Lee , Wenjun Ouyang , Melissa A. Starovasnik , Yan Wu
发明人: David P. Arnott , Mercedes Z. Balazs , Nico Ghilardi , Austin L. Gurney , Philip E. Haas , Sarah Hymowitz , James M. Lee , Wenjun Ouyang , Melissa A. Starovasnik , Yan Wu
IPC分类号: A61K39/395 , A61P7/06 , A61P7/02 , A61P13/12 , A61P25/00 , A61P1/00 , A61P17/00 , A61P17/06 , A61P11/06 , A61P37/06 , A61P19/02 , A61P31/14
CPC分类号: C07K16/244 , A61K38/2073 , A61K2039/505 , C07K14/54 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C07K2319/40 , G01N2500/10 , G01N2800/24 , Y02A50/463
摘要: The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
摘要翻译: 本发明涉及一种新型天然存在的人类细胞因子,其由本文称为白细胞介素17A / F(IL-17A / F)的白细胞介素-17和白细胞介素-17F的异源二聚体组成。 本文还提供了包含那些核酸序列的载体和宿主细胞,包含与异源多肽序列融合的本发明多肽的嵌合多肽分子,与本发明的多肽结合的特异性抗体和用于产生 本发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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公开(公告)号:US07604659B2
公开(公告)日:2009-10-20
申请号:US10983742
申请日:2004-11-09
申请人: James M. Lee
发明人: James M. Lee
CPC分类号: A61B17/8605 , A61B17/0642 , A61B17/3468 , A61B17/8695 , A61B2017/0648
摘要: A minimally invasive orthopedic fastener for the repair of torn rotator cuff tendons. The rotator cuff is thereby repaired transarthroscopically to bring the tendons tight to the bone. This is accomplished by the use of a bone screw having a plurality of vanes pivotally mounted thereon. The vanes are pivotal from a retracted position extending along a length of the screw to an extended position extending substantially perpendicular to the shaft of the screw. The fastener is cannulated and taken down over a guide wire through a minimal incision to the operative site. Under direct vision, the screw is initially rotated into the bone by a screwdriver passed from the proximal end of the cannula to the distal end of the cannula to engage the fastener. The cannula is then partially withdrawn and by continued rotation of the screw, the vanes are moved into a position substantially perpendicular to the screw, thereby entrapping the tendons between the vanes of the screw and the bone.
摘要翻译: 一种用于修复撕裂的肩袖肌腱的微创矫形紧固件。 因此,肩袖可通过关节镜方式修复,以使肌腱紧密地粘到骨上。 这是通过使用具有枢转地安装在其上的多个叶片的骨螺钉来实现的。 叶片从沿着螺杆的长度延伸的缩回位置枢转到基本上垂直于螺杆的轴延伸的延伸位置。 将紧固件插管并通过导丝通过最小切口取下到手术部位。 在直接视觉下,螺钉最初通过从插管的近端传递到套管的远端的螺丝刀旋转到骨头中以接合紧固件。 然后套管部分地撤回并且通过螺杆的持续旋转,叶片被移动到基本上垂直于螺钉的位置,从而将腱夹在螺钉的叶片和骨之间。
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10.
公开(公告)号:US20090240462A1
公开(公告)日:2009-09-24
申请号:US12408532
申请日:2009-03-20
申请人: James M. Lee
发明人: James M. Lee
IPC分类号: G01P15/00
CPC分类号: G01P15/18 , G01P1/127 , G01P15/0891 , G11B19/043
摘要: A method of capturing an event in a MEMS accelerometer stores acceleration data in memory, detects a trigger event based on the acceleration data, and modifies a configuration of the memory so that a specified amount of the acceleration data is saved. A MEMS event capturing system includes an inertial sensor having sensor circuitry and event capturing circuitry implemented with the sensor circuitry. The event capturing circuitry includes memory capable of storing acceleration data received from the inertial sensor and a detection module operatively coupled with the memory that detects a trigger event. The event capturing circuitry also includes a management module operatively coupled with the memory and the detection module that modifies the memory's storage configuration when the trigger event is detected.
摘要翻译: 在MEMS加速度计中捕获事件的方法将加速度数据存储在存储器中,基于加速度数据检测触发事件,并修改存储器的配置,从而保存指定量的加速数据。 MEMS事件捕获系统包括惯性传感器,其具有用传感器电路实现的传感器电路和事件捕获电路。 事件捕获电路包括能够存储从惯性传感器接收的加速度数据的存储器和与该存储器可操作地耦合以检测触发事件的检测模块。 事件捕获电路还包括与存储器可操作地耦合的管理模块和当检测到触发事件时修改存储器的存储配置的检测模块。
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