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    Apparatus for testing blood/biomaterials/device interactions and characteristics
    1.
    发明授权
    Apparatus for testing blood/biomaterials/device interactions and characteristics 失效
    用于测试血液/生物材料/器件相互作用和特性的装置

    公开(公告)号：US5271898A

    公开(公告)日：1993-12-21

    申请号：US56450

    申请日：1993-05-03

    申请人： Michael F. Wolf ,  Paul V. Trescony ,  James R. Keogh

    发明人： Michael F. Wolf ,  Paul V. Trescony ,  James R. Keogh

    IPC分类号： G01N11/00 ,  G01N33/487 ,  G01N33/49

    CPC分类号： G01N11/00 ,  G01N33/49 ,  Y10T436/117497

    摘要： An apparatus designed to test blood, blood contacting biomaterials and devices such as materials and surface-modified materials; vascular grafts, stents, heart valves, catheters, leads, etc., for blood and material responses in vitro under physiological blood flow conditions. The apparatus consists of a stepper-motor driven circular disc(s), upon which a test vehicle, containing either the test materials, coating or device, is mounted. The test vehicle itself consists of a circular, closed-loop of polymer tubing containing a check valve.

    摘要翻译： 设计用于测试血液，血液接触生物材料和诸如材料和表面改性材料的装置的设备; 血管移植物，支架，心脏瓣膜，导管，引线等，用于在生理血流条件下的体外血液和物质反应。 该设备由步进电机驱动的圆盘组成，其上安装有测试材料，涂层或装置的测试车辆。 测试车辆本身由包含止回阀的聚合物管的圆形闭环组成。

    Method for attachment of biomolecules to medical devices surfaces
    3.
    发明授权
    Method for attachment of biomolecules to medical devices surfaces 失效
    将生物分子附着到医疗器械表面的方法

    公开(公告)号：US5925552A

    公开(公告)日：1999-07-20

    申请号：US67188

    申请日：1998-04-27

    申请人： James R. Keogh ,  Paul V. Trescony

    发明人： James R. Keogh ,  Paul V. Trescony

    IPC分类号： A61L27/24 ,  A61L27/28 ,  A61L27/34 ,  A61L29/08 ,  A61L31/08 ,  A61L31/10 ,  A61L33/00 ,  A61L33/12 ,  A61L33/18 ,  C12N11/00 ,  A61K38/43 ,  G01N33/543 ,  C07K17/00

    CPC分类号： A61L33/18 ,  A61L27/24 ,  A61L27/28 ,  A61L27/34 ,  A61L29/085 ,  A61L31/08 ,  A61L31/10 ,  A61L33/0011 ,  A61L33/0029 ,  A61L33/0047 ,  A61L33/0082 ,  A61L33/12 ,  A61L33/128 ,  Y10S530/81 ,  Y10S530/811 ,  Y10S530/812 ,  Y10S530/815 ,  Y10S530/816

    摘要： Methods are provided for forming a coating of an immobilized biomolecule on a surface of a medical device to impart improved biocompatibility for contacting tissue and bodily fluids. A biomolecule such as a glycoprotein having an unsubstituted amide moiety is combined with an amine forming agent to form an amine-functional biomolecule. The amine-functional biomolecule is combined with a medical device surface having a chemical moiety such as aldehyde, epoxide, isocyanate, 1,2-dicarbonyl, phosphate, sulphate or carboxylate to form a chemical bond immobilizing the biomolecule on the surface. The chemical bond may be combined with a reducing agent or a stabilizing agent. The aldehyde moiety may be formed by combining a periodate with a 2-aminoalcohol moiety or a 1,2-dihydroxy moiety. Alternatively, an amine-functional medical device surface is combined with a biomolecule having a chemical moiety that reacts with an amine moiety. In another embodiment, the amine-functional biomolecule is converted to a guanidino-functional biomolecule and is combined with a medical device surface having a chemical moiety that reacts with a guanidino moiety. Alternatively, an amine-functional medical device surface is converted to a guanidino-functional surface and is combined with a biomolecule having the chemical moiety. Biomolecules may be crosslinked by combining the amine-functional or guanidino-functional biomolecule with a biomolecule having a chemical moiety that forms a chemical bond with an amine moiety or a guanidino moiety.

    摘要翻译： 提供了用于在医疗装置的表面上形成固定的生物分子的涂层的方法，以提高用于接触组织和体液的生物相容性。 将具有未取代的酰胺部分的生物分子例如具有未取代的酰胺部分的糖蛋白与胺形成剂合并以形成胺官能的生物分子。 将胺官能的生物分子与具有化学部分的医疗装置表面结合，例如醛，环氧化物，异氰酸酯，1,2-二羰基，磷酸酯，硫酸酯或羧酸酯，以形成将生物分子固定在表面上的化学键。 化学键可以与还原剂或稳定剂组合。 醛部分可以通过将高碘酸酯与2-氨基醇部分或1,2-二羟基部分结合而形成。 或者，将胺官能医疗器械表面与具有与胺部分反应的化学部分的生物分子组合。 在另一个实施方案中，将胺官能的生物分子转化为胍基官能的生物分子，并与具有与胍基部分反应的化学部分的医疗装置表面组合。 或者，将胺官能医疗器械表面转化为胍基官能表面，并与具有化学部分的生物分子组合。 生物分子可以通过将胺官能或胍基官能的生物分子与具有与胺部分或胍基部分形成化学键的化学部分的生物分子结合而交联。

    Method for attachment of biomolecules to medical device surfaces
    6.
    发明授权
    Method for attachment of biomolecules to medical device surfaces 失效
    将生物分子附着到医疗器械表面的方法

    公开(公告)号：US06617142B2

    公开(公告)日：2003-09-09

    申请号：US09257543

    申请日：1999-02-24

    申请人： James R. Keogh ,  Paul V. Trescony

    发明人： James R. Keogh ,  Paul V. Trescony

    IPC分类号： C12N1100

    CPC分类号： A61L33/18 ,  A61L27/24 ,  A61L27/28 ,  A61L27/34 ,  A61L29/085 ,  A61L31/08 ,  A61L31/10 ,  A61L33/0011 ,  A61L33/0029 ,  A61L33/0047 ,  A61L33/0082 ,  A61L33/12 ,  A61L33/128 ,  C08L89/00 ,  Y10S530/81 ,  Y10S530/811 ,  Y10S530/812 ,  Y10S530/815 ,  Y10S530/816

    摘要： Methods are provided for forming a coating of an immobilized biomolecule on a surface of a medical device to impart improved biocompatibility for contacting tissue and bodily fluids. A biomolecule such as a glycoprotein having an unsubstituted amide moiety is combined with an amine forming agent to form an amine-functional biomolecule. The amine-functional biomolecule is combined with a medical device surface having a chemical moiety such as aldehyde, epoxide, isocyanate, 1,2-dicarbonyl, phosphate, sulphate or carboxylate to form a chemical bond immobilizing the biomolecule on the surface. The chemical bond may be combined with a reducing agent or a stabilizing agent. The aldehyde moiety may be formed by combining a periodate with a 2-aminoalcohol moiety or a 1,2-dihydroxy moiety. Alternatively, an amine-functional medical device surface is combined with a biomolecule having a chemical moiety that reacts with an amine moiety. In another embodiment, the amine-functional biomolecule is converted to a guanidino-functional biomolecule and is combined with a medical device surface having a chemical moiety that reacts with a guanidino moiety. Alternatively, an amine-functional medical device surface is converted to a guanidino-functional surface and is combined with a biomolecule having the chemical moiety. Biomolecules may be crosslinked by combining the amine-functional or guanidino-functional biomolecule with a biomolecule having a chemical moiety that forms a chemical bond with an amine moiety or a guanidino moiety.

    摘要翻译： 提供了用于在医疗装置的表面上形成固定的生物分子的涂层的方法，以提高用于接触组织和体液的生物相容性。 将具有未取代的酰胺部分的生物分子例如具有未取代的酰胺部分的糖蛋白与胺形成剂合并以形成胺官能的生物分子。 将胺官能的生物分子与具有化学部分的医疗装置表面结合，例如醛，环氧化物，异氰酸酯，1,2-二羰基，磷酸酯，硫酸酯或羧酸酯，以形成将生物分子固定在表面上的化学键。 化学键可以与还原剂或稳定剂组合。 醛部分可以通过将高碘酸酯与2-氨基醇部分或1,2-二羟基部分结合而形成。 或者，将胺官能医疗器械表面与具有与胺部分反应的化学部分的生物分子组合。 在另一个实施方案中，将胺官能的生物分子转化为胍基官能的生物分子，并与具有与胍基部分反应的化学部分的医疗装置表面组合。 或者，将胺官能医疗器械表面转化为胍基官能表面，并与具有化学部分的生物分子组合。 生物分子可以通过将胺官能或胍基官能的生物分子与具有与胺部分或胍基部分形成化学键的化学部分的生物分子结合而交联。