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公开(公告)号：US07439663B2
公开(公告)日：2008-10-21
申请号：US10747296
申请日：2003-12-29
IPC分类号： H01J1/00
CPC分类号： C02F1/325 , C02F2103/04 , C02F2201/3226 , C02F2201/326 , H01J61/09
摘要： A high pressure gas discharge device and methods of using the device as a UV gas discharge light source are disclosed. The device has a cathode covered partially with a dielectric layer which separates the cathode from an anode. A discharge device utilizes one or more microhollows in the uncovered part of the cathode. Methods of utilizing the discharge devise as a gas discharge light source for producing ultrapure water.
摘要翻译： 公开了一种高压气体放电装置和使用该装置作为UV气体放电光源的方法。 该器件具有阴极部分地覆盖有将阳极与阳极分开的电介质层的阴极。 放电装置利用阴极的未覆盖部分中的一个或多个微霍夫管。 利用放电设备作为制造超纯水的气体放电光源的方法。
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公开(公告)号：US20080174241A1
公开(公告)日：2008-07-24
申请号：US11959391
申请日：2007-12-18
CPC分类号： C02F1/325 , C02F2103/04 , C02F2201/3226 , C02F2201/326 , H01J61/09
摘要： A high pressure gas discharge device and methods of using the device as a UV gas discharge light source are disclosed. The device has a cathode covered partially with a dielectric layer which separates the cathode from an anode. A discharge device utilizes one or more microhollows in the uncovered part of the cathode. Methods of utilizing the discharge devise as a gas discharge light source for producing ultapure water.
摘要翻译： 公开了一种高压气体放电装置和使用该装置作为UV气体放电光源的方法。 该器件具有阴极部分地覆盖有将阳极与阳极分开的电介质层的阴极。 放电装置利用阴极的未覆盖部分中的一个或多个微霍夫管。 使用排放设备作为气体放电光源的方法，用于生产超纯水。
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公开(公告)号：US09173584B2
公开(公告)日：2015-11-03
申请号：US12809007
申请日：2008-12-19
申请人： Karl H. Schoenbach , Shu Xiao
发明人： Karl H. Schoenbach , Shu Xiao
CPC分类号： A61B5/0507 , A61B5/05 , A61B6/03 , A61B2576/00
摘要： An imaging and recordation system is provided. The system includes a high-power, focusing antenna for illuminating biological tissue. The system further includes a power source for powering the antenna. The system further includes a data acquisition module, for recording the dielectric properties of tissues illuminated by the high-power, focusing antenna. The system illuminates the tissues using ultrashort electrical pulses.
摘要翻译： 提供成像和记录系统。 该系统包括用于照射生物组织的大功率聚焦天线。 该系统还包括用于为天线供电的电源。 该系统还包括数据采集模块，用于记录由大功率聚焦天线照射的组织的介电特性。 系统使用超短电脉冲照射组织。
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4.发明授权Method and device for treatment of conditions aggravated by amyloid fibrils 有权用于治疗由淀粉样蛋白原纤维加重的病症的方法和装置公开(公告)号：US08948878B2
公开(公告)日：2015-02-03
申请号：US13161362
申请日：2011-06-15
申请人： Karl H. Schoenbach , Lesley Greene
发明人： Karl H. Schoenbach , Lesley Greene
CPC分类号： A61B18/12 , A61B18/1492 , A61B2018/00446 , A61N1/205 , A61N1/327
摘要： A method and device for treating a condition aggravated by the presence of amyloid fibrils is disclosed. The method includes applying a plurality of ultra-short pulses to target tissue comprising amyloid fibrils. The plurality of ultra-short pulses produce an electric field in the target tissue sufficient to change a molecular structure of the amyloid fibrils without causing the death, destruction, or serious injury of healthy cells surrounding the target tissue. For example, the plurality of ultra-short pulses can be sufficient to change the molecular structure of amyloid fibrils without causing apoptosis or necrosis of surrounding cells. The ultra-short pulses can be applied using an electrode device or a wideband antenna. The ultra-short pulses can have a duration ranging from 1 ps to 10 ns, an amplitude ranging from 100 V to 1 MV, and can apply an electrical field to the target tissue ranging from 1 kV/cm to 1 MV/cm.
摘要翻译： 公开了一种用于治疗由淀粉样蛋白原纤维存在而加重的病症的方法和装置。 该方法包括将多个超短脉冲应用于包含淀粉样蛋白原纤维的靶组织。 多个超短脉冲在目标组织中产生足以改变淀粉样蛋白原纤维的分子结构的电场，而不会导致靶组织周围的健康细胞的死亡，破坏或严重损伤。 例如，多个超短脉冲可以足以改变淀粉样蛋白原纤维的分子结构，而不引起周围细胞的凋亡或坏死。 可以使用电极装置或宽带天线来施加超短脉冲。 超短脉冲可以具有1ps至10ns的持续时间，振幅范围为100V至1MV，并且可以向1KV / cm至1MV / cm的目标组织施加电场。
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公开(公告)号：US08502108B2
公开(公告)日：2013-08-06
申请号：US12459806
申请日：2009-07-08
申请人： Abdel-Aleam H Mohamed , Karl H. Schoenbach , Robert Chiavarini , Robert O. Price , Juergen Kolb
发明人： Abdel-Aleam H Mohamed , Karl H. Schoenbach , Robert Chiavarini , Robert O. Price , Juergen Kolb
IPC分类号： B23K10/00
CPC分类号： H05H1/48 , H05H2001/2412
摘要： A microhollow cathode discharge assembly capable of generating a low temperature, atmospheric pressure plasma micro jet is disclosed. The microhollow assembly has two electrodes: an anode and a cathode separated by a dielectric. A microhollow gas passage is disposed through the three layers. In some embodiments, the passage is tapered such that the area at the first electrode is larger than the area at the second electrode. When a potential is placed across the electrodes and a gas is directed through the gas passage, then a low temperature micro plasma jet can be created at atmospheric pressure or above.
摘要翻译： 公开了能够产生低温大气压等离子体微射流的微气体阴极放电组件。 微孔组件具有两个电极：由电介质隔开的阳极和阴极。 微气体通道穿过三层。 在一些实施例中，通道是锥形的，使得第一电极处的面积大于第二电极处的面积。 当电极放置在电极上并且气体被引导通过气体通道时，则可以在大气压或更高压力下产生低温微等离子体射流。
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6.发明申请Method and System for Treating a Biological Target Region Using Pulsed Electromagnetic Radiation 审中-公开使用脉冲电磁辐射处理生物目标区域的方法和系统公开(公告)号：US20120089209A1
公开(公告)日：2012-04-12
申请号：US13378532
申请日：2010-04-29
申请人： Karl H. Schoenbach , Shu Xiao
发明人： Karl H. Schoenbach , Shu Xiao
IPC分类号： A61B18/18
CPC分类号： A61B18/1815
摘要： A method of treating a patient is described herein. The method can include the steps of identifying a target that contains biological tissue and directing one or more pulses of electromagnetic radiation at the target. The pulses of electromagnetic radiation can cause a temperature increase per unit of time in the biological tissue. Additionally, the temperature increase per unit of time can cause the change in the cell function in the biological tissue and can be within a range of approximately one degree Celsius per second to approximately one degree Celsius per microsecond.
摘要翻译： 本文描述了治疗患者的方法。 该方法可以包括以下步骤：识别包含生物组织的靶并且在靶上引导一个或多个电磁辐射脉冲。 电磁辐射的脉冲可能导致生物组织中每单位时间的温度升高。 此外，每单位时间的温度升高可导致生物组织中细胞功能的变化，并且可以在约1摄氏度/秒至约1摄氏度/微秒的范围内。
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公开(公告)号：US06433480B1
公开(公告)日：2002-08-13
申请号：US09579875
申请日：2000-05-27
IPC分类号： H01J6104
摘要： This invention improves the stability and control of high-pressure glow discharges by means of a microhllow cathode discharge. The microhollow cathode discharge, which is sustained between two closely spaced electrodes with an opening formed in the electrodes, serves as a plasma cathode for the high-pressure glow. Small variations in the microhollow cathode discharge voltage generate large variations in the microhollow cathode discharge current and consequently in the glow discharge current. In this mode of operation the electrical characteristic of this invention resembles that of a vacuum triode. Using the microhollow cathode discharge as a plasma cathode, stable, dc discharges in argon up to atmospheric pressures can be generated. Additionally, parallel operation of these discharges allows for the generation of large volume plasmas at high gas pressure through superposition of individual glow discharges. Thus, this invention allows simultaneous generation of relatively high electron densities at relatively low temperatures with stable, direct current, homogenous glow discharge plasma at relatively high pressure.
摘要翻译： 本发明通过微阴极放电改善了高压辉光放电的稳定性和控制。 保持在具有在电极中形成的开口的两个紧密间隔的电极之间的微气体阴极放电用作用于高压发光的等离子体阴极。 微气体阴极放电电压的微小变化在微气体阴极放电电流和辉光放电电流中产生大的变化。 在这种操作模式下，本发明的电气特性类似于真空三极管的特征。 使用微空气阴极放电作为等离子体阴极，可以产生在氩气中稳定的直流放电至大气压力。 此外，这些放电的并联运行允许通过叠加单个辉光放电而在高气体压力下产生大体积等离子体。 因此，本发明允许在相对较低的温度下以相当高的压力同时产生具有稳定的直流均匀辉光放电等离子体的较高的电子密度。
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公开(公告)号：US5765073A
公开(公告)日：1998-06-09
申请号：US626872
申请日：1996-04-03
IPC分类号： B41J2/44 , B41J2/447 , B41J2/45 , G03G15/32 , H01J17/06 , H01J17/10 , H01J17/12 , H01J17/49 , H01J61/09 , H01J61/70 , H05B41/38 , H05H1/24 , G03G15/043
CPC分类号： H05B41/38 , B41J2/4476 , B41J2/45 , G03G15/326 , H01J17/49 , H01J61/09 , H01J61/70 , G03G15/043
摘要： A field controlled plasma discharge display element is disclosed for light source use in single element and multiple element plasma discharge electrostatic printers. The display element includes a pair of hollow discharge electric field electrodes, and a third electrode positioned external to and aligned with the discharge electric field electrodes for generating a control electric field proximate to the discharge electric field. The control electric field is used to control the intensity of the plasma discharge by distorting the shape of the generated discharge electric field. The single element plasma discharge device is modulated in accordance with the image to be printed and the modulated output is scanned across the photoconductive surface to produce the latent image. The multi-element matrix hollow cathode discharge device, on the other hand, generates the latent image on the photoconductive surface using either a line imaging (using a one by y matrix discharge device) effect or a page imaging (using an x by y matrix discharge device) effect.
摘要翻译： 公开了用于单元件和多元等离子体放电静电打印机中的光源的场控制等离子体放电显示元件。 显示元件包括一对中空放电电场电极和位于放电电极电极外部并对准的第三电极，用于产生接近放电电场的控制电场。 控制电场用于通过使产生的放电电场的形状变形来控制等离子体放电的强度。 单元等离子体放电装置根据要印刷的图像进行调制，并且将调制输出横跨光电导表面扫描以产生潜像。 另一方面，多元素矩阵空心阴极放电装置使用线成像（使用一个一个矩阵放电装置）效应或页面成像（使用x×y矩阵）来生成感光表面上的潜像 放电装置）效果。
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9.发明授权Electron beam controlled bulk semiconductor switch with cathodoluminescent electron activation 失效具有阴极发光电子激活的电子束控制体半导体开关
公开(公告)号：US4916303A
公开(公告)日：1990-04-10
申请号：US351218
申请日：1989-05-15
IPC分类号： H01L31/0296 , H01L31/0304 , H01L31/09
CPC分类号： H01L31/02963 , H01L31/03042 , H01L31/09 , Y02E10/544
摘要： An electron beam controlled semiconductor switch is capable of carrying large currents without being restricted by the space charge limited current condition. The switch includes a block of semiconductor material having ohmic contacts connectable to first and second electrical conductors. Semi-insulating GaAs may be used as the semiconductor material. A shallow donor or acceptor doped layer may be formed at the surface receiving the electron beam for increased band-edge radiation. This recombination radiation ionizes, together with X-rays produced by Bremsstrahlung, the bulk of the semiconductor block to provide relatively high current density and current gain.
摘要翻译： 电子束控制半导体开关能够承受大电流而不受空间电荷限制电流条件的限制。 开关包括具有可连接到第一和第二电导体的欧姆接触的半导体材料块。 可以使用半绝缘GaAs作为半导体材料。 可以在接收电子束的表面处形成浅施主或受主掺杂层，以增加带边辐射。 该复合辐射与由Bremsstrahlung生产的X射线一起电离，半导体块的主体以提供相对高的电流密度和电流增益。
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公开(公告)号：US08822222B2
公开(公告)日：2014-09-02
申请号：US13073785
申请日：2011-03-28
IPC分类号： C12N15/87
摘要： A method and apparatus are provided for delivering an agent into a cell through the application of nanosecond pulse electric fields (“nsPEF's”). The method includes circuitry for delivery of an agent into a cell via known methods followed by the application of nanosecond pulse electric fields to said cell in order to facilitate entry of the agent into the nucleus of the cell. In a preferred embodiment, the present invention is directed to a method of enhancing gene expression in a cell comprising the application of nanosecond pulse electric fields to said cell. An apparatus for generating long and short pulses according to the present invention is also provided. The apparatus includes a pulse generator capable of producing a first pulse having a long duration and low voltage amplitude and a second pulse having a short duration and high voltage amplitude.
摘要翻译： 提供了一种方法和装置，用于通过施加纳秒脉冲电场（“nsPEF”）将试剂输送到电池中。 该方法包括用于通过已知方法将试剂递送到细胞中的电路，随后将纳秒脉冲电场施加到所述细胞，以便促进试剂进入细胞核。 在优选的实施方案中，本发明涉及增强细胞中基因表达的方法，其包括向所述细胞施加纳秒脉冲电场。 还提供了根据本发明的用于产生长脉冲和短脉冲的装置。 该装置包括能够产生具有长持续时间和低电压振幅的第一脉冲和具有短持续时间和高电压振幅的第二脉冲的脉冲发生器。
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