Methods, compositions, and apparatuses for forming macrocyclic compounds
    3.
    发明申请
    Methods, compositions, and apparatuses for forming macrocyclic compounds 有权
    用于形成大环化合物的方法,组合物和装置

    公开(公告)号:US20070217965A1

    公开(公告)日:2007-09-20

    申请号:US11059796

    申请日:2005-02-17

    IPC分类号: B01J8/00

    摘要: This invention relates to methods, compositions, and apparatuses for producing macrocyclic compounds. First, one or more reactants are provided in a reaction medium, which are capable of forming the macrocyclic compound through a desired reaction pathway that includes at least cyclization, and which are further capable of forming undesired oligomers through a undesired reaction pathway that includes undesirable oligomerization. Oligomerization of such reactions in the reaction medium is modulated to reduce formation of undesired oligomers and/or to reduce separation of the undesired oligomers from the reaction medium, relative to a corresponding unmodulated oligomerization reaction, thereby maximizing yields of the macrocyclic compound. The macrocyclic compound so formed is then recovered from the reaction medium. Preferably, the macrocyclic compound spontaneously separates from the reaction medium via phase separation. More preferably, the macrocyclic compound spontaneous precipitates from the reaction medium and therefore can be easily recovered by simple filtration.

    摘要翻译: 本发明涉及生产大环化合物的方法,组合物和装置。 首先,在反应介质中提供一种或多种反应物,其能够通过包含至少环化的所需反应途径形成大环化合物,并且还能够通过不期望的反应途径形成不期望的低聚物,所述反应途径包括不期望的低聚反应 。 相对于相应的未调节的低聚反应,调节反应介质中这种反应的低聚反应以减少不需要的低聚物的形成和/或减少不需要的低聚物与反应介质的分离,从而最大化大环化合物的产率。 然后从反应介质中回收如此形成的大环化合物。 优选地,大环化合物通过相分离从反应介质自发分离。 更优选地,大环化合物从反应介质中自发沉淀,因此可以通过简单的过滤容易地回收。