摘要:
The present invention provides a compound of formula (II): where R1 is a substituted alkyl, heterocyclic, or cycloalkyl, group, and pharmaceutically acceptable salts, enantiomers, stereoisomers, rotamers, tautomers, diastereomers, or racemates thereof, and pharmaceutical compositions comprising these compounds. Also provided are methods of using these compounds to treat a disease or condition mediated by CDK9, such as cancers and other conditions described herein.
摘要:
Benzoxazole and benzothiazole compounds and their oxides, esters, prodrugs, solvates, and pharmaceutically acceptable salts thereof are disclosed. Compositions of the compounds, either alone or in combination with at least one additional therapeutic agent, with a pharmaceutically acceptable carrier, and uses of the compounds, either alone or in combination with at least one additional therapeutic agent are also disclosed. The embodiments are useful for inhibiting cellular proliferation, inhibiting the growth and/or metathesis of tumors, treating or preventing cancer, treating or preventing degenerating bone diseases such as rheumatoid arthritis, and/or inhibiting molecules such as CSF 1R.
摘要:
The present invention provides novel urea mimics and analogues of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, W, and R6 are as defined herein. These compounds are selective inhibitors of the human P2Y1 receptor which can be used as medicaments.
摘要:
The present invention provides novel ureas containing N-aryl or N-heteroaryl substituted heterocycles of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, B, D and W are as defined herein. These compounds are selective inhibitors of the human P2Y1 receptor which can be used as medicaments.
摘要:
One embodiment of the invention includes a method of monitoring behavior of a group of casino game players. The method includes identifying a group of casino game players for profiling; profiling the game players based upon their actions in a gaming establishment; and providing options for game play and service to the game players based upon their profile.
摘要:
In an embodiment of the present invention, a technique is provided for remote attestation. An interface maps a device via a bus to an address space of a chipset in a secure environment for an isolated execution mode. The secure environment is associated with an isolated memory area accessible by at least one processor. The at least one processor operates in one of a normal execution mode and the isolated execution mode. A communication storage corresponding to the address space allows the device to exchange security information with the at least one processor in the isolated execution mode in a remote attestation.
摘要:
A processor includes a feature control unit to enable or disable one or more processor features individually in response to a user selectable setting. The feature control unit is adapted to disable the processor feature(s) if the user setting has not been updated in accordance with an input regardless of the value of the user setting prior to the update and to enable or disable the processor feature(s) in accordance with the updated user setting after it has been updated. The feature control unit may also include a lock unit to prevent changes to the updated user setting and a software feature selection unit to enable or disable processor features in response to a software feature selection setting and, optionally, only enable or disable processor features whose corresponding updated user setting is user enabled. The feature control unit may also include mechanisms to detect illegal feature selection conditions.
摘要:
In one embodiment, a method of remote attestation for a special mode of operation. The method comprises storing an audit log within protected memory of a platform. The audit log is a listing of data representing each of a plurality of IsoX software modules loaded into the platform. The audit log is retrieved from the protected memory in response to receiving a remote attestation request from a remotely located platform. Then, the retrieved audit log is digitally signed to produce a digital signature for transfer to the remotely located platform.
摘要:
Delivering a Direct Proof private key to a device installed in a client computer system in the field may be accomplished in a secure manner without requiring significant non-volatile storage in the device. A unique pseudo-random value is generated and stored in the device at manufacturing time. The pseudo-random value is used to generate a symmetric key for encrypting a data structure holding a Direct Proof private key and a private key digest associated with the device. The resulting-encrypted data structure is stored on a removable storage medium (such as a CD), and distributed to the owner of the client computer system. When the device is initialized on the client computer system, the system checks if a localized encrypted data structure is present in the system. If not, the system obtains the associated encrypted data structure from the removable storage medium. The device decrypts the encrypted data structure using a symmetric key regenerated from its stored pseudo-random value to obtain the Direct Proof private key. If the private key is valid, it may be used for subsequent authentication processing by the device in the client computer system.
摘要:
The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.