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    Estradiol derivative and estratopone containing sustained release intraocular implants and related methods
    1.
    发明申请
    Estradiol derivative and estratopone containing sustained release intraocular implants and related methods 审中-公开
    雌二醇衍生物和雌激素含持续释放眼内植入物及相关方法

    公开(公告)号：US20050244471A1

    公开(公告)日：2005-11-03

    申请号：US10837379

    申请日：2004-04-30

    申请人： Jane Guo Shiah ,  Paul Dickinson

    发明人： Jane Guo Shiah ,  Paul Dickinson

    IPC分类号： A61K9/00 ,  A61K9/20 ,  A61K31/565 ,  A61K31/69 ,  A61F2/00 ,  A61K31/56

    CPC分类号： A61K9/0051 ,  A61K9/204 ,  A61K31/565

    摘要： Biocompatible intraocular implants include an anti-angiogenic agent, such as estradiol derivative or an estratopone and a biodegradable polymer that is effective to facilitate release of the anti-angiogenic agent into an eye for an extended period of time. The therapeutic agents of the implants may be associated with a biodegradable polymer matrix, such as a matrix that is substantially free of a polyvinyl alcohol. The implants may be placed in an eye to treat or reduce the occurrence of one or more ocular conditions, such as angiogenisis, ocular tumors, and the like.

    摘要翻译： 生物相容性眼内植入物包括抗血管生成剂，例如雌二醇衍生物或雌激素和可生物降解的聚合物，其有效促进抗血管生成剂长时间释放到眼睛中。 植入物的治疗剂可以与可生物降解的聚合物基质相关，例如基本上不含聚乙烯醇的基质。 植入物可以放置在眼睛中以治疗或减少一种或多种眼部病症（例如血管生成，眼部肿瘤等）的发生。