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    Biochip platform including dielectric particle layer and optical assay apparatus using the same
    1.
    发明授权
    Biochip platform including dielectric particle layer and optical assay apparatus using the same 失效
    生物芯片平台包括电介质颗粒层和使用其的光学测定装置

    公开(公告)号：US07662614B2

    公开(公告)日：2010-02-16

    申请号：US11330566

    申请日：2006-01-11

    申请人： Jang-seok Ma ,  Heon-su Jeon ,  Soo-hyung Choi ,  In-ho Lee ,  Fu Wang

    发明人： Jang-seok Ma ,  Heon-su Jeon ,  Soo-hyung Choi ,  In-ho Lee ,  Fu Wang

    IPC分类号： C12M1/34

    CPC分类号： G01N21/6428 ,  B82Y20/00

    摘要： Provided are a biochip platform for biochemically analyzing a sample such as DNA or protein, including a dielectric particle layer, and an optical assay apparatus including the same. The biochip platform includes the dielectric particle layer uniformly formed on a substrate. The particle uniformity of the dielectric particle layer enables good wavelength separation of fluorescence signal, and the large surface area of the dielectric particle layer guarantees better amplifications efficiency of fluorescence signal. Furthermore, the biochip platform shows good economical efficiency due to easy fabrication process, and is particularly useful in an optical assay apparatus for analyzing a biochemical sample due to good assay efficiency.

    摘要翻译： 提供了用于生物化学分析诸如DNA或蛋白质的样品（包括电介质颗粒层）的生物芯片平台和包括其的光学测定装置。 生物芯片平台包括均匀地形成在基板上的电介质颗粒层。 电介质颗粒层的粒子均匀性使得荧光信号的波长分离良好，并且电介质颗粒层的大的表面积保证了荧光信号的更好的放大效率。 此外，生物芯片平台由于易于制造工艺而显示出良好的经济效率，并且在由于良好的测定效率分析生物化学样品的光学测定装置中特别有用。

    Biochip platform including dielectric particle layer and optical assay apparatus using the same
    2.
    发明申请
    Biochip platform including dielectric particle layer and optical assay apparatus using the same 失效
    生物芯片平台包括电介质颗粒层和使用其的光学测定装置

    公开(公告)号：US20060189002A1

    公开(公告)日：2006-08-24

    申请号：US11330566

    申请日：2006-01-11

    申请人： Jang-seok Ma ,  Heon-su Jeon ,  Soo-hyung Choi ,  In-ho Lee ,  Fu Wang

    发明人： Jang-seok Ma ,  Heon-su Jeon ,  Soo-hyung Choi ,  In-ho Lee ,  Fu Wang

    IPC分类号： H01L21/00 ,  H01L21/20 ,  H01L29/82

    CPC分类号： G01N21/6428 ,  B82Y20/00

    摘要： Provided are a biochip platform for biochemically analyzing a sample such as DNA or protein, including a dielectric particle layer, and an optical assay apparatus including the same. The biochip platform includes the dielectric particle layer uniformly formed on a substrate. The particle uniformity of the dielectric particle layer enables good wavelength separation of fluorescence signal, and the large surface area of the dielectric particle layer guarantees better amplification efficiency of fluorescence signal. Furthermore, the biochip platform shows good economical efficiency due to easy fabrication process, and is particularly useful in an optical assay apparatus for analyzing a biochemical sample due to good assay efficiency.

    摘要翻译： 提供了用于生物化学分析诸如DNA或蛋白质的样品（包括电介质颗粒层）的生物芯片平台和包括其的光学测定装置。 生物芯片平台包括均匀地形成在基板上的电介质颗粒层。 电介质颗粒层的粒子均匀性使得荧光信号的波长分离良好，并且电介质颗粒层的大的表面积保证了荧光信号的更好的放大效率。 此外，生物芯片平台由于易于制造工艺而显示出良好的经济效率，并且在由于良好的测定效率分析生物化学样品的光学测定装置中特别有用。

    Method of increasing discrimination for single base mismatch using hurdle DNA and artificially mismatched probe
    4.
    发明申请
    Method of increasing discrimination for single base mismatch using hurdle DNA and artificially mismatched probe 有权
    使用障碍DNA和人为错配探针增加单碱基错配的鉴别方法

    公开(公告)号：US20060183142A1

    公开(公告)日：2006-08-17

    申请号：US11335229

    申请日：2006-01-19

    申请人： Soo-hyung Choi ,  Jang-seok Ma ,  Joon-shik Park

    发明人： Soo-hyung Choi ,  Jang-seok Ma ,  Joon-shik Park

    IPC分类号： C12Q1/68 ,  C12P19/34

    CPC分类号： C12Q1/6827 ,  C12Q2537/113 ,  C12Q2527/107 ,  C12Q2525/185

    摘要： A method of increasing discrimination for a target DNA having a polymorphic site is provided. The method includes: synthesizing a first probe by artificially substituting a base of a probe which is fully complementary to a target DNA having a polymorphic site by a mismatched natural base and synthesizing a second probe by artificially substituting a base of another probe having a single base mismatch at a position corresponding to the polymorphic site of the target DNA with a mismatched natural base; synthesizing a first hurdle DNA which is fully complementary to the first probe and is shorter than the first probe and a second hurdle DNA which is fully complementary to the second probe and is shorter than the second probe; immobilizing the first and second probes on a substrate; hybridizing the immobilized first and second probes with the first and second hurdle DNAs, respectively; and hybridizing the target DNA with the hybrids. The addition of a hurdle DNA and variation of a probe base can improve an ability of discriminating a single base mismatch.

    摘要翻译： 提供了增加具有多态位点的靶DNA的鉴别方法。 该方法包括：通过人造取代与具有多态性位点的目标DNA完全互补的基因的错配天然碱合成第一探针，并通过人造地取代具有单个碱基的另一种探针的碱合成第二探针 在对应于具有错配天然碱基的目标DNA的多态性位点的位置处的错配; 合成与第一探针完全互补并且比第一探针短的第一障碍DNA和与第二探针完全互补并且短于第二探针的第二障碍DNA; 将第一和第二探针固定在基底上; 将固定的第一和第二探针分别与第一和第二障碍DNA杂交; 并将靶DNA与杂交体杂交。 障碍DNA的添加和探针碱基的变异可以提高鉴别单一碱基不匹配的能力。

    Kit for positively detecting toxic material
    5.
    发明授权
    Kit for positively detecting toxic material 有权
    用于积极检测有毒物质的试剂盒

    公开(公告)号：US08367367B2

    公开(公告)日：2013-02-05

    申请号：US13155944

    申请日：2011-06-08

    申请人： Jung-im Han ,  Soo-hyung Choi ,  Soo-suk Lee ,  Sung-ouk Jung ,  Joon-shik Park ,  Ki-eun Kim

    发明人： Jung-im Han ,  Soo-hyung Choi ,  Soo-suk Lee ,  Sung-ouk Jung ,  Joon-shik Park ,  Ki-eun Kim

    IPC分类号： C12Q1/26

    CPC分类号： G01N33/5079 ,  G01N2333/90209

    摘要： A method of positively detecting toxic materials within a sample, the method including contacting sub-mitochondrial particles having competent mitochondrial enzymes formed from inner membranes of mitochondria, an electron donor which transmits electrons to an electron transfer system of the sub-mitochondrial particles and the sample, and forming reaction resultants, adjusting a pH of a pH indicator which change color according to a change in pH, adding the pH indicators to each reaction resultant and identifying color changes of the pH indicator. Also provided is a kit for positively detecting toxic materials within a sample.

    摘要翻译： 一种积极检测样品内的有毒物质的方法，该方法包括使具有由线粒体内膜形成的感受态线粒体酶的亚线粒体颗粒，将电子传递到亚线粒体颗粒的电子转移系统的电子给体和样品 ，并形成反应产物，调节pH指示剂的pH值，根据pH的变化改变颜色，向每个反应产物添加pH指示剂并鉴定pH指示剂的颜色变化。 还提供了用于积极检测样品中有毒物质的试剂盒。

    Carbon nanotube gas sensor and method of manufacturing the same
    6.
    发明授权
    Carbon nanotube gas sensor and method of manufacturing the same 有权
    碳纳米管气体传感器及其制造方法

    公开(公告)号：US08052855B2

    公开(公告)日：2011-11-08

    申请号：US11745522

    申请日：2007-05-08

    申请人： Jung-im Han ,  Soo-hyung Choi ,  Jeong-hee Lee ,  Soo-suk Lee ,  Jeong-na Heo

    发明人： Jung-im Han ,  Soo-hyung Choi ,  Jeong-hee Lee ,  Soo-suk Lee ,  Jeong-na Heo

    IPC分类号： G01N27/403 ,  G01N27/414

    CPC分类号： G01N27/127 ,  Y10S977/742 ,  Y10S977/743 ,  Y10S977/953 ,  Y10S977/957

    摘要： A carbon nanotube (“CNT”) gas sensor includes a substrate, an insulating layer formed on the substrate, electrodes formed on the insulating layer, and CNT barriers that protrude higher than the electrodes in spaces between the electrodes to form gas detecting spaces. A method of manufacturing the gas sensor includes forming an insulating layer on a substrate, forming an electrode pattern on the insulating layer, coating CNT paste having a thickness greater than a thickness of electrodes in the electrode pattern on the electrodes and the insulating layer, and patterning and firing the carbon nanotube paste, including using a photolithography method, to retain only portions of the CNT paste coated on spaces between the electrodes.

    摘要翻译： 碳纳米管（“CNT”）气体传感器包括基板，形成在基板上的绝缘层，形成在绝缘层上的电极和在电极之间的空间中比电极突出的CNT势垒，以形成气体检测空间。 制造气体传感器的方法包括在基板上形成绝缘层，在绝缘层上形成电极图案，在电极和绝缘层上涂覆厚度大于电极图案的电极厚度的CNT浆料，以及 包括使用光刻法构图和烧制碳纳米管糊，仅保留涂覆在电极之间的间隙上的部分CNT浆料。

    Microfluidic device using centrifugal force and pump to control fluid movement, microfluidic system comprising the same and method of manufacturing the microfluidic device
    7.
    发明授权
    Microfluidic device using centrifugal force and pump to control fluid movement, microfluidic system comprising the same and method of manufacturing the microfluidic device 有权
    使用离心力和泵来控制流体运动的微流体装置，包括其的微流体系统和制造微流体装置的方法

    公开(公告)号：US07819138B2

    公开(公告)日：2010-10-26

    申请号：US11869835

    申请日：2007-10-10

    申请人： Hun-joo Lee ,  Nam Huh ,  Soo-suk Lee ,  Sung-ouk Jung ,  Soo-hyung Choi

    发明人： Hun-joo Lee ,  Nam Huh ,  Soo-suk Lee ,  Sung-ouk Jung ,  Soo-hyung Choi

    IPC分类号： F15C1/04

    CPC分类号： G05D7/0694 ,  Y10T29/494 ,  Y10T137/0753 ,  Y10T137/2191 ,  Y10T137/86187

    摘要： The microfluidic device includes a rotatable platform, a plurality of connection ports disposed at a portion of the platform proximate to a shaft connection hole, the plurality of connection ports capable of being connected to an external connector for selectively injecting and discharging fluid and being closed by the connector, a trap chamber disposed at a portion of the platform further away from the shaft connection hole than the plurality of connection ports, the trap chamber including an inlet connected with at least one connection port of the plurality of connection ports, an outlet connected with another connection port of the plurality of connection ports and structures which enlarge a contact area with the fluid and a temporary storage including an inlet connected with the outlet of the trap chamber and an outlet connected with another connection port of the plurality of connection ports.

    摘要翻译： 所述微流体装置包括可旋转平台，多个连接端口，设置在所述平台的靠近轴连接孔的部分处，所述多个连接端口能够连接到外部连接器，用于选择性地注入和排出流体并且由 所述连接器，设置在所述平台的远离所述轴连接孔的所述平台部分处的所述收集室，所述收集室包括与所述多个连接端口中的至少一个连接端口连接的入口，所述入口连接到所述入口 多个连接端口中的另一个连接端口和扩大与流体的接触面积的结构以及包括与捕集室的出口连接的入口的临时存储器和与多个连接端口中的另一连接端口连接的出口。

    METHOD AND KIT FOR POSITIVELY DETECTING TOXIC MATERIAL
    8.
    发明申请
    METHOD AND KIT FOR POSITIVELY DETECTING TOXIC MATERIAL 有权
    用于阳极检测毒性材料的方法和工具包

    公开(公告)号：US20070259392A1

    公开(公告)日：2007-11-08

    申请号：US11609979

    申请日：2006-12-13

    申请人： Jung-im Han ,  Soo-hyung Choi ,  Soo-suk Lee ,  Sung-ouk Jung ,  Joon-shik Park ,  Ki-eun Kim

    发明人： Jung-im Han ,  Soo-hyung Choi ,  Soo-suk Lee ,  Sung-ouk Jung ,  Joon-shik Park ,  Ki-eun Kim

    IPC分类号： C12Q1/26 ,  C12Q1/32

    CPC分类号： G01N33/5079 ,  G01N2333/90209

    摘要： A method of positively detecting toxic materials within a sample, the method including contacting sub-mitochondrial particles having competent mitochondrial enzymes formed from inner membranes of mitochondria, an electron donor which transmits electrons to an electron transfer system of the sub-mitochondrial particles and the sample, and forming reaction resultants, adjusting a pH of a pH indicator which change color according to a change in pH, adding the pH indicators to each reaction resultant and identifying color changes of the pH indicator. Also provided is a kit for positively detecting toxic materials within a sample.

    摘要翻译： 一种积极检测样品内的有毒物质的方法，该方法包括使具有由线粒体内膜形成的感受态线粒体酶的亚线粒体颗粒，将电子传递到亚线粒体颗粒的电子转移系统的电子给体和样品 ，并形成反应产物，调节pH指示剂的pH值，根据pH的变化改变颜色，向每个反应产物添加pH指示剂并鉴定pH指示剂的颜色变化。 还提供了用于积极检测样品中有毒物质的试剂盒。

    Method of electrically detecting biomolecule
    10.
    发明申请
    Method of electrically detecting biomolecule 失效
    电气检测生物分子的方法

    公开(公告)号：US20060246478A1

    公开(公告)日：2006-11-02

    申请号：US11345790

    申请日：2006-02-02

    申请人： Kyu-tae Yoo ,  Sung-ouk Jung ,  Jun-hong Min ,  Ji-na Namgoong ,  Soo-hyung Choi ,  Jeo-young Shim

    发明人： Kyu-tae Yoo ,  Sung-ouk Jung ,  Jun-hong Min ,  Ji-na Namgoong ,  Soo-hyung Choi ,  Jeo-young Shim

    IPC分类号： C12Q1/68 ,  G01N33/53 ,  C12M1/34

    CPC分类号： G01N33/54306

    摘要： Provided is a method of sensing biomolecules using a bioFET, the method including: forming a layer including Au on a gate of the bioFET; forming a probe immobilized on a substrate separated from the gate by a predetermined distance, and a biomolecule having a thiol group (—SH) which is incompletely bonded to the probe; reacting the probe with a sample including a target molecule; and measuring a current flowing in a channel region between a source and a drain of the bioFET.

    摘要翻译： 提供了一种使用bioFET感测生物分子的方法，该方法包括：在bioFET的栅极上形成包含Au的层; 形成固定在与栅极分离预定距离的基板上的探针，以及具有与探针不完全结合的硫醇基（-SH）的生物分子; 使探针与包含靶分子的样品反应; 以及测量在bioFET的源极和漏极之间的沟道区域中流动的电流。