公开(公告)号：US20230203078A1

公开(公告)日：2023-06-29

申请号：US17912418

申请日：2021-03-15

Applicant: JANSSEN BIOPHARMA, INC.

Inventor： Sergei Gryaznov ,  Vivek Kumar Rajwanshi ,  Ioannis N. Houpis

IPC: C07H1/00 ,  C07H19/06 ,  C07H19/16 ,  C12N15/11 ,  C07H19/10 ,  C07H19/20

CPC classification number: C07H1/00 ,  C07H19/06 ,  C07H19/16 ,  C12N15/111 ,  C07H19/10 ,  C07H19/20 ,  C12N2310/11 ,  C12N2310/14 ,  C12N2330/30

Abstract: Provided herein are novel synthetic routes to amines through an oxime intermediate, e.g., 3′-N nucleosides and novel and intermediate compounds produced during these synthetic procedures.

公开(公告)号：US12077757B2

公开(公告)日：2024-09-03

申请号：US17063080

申请日：2020-10-05

Applicant: Janssen Biopharma, Inc.

Inventor： Sergei Gryaznov ,  Leonid Beigelman ,  Antitsa Dimitrova Stoycheva ,  Saul Martinez Montero ,  Jin Hong ,  Rajendra K. Pandey ,  Vivek Kumar Rajwanshi ,  Lakshmipathi Pandarinathan ,  Yi Jin ,  Bharat Baral

IPC: C07H21/02 ,  A61K31/712 ,  A61K31/7125 ,  A61K47/54 ,  A61P31/20 ,  C12N15/11 ,  C12N15/113

CPC classification number: C12N15/1131 ,  A61K31/712 ,  A61K31/7125 ,  A61K47/549 ,  A61P31/20 ,  C07H21/02 ,  C12N15/111 ,  C12N2310/11 ,  C12N2310/314 ,  C12N2310/3145 ,  C12N2310/315 ,  C12N2310/3231 ,  C12N2310/341 ,  C12N2310/344 ,  C12N2310/351 ,  C12N2320/32 ,  C12N2310/321 ,  C12N2310/3525

Abstract: Modified oligonucleotides comprising modifications at the 2′ and/or 3′ position(s) along with methods of making and use, e.g., against HBV are disclosed.

公开(公告)号：US10793859B2

公开(公告)日：2020-10-06

申请号：US15705137

申请日：2017-09-14

Applicant: Janssen BioPharma, Inc.

Inventor： Sergei Gryaznov ,  Leonid Beigelman ,  Antitsa Dimitrova Stoycheva ,  Saul Martinez Montero ,  Jin Hong ,  Rajendra K. Pandey ,  Vivek Kumar Rajwanshi ,  Lakshmipathi Pandarinathan ,  Yi Jin ,  Bharat Baral

IPC: C07H21/02 ,  C07H21/04 ,  C12N15/113 ,  C12N15/11 ,  A61K31/712 ,  A61K47/54 ,  A61P31/20 ,  A61K31/7125

Abstract: Modified oligonucleotides comprising modifications at the 2′ and/or 3′ positions(s) along with methods of making and use, e.g., against HBV are disclosed.

公开(公告)号：US10696708B2

公开(公告)日：2020-06-30

申请号：US15895872

申请日：2018-02-13

Applicant: Janssen BioPharma, Inc.

Inventor： Natalia Dyatkina ,  Guangyi Wang ,  Leonid Beigelman ,  Vivek Kumar Rajwanshi

IPC: A01N43/04 ,  A61K31/70 ,  C07H19/06 ,  C07H19/20 ,  C07H19/16 ,  C07H19/10 ,  A61K31/7072 ,  A61K31/7068 ,  A61K31/708 ,  A61K45/06 ,  A61K31/7076

Abstract: Disclosed herein are nucleosides, nucleotides and analogs thereof, pharmaceutical compositions that include one or more of nucleosides, nucleotides and analogs thereof, and methods of synthesizing the same. Also disclosed herein are methods of ameliorating and/or treating a paramyxovirus viral infection, with a nucleoside, a nucleotide and an analog thereof.

公开(公告)号：US11180524B2

公开(公告)日：2021-11-23

申请号：US16647236

申请日：2018-09-14

Applicant: Janssen BioPharma, Inc.

Inventor： Sergei Gryaznov ,  Jin Hong ,  Vivek Kumar Rajwanshi ,  Leonid Beigelman

IPC: C07H19/10 ,  C07H19/00 ,  C07H19/20 ,  C07H1/00

Abstract: The present disclosure relates to compounds and compositions containing 5′-phosphoramidite nucleoside monomers of formulae (I) and (II), and methods of making and use, wherein the substituents are as defined in the appended claims.

公开(公告)号：US12030907B2

公开(公告)日：2024-07-09

申请号：US17514168

申请日：2021-10-29

Applicant: Janssen BioPharma, Inc.

Inventor： Sergei Gryaznov ,  Jin Hong ,  Vivek Kumar Rajwanshi ,  Leonid Beigelman

IPC: C07H19/10 ,  C07H1/00 ,  C07H19/20

CPC classification number: C07H19/10 ,  C07H1/00 ,  C07H19/20

Abstract: A method of making a compound represented by Formula (I):




includes a reducing step, a protecting step, and a phosphitylating step, where X is NH; Y is OCF3, —O(CR42)aCR43, —O(CR42)bOCR43, or —O(CR42)b—CR4═CR42; Z is H; B is adenine (A), guanine (G), thymine (T), cytosine (C), uracil (U), 5-methylcytosine (5-me-C), or a protected version of A, G, T, C, U, or 5-me-C; each R1 is independently C1-6 alkyl or cycloalkyl; R2 is CH2CH2CN or C1-6 alkyl; or R1 and R2 together form an optionally substituted C1-6 cycloalkyl; R3 is H or PG; PG is a protecting group; R4 is independently in each instance H or F; a is 1 or 2; and b is 1, 2, or 3.