公开(公告)号：US12054534B2

公开(公告)日：2024-08-06

申请号：US16949078

申请日：2020-10-13

Applicant: Janssen Biotech, Inc.

Inventor： Rosa Cardoso ,  Michael Diem ,  Shalom Goldberg ,  Linus Hyun ,  Steven Jacobs ,  Donna Klein ,  Karyn O'Neil ,  Tracy Spinka-Doms

IPC: G01N33/574 ,  A61K51/08 ,  C07K14/78 ,  A61K38/00

CPC classification number: C07K14/78 ,  A61K51/08 ,  G01N33/57434 ,  A61K38/00 ,  G01N2333/705

Abstract: PSMA binding FN3 domains, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

公开(公告)号：US20160347840A1

公开(公告)日：2016-12-01

申请号：US15148371

申请日：2016-05-06

Applicant: Janssen Biotech, Inc.

Inventor： Glenn Anderson ,  Rosa Cardoso ,  Michael Diem ,  Francois Gaudet ,  Shalom Goldberg ,  Benjamin Harman ,  Linus Hyun ,  Steven Jacobs ,  Donna Klein ,  Yingzhe Li ,  Jinquan Luo ,  Ronan McDaid ,  Jill Mooney ,  Jennifer Nemeth-Seay ,  Karyn O'Neil ,  Steven Pomerantz ,  Galla Chandra Rao ,  Tracy Spinka-Doms ,  Alexey Teplyakov ,  Leopoldo Luistro ,  Sheng-Jiun Wu

IPC: C07K16/28 ,  C07K14/78 ,  A61K45/06 ,  C07K16/30 ,  A61K39/395

CPC classification number: C07K16/2809 ,  A61K45/06 ,  A61K47/6803 ,  A61K47/6869 ,  A61K49/0045 ,  A61K49/0058 ,  A61K2039/505 ,  C07K14/78 ,  C07K16/3069 ,  C07K2317/24 ,  C07K2317/31 ,  C07K2317/524 ,  C07K2317/53 ,  C07K2317/55 ,  C07K2317/70 ,  C07K2317/73 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2318/20 ,  C07K2319/30 ,  C12Y304/17021

Abstract: Provided herein are isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof wherein a FN3 domain specifically binds human prostate specific membrane antigen (PSMA) and a second antigen-binding site immunospecifically binds CD3. Also described are fusion proteins and related polynucleotides capable of encoding the provided fusion proteins and, cells expressing the provided fusion proteins. In addition, methods of using the provided isolated CD3×PSMA-bispecific antigen-binding molecules or bispecific antigen-binding fragment thereof are described.

Abstract translation: 本文提供了分离的CD3×PSMA-双特异性抗原结合分子或其双特异性抗原结合片段，其中FN3结构域特异性结合人前列腺特异性膜抗原（PSMA）和第二抗原结合位点免疫特异性结合CD3。 还描述了能够编码所提供的融合蛋白的融合蛋白和相关多核苷酸，以及表达所提供的融合蛋白的细胞。 此外，描述了使用所提供的分离的CD3×PSMA-双特异性抗原结合分子或其双特异性抗原结合片段的方法。

公开(公告)号：US20160326232A1

公开(公告)日：2016-11-10

申请号：US15148312

申请日：2016-05-06

Applicant: Janssen Biotech, Inc.

Inventor： Cardosa Rosa ,  Michael Diem ,  Shalom Goldberg ,  Linus Hyun ,  Steven Jacobs ,  Donna Klein ,  Karyn O'Neil ,  Tracy Spinka-Doms

IPC: C07K14/78 ,  G01N33/573 ,  A61K51/08

CPC classification number: C07K14/78 ,  A61K38/00 ,  A61K51/08 ,  G01N33/57434 ,  G01N2333/705

Abstract: PSMA binding FN3 domains, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.

Abstract translation: PSMA结合FN3结构域，它们的缀合物，编码分子的分离的核苷酸，载体，宿主细胞及其制备方法可用于治疗分子的产生以及疾病和病症的治疗和诊断。

公开(公告)号：US20210147510A1

公开(公告)日：2021-05-20

申请号：US16949078

申请日：2020-10-13

Applicant: Janssen Biotech, Inc.

Inventor： Rosa Cardoso ,  Michael Diem ,  Shalom Goldberg ,  Linus Hyun ,  Steven Jacobs ,  Donna Klein ,  Karyn O'Neil ,  Tracy Spinka-Doms

IPC: C07K14/78 ,  A61K51/08 ,  G01N33/574

Abstract: PSMA binding FN3 domains, their conjugates, isolated nucleotides encoding the molecules, vectors, host cells, and methods of making thereof are useful in the generation of therapeutic molecules and treatment and diagnosis of diseases and disorders.