公开(公告)号：US12071466B2

公开(公告)日：2024-08-27

申请号：US16936719

申请日：2020-07-23

Applicant: Janssen Biotech, Inc.

Inventor： Raymond Brittingham ,  Rajkumar Ganesan ,  Sherry La Porte ,  John T. Lee ,  Jinquan Luo ,  Theresa McDevitt ,  Fei Shen ,  Sanjaya Singh ,  Degang Song ,  Sathyadevi Venkataramani ,  Fang Yi ,  Yonghong Zhao

IPC: A61K35/17 ,  A61K38/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/40

CPC classification number: C07K14/7051 ,  A61K35/17 ,  C07K14/70517 ,  C07K14/70596 ,  C07K16/40 ,  A61K38/00 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03

Abstract: The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a human Kallikrein-2 (hK2), and immunoresponsive cells comprising such CARs, for the treatment of cancer.

公开(公告)号：US20230151083A1

公开(公告)日：2023-05-18

申请号：US17917916

申请日：2021-04-07

Applicant: Janssen Biotech, Inc.

Inventor： Kristof Van Kolen ,  Marc Mercken ,  Rupesh Nanjunda ,  Sanjaya Singh ,  Sherry La Porte ,  Jinquan Luo ,  Pharavee Jaiprasart ,  Sathya Venkataramani ,  Rajkumar Ganesan

IPC: C07K16/18 ,  G01N33/68 ,  A61P25/28 ,  C12N15/63

CPC classification number: C07K16/18 ,  G01N33/6896 ,  A61P25/28 ,  C12N15/63 ,  C07K2317/56

Abstract: Monoclonal anti-PHF-tau antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, methods of producing the antibodies and using the antibodies for treating or preventing conditions such as tauopathies.