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公开(公告)号：US20230250171A1
公开(公告)日：2023-08-10
申请号：US18307146
申请日：2023-04-26
Applicant: Janssen Biotech, Inc.
Inventor： Patrick John Doonan , Rajkumar Ganesan , Mehabaw Getahun Derebe , Sathyadevi Venkataramani , Sanjaya Singh , Iqbal S. Grewal , Karla R. Wiehagen
CPC classification number: C07K16/2803 , C07K16/2809 , C07K16/2815 , C07K16/2827 , C07K16/2866 , C07K16/2818 , A61P35/00 , A61K39/4631 , A61K39/464411 , C07K2317/622 , C07K2319/31 , C07K2317/31 , C07K2317/22 , C07K2317/21
Abstract: The invention provides antigen binding domains that bind myeloid cell surface antigen CD33 protein comprising the antigen binding domains that bind CD33, polynucleotides encoding them, vectors, host cells, methods of making and using them.
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2.发明申请公开(公告)号：US20210040210A1
公开(公告)日：2021-02-11
申请号：US16937285
申请日：2020-07-23
Applicant: Janssen Biotech, Inc.
Inventor： Rajkumar Ganesan , John Lee , Jinquan Luo , Theresa McDevitt , Fei Shen , Degang Song , Raymond Brittingham , Sathyadevi Venkataramani , Sanjaya Singh , Yonghong Zhao , Fang Yi , Sherry Lynn La Porte
Abstract: Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vectors, host cells, and methods of making and using them.
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公开(公告)号：US12071466B2
公开(公告)日：2024-08-27
申请号：US16936719
申请日：2020-07-23
Applicant: Janssen Biotech, Inc.
Inventor： Raymond Brittingham , Rajkumar Ganesan , Sherry La Porte , John T. Lee , Jinquan Luo , Theresa McDevitt , Fei Shen , Sanjaya Singh , Degang Song , Sathyadevi Venkataramani , Fang Yi , Yonghong Zhao
IPC: A61K35/17 , A61K38/00 , C07K14/705 , C07K14/725 , C07K16/40
CPC classification number: C07K14/7051 , A61K35/17 , C07K14/70517 , C07K14/70596 , C07K16/40 , A61K38/00 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2319/02 , C07K2319/03
Abstract: The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a human Kallikrein-2 (hK2), and immunoresponsive cells comprising such CARs, for the treatment of cancer.
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4.发明公开公开(公告)号：US20240124583A1
公开(公告)日：2024-04-18
申请号：US18397711
申请日：2023-12-27
Applicant: Janssen Biotech, Inc.
Inventor： Rajkumar Ganesan , John Lee , Jinquan Luo , Theresa McDevitt , Fei Shen , Degang Song , Raymond Brittingham , Sathyadevi Venkataramani , Sanjaya Singh , Yonghong Zhao , Fang Yi , Sherry Lynn LaPorte
CPC classification number: C07K16/2809 , C07K16/34 , C07K2317/14 , C07K2317/31 , C07K2317/565
Abstract: Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vectors, host cells, and methods of making and using them.
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Patent Agency Ranking
5.发明授权公开(公告)号：US12077585B2
公开(公告)日：2024-09-03
申请号：US16937285
申请日：2020-07-23
Applicant: Janssen Biotech, Inc.
Inventor： Rajkumar Ganesan , John Lee , Jinquan Luo , Theresa McDevitt , Fei Shen , Degang Song , Raymond Brittingham , Sathyadevi Venkataramani , Sanjaya Singh , Yonghong Zhao , Fang Yi , Sherry Lynn La Porte
CPC classification number: C07K16/2809 , C07K16/34 , C07K2317/14 , C07K2317/31 , C07K2317/565
Abstract: Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vectors, host cells, and methods of making and using them.
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公开(公告)号：US20230365683A1
公开(公告)日：2023-11-16
申请号：US18307076
申请日：2023-04-26
Applicant: Janssen Biotech, Inc.
Inventor： Patrick John Doonan , Rajkumar Ganesan , Mehabaw Getahun Derebe , Sathyadevi Venkataramani , Sanjaya Singh , Iqbal S. Grewal , Karla R. Wiehagen
CPC classification number: C07K16/2803 , A61K39/4631 , A61K39/464411 , A61K39/4611 , C07K16/2809 , A61K51/1096 , A61K51/1027 , A61P35/00 , C07K2317/622 , C07K2317/22 , C07K2317/92 , C07K2317/24 , C07K2317/31 , C07K2317/77 , C07K2317/73
Abstract: The invention provides antigen binding domains that bind myeloid cell surface antigen CD33 protein comprising the antigen binding domains that bind CD33, polynucleotides encoding them, vectors, host cells, methods of making and using them.
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公开(公告)号：US20210130440A1
公开(公告)日：2021-05-06
申请号：US17061590
申请日：2020-10-02
Applicant: Janssen Biotech, Inc.
Inventor： Sathyadevi Venkataramani , Rajkumar Ganesan , Sanjaya Singh
Abstract: The invention relates to methods of optimizing an antibody with enhanced stability, the method comprising mutating somatic hypermutation with germline amino acid residues and therefore providing enhanced thermal stability, improved biophysical properties and shelf-life while preserving the affinity for the antigen.
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公开(公告)号：US11866499B2
公开(公告)日：2024-01-09
申请号：US16417889
申请日：2019-05-21
Applicant: Janssen Biotech, Inc.
Inventor： Philip Cooper , Robin Ernst , Rajkumar Ganesan , Colleen Kane , Michael Russell , Sanjaya Singh , Sathyadevi Venkataramani , Sheng-Jiun Wu
CPC classification number: C07K16/2809 , A61P35/00 , A61K45/06
Abstract: The disclosure provided herein relates to monospecific and multispecific anti-TMEFF2 antibodies, and methods of producing and using the described antibodies.
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公开(公告)号：US20230365684A1
公开(公告)日：2023-11-16
申请号：US18307127
申请日：2023-04-26
Applicant: Janssen Biotech, Inc.
Inventor： Patrick John Doonan , Rajkumar Ganesan , Mehabaw Getahun Derebe , Sathyadevi Venkataramani , Sanjaya Singh , Iqbal S. Grewal , Karla R. Wiehagen
CPC classification number: C07K16/2803 , A61K39/4631 , A61K39/464411 , A61K39/4611 , C07K16/2809 , A61K51/1096 , A61K51/1027 , A61P35/00 , C07K2317/622 , C07K2317/22 , C07K2317/92 , C07K2317/24 , C07K2317/31 , C07K2317/73 , C07K2317/77
Abstract: The invention provides antigen binding domains that bind myeloid cell surface antigen CD33 protein comprising the antigen binding domains that bind CD33, polynucleotides encoding them, vectors, host cells, methods of making and using them.
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