公开(公告)号：US12162951B2

公开(公告)日：2024-12-10

申请号：US17376830

申请日：2021-07-15

Applicant: Janssen Biotech, Inc.

Inventor： Zemeda Ainekulu ,  Qiang Chen ,  Ellen Chi ,  Wilson Edwards ,  Matt Husovsky ,  Ann Lacombe ,  Quynh Nguyen ,  Paul H. Kim ,  H. Mimi Zhou ,  John T. Lee

IPC: G01N33/53 ,  C07H21/04 ,  C07K1/22 ,  C07K16/42 ,  C12N5/02 ,  C12N15/00 ,  C12P21/06 ,  G01N33/68

Abstract: In certain aspects, the disclosure relates to anti-idiotype antibodies and antigen-binding portions thereof that specifically bind a KL2B413 containing protein, e.g., an antibody or antigen-binding portions thereof. In some aspects, the anti-idiotype antibodies and antigen-binding portions of the present disclosure can be used in methods to detect and quantify cells expressing chimeric antigen receptors that include KL2B413.

公开(公告)号：US12071466B2

公开(公告)日：2024-08-27

申请号：US16936719

申请日：2020-07-23

Applicant: Janssen Biotech, Inc.

Inventor： Raymond Brittingham ,  Rajkumar Ganesan ,  Sherry La Porte ,  John T. Lee ,  Jinquan Luo ,  Theresa McDevitt ,  Fei Shen ,  Sanjaya Singh ,  Degang Song ,  Sathyadevi Venkataramani ,  Fang Yi ,  Yonghong Zhao

IPC: A61K35/17 ,  A61K38/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/40

CPC classification number: C07K14/7051 ,  A61K35/17 ,  C07K14/70517 ,  C07K14/70596 ,  C07K16/40 ,  A61K38/00 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03

Abstract: The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a human Kallikrein-2 (hK2), and immunoresponsive cells comprising such CARs, for the treatment of cancer.

公开(公告)号：US12030937B2

公开(公告)日：2024-07-09

申请号：US17376874

申请日：2021-07-15

Applicant: Janssen Biotech, Inc.

Inventor： Ellen Chi ,  Wilson Edwards ,  Matt Husovsky ,  Ann Lacombe ,  Christian Martinez ,  H. Mimi Zhou ,  John T. Lee

IPC: C07K16/28 ,  G01N33/50

CPC classification number: C07K16/28 ,  G01N33/5005 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/567 ,  G01N2333/705

Abstract: In certain aspects, the disclosure relates to anti-idiotype antibodies and antigen-binding portions thereof that specifically bind a GP5B83 containing protein, e.g., an antibody or antigen-binding portions thereof. In some aspects, the anti-idiotype antibodies and antigen-binding portions of the present disclosure can be used in methods to detect and quantify cells expressing chimeric antigen receptors that include GP5B83.