公开(公告)号：US20210040210A1

公开(公告)日：2021-02-11

申请号：US16937285

申请日：2020-07-23

Applicant: Janssen Biotech, Inc.

Inventor： Rajkumar Ganesan ,  John Lee ,  Jinquan Luo ,  Theresa McDevitt ,  Fei Shen ,  Degang Song ,  Raymond Brittingham ,  Sathyadevi Venkataramani ,  Sanjaya Singh ,  Yonghong Zhao ,  Fang Yi ,  Sherry Lynn La Porte

IPC: C07K16/28 ,  C07K16/34

Abstract: Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vectors, host cells, and methods of making and using them.

公开(公告)号：US12077585B2

公开(公告)日：2024-09-03

申请号：US16937285

申请日：2020-07-23

Applicant: Janssen Biotech, Inc.

Inventor： Rajkumar Ganesan ,  John Lee ,  Jinquan Luo ,  Theresa McDevitt ,  Fei Shen ,  Degang Song ,  Raymond Brittingham ,  Sathyadevi Venkataramani ,  Sanjaya Singh ,  Yonghong Zhao ,  Fang Yi ,  Sherry Lynn La Porte

IPC: C07K16/28 ,  C07K16/34

CPC classification number: C07K16/2809 ,  C07K16/34 ,  C07K2317/14 ,  C07K2317/31 ,  C07K2317/565

Abstract: Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vectors, host cells, and methods of making and using them.

公开(公告)号：US12071466B2

公开(公告)日：2024-08-27

申请号：US16936719

申请日：2020-07-23

Applicant: Janssen Biotech, Inc.

Inventor： Raymond Brittingham ,  Rajkumar Ganesan ,  Sherry La Porte ,  John T. Lee ,  Jinquan Luo ,  Theresa McDevitt ,  Fei Shen ,  Sanjaya Singh ,  Degang Song ,  Sathyadevi Venkataramani ,  Fang Yi ,  Yonghong Zhao

IPC: A61K35/17 ,  A61K38/00 ,  C07K14/705 ,  C07K14/725 ,  C07K16/40

CPC classification number: C07K14/7051 ,  A61K35/17 ,  C07K14/70517 ,  C07K14/70596 ,  C07K16/40 ,  A61K38/00 ,  C07K2317/53 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2319/02 ,  C07K2319/03

Abstract: The present disclosure provides for chimeric antigen receptors (CARs) that specifically target a human Kallikrein-2 (hK2), and immunoresponsive cells comprising such CARs, for the treatment of cancer.

公开(公告)号：US20240124583A1

公开(公告)日：2024-04-18

申请号：US18397711

申请日：2023-12-27

Applicant: Janssen Biotech, Inc.

Inventor： Rajkumar Ganesan ,  John Lee ,  Jinquan Luo ,  Theresa McDevitt ,  Fei Shen ,  Degang Song ,  Raymond Brittingham ,  Sathyadevi Venkataramani ,  Sanjaya Singh ,  Yonghong Zhao ,  Fang Yi ,  Sherry Lynn LaPorte

IPC: C07K16/28 ,  C07K16/34

CPC classification number: C07K16/2809 ,  C07K16/34 ,  C07K2317/14 ,  C07K2317/31 ,  C07K2317/565

Abstract: Embodiments of the present invention provide isolated proteins comprising antigen binding domains that bind kallikrein related peptidase 2 (hK2), including monospecific and bispecific antibodies. Additional embodiments of the invention provide polynucleotides encoding the hk2-specific proteins, vectors, host cells, and methods of making and using them.