公开(公告)号：US20190112342A1

公开(公告)日：2019-04-18

申请号：US16077213

申请日：2017-02-10

申请人： The University of Chicago ,  Janssen Pharmaceuticals, Inc.

发明人： Dominique Missiakas ,  Olaf Schneewind ,  Carla Emolo ,  Lena Thomer ,  Molly McAdow ,  Jeroen Geurtsen ,  Mark De Been

IPC分类号： C07K14/31 ,  A61K39/085 ,  A61K39/40 ,  C07K16/12

摘要： Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Coagulase (Coa). Further aspects relate to immunogenic compositions comprising at least one Staphylococcal coagulase R Domain, wherein the R Domain is 80% identical in sequence to a R Domain.

公开(公告)号：US11931405B2

公开(公告)日：2024-03-19

申请号：US17815705

申请日：2022-07-28

申请人： Janssen Pharmaceuticals, Inc. ,  GlaxoSmithKline Biologicals S.A.

发明人： Jeroen Geurtsen ,  Jan Theunis Poolman ,  Kellen Cristhina Fae ,  Pieter Jan Burghout ,  Eveline Marleen Weerdenburg ,  Patricia Ibarra Yon ,  Darren Robert Abbanat ,  Stefan Jochen Kemmler ,  Michael Thomas Kowarik ,  Manuela Mally ,  Veronica Gambillara Fonck ,  Martin Edward Braun ,  Maria Paula Carranza Sandmeier

IPC分类号： A61K39/108 ,  A61K39/00 ,  A61P31/04 ,  A61P37/04 ,  C07K14/21 ,  C07K19/00 ,  C12N9/10

CPC分类号： A61K39/0258 ,  A61P31/04 ,  A61P37/04 ,  C07K14/21 ,  C07K19/00 ,  C12N9/1051 ,  C12Y204/01 ,  A61K2039/575 ,  A61K2039/6037

摘要： A bioconjugate of an E. coli glucosylated O4 antigen polysaccharide covalently linked to a carrier protein and compositions thereof are provided. Also provided are recombinant host cells for producing the bioconjugate, and methods of producing the bioconjugate using the recombinant host cells. The recombinant host cells contain a nucleic acid encoding a glucosyl transferase capable of modifying the E. coli O4 antigen with glucose branching to produce the glucosylated O4 antigen polysaccharide. Bioconjugates of an E. coli glucosylated O4 antigen polysaccharide described herein can be used alone or in combination with one or more additional E. coli O-antigen polysaccharides to induce antibodies against an E. coli glucosylated antigen, and to vaccinate a subject against extra-intestinal pathogenic E. coli (ExPEC).

公开(公告)号：US20220227819A1

公开(公告)日：2022-07-21

申请号：US17645344

申请日：2021-12-21

申请人： The University of Chicago ,  Janssen Pharmaceuticals, Inc.

发明人： Dominique Missiakas ,  Olaf Schneewind ,  Carla Emolo ,  Lena Thomer ,  Molly McAdow ,  Jeroen Geurtsen ,  Mark De Been

IPC分类号： C07K14/31 ,  C07K16/12 ,  C07K16/40 ,  C12Q1/689 ,  A61K39/085 ,  A61K39/40

摘要： Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Coagulase (Coa). Further aspects relate to immunogenic compositions comprising at least one Staphylococcal coagulase R Domain, wherein the R Domain is 80% identical in sequence to a R Domain.

公开(公告)号：US11725028B2

公开(公告)日：2023-08-15

申请号：US17573249

申请日：2022-01-11

申请人： Janssen Pharmaceuticals, Inc.

发明人： Jan Grijpstra ,  Marleen Eveline Weerdenburg ,  Jeroen Geurtsen ,  Cristhina Kellen Fae ,  Jakob Louris Feitsma

IPC分类号： A61K39/108 ,  A61K39/00 ,  C07K14/245

CPC分类号： C07K14/245 ,  A61K39/00 ,  A61K39/0258

摘要： Polypeptides comprising a FimH lectin domain comprising at least one an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject in need thereof by administration of the polypeptide are further described.

公开(公告)号：US11214600B2

公开(公告)日：2022-01-04

申请号：US16077213

申请日：2017-02-10

申请人： The University of Chicago ,  Janssen Pharmaceuticals, Inc.

发明人： Dominique Missiakas ,  Olaf Schneewind ,  Carla Emolo ,  Lena Thomer ,  Molly McAdow ,  Jeroen Geurtsen ,  Mark De Been

IPC分类号： A61K39/02 ,  A61K39/00 ,  A61K45/00 ,  A61K47/00 ,  A61K39/085 ,  A61K38/00 ,  C07K2/00 ,  C07K4/00 ,  C07K5/00 ,  C07K7/00 ,  C07K14/00 ,  C07K16/00 ,  C07K17/00 ,  C07K14/31 ,  C07K16/12 ,  C07K16/40 ,  C12Q1/689 ,  A61K39/40

摘要： Embodiments concern methods and compositions for treating or preventing a bacterial infection, particularly infection by a Staphylococcus bacterium. Aspects include methods and compositions for providing a passive immune response against the bacteria. In certain embodiments, the methods and compositions involve an antibody that binds Coagulase (Coa). Further aspects relate to immunogenic compositions comprising at least one Staphylococcal coagulase R Domain, wherein the R Domain is 80% identical in sequence to a R Domain.

公开(公告)号：US20190275134A1

公开(公告)日：2019-09-12

申请号：US16299907

申请日：2019-03-12

申请人： Janssen Pharmaceuticals, Inc ,  Janssen Vaccines & Prevention B.V.

发明人： Jan Theunis Poolman ,  Jeroen Geurtsen ,  Kellen Cristhina Fae

IPC分类号： A61K39/108

摘要： Compositions and methods are described for vaccinating against E. coli urinary tract infections. The compositions contain a FimH polypeptide, one or more conjugates containing E. coli O-antigens polysaccharide covalently coupled to a carrier protein, and an adjuvant.

公开(公告)号：US12012435B2

公开(公告)日：2024-06-18

申请号：US17814966

申请日：2022-07-26

申请人： Janssen Pharmaceuticals, Inc.

发明人： Jan Grijpstra ,  Marleen Eveline Weerdenburg ,  Jeroen Geurtsen ,  Cristhina Kellen Fae ,  Jakob Louris Feitsma

IPC分类号： A61K39/02 ,  A61K39/108 ,  C07K14/195 ,  C07K14/245 ,  C07K16/12

CPC分类号： C07K14/195 ,  A61K39/025 ,  A61K39/0258 ,  A61K39/0266 ,  C07K14/245 ,  C07K16/1232

摘要： Polypeptides comprising a FimH lectin domain comprising an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject in need thereof by administration of the polypeptide are further described.

公开(公告)号：US11491220B2

公开(公告)日：2022-11-08

申请号：US16822403

申请日：2020-03-18

申请人： Janssen Pharmaceuticals, Inc. ,  GlaxoSmithKline Biologicals S.A.

发明人： Jeroen Geurtsen ,  Pieter Jan Burghout ,  Eveline Marleen Weerdenburg ,  Jan Theunis Poolman ,  Kellen Cristhina Fae ,  Patricia Ibarra Yon ,  Darren Robert Abbanat ,  Stefan Jochen Kemmler ,  Michael Thomas Kowarik ,  Manuela Mally ,  Veronica Gambillara Fonck ,  Martin Edward Braun ,  Maria Paula Carranza Sandmeier

IPC分类号： A61K39/095 ,  A61K39/085 ,  A61K39/102 ,  A61K39/104 ,  A61K39/09 ,  A61K39/02 ,  A61K47/64 ,  A61K39/00 ,  A61K39/385 ,  A61K39/108

摘要： Methods of producing bioconjugates of O-antigen polysaccharides covalently linked to a carrier protein using recombinant host cells are provided. The recombinant host cells used in the methods described herein encode a particular oligosaccharyl transferase enzyme depending on the O-antigen polysaccharide bioconjugate to be produced. The oligosaccharyl transferase enzymes can be PglB oligosaccharyl transferase or variants thereof. Also provided are compositions containing the bioconjugates, and methods of using the bioconjugates and compositions described herein to vaccinate a subject against extra-intestinal pathogenic E. coli. (ExPEC).

公开(公告)号：US11446370B2

公开(公告)日：2022-09-20

申请号：US16822340

申请日：2020-03-18

申请人： Janssen Pharmaceuticals, Inc. ,  GlaxoSmithKline Biologicals S.A.

发明人： Jeroen Geurtsen ,  Jan Theunis Poolman ,  Kellen Cristhina Fae ,  Pieter Jan Burghout ,  Eveline Marleen Weerdenburg ,  Patricia Ibarra Yon ,  Darren Robert Abbanat ,  Stefan Jochen Kemmler ,  Michael Thomas Kowarik ,  Manuela Mally ,  Veronica Gambillara Fonck ,  Martin Edward Braun ,  Maria Paula Carranza Sandmeier

IPC分类号： A61K39/108 ,  A61P37/04 ,  A61P31/04 ,  C07K14/21 ,  C07K19/00 ,  C12N9/10 ,  A61K39/00

摘要： A bioconjugate of an E. coli glucosylated O4 antigen polysaccharide covalently linked to a carrier protein and compositions thereof are provided. Also provided are recombinant host cells for producing the bioconjugate, and methods of producing the bioconjugate using the recombinant host cells. The recombinant host cells contain a nucleic acid encoding a glucosyl transferase capable of modifying the E. coli O4 antigen with glucose branching to produce the glucosylated O4 antigen polysaccharide. Bioconjugates of an E. coli glucosylated O4 antigen polysaccharide described herein can be used alone or in combination with one or more additional E. coli O-antigen polysaccharides to induce antibodies against an E. coli glucosylated antigen, and to vaccinate a subject against extra-intestinal pathogenic E. coli (ExPEC).

公开(公告)号：US11421003B2

公开(公告)日：2022-08-23

申请号：US17150025

申请日：2021-01-15

申请人： Janssen Pharmaceuticals, Inc.

发明人： Jan Grijpstra ,  Marleen Eveline Weerdenburg ,  Jeroen Geurtsen ,  Cristhina Kellen Fae ,  Jakob Louris Feitsma

IPC分类号： A61K39/102 ,  A61K39/02 ,  C07K14/195 ,  A61K39/108

摘要： Polypeptides comprising a FimH lectin domain comprising an amino acid mutation that causes the FimH lectin domain to be in the low affinity conformation for mannose are described. Pharmaceutical compositions which comprise such polypeptides and methods of stimulating an immune response in a subject in need thereof by administration of the polypeptide are further described.