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公开(公告)号：US09134977B2
公开(公告)日：2015-09-15
申请号：US12714236
申请日：2010-02-26
IPC分类号： G06F9/45
CPC分类号： G06F8/443
摘要： A computer-implemented method and apparatus for optimizing conditional code by identifying conditional code in a source code, adding a no-operation instruction to an executable code corresponding to the source code in place of the conditional code, adding an entry to a table to pair the no-operation instruction to the conditional code, compiling the conditional code, and storing the compiled conditional code separate from the executable code. A computer-implemented method and apparatus to optimize conditional code by loading an executable code to be executed, checking whether conditional code associated with the executable code is enabled for execution, looking up a location of a no-operation instruction in a table and a location of a compiled conditional code in the table, and replacing the no-operation instruction in the executable code with the compiled conditional code.
摘要翻译： 一种用于通过识别源代码中的条件代码来优化条件代码的计算机实现的方法和装置，将不操作指令添加到与源代码相对应的可执行代码以代替条件代码，将条目添加到表中 对条件代码的无操作指令，编译条件代码，以及将编译的条件代码与可执行代码分开存储。 一种通过加载要执行的可执行代码来优化条件代码的计算机实现的方法和装置，检查与可执行代码相关联的条件代码是否被执行，查找表中的无操作指令的位置和位置 的编译条件代码，并用可编译的条件代码替换可执行代码中的无操作指令。
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公开(公告)号：US20110214110A1
公开(公告)日：2011-09-01
申请号：US12714236
申请日：2010-02-26
IPC分类号： G06F9/45
CPC分类号： G06F8/443
摘要： A computer-implemented method and apparatus for optimizing conditional code by identifying conditional code in a source code, adding a no-operation instruction to an executable code corresponding to the source code in place of the conditional code, adding an entry to a table to pair the no-operation instruction to the conditional code, compiling the conditional code, and storing the compiled conditional code separate from the executable code. A computer-implemented method and apparatus to optimize conditional code by loading an executable code to be executed, checking whether conditional code associated with the executable code is enabled for execution, looking up a location of a no-operation instruction in a table and a location of a compiled conditional code in the table, and replacing the no-operation instruction in the executable code with the compiled conditional code.
摘要翻译： 一种用于通过识别源代码中的条件代码来优化条件代码的计算机实现的方法和装置，将不操作指令添加到与源代码相对应的可执行代码以代替条件代码，将条目添加到表中 对条件代码的无操作指令，编译条件代码，以及将编译的条件代码与可执行代码分开存储。 一种计算机实现的方法和装置，通过加载要执行的可执行代码来优化条件代码，检查与可执行代码相关联的条件代码是否被执行，查找表中的无操作指令的位置和位置 的编译条件代码，并用可编译的条件代码替换可执行代码中的无操作指令。
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公开(公告)号：US08748182B2
公开(公告)日：2014-06-10
申请号：US12746674
申请日：2008-12-08
IPC分类号： C12N15/11 , C07K14/705
CPC分类号： C07K14/723 , C12N15/102 , C12N15/1058 , G01N33/6842 , G01N2333/726
摘要： Aspects of the invention relate to methods of producing a mutant GPCR with increased stability relative to its parent GPCR.
摘要翻译： 本发明的方面涉及相对于其母体GPCR具有增加的稳定性的突变体GPCR的制备方法。
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公开(公告)号：US20120270230A1
公开(公告)日：2012-10-25
申请号：US13493898
申请日：2012-06-11
申请人： Richard Henderson , Christopher Gordon Tate , Francesca Magnani , Maria Josefa Serrano-Vega , Yoko Shibata , Antony Johannes Wame , Malcolm Peter Weir
发明人： Richard Henderson , Christopher Gordon Tate , Francesca Magnani , Maria Josefa Serrano-Vega , Yoko Shibata , Antony Johannes Wame , Malcolm Peter Weir
IPC分类号： C07K14/705 , C12N1/21 , C07K1/14 , C07K17/00 , C12N1/19 , C12N15/12 , G01N33/566
CPC分类号： C07K14/723 , C12N15/1034 , G01N33/566 , G01N2333/726
摘要： The invention relates to mutant G-protein coupled receptors with increased conformational stability, and methods of use thereof. In some aspects, polynucleotides encoding the mutant G-protein coupled receptors are provided. In some aspects, host cells comprising the polynucleotides are provided. In some aspects, the invention relates to crystallized forms of the mutant G-protein coupled receptors, and methods of preparing the same.
摘要翻译： 本发明涉及具有增加的构象稳定性的突变型G蛋白偶联受体及其使用方法。 在一些方面，提供了编码突变型G蛋白偶联受体的多核苷酸。 在一些方面，提供了包含多核苷酸的宿主细胞。 在一些方面，本发明涉及突变型G蛋白偶联受体的结晶形式及其制备方法。
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5.发明授权Efficient method of sharing diode pins on multi-channel remote diode temperature sensors 有权在多通道远程二极管温度传感器上共享二极管引脚的高效方法公开(公告)号：US07252432B1
公开(公告)日：2007-08-07
申请号：US10974664
申请日：2004-10-27
申请人： Richard Henderson , Mehmet Aslan
发明人： Richard Henderson , Mehmet Aslan
摘要： A multi-channel remote diode temperature sensor includes a variable current supply configured to provide a base or an elevated current, a bias circuit, an analog-to-digital converter having a first and second input terminals, a logic block and a switch arrangement. The switch arrangement cooperates with the logic block to electrically connect the current supply, bias circuit and analog-to-digital input terminals to first and second data pins. Pairs of anode-to-cathode connected remote diodes in electrical communication with the data pins are monitored by measuring the difference in forward voltages at the two currents. Reversal of the configuration of the switch arrangement paths permits monitoring of the other member of the anode-to-cathode remote diode.
摘要翻译： 多通道远程二极管温度传感器包括被配置为提供基极或升高的电流的可变电流源，偏置电路，具有第一和第二输入端的模数转换器，逻辑块和开关装置。 开关装置与逻辑块配合，将电流源，偏置电路和模拟 - 数字输入端电连接到第一和第二数据引脚。 通过测量两个电流的正向电压差，监控与数据引脚电气连接的阳极至阴极连接的远程二极管对。 开关布置路径的配置的反转允许监视阳极至阴极远端二极管的另一个元件。
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6.发明授权公开(公告)号：US07082377B1
公开(公告)日：2006-07-25
申请号：US10792112
申请日：2004-03-03
申请人： Mehmet Aslan , Qing Feng Ren , Richard Henderson
发明人： Mehmet Aslan , Qing Feng Ren , Richard Henderson
CPC分类号： G01K7/01 , G01K2219/00
摘要： A temperature measurement circuit for a dual junction temperature sensor is provided. The temperature measurement circuit is configured to provide separate bias currents to the junctions in the temperature sensor. The temperature measurement circuit includes two signal channels configured to provide an intermediate differential signal from a differential input signal that is received from the temperature sensor. Also, the temperature measurement circuit may include one or more multiplexer circuits that are configured to control the intermediate differential signal. The temperature sensor circuit further includes a control circuit configured to adjust the bias currents and to control the multiplexer circuits such that several different differential voltages can be provided by the signal channels. Additionally, the temperature measurement circuit includes a conversion circuit that is configured to convert the differential voltage to a temperature signal, and to perform error cancellation based on the different differential voltages provided by the signal channels.
摘要翻译： 提供了一种双结温度传感器的温度测量电路。 温度测量电路被配置为向温度传感器中的接点提供单独的偏置电流。 温度测量电路包括两个信号通道，被配置为从温度传感器接收的差分输入信号提供中间差分信号。 此外，温度测量电路可以包括被配置为控制中间差分信号的一个或多个多路复用器电路。 温度传感器电路还包括配置成调整偏置电流并控制多路复用器电路的控制电路，使得可以由信号通道提供几个不同的差分电压。 此外，温度测量电路包括转换电路，其被配置为将差分电压转换为温度信号，并且基于由信号通道提供的不同差分电压来执行误差消除。
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7.发明申请Automated method and system to calculate the surface distance between two geographical locations, and to filter a data set based on the calculation 有权自动方法和系统计算两个地理位置之间的表面距离，并根据计算过滤数据集公开(公告)号：US20050278117A1
公开(公告)日：2005-12-15
申请号：US10867953
申请日：2004-06-14
申请人： Raghav Gupta , Richard Henderson
发明人： Raghav Gupta , Richard Henderson
CPC分类号： G06F7/552 , G06F7/48 , G06F2207/5523 , Y10S707/99933 , Y10S707/99937 , Y10S707/99945
摘要： A method and apparatus for calculating the surface distance between two geographical locations are described. According to one aspect of the present invention, values are stored in a square look-up table for determining the square of a value. Also, values are stored in a linear to surface distance look-up table for determining the surface distance of a linear value. Cartesian co-ordinates of the two geographic locations and the square look-up table are then used to calculate the square of the linear distance between the two geographical locations and the linear to surface distance look-up table is used to convert the calculated square of the linear distance to a surface distance.
摘要翻译： 描述了用于计算两个地理位置之间的表面距离的方法和装置。 根据本发明的一个方面，将值存储在用于确定值的平方的平方查找表中。 此外，值被存储在线性到表面距离查找表中，用于确定线性值的表面距离。 然后使用两个地理位置和平方查找表的笛卡尔坐标来计算两个地理位置之间的线性距离的平方，并且使用线性到表面距离查找表来将计算出的平方 与表面距离的线性距离。
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公开(公告)号：US5724171A
公开(公告)日：1998-03-03
申请号：US556953
申请日：1996-05-16
CPC分类号： H04N1/10 , G11B7/0031 , G11B7/0033 , H04N2201/0424
摘要： Optical scanning apparatus is disclosed wherein a plurality of reading heads are mounted on a rotating support, and a light source directs light through an optical beam switching means which rotates about an axis colinear with that of the support but at half the rotational speed, whereby the reading heads are caused to be successively operational in turn over a given segment of each revolution of the support, which has a linear transnational movement relative to image-bearing subject(s) to be read.
摘要翻译： PCT No.PCT / GB94 / 00887 Sec。 371日期：1996年5月16日 102（e）日期1996年5月16日PCT 1994年4月26日PCT公布。 公开号WO94 / 27167 日期：1994年11月24日公开了一种光学扫描装置，其中多个读取头安装在旋转支撑件上，光源通过光束切换装置引导光线，该光束切换装置围绕支架的轴线共线旋转， 旋转速度，由此使得读头被依次依次操作在支撑件的每转一圈的给定部分上，该支承件相对于要读取的图像承载主体具有线性跨度运动。
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公开(公告)号：US08618498B2
公开(公告)日：2013-12-31
申请号：US13197632
申请日：2011-08-03
申请人： Gerrit Cornelis Van Hoften , Michael Alwin William Stekelenburg , Richard Henderson , Gregory James McMullan , Abdul Raffey Faruqi , Renato Andrea Danilo Turchetta , Nicola Carlo Guerrini , Joeri Lof , Frank Jeroen Pieter Schuurmans
发明人： Gerrit Cornelis Van Hoften , Michael Alwin William Stekelenburg , Richard Henderson , Gregory James McMullan , Abdul Raffey Faruqi , Renato Andrea Danilo Turchetta , Nicola Carlo Guerrini , Joeri Lof , Frank Jeroen Pieter Schuurmans
IPC分类号： H01J37/244
CPC分类号： H01J37/244 , H01J37/22 , H01J37/26 , H01J37/263 , H01J2237/2441 , H01J2237/24455 , H01J2237/2446 , H01J2237/2447 , H01J2237/24578 , H01J2237/26 , H01J2237/2802
摘要： In a direct electron detector, backscattering of electrons into the detector volume from below the sensor is prevented. In some embodiments, an empty space is maintained below the sensor. In other embodiments, a structure below the sensor includes geometry, such as multiple high aspects ratio channels, either extending to or from the sensor to trap electrons, or a structure of angled surfaces to deflect the electrons that pass through the sensor.
摘要翻译： 在直接电子检测器中，防止电子从传感器下方向检测器体积的后向散射。 在一些实施例中，在传感器下面保持空的空间。 在其他实施例中，传感器下面的结构包括几何，例如多个高方面比例的通道，延伸到传感器或从传感器捕获电子，或倾斜表面的结构以偏转通过传感器的电子。
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公开(公告)号：US20120101199A1
公开(公告)日：2012-04-26
申请号：US13213873
申请日：2011-08-19
申请人： Chunzhao Li , Wilbur Mardis , Richard Henderson , Daphne Benderly
发明人： Chunzhao Li , Wilbur Mardis , Richard Henderson , Daphne Benderly
CPC分类号： C08G18/755 , C08G18/227 , C08G18/2825 , C08G18/3206 , C08G18/3212 , C08G18/4833 , C08G18/6674 , C08K3/20 , C08K5/06 , C08K5/41 , C09D7/43 , C09D7/65
摘要： A viscosity regulating composition having a polymeric structure with an internal hydrophobic unit located within the polymer's backbone, multiple hydrophilic units, and terminal hydrophobic units. In one embodiment, the internal hydrophobic unit may have at least three linked hydrophobic segments, of the same or different hydrophobic segments, with the proviso that the multiple hydrophobic segments are not linked to each other by one or more hydrophilic linking segments, for example water-soluble, polymeric groups.
摘要翻译： 具有聚合物结构的粘度调节组合物，其内部疏水单元位于聚合物主链内，多个亲水单元和末端疏水单元。 在一个实施方案中，内部疏水单元可以具有至少三个相同或不同疏水链段的连接的疏水链段，条件是多个疏水链段不通过一个或多个亲水连接链段彼此连接，例如水 可溶性聚合物。
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