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公开(公告)号:US20080152661A1
公开(公告)日:2008-06-26
申请号:US11840468
申请日:2007-08-17
申请人: David B. Rozema , Darren H. Wakefield , Jason Klein , So Wong , Jon A. Wolff , David L. Lewis , James E. Hagstrom , Andrei Blokhin , Vladimir Trubetskoy , Hans Herweijer
发明人: David B. Rozema , Darren H. Wakefield , Jason Klein , So Wong , Jon A. Wolff , David L. Lewis , James E. Hagstrom , Andrei Blokhin , Vladimir Trubetskoy , Hans Herweijer
IPC分类号: A61K31/70 , A61K39/395 , C12N5/00 , A61K38/00
CPC分类号: C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58 , A61K48/0041
摘要: The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible linkages connecting component parts provides for physiologically responsive activity modulation.
摘要翻译: 本发明涉及可用于将多核苷酸或其它细胞不可渗透分子递送至哺乳动物细胞的化合物,组合物和方法。 描述了将靶向,抗调理作用,抗聚集和转染活性结合到小的生物相容性体内递送载体中的多偶联体系。 连接组成部分的多个可逆连接的使用提供了生理响应活性调节。
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公开(公告)号:USD866870S1
公开(公告)日:2019-11-12
申请号:US29637146
申请日:2018-02-14
申请人: Jason Klein , Austin Hedges , Mark Rogow
设计人: Jason Klein , Austin Hedges , Mark Rogow
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公开(公告)号:US08371596B2
公开(公告)日:2013-02-12
申请号:US12778888
申请日:2010-05-12
申请人: Marc Johnson , Mark Molitor , Jeffrey Michael Galla , Jason Klein , David Roe , Daniel R. Dykstra
发明人: Marc Johnson , Mark Molitor , Jeffrey Michael Galla , Jason Klein , David Roe , Daniel R. Dykstra
CPC分类号: B60G11/27 , B60G9/003 , B60G9/022 , B60G11/28 , B60G21/0551 , B60G2200/314 , B60G2200/315 , B60G2202/135
摘要: A vehicle suspension system includes a first trailing arm assembly and a second trailing assembly each including a mounting bracket adapted to be secured to a vehicle frame and a trailing arm member pivotably coupled to the associated mounting bracket and adapted to be operably coupled to an axle member, wherein the trailing arm members each include an aperture extending therein, wherein the aperture has a relatively constant cross-sectional configuration along a depth thereof. The vehicle suspension system further includes a torsional member extending between the first and second trailing arm members and frictionally secured within the apertures thereof, wherein the torsional member has a relatively constant cross-sectional configuration along a length thereof that is received within the apertures of the trailing arms.
摘要翻译: 车辆悬挂系统包括第一牵引臂组件和第二牵引组件,每个牵引臂组件包括适于固定到车辆框架的安装支架和可枢转地联接到相关联的安装支架的后臂构件,并且适于可操作地联接到轴构件 其中所述尾臂构件各自包括在其中延伸的孔,其中所述孔沿其深度具有相对恒定的横截面构型。 车辆悬架系统还包括在第一和第二牵引臂构件之间延伸并摩擦地固定在其孔内的扭转构件,其中扭转构件具有沿其长度的相对恒定的横截面构造,该横截面构造被容纳在 拖尾臂。
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公开(公告)号:US20050170505A1
公开(公告)日:2005-08-04
申请号:US11046598
申请日:2005-01-28
申请人: Darren Wakefield , David Rozema , Jon Wolff , Vladimir Trubetskoy , James Hagstrom , Vladimir Budker , Jason Klein , So Wong
发明人: Darren Wakefield , David Rozema , Jon Wolff , Vladimir Trubetskoy , James Hagstrom , Vladimir Budker , Jason Klein , So Wong
CPC分类号: C12N15/87 , A61K47/6455 , C12N15/88
摘要: Polyampholyte are able to condense nucleic acid to form small complexes which can be utilized in the delivery of nucleic acid to mammalian cells. The polyampholytes can be formed prior to interaction with nucleic acid or they can be formed in the presence of nucleic acid. Stabilized polycation/nucleic acid complexes can be modified to reduce the positive charge of the polycation and add targeting ligands without destabilizing the complex. The resultant particles retain their small size and are more effective in delivery of nucleic acid to cells in vivo.
摘要翻译: 聚阴离子能够冷凝核酸以形成可用于将核酸递送至哺乳动物细胞的小复合物。 聚阴离子可以在与核酸相互作用之前形成,或者可以在核酸存在下形成。 可以修饰稳定的聚阳离子/核酸复合物以减少聚阳离子的正电荷并添加靶向配体而不使复合物不稳定。 所得颗粒保留其小尺寸并且在体内将核酸递送至细胞更有效。
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公开(公告)号:US08658211B2
公开(公告)日:2014-02-25
申请号:US13368796
申请日:2012-02-08
申请人: David B. Rozema , Darren H. Wakefield , David L. Lewis , Jason Klein , So Wong , Jon A. Wolff , James E. Hagstrom
发明人: David B. Rozema , Darren H. Wakefield , David L. Lewis , Jason Klein , So Wong , Jon A. Wolff , James E. Hagstrom
IPC分类号: A61K9/14 , C07D207/444 , C07H21/02 , C12N15/00 , C12N15/11
CPC分类号: C12N15/87 , A01K2217/058 , A01K2267/0362 , A61K47/58 , A61K48/0041 , C12N15/111 , C12N2310/14 , C12N2310/351 , C12N2320/32 , C12N2800/95 , C12N2810/10
摘要: The present invention is directed to compounds, compositions, and methods useful for delivering polynucleotides or other cell-impermeable molecules to mammalian cells. Described are polyconjugates systems that incorporate targeting, anti-opsonization, anti-aggregation, and transfection activities into small biocompatible in vivo delivery vehicles. The use of multiple reversible or labile linkages connecting component parts provides for physiologically responsive activity modulation.
摘要翻译: 本发明涉及可用于将多核苷酸或其它细胞不可渗透分子递送至哺乳动物细胞的化合物,组合物和方法。 描述了将靶向,抗调理作用,抗聚集和转染活性结合到小的生物相容性体内递送载体中的多偶联体系。 使用连接组成部分的多个可逆或不稳定的连接提供了生理响应活性调节。
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公开(公告)号:US20110115184A1
公开(公告)日:2011-05-19
申请号:US12778888
申请日:2010-05-12
申请人: Marc Johnson , Mark Molitor , Jeffrey Michael Galla , Jason Klein , David Roe , Daniel R. Dykstra
发明人: Marc Johnson , Mark Molitor , Jeffrey Michael Galla , Jason Klein , David Roe , Daniel R. Dykstra
IPC分类号: B60G9/02
CPC分类号: B60G11/27 , B60G9/003 , B60G9/022 , B60G11/28 , B60G21/0551 , B60G2200/314 , B60G2200/315 , B60G2202/135
摘要: A vehicle suspension system includes a first trailing arm assembly and a second trailing assembly each including a mounting bracket adapted to be secured to a vehicle frame and a trailing arm member pivotably coupled to the associated mounting bracket and adapted to be operably coupled to an axle member, wherein the trailing arm members each include an aperture extending therein, wherein the aperture has a relatively constant cross-sectional configuration along a depth thereof. The vehicle suspension system further includes a torsional member extending between the first and second trailing arm members and frictionally secured within the apertures thereof, wherein the torsional member has a relatively constant cross-sectional configuration along a length thereof that is received within the apertures of the trailing arms.
摘要翻译: 车辆悬挂系统包括第一牵引臂组件和第二牵引组件,每个牵引臂组件包括适于固定到车辆框架的安装支架和可枢转地联接到相关联的安装支架的后臂构件,并且适于可操作地联接到轴构件 其中所述尾臂构件各自包括在其中延伸的孔,其中所述孔沿其深度具有相对恒定的横截面构型。 车辆悬架系统还包括在第一和第二牵引臂构件之间延伸并摩擦地固定在其孔内的扭转构件,其中扭转构件具有沿其长度的相对恒定的横截面构造,该横截面构造被容纳在 拖尾臂。
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公开(公告)号:US06843490B2
公开(公告)日:2005-01-18
申请号:US10211403
申请日:2002-08-02
申请人: John Raidel, II , Bruce Barton , Jason Klein , Emmitt Scammahorn
发明人: John Raidel, II , Bruce Barton , Jason Klein , Emmitt Scammahorn
CPC分类号: B60G7/02 , B60G9/003 , B60G2200/31 , B60G2202/152 , B60G2204/143 , B60G2204/41 , B60G2204/43 , B60G2204/44
摘要: The present invention provides a suspension beam and bush attachment assembly. The assembly comprises a longitudinally extending control arm, a bush eye clamp, and a mounting bracket. The control arm has a bush end, a mid-region, an axle mount formed opposite of the bush end, and one or more fastener bore. The bush eye clamp is transversely mounted to the bush end of the control arm and has a center bore configured for receiving a bush therein and an axial slot biasing the bushing eye clamp open for bush insertion. To securely position the bush within the bush eye clamp, the mounting bracket is affixed to the bushing eye clamp and has one or more fastener bores substantially aligned with the one or more fastener bores of the control arm such that securing a fastener through each of the bores of the bracket and control arm couples the bracket to the control arm and biases the axial slot into a substantially closed position to contact and compress a perimeter of the bush with the bush eye clamp.
摘要翻译: 本发明提供一种悬挂梁和衬套附接组件。 组件包括纵向延伸的控制臂,衬套夹钳和安装支架。 控制臂具有衬套端部,中部区域,与衬套端部相对的轴向安装件,以及一个或多个紧固件孔。 衬套夹钳横向地安装到控制臂的衬套端部并且具有构造成用于在其中容纳衬套的中心孔和用于衬套插入的用于偏置衬套眼夹的开口的轴向槽。 为了将衬套牢固地定位在衬套夹钳内,安装支架固定到衬套眼夹上,并且具有一个或多个紧固件孔,其基本上与控制臂的一个或多个紧固件孔对准,使得将紧固件固定在每个 支架和控制臂的孔将支架连接到控制臂,并将轴向狭槽偏压到基本上关闭的位置,以用衬套夹钳接触和压缩衬套的周边。
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公开(公告)号:US09961943B2
公开(公告)日:2018-05-08
申请号:US12938447
申请日:2010-11-03
申请人: Jason Klein
发明人: Jason Klein
CPC分类号: A41B11/003 , A41D2400/60 , D04B1/04 , D04B1/26
摘要: An athletic sock formed from a yarn comprising Coolmax® polyester fibers, cotton fibers and Lycra® polyurethane-polyurea copolymer fiber. The sock has a toe portion, at least one compression portion, a heel and ankle portion, and an upper band at the top portion of the sock.
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9.
公开(公告)号:US20150161663A1
公开(公告)日:2015-06-11
申请号:US14101944
申请日:2013-12-10
CPC分类号: G06Q30/0252 , G06Q50/01
摘要: Exemplary embodiments of the present disclosure relate to a live event (data feed) interaction environment including one or more systems that are programmed and/or configured to facilitate the formation of, distribution of, rendering of, and/or interaction with a data feed for a scheduled live event that includes a schedule of one or more intra-event activities, coupons, and/or any other suitable information, including, for example, social media network feeds. The environment can include a back end feed generation system can be implemented that allows an organizer to specify a schedule of live events and to construct data feeds for the scheduled live events that can be transmitted to user of the environment before, during, and/or after the live event. The environment can include a front end data feed interaction system can be implemented that allows user to view and interact with the data feeds transmitted by the back end system to, for example, participate in the intra-event activities, accumulate and/or redeem coupons, and/or communicate with other users and/or the organizer via one or more social media networks.
摘要翻译: 本公开的示例性实施例涉及直播事件(数据馈送)交互环境,包括一个或多个被编程和/或配置为促进数据馈送的形成,分发,渲染和/或与数据馈送相互作用的系统, 包括一个或多个事件内活动,优惠券和/或任何其他合适的信息(包括例如社交媒体网络馈送)的时间表的预定的直播活动。 环境可以包括可以实现后端馈送生成系统,其允许组织者指定实况事件的调度并且为预定的直播节目构建数据馈送,该播放节目可以在之前,之中和/或之前传送给环境的用户 在现场活动之后。 环境可以包括前端数据馈送交互系统,其可以被实现,其允许用户查看和后端系统发送的数据源进行交互,例如参与事件内活动,累积和/或兑换优惠券 ,和/或经由一个或多个社交媒体网络与其他用户和/或组织者进行通信。
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公开(公告)号:US20140325744A1
公开(公告)日:2014-11-06
申请号:US13874808
申请日:2013-05-01
申请人: Jason Klein , Aaron Engel
发明人: Jason Klein , Aaron Engel
CPC分类号: A42B3/20
摘要: A shock absorber, for use with headgear having a faceguard, has a sliding member that does not extend beyond the support structure of the shock absorber in a way that would leave it vulnerable to damage. A headgear having a faceguard provides a protected mounting location for mounting a shock absorber for the faceguard.
摘要翻译: 与具有防护面具的头饰一起使用的减震器具有滑动构件,其不会以使其容易受到损坏的方式延伸超过减震器的支撑结构。 具有面罩的头盔提供了用于安装面罩的减震器的受保护的安装位置。
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