-
公开(公告)号:US07923446B2
公开(公告)日:2011-04-12
申请号:US11756253
申请日:2007-05-31
申请人: Jason Shaoyun Xiang , Steve Yikkai Tam , Yonghan Hu , Phaik-Eng Sum , David Brian How , Darrin William Hopper , Matthew Douglas Vera , Joshua James Sabatini , Thomas Saltmarsh Rush, III , Elisabeth Ann Morris , Katy Evangelia Georgiadis
发明人: Jason Shaoyun Xiang , Steve Yikkai Tam , Yonghan Hu , Phaik-Eng Sum , David Brian How , Darrin William Hopper , Matthew Douglas Vera , Joshua James Sabatini , Thomas Saltmarsh Rush, III , Elisabeth Ann Morris , Katy Evangelia Georgiadis
IPC分类号: C07D217/02 , A61K31/47 , A61K31/50
CPC分类号: C07D213/30 , A61K31/4188 , A61K31/424 , A61K31/429 , C07C311/29 , C07C311/46 , C07C2601/08 , C07C2602/10 , C07D213/64 , C07D213/643 , C07D215/14 , C07D215/227 , C07D215/233 , C07D217/18 , C07D235/12 , C07D239/34 , C07D239/60 , C07D261/14 , C07D263/22 , C07D263/58 , C07D277/64 , C07D277/68 , C07D295/096 , C07D295/192 , C07D307/79 , C07D307/80 , C07D307/82 , C07D307/84 , C07D319/18 , C07D321/10 , C07D333/20 , C07D333/36 , C07D333/66
摘要: The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
摘要翻译: 本发明涉及联芳基磺酰胺及其作为例如金属蛋白酶抑制剂的用途。
-
公开(公告)号:US07268135B2
公开(公告)日:2007-09-11
申请号:US11000711
申请日:2004-12-01
申请人: Jason Shaoyun Xiang , Steve Yikkai Tam , Yonghan Hu , Phaik-Eng Sum , David Brian How , Darrin William Hopper , Matthew Douglas Vera , Joshua James Sabatini , Thomas Saltmarsh Rush, III
发明人: Jason Shaoyun Xiang , Steve Yikkai Tam , Yonghan Hu , Phaik-Eng Sum , David Brian How , Darrin William Hopper , Matthew Douglas Vera , Joshua James Sabatini , Thomas Saltmarsh Rush, III
IPC分类号: C07D217/02 , A61K31/50
CPC分类号: C07D213/30 , A61K31/4188 , A61K31/424 , A61K31/429 , C07C311/29 , C07C311/46 , C07C2601/08 , C07C2602/10 , C07D213/64 , C07D213/643 , C07D215/14 , C07D215/227 , C07D215/233 , C07D217/18 , C07D235/12 , C07D239/34 , C07D239/60 , C07D261/14 , C07D263/22 , C07D263/58 , C07D277/64 , C07D277/68 , C07D295/096 , C07D295/192 , C07D307/79 , C07D307/80 , C07D307/82 , C07D307/84 , C07D319/18 , C07D321/10 , C07D333/20 , C07D333/36 , C07D333/66
摘要: The present invention relates to biaryl sulfonamides and their use as, for example, metalloproteinase inhibitors.
摘要翻译: 本发明涉及联芳基磺酰胺及其作为例如金属蛋白酶抑制剂的用途。
-
公开(公告)号:US08101590B2
公开(公告)日:2012-01-24
申请号:US11513972
申请日:2006-08-31
申请人: Phaik-Eng Sum , Tarek Suhayl Mansour , David Brian How , Darrin William Hopper , Matthew Douglas Vera , Joshua James Sabatini , Jaechul Shim
发明人: Phaik-Eng Sum , Tarek Suhayl Mansour , David Brian How , Darrin William Hopper , Matthew Douglas Vera , Joshua James Sabatini , Jaechul Shim
IPC分类号: A61K31/65 , C07C237/26
CPC分类号: C07D333/38 , C07C237/26 , C07C271/22 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2603/46 , C07C2603/74 , C07D207/416 , C07D209/42 , C07D213/81 , C07D213/82 , C07D215/48 , C07D307/68 , C07D307/84 , C07D317/34
摘要: This invention provides compounds of Formula I having the structure where R1, R2, R3 and A are defined in the specification or a pharmaceutically acceptable salt thereof useful as antibacterial agents. Compounds according to Formula (II): where Q, R4, R5, R6 and R10 and A are defined in the specification are useful as chemical intermediates.
摘要翻译: 本发明提供式I化合物,其具有在说明书中定义R1,R2,R3和A的结构或其药学上可接受的盐作为抗菌剂。 根据式(II)的化合物:其中Q,R 4,R 5,R 6和R 10和A在说明书中定义可用作化学中间体。
-
公开(公告)号:US07176225B2
公开(公告)日:2007-02-13
申请号:US11007621
申请日:2004-12-08
申请人: Phaik-Eng Sum , David Brian How , Darrin William Hopper , Matthew Douglas Vera , Joshua James Sabatini
发明人: Phaik-Eng Sum , David Brian How , Darrin William Hopper , Matthew Douglas Vera , Joshua James Sabatini
IPC分类号: A61K31/423 , C07D263/52
CPC分类号: C07C237/26 , A61K31/65 , C07C2603/46 , C07D263/52 , C07D413/04 , C07D413/06 , C07D417/04
摘要: This invention provides compounds of the formula: wherein A″, X and Y are defined in the specification. These compounds are useful as antibacterial agents.
摘要翻译: 本发明提供下式的化合物:其中A“,X和Y在说明书中定义。 这些化合物可用作抗菌剂。
-
公开(公告)号:US20080177080A1
公开(公告)日:2008-07-24
申请号:US12053856
申请日:2008-03-24
申请人: Phaik-Eng Sum , David Brian How , Darrin William Hopper , Matthew Douglas Vera , Joshua James Sabatini
发明人: Phaik-Eng Sum , David Brian How , Darrin William Hopper , Matthew Douglas Vera , Joshua James Sabatini
IPC分类号: C07D263/52
CPC分类号: C07C237/26 , A61K31/65 , C07C2603/46 , C07D263/52 , C07D413/04 , C07D413/06 , C07D417/04
摘要: This invention provides compounds of the formula: wherein A″, X and Y are defined in the specification. These compounds are useful as antibacterial agents.
摘要翻译: 本发明提供下式的化合物:其中A“,X和Y在说明书中定义。 这些化合物可用作抗菌剂。
-
公开(公告)号:US07365087B2
公开(公告)日:2008-04-29
申请号:US11638138
申请日:2006-12-13
申请人: Phaik-Eng Sum , David Brian How , Darrin William Hopper , Matthew Douglas Vera , Joshua James Sabatini
发明人: Phaik-Eng Sum , David Brian How , Darrin William Hopper , Matthew Douglas Vera , Joshua James Sabatini
IPC分类号: A61K31/423 , C07D263/52 , C07C237/26
CPC分类号: C07C237/26 , A61K31/65 , C07C2603/46 , C07D263/52 , C07D413/04 , C07D413/06 , C07D417/04
摘要: This invention provides compounds of the formula: wherein A″, X and Y are defined in the specification. These compounds are useful as antibacterial agents.
摘要翻译: 本发明提供下式的化合物:其中A“,X和Y在说明书中定义。 这些化合物可用作抗菌剂。
-
公开(公告)号:US07553873B2
公开(公告)日:2009-06-30
申请号:US11484005
申请日:2006-07-11
申请人: Phaik-Eng Sum , Jerauld Stanley Skotnicki , Steve Yik-Kai Tam , Tarek Suhayl Mansour , David Brian How , Joshua James Sabatini , Jason Shaoyun Xiang , Eric Feyfant
发明人: Phaik-Eng Sum , Jerauld Stanley Skotnicki , Steve Yik-Kai Tam , Tarek Suhayl Mansour , David Brian How , Joshua James Sabatini , Jason Shaoyun Xiang , Eric Feyfant
IPC分类号: A61K31/166 , A61K31/192 , C07C63/06 , C07C237/28
CPC分类号: C07D213/82 , C07B2200/07 , C07C231/16 , C07C233/83 , C07C235/84 , C07C237/22 , C07C237/42 , C07C259/06 , C07C323/32 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2603/18 , C07C2603/74 , C07D213/38 , C07D239/26 , C07D239/42 , C07D277/30 , C07D307/52 , C07D307/68 , C07D307/79 , C07D307/85 , C07D317/58 , C07D333/20 , C07D333/22 , C07D333/28 , C07D333/38 , C07D409/04
摘要: The present invention relates to modulators of metalloproteinase activity.
摘要翻译: 本发明涉及金属蛋白酶活性的调节剂。
-
公开(公告)号:US07998965B2
公开(公告)日:2011-08-16
申请号:US12465840
申请日:2009-05-14
申请人: Phaik-Eng Sum , Jerauld Stanley Skotnicki , Steve Yik-Kai Tam , Tarek Suhayl Mansour , David Brian How , Joshua James Sabatini , Jason Shaoyun Xiang , Eric Feyfant
发明人: Phaik-Eng Sum , Jerauld Stanley Skotnicki , Steve Yik-Kai Tam , Tarek Suhayl Mansour , David Brian How , Joshua James Sabatini , Jason Shaoyun Xiang , Eric Feyfant
IPC分类号: A61K31/4965 , A61K31/16 , A61K31/34 , A61K31/44 , A61K31/38 , C07C237/00 , C07D307/87 , C07D333/02 , C07D241/02
CPC分类号: C07D213/82 , C07B2200/07 , C07C231/16 , C07C233/83 , C07C235/84 , C07C237/22 , C07C237/42 , C07C259/06 , C07C323/32 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2603/18 , C07C2603/74 , C07D213/38 , C07D239/26 , C07D239/42 , C07D277/30 , C07D307/52 , C07D307/68 , C07D307/79 , C07D307/85 , C07D317/58 , C07D333/20 , C07D333/22 , C07D333/28 , C07D333/38 , C07D409/04
摘要: The present invention relates to modulators of metalloproteinase activity.
摘要翻译: 本发明涉及金属蛋白酶活性的调节剂。
-
公开(公告)号:US20100010012A1
公开(公告)日:2010-01-14
申请号:US12465840
申请日:2009-05-14
申请人: Phaik-Eng Sum , Jerauld Stanley Skotnicki , Steve Yik-Kai Tam , Tarek Suhayl Mansour , David Brian How , Joshua James Sabatini , Jason Shaoyun Xiang , Eric Feyfant
发明人: Phaik-Eng Sum , Jerauld Stanley Skotnicki , Steve Yik-Kai Tam , Tarek Suhayl Mansour , David Brian How , Joshua James Sabatini , Jason Shaoyun Xiang , Eric Feyfant
IPC分类号: A61K31/4965 , C07C237/00 , A61K31/16 , C07D307/87 , A61K31/34 , C07D213/56 , A61K31/44 , A61K31/38 , C07D333/02 , C07D241/02
CPC分类号: C07D213/82 , C07B2200/07 , C07C231/16 , C07C233/83 , C07C235/84 , C07C237/22 , C07C237/42 , C07C259/06 , C07C323/32 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2603/18 , C07C2603/74 , C07D213/38 , C07D239/26 , C07D239/42 , C07D277/30 , C07D307/52 , C07D307/68 , C07D307/79 , C07D307/85 , C07D317/58 , C07D333/20 , C07D333/22 , C07D333/28 , C07D333/38 , C07D409/04
摘要: The present invention relates to modulators of metalloproteinase activity.
摘要翻译: 本发明涉及金属蛋白酶活性的调节剂。
-
公开(公告)号:US20080269213A1
公开(公告)日:2008-10-30
申请号:US11895222
申请日:2007-08-23
申请人: Matthew G. Bursavich , Sabrina Lombardi , Adam M. Gilbert , Leif Mark Laakso , Gulnaz Khafizova , David Brian How , Joshua James Sabatini , Phaik-Eng Sum , Jeremy Clemens
发明人: Matthew G. Bursavich , Sabrina Lombardi , Adam M. Gilbert , Leif Mark Laakso , Gulnaz Khafizova , David Brian How , Joshua James Sabatini , Phaik-Eng Sum , Jeremy Clemens
IPC分类号: A61K31/5377 , C07D401/12 , A61K31/4709 , A61K31/47 , A61P9/10 , C07D215/14 , C07D413/02
CPC分类号: C07D215/28 , C07D215/26 , C07D401/06 , C07D401/12 , C07D405/06 , C07D409/10 , C07D417/10
摘要: The present invention relates to 8-Hydroxyquinoline Compounds; compositions comprising an 8-Hydroxyquinoline Compound; and methods for treating or preventing a metalloproteinase-related disorder, such as, an arthritic disorder, osteoarthritis, malignant neoplasm, rheumatoid arthritis, asthma, chronic obstructive pulmonary disease, atherosclerosis, age-related macular degeneration, myocardial infarction, a corneal ulceration, an ocular surface disease, hepatitis, an aortic aneurysm, tendonitis, a central nervous system disorder, abnormal wound healing, angiogenesis, restenosis, cirrhosis, multiple sclerosis, glomerulonephritis, graft versus host disease, diabetes, an inflammatory bowel disease, shock, invertebral disc degeneration, stroke, osteopenia or a periodontal disease or comprising administering an effective dose of an 8-Hydroxyquinoline Compound to a mammal in need thereof.
摘要翻译: 本发明涉及8-羟基喹啉化合物; 包含8-羟基喹啉化合物的组合物; 以及用于治疗或预防金属蛋白酶相关疾病如关节炎疾病,骨关节炎,恶性肿瘤,类风湿性关节炎,哮喘,慢性阻塞性肺病,动脉粥样硬化,年龄相关性黄斑变性,心肌梗塞,角膜溃疡, 眼表疾病,肝炎,主动脉瘤,腱炎,中枢神经系统疾病,伤口愈合异常,血管生成,再狭窄,肝硬化,多发性硬化,肾小球性肾炎,移植物抗宿主病,糖尿病,炎性肠病,休克,椎间盘退变 ,中风,骨质减少或牙周病,或包括向有需要的哺乳动物施用有效剂量的8-羟基喹啉化合物。
-
-
-
-
-
-
-
-
-