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1.发明申请CONTROLLED RELEASE CYTOTOXIC AGENT COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS 有权受控释放的细胞毒性剂组合物和治疗情况的方法公开(公告)号：US20090324552A1
公开(公告)日：2009-12-31
申请号：US12493611
申请日：2009-06-29
申请人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
发明人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
IPC分类号： A61K35/74
CPC分类号： A61K31/00 , A61K9/0046
摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with cytotoxic agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开的是通过将这些组合物和制剂直接施用到或通过灌注到目标耳结构中来治疗耳科疾病或具有细胞毒性剂组合物和制剂的制剂局部施用于患有耳科疾病或病症的个体的组合物和方法 （s）。
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2.发明申请公开(公告)号：US20100036000A1
公开(公告)日：2010-02-11
申请号：US12506127
申请日：2009-07-20
申请人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
发明人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
CPC分类号： A61K9/0046 , A61K8/042 , A61K9/0019 , A61K9/0024 , A61K9/06 , A61K9/10 , A61K9/14 , A61K9/1641 , A61K31/43 , A61K31/496 , A61K31/522 , A61K31/573 , A61K31/7036 , A61K47/02 , A61K47/10 , A61K47/34
摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with antimicrobial agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开的是通过将这些组合物和制剂直接施用到或通过灌注到目标耳结构中来治疗耳科疾病或病症的组合物和方法，所述抗微生物剂组合物和制剂局部施用于患有耳科疾病或病症的个体 （s）。
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3.发明申请CONTROLLED RELEASE ION CHANNEL MODULATOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS 有权控制释放离子通道调节剂组合物和治疗口臭的方法公开(公告)号：US20100015228A1
公开(公告)日：2010-01-21
申请号：US12506664
申请日：2009-07-21
申请人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
发明人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
IPC分类号： A61K9/10
CPC分类号： A61K9/0046 , A61K9/0019 , A61K9/06 , A61K9/122 , A61K9/127 , A61K9/1647 , A61K9/5153 , A61K9/7007 , A61K31/24 , A61K31/27 , A61K31/44 , A61K31/444 , A61K47/34 , A61K47/36 , A61K47/38 , A61K47/40
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with ion channel modulators. In these methods, the ion channel modulator compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the ion channel modulator compositions and formulations onto the auris interna target areas, or via perfusion into the auris interna structures.
摘要翻译： 本文公开了用离子通道调节剂治疗耳部疾病的组合物和方法。 在这些方法中，离子通道调节剂组合物和制剂通过将离子通道调节剂组合物和制剂直接施用到内耳目标区域上，或通过灌注到内耳结构中而局部施用于患有耳科疾病的个体。
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4.发明申请公开(公告)号：US20100009952A1
公开(公告)日：2010-01-14
申请号：US12466310
申请日：2009-05-14
申请人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Michael Christopher SCAIFE , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Carl LEBEL , Andrew M. TRAMMEL , Jeffrey P. Harris
发明人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Michael Christopher SCAIFE , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Carl LEBEL , Andrew M. TRAMMEL , Jeffrey P. Harris
IPC分类号： A61K31/573 , A61P27/16
CPC分类号： A61K9/0046 , A61K9/06 , A61K31/573 , A61K45/06 , A61K47/10
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with steroid, NSAID, and/or adenosine triphosphatase (“ATPase”) modulator agents. In these methods, the steroidal, NSAID, and/or ATPase compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开了用类固醇，NSAID和/或腺苷三磷酸酶（“ATPase”）调节剂治疗耳部疾病的组合物和方法。 在这些方法中，通过将这些组合物和制剂直接施用到或通过灌注到目标耳结构中，将甾体，NSAID和/或ATP酶组合物和制剂局部施用于患有耳科疾病的个体。
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5.发明申请CONTROLLED-RELEASE OTIC STRUCTURE MODULATING AND INNATE IMMUNE SYSTEM MODULATING COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS 审中-公开控制释放的油性结构调节和免疫系统调节组合物和治疗病情的方法公开(公告)号：US20100021416A1
公开(公告)日：2010-01-28
申请号：US12506091
申请日：2009-07-20
申请人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
发明人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
CPC分类号： A61K31/663 , A61K9/0046 , A61K31/5513 , A61K31/66 , A61K38/1748 , A61K38/29 , A61K38/39 , A61K38/47 , A61K38/4886 , A61K47/34 , A61K2300/00
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with otic structure modulating compositions administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and compositions onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开的是通过将这些组合物和组合物直接施用到或通过灌注到目标耳结构中来治疗耳部疾病的组合物和方法，其中耳用结构调节组合物局部施用于患有耳科疾病的个体。
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6.发明申请公开(公告)号：US20100004225A1
公开(公告)日：2010-01-07
申请号：US12486697
申请日：2009-06-17
申请人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Michael Christopher SCAIFE , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Carl LEBEL , Andrew M. TRAMMEL , Jeffrey P. HARRIS
发明人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Michael Christopher SCAIFE , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Carl LEBEL , Andrew M. TRAMMEL , Jeffrey P. HARRIS
IPC分类号： A61K31/551
CPC分类号： A61K47/34 , A61K9/14 , A61K31/5377 , A61K31/5517 , A61K31/724
摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with aural pressure modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开的是用于治疗耳科疾病或病症的组合物和方法，所述耳科疾病或病症具有耳神经压力调节剂组合物和通过直接将这些组合物和制剂直接施用于或经由灌注到目标物中而局部施用于患有耳科疾病或病症的个体的制剂 耳结构。
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公开(公告)号：US20090306225A1
公开(公告)日：2009-12-10
申请号：US12427663
申请日：2009-04-21
申请人： Jay LICHTER , Benedikt VOLLRATH , Andrew M. TRAMMEL , Sergio G. DURON , Fabrice PIU , Luis A. DELLAMARY , Qiang YE , Carl LEBEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
发明人： Jay LICHTER , Benedikt VOLLRATH , Andrew M. TRAMMEL , Sergio G. DURON , Fabrice PIU , Luis A. DELLAMARY , Qiang YE , Carl LEBEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
CPC分类号： A61K9/0046 , A61K9/06 , A61K9/127 , A61K9/14 , A61K9/16 , A61K31/05 , A61K31/13 , A61K31/137 , A61K31/325 , A61K31/43 , A61K31/436 , A61K31/519 , A61K31/5513 , A61K31/5517 , A61K38/18 , A61K38/1808 , A61K38/1825 , A61K38/185 , A61K38/1858 , A61K38/1883 , A61K47/14 , A61K47/18 , A61K47/32 , A61K47/38 , A61K2039/505 , C07K16/241 , C07K2317/21 , C07K2317/76
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agents and auris pressure modulators. In these methods, the auris compositions and formulations are administered locally to an individual afflicted with an otic disorder, through direct application of the immunomodulating and/or auris pressure modulating compositions and formulations onto the auris media and/or auris interna target areas, or via perfusion into the auris media and/or auris interna structures.
摘要翻译： 本文公开了用免疫调节剂和耳压调节剂治疗耳部疾病的组合物和方法。 在这些方法中，通过将免疫调节和/或耳压调节组合物和制剂直接施用到耳朵介质和/或内耳目标区域上，或通过 灌注到耳朵介质和/或耳内结构中。
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8.发明申请CONTROLLED RELEASE AURIS SENSORY CELL MODULATOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS 有权控制释放的感染细胞调节剂组合物和治疗卵巢疾病的方法公开(公告)号：US20100015263A1
公开(公告)日：2010-01-21
申请号：US12504553
申请日：2009-07-16
申请人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
发明人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL , Michael Christopher SCAIFE , Jeffrey P. HARRIS
CPC分类号： A61K31/517 , A61K9/0046 , A61K31/135 , A61K31/137 , A61K31/4535 , A61K31/47 , A61K47/10 , A61K47/32 , A61K47/34
摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with auris sensory cell modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开了用于治疗耳科疾病或病症的组合物和方法，其中耳蜗感觉细胞调节剂组合物和制剂在局部施用于患有耳科疾病或病症的个体，通过将这些组合物和制剂直接施用于或经由灌注至 目标耳结构。
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9.发明申请CONTROLLED RELEASE IMMUNOMODULATOR COMPOSITIONS AND METHODS FOR THE TREATMENT OF OTIC DISORDERS 有权受控释放的免疫调节剂组合物和治疗口臭的方法公开(公告)号：US20090297533A1
公开(公告)日：2009-12-03
申请号：US12472034
申请日：2009-05-26
申请人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Michael Christopher SCAIFE , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Carl LEBEL , Jeffrey P. Harris , Andrew M. TRAMMEL
发明人： Jay LICHTER , Benedikt VOLLRATH , Sergio G. DURON , Michael Christopher SCAIFE , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Carl LEBEL , Jeffrey P. Harris , Andrew M. TRAMMEL
IPC分类号： A61K39/395 , A61K31/4353 , A61P27/16
CPC分类号： C07K16/241 , A61K9/0046 , A61K39/39591 , A61K47/34
摘要： Disclosed herein are compositions and methods for the treatment of otic disorders with immunomodulating agent compositions and formulations administered locally to an individual afflicted with an otic disorder, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
摘要翻译： 本文公开了通过将免疫调节剂组合物和制剂局部施用于患有耳科疾病的个体，通过将这些组合物和制剂直接施用到或经由灌注到目标耳结构中来治疗耳部疾病的组合物和方法。
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10.发明申请公开(公告)号：US20100273864A1
公开(公告)日：2010-10-28
申请号：US12767461
申请日：2010-04-26
申请人： Jay LICHTER , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL
发明人： Jay LICHTER , Carl LEBEL , Fabrice PIU , Qiang YE , Luis A. DELLAMARY , Andrew M. TRAMMEL
CPC分类号： A61K31/517 , A61K9/0046 , A61K31/135 , A61K31/137 , A61K31/4535 , A61K31/47 , A61K47/10 , A61K47/32 , A61K47/34
摘要： Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with auris sensory cell modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
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