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公开(公告)号：US20140100230A1
公开(公告)日：2014-04-10
申请号：US14102020
申请日：2013-12-10
申请人： Jayhong A. Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
发明人： Jayhong A. Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
IPC分类号： C07D409/12 , C07D405/14 , C07D409/06 , C07D251/16 , C07D251/46 , C07D235/30 , C07D263/58 , C07D251/52
CPC分类号： A61K31/423 , A61K31/00 , A61K31/164 , A61K31/4184 , A61K31/4196 , A61K31/53 , C07D235/30 , C07D251/16 , C07D251/46 , C07D251/52 , C07D263/58 , C07D405/14 , C07D409/06 , C07D409/12
摘要： Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
摘要翻译： 描述了通过施用有效量的TRPC5拮抗剂（例如本文公开的化合物）来治疗受试者中TRPC5介导的病症的方法。
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公开(公告)号：US09139573B2
公开(公告)日：2015-09-22
申请号：US14102020
申请日：2013-12-10
申请人： Jayhong A. Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
发明人： Jayhong A. Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
IPC分类号： A61K31/00 , A61K31/164 , A61K31/53 , C07D409/12 , A61K31/4184 , C07D235/30 , C07D251/16 , C07D251/46 , C07D251/52 , C07D263/58 , C07D405/14 , C07D409/06
CPC分类号： A61K31/423 , A61K31/00 , A61K31/164 , A61K31/4184 , A61K31/4196 , A61K31/53 , C07D235/30 , C07D251/16 , C07D251/46 , C07D251/52 , C07D263/58 , C07D405/14 , C07D409/06 , C07D409/12
摘要： Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
摘要翻译： 描述了通过施用有效量的TRPC5拮抗剂（例如本文公开的化合物）来治疗受试者中TRPC5介导的病症的方法。
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公开(公告)号：US08633233B2
公开(公告)日：2014-01-21
申请号：US13057527
申请日：2009-08-06
申请人： Jayhong Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
发明人： Jayhong Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
IPC分类号： A61K31/41 , A61K31/415
CPC分类号： A61K31/423 , A61K31/00 , A61K31/164 , A61K31/4184 , A61K31/4196 , A61K31/53 , C07D235/30 , C07D251/16 , C07D251/46 , C07D251/52 , C07D263/58 , C07D405/14 , C07D409/06 , C07D409/12
摘要： Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
摘要翻译： 描述了通过施用有效量的TRPC5拮抗剂（例如本文公开的化合物）来治疗受试者中TRPC5介导的病症的方法。
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公开(公告)号：US20110319417A1
公开(公告)日：2011-12-29
申请号：US13057527
申请日：2009-08-06
申请人： Jayhong Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
发明人： Jayhong Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
IPC分类号： A61K31/423 , A61K31/53 , A61P25/08 , A61P25/00 , A61P25/22 , A61K31/4196 , A61K31/454
CPC分类号： A61K31/423 , A61K31/00 , A61K31/164 , A61K31/4184 , A61K31/4196 , A61K31/53 , C07D235/30 , C07D251/16 , C07D251/46 , C07D251/52 , C07D263/58 , C07D405/14 , C07D409/06 , C07D409/12
摘要： Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
摘要翻译： 描述了通过施用有效量的TRPC5拮抗剂（例如本文公开的化合物）来治疗受试者中TRPC5介导的病症的方法。
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公开(公告)号：US09486455B2
公开(公告)日：2016-11-08
申请号：US13040859
申请日：2011-03-04
申请人： Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , Magdalene M. Moran , Howard Ng , Amy Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen
发明人： Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , Magdalene M. Moran , Howard Ng , Amy Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen
IPC分类号： A01N43/58 , A01N43/60 , A61K31/517 , A61K31/519
CPC分类号： A61K31/519 , A61K31/517
摘要： The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
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公开(公告)号：US20110151559A1
公开(公告)日：2011-06-23
申请号：US13040859
申请日：2011-03-04
申请人： Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , Magdalene M. Moran , Howard Ng , Amy Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen
发明人： Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , Magdalene M. Moran , Howard Ng , Amy Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen
IPC分类号： C12N5/00
CPC分类号： A61K31/519 , A61K31/517
摘要： The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
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公开(公告)号：US20090018147A1
公开(公告)日：2009-01-15
申请号：US12152131
申请日：2008-05-12
申请人： Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , Magdalene M. Moran , Howard Ng , Amy Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen
发明人： Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , Magdalene M. Moran , Howard Ng , Amy Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen
IPC分类号： A61K31/517 , A61P25/00 , A61P17/00 , A61K31/519 , A61P29/00 , A61P19/02
CPC分类号： A61K31/519 , A61K31/517
摘要： The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
摘要翻译： 本申请涉及用于治疗与TRPV3有关的疼痛和其它病症的化合物和方法。
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8.发明授权Substituted pyrimido 4.5-d pyrimidin-4-one compounds for modulating TRPV3 function 有权用于调节TRPV3功能的取代的嘧啶基4.5-d嘧啶-4-酮化合物公开(公告)号：US08552009B2
公开(公告)日：2013-10-08
申请号：US13022107
申请日：2011-02-07
申请人： Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , William C. Lumma, Jr. , Magdalene M. Moran , Amy S. Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen , Anu Mahadevan , Peter Meltzer
发明人： Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , William C. Lumma, Jr. , Magdalene M. Moran , Amy S. Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen , Anu Mahadevan , Peter Meltzer
IPC分类号： A61K31/519
CPC分类号： C07D487/04 , A61K31/517 , C07D239/91 , C07D401/06 , C07D471/04
摘要： The present application relates to compounds of Formula I as defined herein, and methods for treating pain and other conditions related to TRPV3.
摘要翻译： 本申请涉及本文定义的式I化合物，以及用于治疗与TRPV3有关的疼痛和其它病症的方法。
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公开(公告)号：US08541423B2
公开(公告)日：2013-09-24
申请号：US13444213
申请日：2012-04-11
申请人： Magdalene M. Moran , Christopher Fanger , Jayhong A. Chong , Colleen McNamara , Xiaoguang Zhen , Josh Mandel-Brehm
发明人： Magdalene M. Moran , Christopher Fanger , Jayhong A. Chong , Colleen McNamara , Xiaoguang Zhen , Josh Mandel-Brehm
IPC分类号： A61P29/00 , A61K31/522 , A61K31/513 , C07D239/06
CPC分类号： C07D473/08 , A61K31/505 , A61K31/513 , A61K31/522 , A61K31/555 , C07D239/22 , C07K14/705
摘要： The present application relates to compounds and methods for treating pain, incontinence and other conditions.
摘要翻译： 本申请涉及治疗疼痛，失禁等条件的化合物和方法。
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公开(公告)号：US20130123283A1
公开(公告)日：2013-05-16
申请号：US13444213
申请日：2012-04-11
申请人： Magdalene M. Moran , Christopher Fanger , Jayhong A. Chong , Colleen McNamara , Xiaoguang Zhen , Josh Mendel-Brehm
发明人： Magdalene M. Moran , Christopher Fanger , Jayhong A. Chong , Colleen McNamara , Xiaoguang Zhen , Josh Mendel-Brehm
IPC分类号： C07D473/08
CPC分类号： C07D473/08 , A61K31/505 , A61K31/513 , A61K31/522 , A61K31/555 , C07D239/22 , C07K14/705
摘要： The present application relates to compounds and methods for treating pain, incontinence and other conditions.
摘要翻译： 本申请涉及治疗疼痛，失禁等条件的化合物和方法。
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