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公开(公告)号:US08633233B2
公开(公告)日:2014-01-21
申请号:US13057527
申请日:2009-08-06
申请人: Jayhong Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
发明人: Jayhong Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
IPC分类号: A61K31/41 , A61K31/415
CPC分类号: A61K31/423 , A61K31/00 , A61K31/164 , A61K31/4184 , A61K31/4196 , A61K31/53 , C07D235/30 , C07D251/16 , C07D251/46 , C07D251/52 , C07D263/58 , C07D405/14 , C07D409/06 , C07D409/12
摘要: Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
摘要翻译: 描述了通过施用有效量的TRPC5拮抗剂(例如本文公开的化合物)来治疗受试者中TRPC5介导的病症的方法。
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公开(公告)号:US20110319417A1
公开(公告)日:2011-12-29
申请号:US13057527
申请日:2009-08-06
申请人: Jayhong Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
发明人: Jayhong Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
IPC分类号: A61K31/423 , A61K31/53 , A61P25/08 , A61P25/00 , A61P25/22 , A61K31/4196 , A61K31/454
CPC分类号: A61K31/423 , A61K31/00 , A61K31/164 , A61K31/4184 , A61K31/4196 , A61K31/53 , C07D235/30 , C07D251/16 , C07D251/46 , C07D251/52 , C07D263/58 , C07D405/14 , C07D409/06 , C07D409/12
摘要: Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
摘要翻译: 描述了通过施用有效量的TRPC5拮抗剂(例如本文公开的化合物)来治疗受试者中TRPC5介导的病症的方法。
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公开(公告)号:US20140100230A1
公开(公告)日:2014-04-10
申请号:US14102020
申请日:2013-12-10
申请人: Jayhong A. Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
发明人: Jayhong A. Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
IPC分类号: C07D409/12 , C07D405/14 , C07D409/06 , C07D251/16 , C07D251/46 , C07D235/30 , C07D263/58 , C07D251/52
CPC分类号: A61K31/423 , A61K31/00 , A61K31/164 , A61K31/4184 , A61K31/4196 , A61K31/53 , C07D235/30 , C07D251/16 , C07D251/46 , C07D251/52 , C07D263/58 , C07D405/14 , C07D409/06 , C07D409/12
摘要: Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
摘要翻译: 描述了通过施用有效量的TRPC5拮抗剂(例如本文公开的化合物)来治疗受试者中TRPC5介导的病症的方法。
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公开(公告)号:US09139573B2
公开(公告)日:2015-09-22
申请号:US14102020
申请日:2013-12-10
申请人: Jayhong A. Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
发明人: Jayhong A. Chong , Christopher Fanger , Magdalene M. Moran , Elisha Singer , Timothy Strassmaier , Howard Ng
IPC分类号: A61K31/00 , A61K31/164 , A61K31/53 , C07D409/12 , A61K31/4184 , C07D235/30 , C07D251/16 , C07D251/46 , C07D251/52 , C07D263/58 , C07D405/14 , C07D409/06
CPC分类号: A61K31/423 , A61K31/00 , A61K31/164 , A61K31/4184 , A61K31/4196 , A61K31/53 , C07D235/30 , C07D251/16 , C07D251/46 , C07D251/52 , C07D263/58 , C07D405/14 , C07D409/06 , C07D409/12
摘要: Methods of treating a TRPC5 mediated disorder in a subject by administering an effective amount of a TRPC5 antagonist, such as a compound disclosed herein, are described.
摘要翻译: 描述了通过施用有效量的TRPC5拮抗剂(例如本文公开的化合物)来治疗受试者中TRPC5介导的病症的方法。
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公开(公告)号:US09486455B2
公开(公告)日:2016-11-08
申请号:US13040859
申请日:2011-03-04
申请人: Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , Magdalene M. Moran , Howard Ng , Amy Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen
发明人: Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , Magdalene M. Moran , Howard Ng , Amy Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen
IPC分类号: A01N43/58 , A01N43/60 , A61K31/517 , A61K31/519
CPC分类号: A61K31/519 , A61K31/517
摘要: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
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公开(公告)号:US20110151559A1
公开(公告)日:2011-06-23
申请号:US13040859
申请日:2011-03-04
申请人: Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , Magdalene M. Moran , Howard Ng , Amy Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen
发明人: Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , Magdalene M. Moran , Howard Ng , Amy Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen
IPC分类号: C12N5/00
CPC分类号: A61K31/519 , A61K31/517
摘要: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
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公开(公告)号:US20090018147A1
公开(公告)日:2009-01-15
申请号:US12152131
申请日:2008-05-12
申请人: Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , Magdalene M. Moran , Howard Ng , Amy Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen
发明人: Jayhong A. Chong , Christopher Fanger , Glenn R. Larsen , Magdalene M. Moran , Howard Ng , Amy Ripka , Dennis John Underwood , Manfred Weigele , Xiaoguang Zhen
IPC分类号: A61K31/517 , A61P25/00 , A61P17/00 , A61K31/519 , A61P29/00 , A61P19/02
CPC分类号: A61K31/519 , A61K31/517
摘要: The present application relates to compounds and methods for treating pain and other conditions related to TRPV3.
摘要翻译: 本申请涉及用于治疗与TRPV3有关的疼痛和其它病症的化合物和方法。
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公开(公告)号:US20090143377A1
公开(公告)日:2009-06-04
申请号:US12144354
申请日:2008-06-23
申请人: Howard Ng , Manfred Weigele , Magdalene Moran , Jayhong Chong , Christopher Fanger , Glenn R. Larsen , Donato Del Camino , Neil Hayward , Steven P. Adams , Amy Ripka
发明人: Howard Ng , Manfred Weigele , Magdalene Moran , Jayhong Chong , Christopher Fanger , Glenn R. Larsen , Donato Del Camino , Neil Hayward , Steven P. Adams , Amy Ripka
IPC分类号: A61K31/522 , A61K31/5377 , A61P43/00
CPC分类号: A61K31/105 , A61K31/11 , C07D487/04
摘要: Compounds and compositions for treating disorders related to TRPA1 are described herein.
摘要翻译: 本文描述了用于治疗与TRPA1相关的疾病的化合物和组合物。
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公开(公告)号:US08163761B2
公开(公告)日:2012-04-24
申请号:US12144354
申请日:2008-06-23
申请人: Howard Ng , Manfred Weigele , Magdalene Moran , Jayhong Chong , Christopher Fanger , Glenn R. Larsen , Donato Del Camino , Neil Hayward , Steven P. Adams , Amy Ripka
发明人: Howard Ng , Manfred Weigele , Magdalene Moran , Jayhong Chong , Christopher Fanger , Glenn R. Larsen , Donato Del Camino , Neil Hayward , Steven P. Adams , Amy Ripka
IPC分类号: A61K31/519 , A61K31/535 , A01N43/90
CPC分类号: A61K31/105 , A61K31/11 , C07D487/04
摘要: Compounds and compositions for treating disorders related to TRPA1 are described herein.
摘要翻译: 本文描述了用于治疗与TRPA1相关的疾病的化合物和组合物。
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公开(公告)号:US20130059869A1
公开(公告)日:2013-03-07
申请号:US13402720
申请日:2012-02-22
申请人: Howard Ng , Manfred Weigele , Magdalene Moran , Jayhong Chong , Christopher Fanger , Glenn R. Larsen , Donato Del Camino , Neil Hayward , Steven P. Adams , Amy Ripka
发明人: Howard Ng , Manfred Weigele , Magdalene Moran , Jayhong Chong , Christopher Fanger , Glenn R. Larsen , Donato Del Camino , Neil Hayward , Steven P. Adams , Amy Ripka
摘要: Compounds and compositions for treating disorders related to TRPA1 are described herein.
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