公开(公告)号：US4652717A

公开(公告)日：1987-03-24

申请号：US787982

申请日：1985-10-16

申请人： Jean P. Briffod ,  Roland Martin

发明人： Jean P. Briffod ,  Roland Martin

IPC分类号： B23H7/02 ,  B23H7/04 ,  B23H1/02

CPC分类号： B23H7/04

摘要： In a travelling wire EDM apparatus the thermal stresses of the electrode wire are substantially reduced by detecting the position of the triggering electrical discharges preceding the machining electrical discharges, and by controlling the supply of the machining electrical discharge current at one end of the machining zone, at the other end of the machining zone or at both ends of the machining zone. When a machining electrical discharge is located between one end of the machining zone and a first reference position, the machining current is applied at that end. When the electrical discharge is located between the other end of the machining zone and a second reference position, machining current is supplied at that second end. When the electrical discharge is located between the two reference positions, the machining current is applied simultaneously at both ends of the machining zone.

摘要翻译： 在行走线EDM装置中，通过检测在加工放电之前的触发放电的位置，并且通过控制加工区域的一端的加工放电电流的供给，电极线的热应力大大减小， 在加工区域的另一端或加工区域的两端。 当加工放电位于加工区域的一端和第一基准位置之间时，在该端施加加工电流。 当放电位于加工区域的另一端和第二基准位置之间时，在该第二端提供加工电流。 当放电位于两个基准位置之间时，在加工区域的两端同时施加加工电流。

公开(公告)号：US20130095069A1

公开(公告)日：2013-04-18

申请号：US13612763

申请日：2012-09-12

申请人： Roland Martin ,  Henry McFarland ,  Bibiana Bielekova ,  Thomas Waldmann

发明人： Roland Martin ,  Henry McFarland ,  Bibiana Bielekova ,  Thomas Waldmann

IPC分类号： A61K39/395 ,  A61K38/21

CPC分类号： C07K16/2866 ,  A61B5/0042 ,  A61B5/055 ,  A61B5/4848 ,  A61K31/7052 ,  A61K38/215 ,  A61K39/39541 ,  A61K39/3955 ,  A61K49/06 ,  A61K2039/505 ,  A61K2039/54 ,  A61K2039/545 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/76 ,  A61K2300/00

摘要： Disclosed is a method of administering an interleukin-2 receptor (IL-2R) antagonist to a subject to treat an autoimmune disease. In particular embodiments, the IL-2R antagonist is an anti-IL-2R monoclonal antibody specific for one or more chains of the IL-2R, such as the alpha-chain, for example daclizumab. In other particular embodiments the autoimmune disease is multiple sclerosis. In certain embodiments administration of interferon-beta is combined with administration of an antagonist of the IL-2R to provide significant clinical improvement in a subject with an autoimmune disease.

公开(公告)号：US20070237717A1

公开(公告)日：2007-10-11

申请号：US11578207

申请日：2004-04-05

申请人： Roland Martin ,  Louis Staudt ,  Henry McFarland ,  Claus-Steffen Sturzebecher

发明人： Roland Martin ,  Louis Staudt ,  Henry McFarland ,  Claus-Steffen Sturzebecher

IPC分类号： A61K49/00 ,  C12Q1/68

CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/158

摘要： A variety of therapies are used to treat autoimmune diseases such as multiple sclerosis. However, there is no single therapy that can be used to treat all subjects. Thus, a method is provided to determine if a subject with an autoimmune disease, such as multiple sclerosis, will respond to a therapeutic protocol. The method includes analyzing the expression of genes expressed by the immune system. Although the expression of a single gene can be assessed, such as interleukin-8, the methods include evaluating the expression profile of a subject using an array (such as a microarray) to determine if the subject is appropriately responding to the therapeutic protocol.

摘要翻译： 多种疗法用于治疗多发性硬化症等自身免疫性疾病。 然而，没有一种可用于治疗所有受试者的治疗方法。 因此，提供了一种方法来确定具有自身免疫性疾病如多发性硬化的受试者是否将对治疗方案作出反应。 该方法包括分析由免疫系统表达的基因的表达。 虽然可以评估单一基因的表达，例如白介素-8，但是所述方法包括使用阵列（例如微阵列）评估受试者的表达谱以确定受试者是否适当地响应于治疗方案。

公开(公告)号：US06776265B2

公开(公告)日：2004-08-17

申请号：US10101208

申请日：2002-03-20

申请人： Roland Martin

发明人： Roland Martin

IPC分类号： F16D6600

CPC分类号： F16D66/02 ,  F16D65/12 ,  F16D2065/1328 ,  F16D2200/0039

摘要： A device can indicate the total load of a brake disk made of carbon-fiber-reinforced ceramic material. In order to create such a device, which can be used for brake disks and other friction elements made of carbon-fiber-reinforced ceramic material, an indicator element can be provided in the brake disk starting from the friction surface. The oxidation stability of this indicator element is reduced with respect to the material of the brake disk.

摘要翻译： 装置可以指示由碳纤维增强的陶瓷材料制成的制动盘的总负载。 为了制造可用于制动盘和由碳纤维增强陶瓷材料制成的其它摩擦元件的这种装置，可以从摩擦表面开始在制动盘中设置指示元件。 相对于制动盘的材料，该指示元件的氧化稳定性降低。

公开(公告)号：US06602514B1

公开(公告)日：2003-08-05

申请号：US09744945

申请日：2001-01-31

申请人： Joachim Bünger ,  Hans-Jürgen Driller ,  Roland Martin

发明人： Joachim Bünger ,  Hans-Jürgen Driller ,  Roland Martin

IPC分类号： A61K742

CPC分类号： A61Q19/007 ,  A61K8/4953 ,  A61Q17/00 ,  A61Q17/04 ,  A61Q19/00

摘要： The use of one or more compounds chosen from the compounds of the formulae Ia and Ib the physiologically compatible salts of the compounds of the formulae Ia and Ib and the stereoisomeric forms of the compounds of the formulae Ia and Ib, where R1, R2, R3, R4 and n have the meanings given in claim 1, for the preparation of a cosmetic formulation is advantageously suitable, e.g., for protecting cells, proteins and/or biomembranes of the human skin, for protecting the microflora of the human skin, and/or for stabilizing the skin barrier.

摘要翻译： 使用一种或多种选自式Ia和Ib化合物的化合物是式Ia和Ib化合物的生理上相容的盐和式Ia和Ib化合物的立体异构形式，其中R1，R2，R3， R4和n具有权利要求1中给出的含义，对于化妆品制剂的制备有利地适合于例如用于保护人皮肤的细胞，蛋白质和/或生物膜，用于保护人皮肤的微生物群落和/或 用于稳定皮肤屏障。

公开(公告)号：US06548469B2

公开(公告)日：2003-04-15

申请号：US10166179

申请日：2002-06-11

申请人： Mohammad Jalalian ,  Maria Elisabeth Prenzel ,  Roland Martin ,  Francesc Rosell I Oller

发明人： Mohammad Jalalian ,  Maria Elisabeth Prenzel ,  Roland Martin ,  Francesc Rosell I Oller

IPC分类号： C11D942

CPC分类号： C11D3/48 ,  A01N37/44 ,  Y10S424/10 ,  Y10S514/919 ,  A01N2300/00

摘要： The present invention relates to cleaning compositions which comprise the insect repellent ethyl 3-(N-butylacetamino)propionate and the use of this insect repellent in all types of cleaning compositions for repelling insects. This invention furthermore relates to a method for cleaning and for simultaneously repelling insects in which cleaning compositions comprising ethyl 3-(N-butylacetamino)propionate are used.

公开(公告)号：US06392183B1

公开(公告)日：2002-05-21

申请号：US09599780

申请日：2000-06-21

申请人： Roland Martin ,  Aldo Gamboni ,  Maurizio Tognolini ,  Gilbert Bovay

发明人： Roland Martin ,  Aldo Gamboni ,  Maurizio Tognolini ,  Gilbert Bovay

IPC分类号： B23H102

CPC分类号： B23H1/022 ,  B23H2300/20

摘要： In the process of machining by electroerosion, there is adjusted during a first transitory phase the machining current increase of the discharges after triggering a discharge between the electrode and the piece, such that a parameter connected to this increase will be substantially equal to a reference value corresponding to a minimum wear value of the electrode. Then, the machining current is maintained during a second phase at a reference value. The adjustment is carried out by acting on the adjustable internal voltage of a low impedance adjustable voltage source connected between the electrode and the piece. The adjustment can be carried out by a servo control loop with a regulator of the internal voltage, a device for generating discharges, parts adapted to determine the slope of increase of the current of a discharge, a member determining the mean slope of N discharges and a member adapted to compute the difference between the mean slope and a pre-established reference slope.

摘要翻译： 在通过电蚀加工的过程中，在第一暂态阶段中调整在触发电极和片之间的放电之后放电的加工电流增加，使得与该增加相关联的参数将基本上等于参考值 对应于电极的最小磨损值。 然后，在参考值的第二阶段期间维持加工电流。 通过作用在连接在电极和片之间的低阻抗可调电压源的可调内部电压来进行调整。 该调节可以通过具有内部电压调节器的伺服控制回路，用于产生放电的装置，适于确定放电电流的增加的斜率的部件，确定N次放电的平均斜率的部件，以及 适于计算平均斜率与预先建立的参考斜率之间的差异的构件。

公开(公告)号：US06386341B1

公开(公告)日：2002-05-14

申请号：US09583578

申请日：2000-05-31

申请人： Roland Martin

发明人： Roland Martin

IPC分类号： F16D6512

CPC分类号： F16D65/12 ,  F16D2065/1316 ,  F16D2065/132 ,  F16D2065/1324 ,  F16D2065/1328 ,  F16D2065/1392 ,  F16D2069/004 ,  F16D2200/0039 ,  F16D2200/0052 ,  F16D2200/006

摘要： A brake disk made of a fiber-reinforced material includes two assembled friction rings. The friction rings, on interior sides, are provided with ribs. The two friction rings are supported with respect to one another along at least a portion of the ribs. In order to provide a suitable shaping of faces of the ribs, faces used as coupling faces are constructed such that a coupling of the friction rings is caused in precisely one rotating direction and, in a particular case, such that the coupling faces are arranged in an alternating manner.

摘要翻译： 由纤维增强材料制成的制动盘包括两个组装的摩擦环。 在内侧的摩擦环设有肋。 两个摩擦环沿着肋的至少一部分相对于彼此支撑。 为了提供肋的面的适当成形，用作连接面的面被构造成使得摩擦环的联接在精确的一个旋转方向上产生，并且在特定情况下，使得联接面布置在 交替的方式。

公开(公告)号：US06186286B1

公开(公告)日：2001-02-13

申请号：US09210893

申请日：1998-12-16

申请人： Harald Häussler ,  Helmut Pietsch ,  Roland Martin ,  Carsten-Jörg Mertens ,  Artur Grunwald ,  Thomas Klaas ,  Michael Pehle ,  Reinhold Pittius

发明人： Harald Häussler ,  Helmut Pietsch ,  Roland Martin ,  Carsten-Jörg Mertens ,  Artur Grunwald ,  Thomas Klaas ,  Michael Pehle ,  Reinhold Pittius

IPC分类号： F16D5508

CPC分类号： F16D65/092 ,  F16D55/38 ,  F16D65/183 ,  F16D2055/0008 ,  F16D2055/0016 ,  F16D2055/0062 ,  F16D2065/1368 ,  F16D2121/14 ,  F16D2125/40 ,  F16D2125/70

摘要： A braking device for wheels of vehicles such as trailers includes a caliper in which brake linings are guided. Between these linings, at least one brake disk is displaceably held on driving toothing of a wheel hub. A pneumatically operable mechanical adjusting device interacts with the brake linings. The braking device includes at least one brake disk in a caliper which is fixed. On one end, the caliper is connected by a fastening element with an axle element of the vehicle. On the caliper, an enclosing housing for bearing the adjusting device is held. By way of a bearing plate, the adjusting device is also supported on the caliper. Pressure pistons of the device are guided by a one-part yoke in a jointly axially adjustable manner and can be acted upon by pressure with respect to the brake linings and the brake disks.

摘要翻译： 用于诸如拖车的车辆的车轮的制动装置包括其中制动衬片被引导的卡钳。 在这些内衬之间，至少一个制动盘可移动地保持在轮毂的驱动齿上。 气动可操作的机械调节装置与制动衬片相互作用。 制动装置包括至少一个固定的制动盘。 一方面，卡钳通过具有车辆的轴元件的紧固元件连接。 在卡钳上，保持用于承载调节装置的封闭壳体。 通过支承板，调节装置也支撑在卡钳上。 装置的压力活塞由共同轴向调节的一个部分的轭引导，并且可以相对于制动衬片和制动盘的压力作用。

公开(公告)号：US6116386A

公开(公告)日：2000-09-12

申请号：US99938

申请日：1998-06-19

申请人： Roland Martin

发明人： Roland Martin

IPC分类号： F16D65/12

CPC分类号： F16D65/123 ,  F16D2065/1316 ,  F16D2065/1328 ,  F16D2065/1348 ,  F16D2065/136 ,  F16D2065/1392 ,  F16D2065/1396

摘要： A brake disk, particularly a ventilated brake disk, has at least one friction ring connected with a brake disk chamber by fastening screws. Each fastening screw is provided with a cylindrical projection which is adjoined on the end side by a threaded portion. The cylindrical projection of the fastening screw is arranged in a bore of the friction ring. The threaded portion of the screw can be screwed into the brake chamber.

摘要翻译： 制动盘，特别是通风制动盘，具有通过紧固螺钉与制动盘室连接的至少一个摩擦环。 每个紧固螺钉设置有圆柱形凸起，该凸起在端部侧通过螺纹部分相邻。 紧固螺钉的圆柱形突出部布置在摩擦环的孔中。 螺钉的螺纹部分可以拧入制动室。