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公开(公告)号：US5958927A
公开(公告)日：1999-09-28
申请号：US165844
申请日：1998-10-02
IPC分类号： A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/445 , A61P25/00 , A61P25/04 , A61P43/00 , C07D311/18 , C07D319/18 , C07D401/10 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , A61K31/495 , C07D405/10 , C07D409/10 , C07D411/10
CPC分类号： C07D405/04 , C07D311/18 , C07D319/18 , C07D405/14 , C07D409/04
摘要： A compound of formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, X-Y, A, Z and Z' are as defined in the description, in the form of the cis or trans isomers each in racemic or optically active form, and acid addition salts thereof, and medicinal products containing the same are useful in the treatment of diseases of the central nervous system or of manifestations of pain.
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公开(公告)号：US6060487A
公开(公告)日：2000-05-09
申请号：US273889
申请日：1999-03-22
IPC分类号： A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/445 , A61P25/00 , A61P25/04 , A61P43/00 , C07D311/18 , C07D319/18 , C07D401/10 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04
CPC分类号： C07D405/04 , C07D311/18 , C07D319/18 , C07D405/14 , C07D409/04
摘要： A compound of formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, X--Y, A, Z and Z' are as defined in the description, in the form of the cis or trans isomers each in racemic or optically active form, and acid addition salts thereof, and medicinal products containing the same are useful in the treatment of diseases of the central nervous system or of manifestations of pain.
摘要翻译： 式（I）化合物：其中R1，R2，R3，R4，XY，A，Z和Z'如说明书中所定义，以顺式或反式异构体的形式，各自为外消旋或旋光活性形式，以及 其酸加成盐和含有它们的药物可用于治疗中枢神经系统疾病或疼痛的表现。
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公开(公告)号：US5753662A
公开(公告)日：1998-05-19
申请号：US655457
申请日：1996-05-30
申请人： Jean-Louis Peglion , Aimee Dessinges , Bertrand Goument , Mark Millan , Adrian Newman-Tancredi , Alain Gobert
发明人： Jean-Louis Peglion , Aimee Dessinges , Bertrand Goument , Mark Millan , Adrian Newman-Tancredi , Alain Gobert
IPC分类号： A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/495 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/26 , A61P43/00 , C07D307/79 , C07D307/81 , C07D319/18 , C07D321/10 , C07D405/04 , C07D409/12 , C07D405/00 , C07D407/00
CPC分类号： C07D307/79 , C07D319/18 , C07D321/10 , C07D405/04 , C07D409/12
摘要： A compound selected from those of formula: ##STR1## wherein: A--B, n, D and E are as defined in the specification, their racemic mixtures, and their optical isomers, and also the physiologically tolerable salts thereof with appropriate acids. The products of the invention may be used therapeutically.
摘要翻译： 选自下式的化合物：其中：A-B，n，D和E如说明书中所定义，它们的外消旋混合物及其旋光异构体，以及其与适当的酸的生理上可耐受的盐。 本发明的产品可以在治疗上使用。
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公开(公告)号：US5684020A
公开(公告)日：1997-11-04
申请号：US792179
申请日：1997-01-30
申请人： Jean-Louis Peglion , Aimee Dessinges , Bertrand Goument , Mark Millan , Adrian Newman-Tancredi , Alain Gobert
发明人： Jean-Louis Peglion , Aimee Dessinges , Bertrand Goument , Mark Millan , Adrian Newman-Tancredi , Alain Gobert
IPC分类号： A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/495 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/26 , A61P43/00 , C07D307/79 , C07D307/81 , C07D319/18 , C07D321/10 , C07D405/04 , C07D409/12 , C07D407/14
CPC分类号： C07D307/79 , C07D319/18 , C07D321/10 , C07D405/04 , C07D409/12
摘要： A compound selected from those of formula: ##STR1## wherein: A-B, n, D and E are as defined in the specification, their racemic mixtures, and their optical isomers, and also the physiologically tolerable salts thereof with appropriate acids. The products of the invention may be used therapeutically.
摘要翻译： 选自下式的化合物：其中：A-B，n，D和E如说明书中所定义，它们的外消旋混合物及其旋光异构体，以及其与适当的酸的生理上可耐受的盐。 本发明的产品可以在治疗上使用。
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公开(公告)号：US6153625A
公开(公告)日：2000-11-28
申请号：US374161
申请日：1999-08-13
IPC分类号： C07D211/58 , A61K31/00 , A61K31/443 , A61K31/445 , A61P3/00 , A61P3/04 , A61P9/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07D405/04 , C07D405/12 , C07D409/12 , C07D411/12
CPC分类号： C07D405/04
摘要： A compound selected from those of formula (I): ##STR1## wherein: R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, represent hydrogen, halogen, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, trihaloalkyl, or any pair may form a heterocycle,R.sub.5 represents hydrogen, alkyl, or arylalkyl,R.sub.6 represents hydrogen, halogen, alkyl, hydroxy, alkoxy, or trihaloalkyl,A, together with the carbons of the phenyl, represents a heterocycle,their isomers and addition pharmaceutically-acceptable acid or base salts thereof, and medicinal products containing the same which are useful in the treatment of pathologies in which 5HT.sub.1B receptors are involved.
摘要翻译： 选自式（I）的化合物的化合物：其中：R 1，R 2，R 3和R 4可以相同或不同，表示氢，卤素，烷基，烯基，炔基，羟基，烷氧基，三卤代烷基或任何一对可形成 杂环，R 5表示氢，烷基或芳烷基，R 6表示氢，卤素，烷基，羟基，烷氧基或三卤代烷基，A与苯基的碳一起代表杂环，其异构体和加成药学上可接受的酸或 其盐类和含有该物质的药物可用于治疗涉及5HT1B受体的病理学。
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公开(公告)号：US6153640A
公开(公告)日：2000-11-28
申请号：US533684
申请日：2000-03-23
申请人： Jean-Louis Peglion , Bertrand Goument , Aimee Dessinges , Mark Millan , Jean-Michel Rivet , Anne Dekeyne
发明人： Jean-Louis Peglion , Bertrand Goument , Aimee Dessinges , Mark Millan , Jean-Michel Rivet , Anne Dekeyne
IPC分类号： C07D491/056 , A61K31/403 , A61K31/407 , A61K31/4245 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/30 , A61P43/00 , C07D209/00 , C07D209/70 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D209/58
CPC分类号： C07D403/12 , C07D209/70 , C07D405/12 , C07D409/12
摘要： A compound of formula (I): ##STR1## wherein: R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, represent a group as defined in the description,R.sub.4 represents hydrogen, alky, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroarylalkyl,R.sub.5 represents aryl, or heteroaryl, each optionally substituted,n is an integer from 1 to 3 inclusive,their isomers and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are usefull in the treatment of disease like depression, panic attacks, obsessive-compulsive disorders, phobias, impulsive disorders, drug abuse or anxiety.
摘要翻译： 式（I）的化合物：其中：R 1，R 2和R 3可以相同或不同，表示说明书中定义的基团，R 4表示氢，烷基，烯基，炔基，环烷基，环烷基烷基，芳基，芳基烷基 ，杂环烷基，杂环烷基烷基，杂芳基或杂芳基烷基，R 5表示芳基或杂芳基，各自任选取代，n是1至3的整数，包括其中的整数，它们与药学上可接受的酸或碱的异构体和加成盐，以及含 同样的治疗疾病如抑郁症，惊恐发作，强迫症，恐惧症，冲动性疾病，药物滥用或焦虑症也是有用的。
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公开(公告)号：US6107345A
公开(公告)日：2000-08-22
申请号：US261803
申请日：1999-03-03
申请人： Jean-Louis Peglion , Aimee Dessinges , Jean-Christophe Harmange , Mark Millan , Adrian Newman-Tancredi , Mauricette Brocco
发明人： Jean-Louis Peglion , Aimee Dessinges , Jean-Christophe Harmange , Mark Millan , Adrian Newman-Tancredi , Mauricette Brocco
IPC分类号： C07D233/50 , A61K31/00 , A61K31/135 , A61K31/33 , A61K31/35 , A61K31/351 , A61K31/38 , A61K31/382 , A61K31/415 , A61K31/4164 , A61K31/4168 , A61K31/445 , A61K31/4465 , A61K31/451 , A61P1/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/30 , A61P43/00 , C07C215/42 , C07C217/58 , C07C217/74 , C07D211/44 , C07D233/48 , C07D263/28 , C07D309/10 , C07D335/02 , C07D345/00 , A61K31/133
CPC分类号： C07D309/10 , C07C215/42 , C07C217/74 , C07D233/48 , C07D263/28 , C07D335/02
摘要： A compound of formula (I): ##STR1## wherein: Z.sub.1, Z.sub.2, Z.sub.3, Z.sub.4, which may be identical or different, represent a group as defined in the description,X represents oxygen, S(O).sub.p, --(CH.sub.2).sub.n -- or --CH.sub.2 --Y--CH.sub.2 -- wherein p, n and Y are as defined in the description,A represents ##STR2## wherein m, R.sub.1, R.sub.2 and G are as defined in the description, their isomers and addition salts thereof with a pharmaceutically-acceptable acid, and medicinal products containing the same are useful in the treatment of diseases like depression, panic attacks, obsessive compulsive disorders, phobias, impulsive disorders, drug abuse or anxiety.
摘要翻译： 式（I）的化合物：其中：可以相同或不同的Z 1，Z 2，Z 3，Z 4表示如说明书中所定义的基团，X表示氧，S（O）p， - （CH 2）n - 或-CH 2 -Y-CH 2 - ，其中p，n和Y如说明书中所定义，A表示其中m，R 1，R 2和G如说明书中所定义，其异构体和加成盐与药学上可接受的酸 和含有它们的药用产品可用于治疗抑郁症，恐慌发作，强迫症，恐惧症，冲动性疾病，药物滥用或焦虑症等疾病。
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公开(公告)号：US06399616B1
公开(公告)日：2002-06-04
申请号：US09641777
申请日：2000-08-18
IPC分类号： A61K31496
CPC分类号： C07D471/04 , C07D491/04 , C07D495/04
摘要： A compound selected from those of formula (I): wherein: W represents optionally substituted naphthyl, n represents an integer from 2 to 3 inclusive, Z represents a single bond, A represents nitrogen, Q represents nitrogen, M, together with the carbon of pyridyl to which it is bonded, represents thieno, furo, pyrrolo or oxopyrrolo, Its optical isomers and pharmaceutically-acceptable acid or base additional salts thereof, and Medicinal products containing the same which are useful in the treatment of CNS disorders. It being understood that “aryl” is phenyl, naphthyl, dihydronaphthyl, or tetrahydronaphthyl.
摘要翻译： 选自式（I）的化合物：其中：W表示任选取代的萘基，n表示2〜3的整数，Z表示单键，A表示氮，Q表示氮，M表示与 吡咯基，吡咯基或氧吡咯，其光学异构体和药学上可接受的酸或碱的另外的盐，和含有它们的可用于治疗CNS病症的药物。可以理解的是“ 芳基“是苯基，萘基，二氢萘基或四氢萘基。
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公开(公告)号：US07612061B2
公开(公告)日：2009-11-03
申请号：US12291485
申请日：2008-11-10
申请人： Jean-Louis Peglion , Aimee Dessinges , Bertrand Goument , Mark Millan , Clotilde Mannoury La Cour
发明人： Jean-Louis Peglion , Aimee Dessinges , Bertrand Goument , Mark Millan , Clotilde Mannoury La Cour
IPC分类号： A61K31/551 , C07D295/081
CPC分类号： C07D313/08 , C07D211/22 , C07D213/81 , C07D215/42 , C07D243/08 , C07D249/12 , C07D295/096 , C07D295/155 , C07D311/68 , C07D319/20 , C07D405/04
摘要： A compound selected from those of formula (I): wherein: R1, R2, R3 and R4, which may be the same or different, each represent an atom or group selected from hydrogen, halogen, alkyl, alkoxy, phenyl and cyano, X represents a bond, an oxygen atom or a group selected from —(CH2)m—, —OCH2— and —NR5—, wherein m represents 1 or 2, and R5 is as defined in the description, Y represents an oxygen atom or a group selected from NR7 and CHR8, wherein R7 and R8 are as defined in the description, Z represents a nitrogen atom or a CH group, n represents 1 or 2, Ak represents an alkylene chain, Ar represents an aryl or heteroaryl group, its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid. Medical products containing the same which are useful in the treatment of conditions requiring a serotonin reuptake inhibitor and/or NK1 antagonist.
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公开(公告)号：US5593989A
公开(公告)日：1997-01-14
申请号：US456504
申请日：1995-06-01
申请人： Jean-Louis Peglion , Joel Vian , Bertrand Goument , Mark Millan , Val erie Audinot , Jean-Charles Schwartz , Pierre Sokoloff
发明人： Jean-Louis Peglion , Joel Vian , Bertrand Goument , Mark Millan , Val erie Audinot , Jean-Charles Schwartz , Pierre Sokoloff
IPC分类号： A61K31/435 , A61K31/4741 , A61K31/535 , A61K31/5383 , A61P25/00 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , C07D491/04 , C07D491/048 , C07D491/153 , C07D498/04 , C07D498/14
CPC分类号： C07D491/04
摘要： New compounds of formula: ##STR1## wherein A--B, X, Y, R and n are as defined in the description. The geometric isomers, racemate and optical isomers thereof and the addition salts with pharmaceutically acceptable acids, and medicinal products containing the same are useful for treating psychotic disorders, depression, Parkinson's disease, memory disorders and disorders associated with drug abuse.
摘要翻译： 新化合物：其中A-B，X，Y，R和n如说明书中所定义。 其几何异构体，外消旋物和旋光异构体以及与药学上可接受的酸的加成盐以及含有它们的药物可用于治疗精神病，抑郁症，帕金森病，记忆障碍和与药物滥用相关的病症。
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