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公开(公告)号：US5753662A
公开(公告)日：1998-05-19
申请号：US655457
申请日：1996-05-30
申请人： Jean-Louis Peglion , Aimee Dessinges , Bertrand Goument , Mark Millan , Adrian Newman-Tancredi , Alain Gobert
发明人： Jean-Louis Peglion , Aimee Dessinges , Bertrand Goument , Mark Millan , Adrian Newman-Tancredi , Alain Gobert
IPC分类号： A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/495 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/26 , A61P43/00 , C07D307/79 , C07D307/81 , C07D319/18 , C07D321/10 , C07D405/04 , C07D409/12 , C07D405/00 , C07D407/00
CPC分类号： C07D307/79 , C07D319/18 , C07D321/10 , C07D405/04 , C07D409/12
摘要： A compound selected from those of formula: ##STR1## wherein: A--B, n, D and E are as defined in the specification, their racemic mixtures, and their optical isomers, and also the physiologically tolerable salts thereof with appropriate acids. The products of the invention may be used therapeutically.
摘要翻译： 选自下式的化合物：其中：A-B，n，D和E如说明书中所定义，它们的外消旋混合物及其旋光异构体，以及其与适当的酸的生理上可耐受的盐。 本发明的产品可以在治疗上使用。
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公开(公告)号：US5684020A
公开(公告)日：1997-11-04
申请号：US792179
申请日：1997-01-30
申请人： Jean-Louis Peglion , Aimee Dessinges , Bertrand Goument , Mark Millan , Adrian Newman-Tancredi , Alain Gobert
发明人： Jean-Louis Peglion , Aimee Dessinges , Bertrand Goument , Mark Millan , Adrian Newman-Tancredi , Alain Gobert
IPC分类号： A61K31/443 , A61K31/4433 , A61K31/445 , A61K31/495 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/26 , A61P43/00 , C07D307/79 , C07D307/81 , C07D319/18 , C07D321/10 , C07D405/04 , C07D409/12 , C07D407/14
CPC分类号： C07D307/79 , C07D319/18 , C07D321/10 , C07D405/04 , C07D409/12
摘要： A compound selected from those of formula: ##STR1## wherein: A-B, n, D and E are as defined in the specification, their racemic mixtures, and their optical isomers, and also the physiologically tolerable salts thereof with appropriate acids. The products of the invention may be used therapeutically.
摘要翻译： 选自下式的化合物：其中：A-B，n，D和E如说明书中所定义，它们的外消旋混合物及其旋光异构体，以及其与适当的酸的生理上可耐受的盐。 本发明的产品可以在治疗上使用。
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公开(公告)号：US6107345A
公开(公告)日：2000-08-22
申请号：US261803
申请日：1999-03-03
申请人： Jean-Louis Peglion , Aimee Dessinges , Jean-Christophe Harmange , Mark Millan , Adrian Newman-Tancredi , Mauricette Brocco
发明人： Jean-Louis Peglion , Aimee Dessinges , Jean-Christophe Harmange , Mark Millan , Adrian Newman-Tancredi , Mauricette Brocco
IPC分类号： C07D233/50 , A61K31/00 , A61K31/135 , A61K31/33 , A61K31/35 , A61K31/351 , A61K31/38 , A61K31/382 , A61K31/415 , A61K31/4164 , A61K31/4168 , A61K31/445 , A61K31/4465 , A61K31/451 , A61P1/00 , A61P25/18 , A61P25/20 , A61P25/24 , A61P25/30 , A61P43/00 , C07C215/42 , C07C217/58 , C07C217/74 , C07D211/44 , C07D233/48 , C07D263/28 , C07D309/10 , C07D335/02 , C07D345/00 , A61K31/133
CPC分类号： C07D309/10 , C07C215/42 , C07C217/74 , C07D233/48 , C07D263/28 , C07D335/02
摘要： A compound of formula (I): ##STR1## wherein: Z.sub.1, Z.sub.2, Z.sub.3, Z.sub.4, which may be identical or different, represent a group as defined in the description,X represents oxygen, S(O).sub.p, --(CH.sub.2).sub.n -- or --CH.sub.2 --Y--CH.sub.2 -- wherein p, n and Y are as defined in the description,A represents ##STR2## wherein m, R.sub.1, R.sub.2 and G are as defined in the description, their isomers and addition salts thereof with a pharmaceutically-acceptable acid, and medicinal products containing the same are useful in the treatment of diseases like depression, panic attacks, obsessive compulsive disorders, phobias, impulsive disorders, drug abuse or anxiety.
摘要翻译： 式（I）的化合物：其中：可以相同或不同的Z 1，Z 2，Z 3，Z 4表示如说明书中所定义的基团，X表示氧，S（O）p， - （CH 2）n - 或-CH 2 -Y-CH 2 - ，其中p，n和Y如说明书中所定义，A表示其中m，R 1，R 2和G如说明书中所定义，其异构体和加成盐与药学上可接受的酸 和含有它们的药用产品可用于治疗抑郁症，恐慌发作，强迫症，恐惧症，冲动性疾病，药物滥用或焦虑症等疾病。
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公开(公告)号：US5958927A
公开(公告)日：1999-09-28
申请号：US165844
申请日：1998-10-02
IPC分类号： A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/445 , A61P25/00 , A61P25/04 , A61P43/00 , C07D311/18 , C07D319/18 , C07D401/10 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04 , A61K31/495 , C07D405/10 , C07D409/10 , C07D411/10
CPC分类号： C07D405/04 , C07D311/18 , C07D319/18 , C07D405/14 , C07D409/04
摘要： A compound of formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, X-Y, A, Z and Z' are as defined in the description, in the form of the cis or trans isomers each in racemic or optically active form, and acid addition salts thereof, and medicinal products containing the same are useful in the treatment of diseases of the central nervous system or of manifestations of pain.
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公开(公告)号：US6153625A
公开(公告)日：2000-11-28
申请号：US374161
申请日：1999-08-13
IPC分类号： C07D211/58 , A61K31/00 , A61K31/443 , A61K31/445 , A61P3/00 , A61P3/04 , A61P9/00 , A61P25/00 , A61P25/04 , A61P25/06 , A61P25/18 , A61P25/22 , A61P25/24 , A61P43/00 , C07D405/04 , C07D405/12 , C07D409/12 , C07D411/12
CPC分类号： C07D405/04
摘要： A compound selected from those of formula (I): ##STR1## wherein: R.sub.1, R.sub.2, R.sub.3 and R.sub.4, which may be identical or different, represent hydrogen, halogen, alkyl, alkenyl, alkynyl, hydroxy, alkoxy, trihaloalkyl, or any pair may form a heterocycle,R.sub.5 represents hydrogen, alkyl, or arylalkyl,R.sub.6 represents hydrogen, halogen, alkyl, hydroxy, alkoxy, or trihaloalkyl,A, together with the carbons of the phenyl, represents a heterocycle,their isomers and addition pharmaceutically-acceptable acid or base salts thereof, and medicinal products containing the same which are useful in the treatment of pathologies in which 5HT.sub.1B receptors are involved.
摘要翻译： 选自式（I）的化合物的化合物：其中：R 1，R 2，R 3和R 4可以相同或不同，表示氢，卤素，烷基，烯基，炔基，羟基，烷氧基，三卤代烷基或任何一对可形成 杂环，R 5表示氢，烷基或芳烷基，R 6表示氢，卤素，烷基，羟基，烷氧基或三卤代烷基，A与苯基的碳一起代表杂环，其异构体和加成药学上可接受的酸或 其盐类和含有该物质的药物可用于治疗涉及5HT1B受体的病理学。
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公开(公告)号：US6060487A
公开(公告)日：2000-05-09
申请号：US273889
申请日：1999-03-22
IPC分类号： A61K31/4418 , A61K31/443 , A61K31/4433 , A61K31/445 , A61P25/00 , A61P25/04 , A61P43/00 , C07D311/18 , C07D319/18 , C07D401/10 , C07D401/14 , C07D405/04 , C07D405/14 , C07D409/04
CPC分类号： C07D405/04 , C07D311/18 , C07D319/18 , C07D405/14 , C07D409/04
摘要： A compound of formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, X--Y, A, Z and Z' are as defined in the description, in the form of the cis or trans isomers each in racemic or optically active form, and acid addition salts thereof, and medicinal products containing the same are useful in the treatment of diseases of the central nervous system or of manifestations of pain.
摘要翻译： 式（I）化合物：其中R1，R2，R3，R4，XY，A，Z和Z'如说明书中所定义，以顺式或反式异构体的形式，各自为外消旋或旋光活性形式，以及 其酸加成盐和含有它们的药物可用于治疗中枢神经系统疾病或疼痛的表现。
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公开(公告)号：US20090076030A1
公开(公告)日：2009-03-19
申请号：US12291485
申请日：2008-11-10
申请人： Jean-Louis Peglion , Aimee Dessinges , Bertrand Goument , Mark Millan , Clotilde Mannoury La Cour
发明人： Jean-Louis Peglion , Aimee Dessinges , Bertrand Goument , Mark Millan , Clotilde Mannoury La Cour
IPC分类号： A61K31/496 , C07D241/04 , C07D405/04 , A61K31/495 , A61P25/22 , A61P25/24 , A61P1/00 , A61K31/4965 , C07D241/02
CPC分类号： C07D313/08 , C07D211/22 , C07D213/81 , C07D215/42 , C07D243/08 , C07D249/12 , C07D295/096 , C07D295/155 , C07D311/68 , C07D319/20 , C07D405/04
摘要： A compound selected from those of formula (I): wherein: R1, R2, R3 and R4, which may be the same or different, each represent an atom or group selected from hydrogen, halogen, alkyl, alkoxy, phenyl and cyano, X represents a bond, an oxygen atom or a group selected from —(CH2)m—, —OCH2— and —NR5—, wherein m represents 1 or 2, and R5 is as defined in the description, Y represents an oxygen atom or a group selected from NR7 and CHR8, wherein R7 and R8 are as defined in the description, Z represents a nitrogen atom or a CH group, n represents 1 or 2, Ak represents an alkylene chain, Ar represents an aryl or heteroaryl group, its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid. Medical products containing the same which are useful in the treatment of conditions requiring a serotonin reuptake inhibitor and/or NK1 antagonist.
摘要翻译： 选自式（I）的化合物：其中：R 1，R 2，R 3和R 4可以相同或不同，表示选自氢，卤素，烷基，烷氧基，苯基和氰基的原子或基团，X 表示键，氧原子或选自 - （CH 2）m - ， - OCH 2 - 和-NR 5 - 的基团，其中m表示1或2，R 5如说明书中所定义，Y表示氧原子或 选自NR7和CHR8的基团，其中R7和R8如说明书中所定义，Z表示氮原子或CH基团，n表示1或2，Ak表示亚烷基链，Ar表示芳基或杂芳基，其光学 异构体及其与药学上可接受的酸的加成盐。 含有该药物的药物可用于治疗需要5-羟色胺再摄取抑制剂和/或NK1拮抗剂的病症。
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公开(公告)号：US6153640A
公开(公告)日：2000-11-28
申请号：US533684
申请日：2000-03-23
申请人： Jean-Louis Peglion , Bertrand Goument , Aimee Dessinges , Mark Millan , Jean-Michel Rivet , Anne Dekeyne
发明人： Jean-Louis Peglion , Bertrand Goument , Aimee Dessinges , Mark Millan , Jean-Michel Rivet , Anne Dekeyne
IPC分类号： C07D491/056 , A61K31/403 , A61K31/407 , A61K31/4245 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/30 , A61P43/00 , C07D209/00 , C07D209/70 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D209/58
CPC分类号： C07D403/12 , C07D209/70 , C07D405/12 , C07D409/12
摘要： A compound of formula (I): ##STR1## wherein: R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, represent a group as defined in the description,R.sub.4 represents hydrogen, alky, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heterocycloalkyl, heterocycloalkylalkyl, heteroaryl, or heteroarylalkyl,R.sub.5 represents aryl, or heteroaryl, each optionally substituted,n is an integer from 1 to 3 inclusive,their isomers and addition salts thereof with a pharmaceutically-acceptable acid or base, and medicinal products containing the same are usefull in the treatment of disease like depression, panic attacks, obsessive-compulsive disorders, phobias, impulsive disorders, drug abuse or anxiety.
摘要翻译： 式（I）的化合物：其中：R 1，R 2和R 3可以相同或不同，表示说明书中定义的基团，R 4表示氢，烷基，烯基，炔基，环烷基，环烷基烷基，芳基，芳基烷基 ，杂环烷基，杂环烷基烷基，杂芳基或杂芳基烷基，R 5表示芳基或杂芳基，各自任选取代，n是1至3的整数，包括其中的整数，它们与药学上可接受的酸或碱的异构体和加成盐，以及含 同样的治疗疾病如抑郁症，惊恐发作，强迫症，恐惧症，冲动性疾病，药物滥用或焦虑症也是有用的。
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公开(公告)号：US5726208A
公开(公告)日：1998-03-10
申请号：US728759
申请日：1996-10-11
申请人： Jean-Louis Peglion , Bertrand Goument , Jean-Christophe Harmange , Joel Vian , Aimee Dessinges , Mark Millan , Valerie Audinot
发明人： Jean-Louis Peglion , Bertrand Goument , Jean-Christophe Harmange , Joel Vian , Aimee Dessinges , Mark Millan , Valerie Audinot
IPC分类号： A61K31/35 , A61K31/352 , A61K31/38 , A61K31/381 , A61K31/40 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , C07C225/20 , C07D311/78 , C07D311/92 , C07D311/94 , C07D333/74 , C07D405/12 , A61K31/135 , A61K31/165 , C07C211/43 , C07D335/08
CPC分类号： C07D311/94 , C07C225/20 , C07D311/92 , C07D333/74 , C07C2103/16
摘要： New compounds of formula: ##STR1## wherein: --A--D--E, X, n, Y and Z are as defined in the description, in racemic form and in the form of optical isomers, and their addition salts with pharmaceutically acceptable acids. Those compounds may be used as medicaments.
摘要翻译： 新化合物：其中：-A-D-E，X，n，Y和Z如说明书中所定义，以外消旋形式和旋光异构体的形式，以及它们与药学上可接受的酸的加成盐。 那些化合物可以用作药物。
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公开(公告)号：US20090075982A1
公开(公告)日：2009-03-19
申请号：US12291560
申请日：2008-11-12
申请人： Jean-Louis Peglion , Aimee Dessinges , Bertrand Goument , Mark Millan , Clotilde Mannoury La Cour
发明人： Jean-Louis Peglion , Aimee Dessinges , Bertrand Goument , Mark Millan , Clotilde Mannoury La Cour
IPC分类号： A61K31/551 , C07D243/08
CPC分类号： C07D313/08 , C07D211/22 , C07D213/81 , C07D215/42 , C07D243/08 , C07D249/12 , C07D295/096 , C07D295/155 , C07D311/68 , C07D319/20 , C07D405/04
摘要： A compound selected from those of formula (I): wherein: R1, R2, R3 and R4, which may be the same or different, each represent an atom or group selected from hydrogen, halogen, alkyl, alkoxy, phenyl and cyano, X represents a bond, an oxygen atom or a group selected from —(CH2)m—, —OCH2— and —NR5—, wherein m represents 1 or 2, and R5 is as defined in the description, Y represents an oxygen atom or a group selected from NR7 and CHR8, wherein R7 and R8 are as defined in the description, Z represents a nitrogen atom or a CH group, n represents 1 or 2, Ak represents an alkylene chain, Ar represents an aryl or heteroaryl group, its optical isomers, and addition salts thereof with a pharmaceutically acceptable acid. Medical products containing the same which are useful in the treatment of conditions requiring a serotonin reuptake inhibitor and/or NK1 antagonist.
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