摘要:
The compounds are 2,4-disubstituted 3-ethoxycarbonyl 5-methoxycarbonyl 6-methyl 1,4-dihydropyridines in their dextrorotatory form, useful to potentiate the activity of cytotoxic agents and to increase the sensitivity of tumor cells to antitumor agents.A compound disclosed is d-2-{[2-(2-(N-p-nitrobenzylamino)ethoxy)ethoxy]methyl}-4-(2,3-dichlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine.
摘要:
A compound of formula (I) ##STR1## in which: m, and n, which may be identical or different, represent 0 or 1,X and Y, which may be identical or different, represent hydrogen or halogen or alky, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylamino or dialkylamino,Z represent a linear or branched C.sub.4 to C.sub.12 alkylene chain in which one or more --CH.sub.2 -- are optionally replaced by any one of the following atoms or groups: --NR--, --O--, --S--, --SO--, --SO.sub.2 --, or --CONH--, or by a substituted or unsubstituted heterocylcic,A forms, with two adjacent carbon atoms of the phenyl ring, a phenyl, naphthyl or tetrahydronaphthyl ring or a heterocycle, ##STR2## and medicinal products containing the same are useful as anticancer agent.
摘要:
A compound selected from those of formula (I): wherein: W1, with the carbon atoms to which it is bonded, represents phenyl or pyridyl, Z represents a group selected from hydrogen, halogen, linear or branched (C1-C6)alkyl, aryl, aryl-(C1-C6)alkyl, aryloxy, aryl-(C1-C6)alkoxy, hydroxy and linear or branched (C1-C6)alkoxy, R1 is as defined in the description, R2 represents hydrogen or —CH2CH2O—R8, R3 and R4 each represents hydrogen, linear or branched (C1-C6)alkyl, aryl or aryl-(C1-C6)alkyl, n represents an integer of from 1 to 6 inclusive, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要:
A compound selected from those of formula (I): wherein: X and Y represent a group selected from hydrogen, halogen, alkoxy, nitro, cyano, alkyl, alkenyl, polyhaloalkyl and —NRaRb wherein Ra and Rb are as defined in the description, Z represents oxygen or NRc wherein Rc is as defined in the description, Ar represents aryl or heteroaryl, R1 represents hydrogen or alkyl, R2 represents a group selected from hydrogen, alkyl, —ORa and —NRaRb wherein Ra and Rb are as defined in the description, R3 and R4 represent hydrogen or alkyl, R5 represents hydrogen, ORc, NRcRd, W1—C(W2)—U—V, W1—C(W2)—W3-T1 or Z-CO—CH═CHAr wherein Rc, Rd, W1, W2, W3, U, V, T, Z and Ar are as defined in the description, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要翻译:选自式(I)的化合物:其中:X和Y表示选自氢,卤素,烷氧基,硝基,氰基,烷基,烯基,多卤代烷基和-NR a R 其中R a a和R b b如说明书中所定义,Z表示氧或NR C c,其中R - >如说明书中所定义,Ar表示芳基或杂芳基,R 1表示氢或烷基,R 2表示选自氢,烷基 其中R a a和R b都是 - , - - - - - - - - >如说明书中所定义,R 3和R 4代表氢或烷基,R 5表示氢,或C 1-4烷基, R 1,R 2,R 2,R 2,R 2,R 2, (W 2)-W 3 -T 1或Z-CO-CH-CHAr其中R R 1,R 2,W 3,W 2,W 3,U 3, ,V,T,Z和Ar定义如下 在其描述中,其异构体及其与药学上可接受的酸或碱的加成盐,以及含有该物质的药物可用于治疗癌症。
摘要:
A compound of formula (I): wherein: R represents hydrogen, optionally substituted alkyl or alkenyl, R1 to R8, which may be identical or different, each represents hydrogen, optionally substituted alkyl, hydroxy, acyloxy, optionally substituted amino, carboxy, optionally substituted alkoxy, or alkenyloxy, or one of R1 to R8 forms, with another of R1 to R8 that is adjacent, an alkylenedioxy group, X represents oxygen or NR16 wherein R16 represents hydrogen, alkyl, aryl or arylalkyl, R9 represents hydrogen, aryl, heteroaryl, or optionally substituted, saturated or unsaturated alkyl, an isomer thereof, or an addition salt thereof with a pharmaceutically acceptable acid or base. Medicinal products containing the same which are useful as anti-cancer agents.
摘要:
A compound of formula (I) in which: m, and n, which may be identical or different, represent 0 or 1, X and Y, which may be identical or different, represent hydrogen or halogen or alkyl, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylamino, or dialkylamino, Z represent a linear or branched C4 to C12 alkylene chain in which one or more —CH2— are optionally replaced by any one of the following atoms or groups: —NR—, —O—, —S—, —SO—, SO2—, or —CONH—, or by a substituted or unsubstituted heterocylcic, A forms, with two adjacent carbon atoms of the phenyl ring, a phenyl, naphthyl or tetrahydronaphthyl ring or a heterocycle, represents any one of the groups as defined in the description, its optical isomers and its addition salts with a pharamaceutically and acceptable acid or base, and medicinal products containing the same which are useful as anticancer agents.
摘要翻译:式(I)化合物,其中m和n可以相同或不同,表示0或1,X和Y可以相同或不同,表示氢或卤素或烷基,三卤代烷基,烷氧基,羟基 ,氰基,硝基,氨基,烷基氨基或二烷基氨基,Z表示直链或支链的C 4至C 12亚烷基链,其中一个或多个-CH 2 - 任选被以下任何一个原子或基团取代:-NR-,-O - , - S - , - SO - ,SO2-或-CONH-,或通过取代或未取代的杂环A形式与苯环的两个相邻碳原子,苯基,萘基或四氢萘基环或杂环, 表示在描述中定义的任何一个基团,其光学异构体及其与药物和可接受的酸或碱的加成盐,以及含有该组的药物,其可用作抗癌剂。
摘要:
A compound of formula (I) ##STR1## in which: X and Y, which may be identical or different, represent hydrogen or halogen or alkyl, trihaloalkyl, alkoxy, hydroxyl, cyano, nitro, amino, alkylamino, or dialkylamino, Z represent a linear or branched C.sub.4 to C.sub.12 alkylene chain in which one or more --CH.sub.2 -- are optionally replaced by any one of the following atoms or groups: --NR--, --O--, --S--, --SO--, --SO.sub.2 --, or --CONH--, A forms, with two adjacent carbon atoms of the phenyl ring, a phenyl, naphthyl or tetrahydronaphthyl ring or a heterocycle, ##STR2## represents any one of the groups as defined in the description, its optical isomers and its addition salts with a pharmaceutically-acceptable acid or base, and medicinal products containing the same which are useful as anticancer agents.
摘要翻译:式(I)化合物其中:X和Y可以相同或不同,表示氢或卤素或烷基,三卤代烷基,烷氧基,羟基,氰基,硝基,氨基,烷基氨基或二烷基氨基 Z表示直链或支链的C 4至C 12亚烷基链,其中一个或多个-CH 2 - 任选被以下原子或基团中的任何一个取代:-NR - , - O - , - S - , - SO-, - SO 2 - 或-CONH-,A形式,其具有苯环的两个相邻碳原子,苯基,萘基或四氢萘基环或杂环,IMAGE表示说明书中定义的任何一个基团,其旋光异构体 及其与药学上可接受的酸或碱的加成盐,以及含有该盐的药物,可用作抗癌剂。
摘要:
The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN—NH and N—R2, R3 is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4 is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof
摘要翻译:本发明涉及式(I)化合物,其中R 1是选自氢,烷基,芳基,芳亚烷基,杂芳基,杂芳基烷基,烷基羰基,芳基羰基,芳基烷基羰基,烷氧基羰基,芳氧基羰基,芳基烷氧基羰基, 杂环烷氧基羰基,烷基磺酰基,芳基磺酰基,芳基烷基磺酰基,膦酸和Si(R a)2 R b,Y是选自HN-NH和NR 2 R 3是氢原子,烷基,环烷基,芳基,芳基烷基,R 4是氢原子或烷基,对映异构体,非对映异构体及其盐
摘要:
A compound selected from those of formula (I): wherein: W1, with the carbon atoms to which it is bonded, represents phenyl or pyridyl, Z represents a group selected from hydrogen, halogen, linear or branched (C1-C6)alkyl, aryl, aryl-(C1-C6)alkyl, aryloxy, aryl-(C1-C6)alkoxy, hydroxy and linear or branched (C1-C6)alkoxy, R1 is as defined in the description, R2 represents hydrogen or —CH2CH2O—R8, R3 and R4 each represents hydrogen, linear or branched (C1-C6)alkyl, aryl or aryl-(C1-C6)alkyl, n represents an integer of from 1 to 6 inclusive, its isomers, and addition salts thereof with a pharmaceutically acceptable acid or base, and medicinal products containing the same which are useful in the treatment of cancer.
摘要:
The invention relates to compounds of formula (I), wherein R1 is a group selected from hydrogen, alkyl, aryl, aryalkil, heteroaryl, heteroarylalkyl, alkylcarbonyl, arylcarbonyl, arylalkylcarbonyl, alkoxycarbonyl, aryloxycarbonyl, arylalkoxycarbonyl, heterocycloalkoxycarbonyl, alkylsulfonyl, arylsulfonyl, arylalkylsulfonyl, phosphonic and Si(Ra)2Rb, Y is a group selected from HN—NH and N—R2, R3 is a hydrogen atom, an alkyl, cycloalkyl, aryl, arylalkyl group, R4 is hydrogen atom or an alkyl group, enantiomers, diastereoisomers and the salts thereof.
摘要翻译:本发明涉及式(I)化合物,其中R 1是选自氢,烷基,芳基,芳亚烷基,杂芳基,杂芳基烷基,烷基羰基,芳基羰基,芳基烷基羰基,烷氧基羰基,芳氧基羰基,芳基烷氧基羰基, 杂环烷氧基羰基,烷基磺酰基,芳基磺酰基,芳基烷基磺酰基,膦酸和Si(R a)2 R b,Y是选自HN-NH和NR 2 R 3是氢原子,烷基,环烷基,芳基,芳基烷基,R 4是氢原子或烷基,对映异构体,非对映异构体及其盐 。