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    Method for forming a carbon-carbon or carbon-heteroatom bond
    2.
    发明申请
    Method for forming a carbon-carbon or carbon-heteroatom bond 审中-公开
    形成碳 - 碳或碳 - 杂原子键的方法

    公开(公告)号：US20090240061A1

    公开(公告)日：2009-09-24

    申请号：US10568850

    申请日：2004-07-28

    申请人： Jean-Francis Spindler ,  Marc Taillefer ,  Henri-Jean Cristau ,  Pascal Philippe Cellier ,  Armelle Ouali

    发明人： Jean-Francis Spindler ,  Marc Taillefer ,  Henri-Jean Cristau ,  Pascal Philippe Cellier ,  Armelle Ouali

    IPC分类号： C07D231/12 ,  C07C41/01 ,  C07C67/00

    CPC分类号： C07D231/12 ,  C07B37/04 ,  C07B41/04 ,  C07C41/16 ,  C07C67/343 ,  C07C69/612 ,  C07C43/275

    摘要： The invention relates to a method for forming a carbon-carbon or carbon-heteroatom bond by reacting an unsaturated compound carrying a leaving group and a nucleophilic compound, in the absence of a ligand. The aim of the invention is especially to form carbon-nitrogen bonds according to a method for the arylation of nitrogenated organic derivatives. According to the inventive method, a carbon-carbon or carbon-heteroatom bond is formed by reacting an unsaturated compound carrying a leaving group with a nucleophilic compound donating a carbon atom or a heteroatom (HE) that can substitute the leaving group, thus forming a C—C or C—HE bond, in the presence of a copper-based catalyst and a base. Said metal is characterised in that the reaction takes place in the absence of a ligand and in a nitrile-type solvent.

    摘要翻译： 本发明涉及通过在不存在配体的情况下使带有离去基团的不饱和化合物与亲核化合物反应形成碳 - 碳或碳 - 杂原子键的方法。 本发明的目的是根据氮化有机衍生物的芳基化方法形成碳 - 氮键。 根据本发明的方法，通过使带有离去基团的不饱和化合物与赋予碳原子的亲核化合物或可以代替离去基团的杂原子（HE）反应形成碳 - 碳或碳 - 杂原子键，从而形成 CC或C-HE键，在铜基催化剂和碱的存在下进行。 所述金属的特征在于反应在不存在配体的情况下和腈类溶剂中进行。

    Process for arylating or vinylating or alkynating a nucleophilic compound
    3.
    发明授权
    Process for arylating or vinylating or alkynating a nucleophilic compound 失效
    用于芳基化或乙烯化或炔化亲核化合物的方法

    公开(公告)号：US07202367B2

    公开(公告)日：2007-04-10

    申请号：US10159829

    申请日：2002-05-31

    申请人： Pascal Philippe Cellier ,  Henri-Jean Cristau ,  Jean-Francis Spindler ,  Marc Taillefer

    发明人： Pascal Philippe Cellier ,  Henri-Jean Cristau ,  Jean-Francis Spindler ,  Marc Taillefer

    IPC分类号： C07D249/02 ,  C07D233/04 ,  C07D233/54 ,  C07D235/04 ,  C07D257/04

    CPC分类号： C07D213/53 ,  C07D209/08 ,  C07D231/12 ,  C07D233/06 ,  C07D233/56 ,  C07D249/08

    摘要： The present invention concerns a process for arylating or vinylating or alkynating a nucleophilic compound. More particularly, the invention concerns arylating nitrogen-containing organic derivatives. The arylating or vinylating or alkynating process of the invention consists of reacting a nucleophilic compound with a compound carrying a leaving group and is characterized in that the reaction is carried out in the presence of an effective quantity of a catalyst based on a metallic element M selected from groups (VIII), (Ib) and (IIb) of the periodic table and at least one ligand comprising at least one imine function and at least one supplemental nitrogen atom as the chelating atoms.

    摘要翻译： 本发明涉及对亲核化合物进行芳基化或乙烯化或炔化的方法。 更具体地说，本发明涉及芳基化含氮有机衍生物。 本发明的芳基化或乙烯化或炔化方法包括使亲核化合物与携带离去基团的化合物反应，其特征在于反应在选择的金属元素M的有效量的催化剂存在下进行 来自周期表的基团（VIII），（Ib）和（IIb）和至少一种含有至少一个亚胺官能团的配体和至少一个补充氮原子作为螯合原子。

    USE OF A COMPOSITION OF AN IONIC NATURE AS A SUBSTITUTION REAGENT, A COMPOSITION CONSTITUTING A FLUORINATION REAGENT AND A METHOD USING SAME
    6.
    发明申请
    USE OF A COMPOSITION OF AN IONIC NATURE AS A SUBSTITUTION REAGENT, A COMPOSITION CONSTITUTING A FLUORINATION REAGENT AND A METHOD USING SAME 审中-公开
    使用作为替代试剂的离子性质的组合物，构成荧光试剂的组合物和使用其的方法

    公开(公告)号：US20090036718A1

    公开(公告)日：2009-02-05

    申请号：US12113232

    申请日：2008-05-01

    申请人： Rene GREE ,  Vincent Schanen ,  Jean-Francis Spindler ,  Maxime Garayt ,  Virginie Le Boulaire ,  Danielle Gree

    发明人： Rene GREE ,  Vincent Schanen ,  Jean-Francis Spindler ,  Maxime Garayt ,  Virginie Le Boulaire ,  Danielle Gree

    IPC分类号： C07C25/13

    CPC分类号： C07D231/12 ,  C07B39/00 ,  C07C17/208 ,  C07C205/12 ,  C07D233/56 ,  C07D249/08 ,  C07F9/54 ,  Y02P20/542 ,  C07C25/13 ,  C07C22/08

    摘要： The invention relates to processes for aromatic nucleophilic substitution by contacting a substrate of formula (III) Ar-Ξ  (III) where Ar is an aromatic group where the nucleus carrying the group Ξ is electron-poor, either because it contains at least one heteroatom in its ring or because the sum of the Hammett constants, σp, of its substituents, apart from said Ξ, is at least 0.2, and Ξ is a leaving group, with a composition containing at least one ionic compound whose cation is of general formula G: (R10)(R9)N—[C(R8)═C(R6)]ν—C(R5)═N+(R1)(R2)  (G) wherein: ν is an integer from 0 to 4, inclusive; R1, R2, R5, R6 and R8, which are identical or different, are a hydrogen or a hydrocarbon group; and R9 and R10, which are identical or different, are a hydrocarbon group; or one or two of the substituents R1, R2, R5, R8, R9, and R10 are connected to other remaining substituent(s) to form one or two or more rings.

    摘要翻译： 本发明涉及芳族亲核取代的方法，该方法是通过使式（III）的底物与式（III）<？in-line-formula description =“In-line Formulas”end =“lead”→Ar-Xi（III） line-formula description =“In-line Formulas”end =“tail”？>其中Ar是芳族基团，其中携带基团Xi的核是电子贫乏的，或者是因为它在其环中含有至少一个杂原子，或者因为 除了所述Xi之外，其取代基的哈米特常数sigmap的和为至少0.2，并且Xi为离去基团，组合物含有至少一种阳离子为通式G的离子化合物： （R 10）（R 9）N- [C（R 8）-C（R 6）] nu-C（R 5）-N +（R 1）（R 2） ）（G）<？in-line-formula description =“In-line Formulas”end =“tail”？>其中：nu是0至4的整数，包括0和4; R 1，R 2，R 5，R 6和R 8相同或不同，为氢或烃基; 和R 9和R 10相同或不同，为烃基; 或取代基R 1，R 2，R 5，R 8，R 9和R 10中的一个或两个连接到其它剩余的取代基以形成一个或两个或更多个环。

    Process for saparating a hydroxybenzonitrile-type compound
    7.
    发明申请
    Process for saparating a hydroxybenzonitrile-type compound 审中-公开
    皂化羟基苄腈型化合物的方法

    公开(公告)号：US20060149093A1

    公开(公告)日：2006-07-06

    申请号：US10311100

    申请日：2001-06-13

    申请人： Jean-Francis Spindler ,  Roland Jacquot ,  Michel Alas

    发明人： Jean-Francis Spindler ,  Roland Jacquot ,  Michel Alas

    IPC分类号： C07C255/50

    CPC分类号： C07C253/34 ,  C07C255/53

    摘要： The invention concerns a method for separating a hydroxybenzonitrile-type compound obtained by an amination/dehydration process. More particularly, the invention concerns 2-hydroxybenzonitrile, also called 2-cyanophenol. The inventive method for separating a hydroxybenzonitrile compound from a reaction gas flow comprising it wholly or partly in the form of an ammonium salt is characterized in that it consists in displacing the ammonium ions, through a physical treatment carried out on the reaction gas flow derived from its preparation or from the solid previously recuperated from said flow or according to a chemical treatment carried out on the reaction gas flow, after liquefaction.

    摘要翻译： 本发明涉及一种分离通过胺化/脱水方法获得的羟基苄腈型化合物的方法。 更具体地说，本发明涉及2-羟基苄腈，也称为2-氰基苯酚。 本发明的从羟基苄腈化合物全部或部分地以铵盐形式分离出的反应气流的方法的特征在于它通过对衍生自...的反应气体流进行的物理处理 其制备方法或者从之前从所述流动中恢复的固体或根据在液化后对反应气流进行的化学处理。

    Continuous preparation of amines by nitrile compound hydrogenation
    8.
    发明授权
    Continuous preparation of amines by nitrile compound hydrogenation 有权
    通过腈化合物氢化连续制备胺

    公开(公告)号：US08329955B2

    公开(公告)日：2012-12-11

    申请号：US12681397

    申请日：2008-10-02

    申请人： Didier Letourneur ,  Philippe Leconte ,  Jean-Francis Spindler ,  Patrick Lermusiaux ,  Vincent Boschat

    发明人： Didier Letourneur ,  Philippe Leconte ,  Jean-Francis Spindler ,  Patrick Lermusiaux ,  Vincent Boschat

    IPC分类号： C07C209/48

    CPC分类号： C07C209/48 ,  Y02P20/584 ,  C07C211/12

    摘要： Amino compounds are continuously prepared by hydrogenation of nitrile compounds in the presence of a catalyst, and more particularly diamines are prepared by the continuous hydrogenation of dinitrile compounds in the presence of a Raney metal catalyst and in the absence of an alcoholic solvent; the subject process includes extracting a portion of the catalyst present in the reaction medium, the extracted portion of the catalyst is submitted to a regeneration for providing a catalyst having a catalytic activity lower than that of a fresh catalyst but still high and the regenerated catalyst is recycled to the reaction medium together with fresh catalyst according to a predetermined ratio, whereby the consumption of catalyst is reduced per ton of amines produced.

    摘要翻译： 通过在催化剂存在下氢化腈化合物来连续制备氨基化合物，更特别地，二胺通过在阮内金属催化剂和不存在醇溶剂的情况下连续氢化二腈化合物来制备; 本发明方法包括提取存在于反应介质中的部分催化剂，催化剂的提取部分进行再生以提供催化活性低于新鲜催化剂但仍高的催化剂，再生催化剂为 根据预定比例与新鲜催化剂一起再循环到反应介质中，由此每吨生产的胺减少催化剂的消耗。

    CONTINUOUS PREPARATION OF AMINES BY NITRILE COMPOUND HYDROGENATION
    9.
    发明申请
    CONTINUOUS PREPARATION OF AMINES BY NITRILE COMPOUND HYDROGENATION 有权
    通过硝酸盐化合物氢化反应连续制备氨基酸

    公开(公告)号：US20100267989A1

    公开(公告)日：2010-10-21

    申请号：US12681397

    申请日：2008-10-02

    申请人： Didier Letourneur ,  Philippe Leconte ,  Jean-Francis Spindler ,  Patrick Lermusiaux ,  Vincent Boschat

    发明人： Didier Letourneur ,  Philippe Leconte ,  Jean-Francis Spindler ,  Patrick Lermusiaux ,  Vincent Boschat

    IPC分类号： C07C211/12

    CPC分类号： C07C209/48 ,  Y02P20/584 ,  C07C211/12

    摘要： Amino compounds are continuously prepared by hydrogenation of nitrile compounds in the presence of a catalyst, and more particularly diamines are prepared by the continuous hydrogenation of dinitrile compounds in the presence of a Raney metal catalyst and in the absence of an alcoholic solvent; the subject process includes extracting a portion of the catalyst present in the reaction medium, the extracted portion of the catalyst is submitted to a regeneration for providing a catalyst having a catalytic activity lower than that of a fresh catalyst but still high and the regenerated catalyst is recycled to the reaction medium together with fresh catalyst according to a predetermined ratio, whereby the consumption of catalyst is reduced per ton of amines produced.

    摘要翻译： 通过在催化剂存在下氢化腈化合物来连续制备氨基化合物，更特别地，二胺通过在阮内金属催化剂和不存在醇溶剂的情况下连续氢化二腈化合物来制备; 本发明方法包括提取存在于反应介质中的部分催化剂，催化剂的提取部分进行再生以提供催化活性低于新鲜催化剂但仍高的催化剂，再生催化剂为 根据预定比例与新鲜催化剂一起再循环到反应介质中，由此每吨生产的胺减少催化剂的消耗。

    Method for forming a carbon-carbon or carbon-heteroatom linkage
    10.
    发明申请
    Method for forming a carbon-carbon or carbon-heteroatom linkage 审中-公开
    形成碳 - 碳或碳 - 杂原子键的方法

    公开(公告)号：US20050065350A1

    公开(公告)日：2005-03-24

    申请号：US10499453

    申请日：2002-12-20

    申请人： Marc Taillefer ,  Henri-Jean Cristau ,  Passcal Cellier ,  Jean-Francis Spindler

    发明人： Marc Taillefer ,  Henri-Jean Cristau ,  Passcal Cellier ,  Jean-Francis Spindler

    IPC分类号： C07D295/02 ,  C07B37/04 ,  C07B41/04 ,  C07B43/00 ,  C07B61/00 ,  C07C41/01 ,  C07C43/263 ,  C07C269/06 ,  C07C271/28 ,  C07D209/08 ,  C07D231/12 ,  C07D233/58 ,  C07D263/22 ,  C07D213/53 ,  C07D209/04

    CPC分类号： C07B37/04 ,  B01J31/2243 ,  B01J2231/4283 ,  B01J2531/16

    摘要： The present invention concerns a process for creating a carbon-carbon or carbon-heteroatom bond by reacting an unsaturated compound carrying a leaving group with a nucleophilic compound. The invention also concerns the creation of a carbon-nitrogen bond using a process for arylating organic nitrogen-containing derivatives. The process of the invention is a process for creating a carbon-carbon or carbon-heteroatom bond by reacting an unsaturated compound carrying a leaving group with a nucleophilic compound carrying a carbon atom or a heteroatom (HE) that can substitute for the leaving group, creating a C—C or C-HE bond, characterized in that the reaction takes place in the presence of an effective quantity of a catalyst based on a metallic element M selected from group (VIII), (IB) and (IIB) of the periodic table and at least one at least bidentate ligand comprising at least two chelation atoms, namely at least one oxygen atom and at least one nitrogen atom.

    摘要翻译： 本发明涉及通过使带有离去基团的不饱和化合物与亲核化合物反应来产生碳 - 碳或碳 - 杂原子键的方法。 本发明还涉及使用用于芳基化有机含氮衍生物的方法产生碳 - 氮键。 本发明的方法是通过使带有离去基团的不饱和化合物与携带碳原子的亲核化合物或可代替离去基团的杂原子（HE）反应来生成碳 - 碳或碳 - 杂原子键的方法， 产生CC或C-HE键，其特征在于反应在有选择的元素周期表第（VIII），（IB）和（IIB）族金属元素M的有效量的催化剂的存在下进行 和包含至少两个螯合原子，即至少一个氧原子和至少一个氮原子的至少一个至少二齿配体。