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    Method for forming a carbon-carbon or carbon-heteroatom bond
    1.
    发明申请
    Method for forming a carbon-carbon or carbon-heteroatom bond 审中-公开
    形成碳 - 碳或碳 - 杂原子键的方法

    公开(公告)号：US20090240061A1

    公开(公告)日：2009-09-24

    申请号：US10568850

    申请日：2004-07-28

    申请人： Jean-Francis Spindler ,  Marc Taillefer ,  Henri-Jean Cristau ,  Pascal Philippe Cellier ,  Armelle Ouali

    发明人： Jean-Francis Spindler ,  Marc Taillefer ,  Henri-Jean Cristau ,  Pascal Philippe Cellier ,  Armelle Ouali

    IPC分类号： C07D231/12 ,  C07C41/01 ,  C07C67/00

    CPC分类号： C07D231/12 ,  C07B37/04 ,  C07B41/04 ,  C07C41/16 ,  C07C67/343 ,  C07C69/612 ,  C07C43/275

    摘要： The invention relates to a method for forming a carbon-carbon or carbon-heteroatom bond by reacting an unsaturated compound carrying a leaving group and a nucleophilic compound, in the absence of a ligand. The aim of the invention is especially to form carbon-nitrogen bonds according to a method for the arylation of nitrogenated organic derivatives. According to the inventive method, a carbon-carbon or carbon-heteroatom bond is formed by reacting an unsaturated compound carrying a leaving group with a nucleophilic compound donating a carbon atom or a heteroatom (HE) that can substitute the leaving group, thus forming a C—C or C—HE bond, in the presence of a copper-based catalyst and a base. Said metal is characterised in that the reaction takes place in the absence of a ligand and in a nitrile-type solvent.

    摘要翻译： 本发明涉及通过在不存在配体的情况下使带有离去基团的不饱和化合物与亲核化合物反应形成碳 - 碳或碳 - 杂原子键的方法。 本发明的目的是根据氮化有机衍生物的芳基化方法形成碳 - 氮键。 根据本发明的方法，通过使带有离去基团的不饱和化合物与赋予碳原子的亲核化合物或可以代替离去基团的杂原子（HE）反应形成碳 - 碳或碳 - 杂原子键，从而形成 CC或C-HE键，在铜基催化剂和碱的存在下进行。 所述金属的特征在于反应在不存在配体的情况下和腈类溶剂中进行。

    Process for arylating or vinylating or alkynating a nucleophilic compound
    3.
    发明授权
    Process for arylating or vinylating or alkynating a nucleophilic compound 失效
    用于芳基化或乙烯化或炔化亲核化合物的方法

    公开(公告)号：US07202367B2

    公开(公告)日：2007-04-10

    申请号：US10159829

    申请日：2002-05-31

    申请人： Pascal Philippe Cellier ,  Henri-Jean Cristau ,  Jean-Francis Spindler ,  Marc Taillefer

    发明人： Pascal Philippe Cellier ,  Henri-Jean Cristau ,  Jean-Francis Spindler ,  Marc Taillefer

    IPC分类号： C07D249/02 ,  C07D233/04 ,  C07D233/54 ,  C07D235/04 ,  C07D257/04

    CPC分类号： C07D213/53 ,  C07D209/08 ,  C07D231/12 ,  C07D233/06 ,  C07D233/56 ,  C07D249/08

    摘要： The present invention concerns a process for arylating or vinylating or alkynating a nucleophilic compound. More particularly, the invention concerns arylating nitrogen-containing organic derivatives. The arylating or vinylating or alkynating process of the invention consists of reacting a nucleophilic compound with a compound carrying a leaving group and is characterized in that the reaction is carried out in the presence of an effective quantity of a catalyst based on a metallic element M selected from groups (VIII), (Ib) and (IIb) of the periodic table and at least one ligand comprising at least one imine function and at least one supplemental nitrogen atom as the chelating atoms.

    摘要翻译： 本发明涉及对亲核化合物进行芳基化或乙烯化或炔化的方法。 更具体地说，本发明涉及芳基化含氮有机衍生物。 本发明的芳基化或乙烯化或炔化方法包括使亲核化合物与携带离去基团的化合物反应，其特征在于反应在选择的金属元素M的有效量的催化剂存在下进行 来自周期表的基团（VIII），（Ib）和（IIb）和至少一种含有至少一个亚胺官能团的配体和至少一个补充氮原子作为螯合原子。

    Method of forming a carbon-carbon or carbon-heteroatom linkage
    4.
    发明申请
    Method of forming a carbon-carbon or carbon-heteroatom linkage 审中-公开
    形成碳 - 碳或碳 - 杂原子键的方法

    公开(公告)号：US20050234239A1

    公开(公告)日：2005-10-20

    申请号：US10515856

    申请日：2003-06-02

    申请人： Marc Taillefer ,  Henri-Jean Cristau ,  Pascal-Philippe Cellier

    发明人： Marc Taillefer ,  Henri-Jean Cristau ,  Pascal-Philippe Cellier

    IPC分类号： C07C43/275 ,  C07D209/08 ,  C07D213/53 ,  C07D213/64 ,  C07D231/12 ,  C07D233/06 ,  C07D263/22 ,  C07F1/08 ,  C07D41/14

    CPC分类号： C07D213/643 ,  C07D207/267 ,  C07D207/323 ,  C07D209/08 ,  C07D213/64 ,  C07D231/12 ,  C07D233/58 ,  C07D249/08 ,  C07D263/18

    摘要： The invention relates to a method of creating a carbon-carbon or carbon-heteroatom linkage by reacting an unsaturated compound bearing a leaving group and a nucleophilic compound. More specifically, the invention relates to the creation of a carbon-nitrogen linkage involving the arylation of nitrogenous organic derivatives. The inventive method consists in creating a carbon-carbon or carbon-heteroatom linkage by reacting an unsaturated compound bearing a leaving group and a nucleophilic compound providing a carbon atom or a heteroatom (HE) capable of being substituted for the leaving group, thereby creating a C—C or C-HE linkage. The invention is characterised in that the reaction is carried out in the presence of an effective quantity of a catalyst based on copper and at least one ligand comprising at least one imine function and at least one additional nitrogen atom as chelating atoms

    摘要翻译： 本发明涉及通过使具有离去基团的不饱和化合物与亲核化合物反应来生成碳 - 碳或碳 - 杂原子键的方法。 更具体地说，本发明涉及产生含氮有机衍生物的芳基化的碳 - 氮键。 本发明的方法包括通过使具有离去基团的不饱和化合物与提供碳原子的亲核化合物或能够取代离去基团的杂原子（HE）反应来产生碳 - 碳或碳 - 杂原子键，从而产生 CC或C-HE连锁。 本发明的特征在于反应在有效量的基于铜和至少一种包含至少一个亚胺官能团的配体和至少一个另外的氮原子作为螯合原子的催化剂存在下进行

    Method for forming a carbon-carbon or carbon-heteroatom linkage
    5.
    发明申请
    Method for forming a carbon-carbon or carbon-heteroatom linkage 审中-公开
    形成碳 - 碳或碳 - 杂原子键的方法

    公开(公告)号：US20050065350A1

    公开(公告)日：2005-03-24

    申请号：US10499453

    申请日：2002-12-20

    申请人： Marc Taillefer ,  Henri-Jean Cristau ,  Passcal Cellier ,  Jean-Francis Spindler

    发明人： Marc Taillefer ,  Henri-Jean Cristau ,  Passcal Cellier ,  Jean-Francis Spindler

    IPC分类号： C07D295/02 ,  C07B37/04 ,  C07B41/04 ,  C07B43/00 ,  C07B61/00 ,  C07C41/01 ,  C07C43/263 ,  C07C269/06 ,  C07C271/28 ,  C07D209/08 ,  C07D231/12 ,  C07D233/58 ,  C07D263/22 ,  C07D213/53 ,  C07D209/04

    CPC分类号： C07B37/04 ,  B01J31/2243 ,  B01J2231/4283 ,  B01J2531/16

    摘要： The present invention concerns a process for creating a carbon-carbon or carbon-heteroatom bond by reacting an unsaturated compound carrying a leaving group with a nucleophilic compound. The invention also concerns the creation of a carbon-nitrogen bond using a process for arylating organic nitrogen-containing derivatives. The process of the invention is a process for creating a carbon-carbon or carbon-heteroatom bond by reacting an unsaturated compound carrying a leaving group with a nucleophilic compound carrying a carbon atom or a heteroatom (HE) that can substitute for the leaving group, creating a C—C or C-HE bond, characterized in that the reaction takes place in the presence of an effective quantity of a catalyst based on a metallic element M selected from group (VIII), (IB) and (IIB) of the periodic table and at least one at least bidentate ligand comprising at least two chelation atoms, namely at least one oxygen atom and at least one nitrogen atom.

    摘要翻译： 本发明涉及通过使带有离去基团的不饱和化合物与亲核化合物反应来产生碳 - 碳或碳 - 杂原子键的方法。 本发明还涉及使用用于芳基化有机含氮衍生物的方法产生碳 - 氮键。 本发明的方法是通过使带有离去基团的不饱和化合物与携带碳原子的亲核化合物或可代替离去基团的杂原子（HE）反应来生成碳 - 碳或碳 - 杂原子键的方法， 产生CC或C-HE键，其特征在于反应在有选择的元素周期表第（VIII），（IB）和（IIB）族金属元素M的有效量的催化剂的存在下进行 和包含至少两个螯合原子，即至少一个氧原子和至少一个氮原子的至少一个至少二齿配体。