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公开(公告)号：US20120264637A1
公开(公告)日：2012-10-18
申请号：US13502108
申请日：2010-10-15
申请人： Jeanine Wiener-Kronish , Susan Lynch , Eoin Brodie
发明人： Jeanine Wiener-Kronish , Susan Lynch , Eoin Brodie
CPC分类号： C12Q1/6883 , C12Q2600/118
摘要： Methods and systems for designing and using organism specific and/or operational taxon unit (OTU)-specific probes. The methods and systems allow for detecting, identifying and quantitating a plurality of biomolecules or microorganisms in a sample based on the hybridization or binding of target molecules in the sample with the probes, including the detection of rare OTU's in a sample. In some cases, methods are provided for selecting an oligonucleotide probe specific for a node on a clustering tree.
摘要翻译： 用于设计和使用有机体特异性和/或操作性分类单位（OTU）特异性探针的方法和系统。 方法和系统允许基于样品中的靶分子与探针的杂交或结合来检测，鉴定和定量样品中的多个生物分子或微生物，包括检测样品中罕见的OTU。 在一些情况下，提供了用于选择专用于聚类树上的节点的寡核苷酸探针的方法。
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公开(公告)号：US20150224152A1
公开(公告)日：2015-08-13
申请号：US14526911
申请日：2014-10-29
申请人： Dan Littman , Ivaylo Ivanov , Eoin Brodie , Yoshinori Umesaki , Kenya Honda
发明人： Dan Littman , Ivaylo Ivanov , Eoin Brodie , Yoshinori Umesaki , Kenya Honda
CPC分类号： A61K35/74 , A61K39/39 , A61K2035/122 , A61K2039/55594 , C12Q1/6881 , C12Q2600/158 , C12Q2600/16 , Y02A50/484
摘要： The present invention relates to methods for treating or reducing the risk of or preventing diseases caused by or associated with pathogenic bacteria. More particularly, the present invention relates to methods for treating or reducing the risk of or preventing diseases caused by or associated with pathogenic bacteria of the gastrointestinal (GI) tract. The present invention further relates to methods for promoting pathways induced by commensal bacteria of the GI tract that lead to Th17 differentiation, which in turn leads to localized and systemic accumulation of Th17 cells. Compositions and medicaments are also described herein that are used alleviate and/or prevent symptoms associated with diseases caused by or associated with pathogenic bacteria. Accordingly, the compositions, medicaments and methods described herein may be used to address the needs of patients or subjects that would benefit from increased Th17 cell differentiation.
摘要翻译： 本发明涉及用于治疗或降低由病原菌引起或与其相关的疾病的风险或预防疾病的方法。 更具体地，本发明涉及用于治疗或降低由胃肠道（GI）道的病原菌引起或与之相关的疾病的风险或预防疾病的方法。 本发明还涉及促进导致Th17分化的胃肠道共生细菌诱导的途径的方法，其又导致Th17细胞的局部和全身积累。 本文还描述了组合物和药物，其用于缓解和/或预防与由致病细菌引起或与病原体细菌相关的疾病相关的症状。 因此，本文所述的组合物，药物和方法可用于满足将从Th17细胞分化增加中受益的患者或受试者的需要。
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公开(公告)号：US20120165215A1
公开(公告)日：2012-06-28
申请号：US13379839
申请日：2010-06-25
申请人： Gary L. Andersen , Todd Z. Desantis , Eoin Brodie
发明人： Gary L. Andersen , Todd Z. Desantis , Eoin Brodie
CPC分类号： C12Q1/689 , C12Q1/6837 , C12Q2600/158 , C12Q2537/165
摘要： The present invention discloses methods and systems for designing and using organism-specific and/or operational taxon unit (OTU)-specific probes. The methods and systems allow for detecting, identifying and quantitating a plurality of biomolecules or microrganisms in a sample based on the hybridization or binding of target molecules in the sample with the probes. Some embodiments provide methods of selecting an oligonucleotide probe specific for a node on a clustering tree. Other embodiments provide methods of selecting organism-specific or OTU-specific oligonucleotide probes for use in accurately detecting a plurality of organisms in a sample with high confidence. Some embodiments provide methods and systems to detect the presence of a rare OTU in a sample.
摘要翻译： 本发明公开了用于设计和使用生物体特异性和/或操作性分类单位（OTU）特异性探针的方法和系统。 方法和系统允许基于样品中的靶分子与探针的杂交或结合来检测，鉴定和定量样品中的多个生物分子或微生物。 一些实施方案提供了选择对聚类树上的节点特异的寡核苷酸探针的方法。 其他实施方案提供了选择生物体特异性或OTU特异性寡核苷酸探针的方法，用于以高置信度精确检测样品中的多种生物体。 一些实施例提供了用于检测样品中稀有OTU的存在的方法和系统。
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公开(公告)号：US20120276149A1
公开(公告)日：2012-11-01
申请号：US13501615
申请日：2010-10-15
申请人： Dan Littman , Ivaylo Ivanov , Eoin Brodie , Yoshinori Umesaki , Kenya Honda
发明人： Dan Littman , Ivaylo Ivanov , Eoin Brodie , Yoshinori Umesaki , Kenya Honda
CPC分类号： A61K35/74 , A61K39/39 , A61K2035/122 , A61K2039/55594 , C12Q1/6881 , C12Q2600/158 , C12Q2600/16 , Y02A50/484
摘要： The present invention relates to methods for treating or reducing the risk of or preventing diseases caused by or associated with pathogenic bacteria. More particularly, the present invention relates to methods for treating or reducing the risk of or preventing diseases caused by or associated with pathogenic bacteria of the gastrointestinal (GI) tract. The present invention further relates to methods for promoting pathways induced by commensal bacteria of the GI tract that lead to Th17 differentiation, which in turn leads to localized and systemic accumulation of Th17 cells. Compositions and medicaments are also described herein that are used alleviate and/or prevent symptoms associated with diseases caused by or associated with pathogenic bacteria. Accordingly, the compositions, medicaments and methods described herein may be used to address the needs of patients or subjects that would benefit from increased Th17 cell differentiation.
摘要翻译： 本发明涉及用于治疗或降低由病原菌引起或与其相关的疾病的风险或预防疾病的方法。 更具体地，本发明涉及用于治疗或降低由胃肠道（GI）道的病原菌引起或与之相关的疾病的风险或预防疾病的方法。 本发明还涉及促进导致Th17分化的胃肠道共生细菌诱导的途径的方法，其又导致Th17细胞的局部和全身积累。 本文还描述了组合物和药物，其用于缓解和/或预防与由致病细菌引起或与病原体细菌相关的疾病相关的症状。 因此，本文所述的组合物，药物和方法可用于满足将从Th17细胞分化增加中受益的患者或受试者的需要。
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公开(公告)号：US20110195862A1
公开(公告)日：2011-08-11
申请号：US13023468
申请日：2011-02-08
CPC分类号： G01N33/6848 , C12Q1/6837 , C12Q2565/627 , C12Q2545/114
摘要： Polymer arrays suitable to perform quantitative and qualitative detection as well as sorting of a target molecules and related devices methods and systems.
摘要翻译： 聚合物阵列适用于进行定量和定性检测以及靶分子和相关器件方法和系统的分选。
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