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    Lead with fibrous matrix coating and methods related thereto
    1.
    发明授权
    Lead with fibrous matrix coating and methods related thereto 有权
    带有纤维基质涂层及其相关方法

    公开(公告)号：US07689291B2

    公开(公告)日：2010-03-30

    申请号：US11381018

    申请日：2006-05-01

    申请人： Jeannette C. Polkinghorne ,  Xiangchun Jiang ,  Daniel J. Cooke

    发明人： Jeannette C. Polkinghorne ,  Xiangchun Jiang ,  Daniel J. Cooke

    IPC分类号： A61N1/00

    CPC分类号： A61N1/056 ,  A61N1/0568 ,  A61N2001/0585 ,  D01D5/0084 ,  Y10S977/904 ,  Y10S977/931

    摘要： A lead includes a lead body extending from a lead proximal end portion to a lead distal end portion and having an intermediate portion therebetween, one or more tissue sensing/stimulation electrodes disposed along the lead body, one or more terminal connections disposed along the lead proximal end portion. The lead further includes one or more conductors contained within the lead body extending between the tissue sensing/stimulation electrodes and the terminal connections, and a fibrous matrix coating is disposed onto at least a portion of the lead body and/or sensing/stimulation electrodes.

    摘要翻译： 引线包括从引线近端部分延伸到引线远端部分并且在其间具有中间部分的引线体，沿着引线主体设置的一个或多个组织感测/刺激电极，沿着引线近端设置的一个或多个端子连接 端部。 引线还包括一个或多个导体，其包含在组织感测/刺激电极和端子连接之间延伸的引线体内，并且纤维基质涂层设置在引线体和/或感测/刺激电极的至少一部分上。

    DRUG ELUTING COATINGS FOR A MEDICAL LEAD AND METHOD
    2.
    发明申请
    DRUG ELUTING COATINGS FOR A MEDICAL LEAD AND METHOD 审中-公开
    用于医疗铅和药物的药物涂覆涂料

    公开(公告)号：US20120052184A1

    公开(公告)日：2012-03-01

    申请号：US13288487

    申请日：2011-11-03

    申请人： Harshad M. Borgaonkar ,  Ronald W. Heil, JR. ,  Arienne P. Simon ,  Jeannette C. Polkinghorne ,  Daniel J. Cooke

    发明人： Harshad M. Borgaonkar ,  Ronald W. Heil, JR. ,  Arienne P. Simon ,  Jeannette C. Polkinghorne ,  Daniel J. Cooke

    IPC分类号： B05D5/00 ,  B05D3/00 ,  B05D7/00

    CPC分类号： A61N1/056 ,  A61N1/0568

    摘要： A medical electrical lead includes a drug eluting coating provided over at least a portion of the lead body. The drug eluting coating can be provided over at least a portion of the lead body and adjacent to at least one electrode located on the lead body. The drug eluting coating can include at least one matrix polymer layer including a polymer admixed with a therapeutic agent. The therapeutic agent, for example, can be an anti-proliferative agent or an anti-inflammatory agent. The matrix polymer can include a medical adhesive. The rate of elution of the drug from the matrix polymer layer is affected by the drug to polymer ratio of the drug in the matrix polymer layer.

    摘要翻译： 医用电引线包括提供在引线主体的至少一部分上的药物洗脱涂层。 药物洗脱涂层可以提供在引线主体的至少一部分上并与位于引线主体上的至少一个电极相邻。 药物洗脱涂层可以包括至少一种包含与治疗剂混合的聚合物的基质聚合物层。 治疗剂例如可以是抗增殖剂或抗炎剂。 基质聚合物可以包括医用粘合剂。 药物从基质聚合物层的洗脱速率受基质聚合物层中药物与聚合物的比例的影响。

    DRUG ELUTING COATINGS FOR A MEDICAL LEAD AND METHOD
    3.
    发明申请
    DRUG ELUTING COATINGS FOR A MEDICAL LEAD AND METHOD 审中-公开
    用于医疗铅和药物的药物涂覆涂料

    公开(公告)号：US20090054961A1

    公开(公告)日：2009-02-26

    申请号：US12234081

    申请日：2008-09-19

    申请人： Harshad M. Borgaonkar ,  Ronald W. Heil, JR. ,  Arienne P. Simon ,  Jeannette C. Polkinghorne ,  Daniel J. Cooke

    发明人： Harshad M. Borgaonkar ,  Ronald W. Heil, JR. ,  Arienne P. Simon ,  Jeannette C. Polkinghorne ,  Daniel J. Cooke

    IPC分类号： A61N1/05

    CPC分类号： A61N1/056 ,  A61N1/0568

    摘要： A medical electrical lead includes a drug eluting coating provided over at least a portion of the lead body. The drug eluting coating can be provided over at least a portion of the lead body and adjacent to at least one electrode located on the lead body. The drug eluting coating can include at least one matrix polymer layer including a polymer admixed with a therapeutic agent. The therapeutic agent, for example, can be an anti-proliferative agent or an anti-inflammatory agent. The matrix polymer can include a medical adhesive. The rate of elution of the drug from the matrix polymer layer is affected by the drug to polymer ratio of the drug in the matrix polymer layer.

    摘要翻译： 医用电引线包括提供在引线主体的至少一部分上的药物洗脱涂层。 药物洗脱涂层可以提供在引线主体的至少一部分上并且邻近位于引线主体上的至少一个电极。 药物洗脱涂层可以包括至少一种包含与治疗剂混合的聚合物的基质聚合物层。 治疗剂例如可以是抗增殖剂或抗炎剂。 基质聚合物可以包括医用粘合剂。 药物从基质聚合物层的洗脱速率受基质聚合物层中药物与聚合物的比例的影响。

    Electrodes With Increased Surface Area And Methods of Making
    4.
    发明申请
    Electrodes With Increased Surface Area And Methods of Making 审中-公开
    电极表面积增加和制造方法

    公开(公告)号：US20080202940A1

    公开(公告)日：2008-08-28

    申请号：US11677905

    申请日：2007-02-22

    申请人： Xiangchun Jiang ,  Ronald W. Heil ,  Daniel J. Cooke

    发明人： Xiangchun Jiang ,  Ronald W. Heil ,  Daniel J. Cooke

    IPC分类号： B23H3/06

    CPC分类号： A61N1/056 ,  C25F3/02

    摘要： Disclosed herein, among other things, are high surface area electrodes and methods of making the same. In an embodiment, the invention includes a method of increasing the surface area of an electrode of an implantable medical device including immersing the electrode in an electrolyte solution and oxidatively removing material from the surface of the electrode. In an embodiment, the invention includes a method of increasing the surface area of an electrode of an implantable medical device including immersing the electrode in an electrolyte solution and applying an oscillating electrical potential. In an embodiment, the invention includes a method of manufacturing an implantable stimulation lead including welding an electrode to a conductor and increasing the surface area of the electrode by oxidatively removing a portion of the electrode surface. Other aspects and embodiments are provided herein.

    摘要翻译： 这里公开的是高表面积电极及其制造方法。 在一个实施方案中，本发明包括增加可植入医疗装置的电极的表面积的方法，包括将电极浸入电解质溶液中并从电极的表面氧化去除材料。 在一个实施例中，本发明包括增加可植入医疗装置的电极的表面积的方法，包括将电极浸入电解质溶液中并施加振荡电位。 在一个实施例中，本发明包括一种制造可植入刺激引线的方法，包括将电极焊接到导体，并通过氧化去除电极表面的一部分来增加电极的表面积。 本文提供了其它方面和实施例。

    MRI operation modes for implantable medical devices
    7.
    发明授权
    MRI operation modes for implantable medical devices 有权
    可植入医疗器械的MRI操作模式

    公开(公告)号：US08543207B2

    公开(公告)日：2013-09-24

    申请号：US13178571

    申请日：2011-07-08

    申请人： Daniel J. Cooke ,  Jeffrey A. Von Arx

    发明人： Daniel J. Cooke ,  Jeffrey A. Von Arx

    IPC分类号： A61N1/37

    CPC分类号： A61N1/3718 ,  A61N1/02 ,  A61N1/36092 ,  A61N1/3688 ,  A61N1/3931 ,  A61N1/3962 ,  Y10S128/901

    摘要： One embodiment of the present invention relates to an implantable medical device (“IMD”) that can be programmed from one operational mode to another operational mode when in the presence of electro-magnetic interference (“EMI”). In accordance with this particular embodiment, the IMD includes a communication interface for receiving communication signals from an external device, such as a command to switch the IMD from a first operation mode to a second operation mode. The IMD further includes a processor in electrical communication with the communication interface, which is operable to switch or reprogram the IMD from the first operation mode to the second operation mode upon receiving a command to do so. In addition, the IMD includes a timer operable to measure a time period from when the processor switches the IMD to the second operation mode. In accordance with this aspect of the invention, the processor is in electrical communication with the timer, and is further operable to switch the IMD from the second operation mode back to the first operation mode when the measured time period reaches a predetermined time period.

    摘要翻译： 本发明的一个实施例涉及当存在电磁干扰（“EMI”）时可从一个操作模式编程到另一个操作模式的可植入医疗装置（“IMD”）。 根据该特定实施例，IMD包括用于从外部设备接收通信信号的通信接口，诸如将IMD从第一操作模式切换到第二操作模式的命令。 IMD还包括与通信接口电通信的处理器，其可操作以在接收到这样做的命令时将IMD从第一操作模式切换或重新编程到第二操作模式。 另外，IMD包括一个定时器，可操作以测量从处理器将IMD切换到第二操作模式的时间段。 根据本发明的这个方面，处理器与定时器电通信，并且当测量的时间段达到预定的时间周期时，进一步可操作地将IMD从第二操作模式切换回第一操作模式。

    Optical Window Assembly for Implantable Medical Device
    8.
    发明申请
    Optical Window Assembly for Implantable Medical Device 审中-公开
    用于植入式医疗设备的光学窗组件

    公开(公告)号：US20090221885A1

    公开(公告)日：2009-09-03

    申请号：US12391761

    申请日：2009-02-24

    申请人： Peter Hall ,  Daniel J. Cooke ,  Michael John Kane

    发明人： Peter Hall ,  Daniel J. Cooke ,  Michael John Kane

    IPC分类号： A61B5/1473 ,  B23K31/02

    CPC分类号： A61B5/14542 ,  A61B5/1473

    摘要： Embodiments of the invention are related to optical window assemblies for implantable medical devices, amongst other things. In an embodiment, the invention includes an optical window assembly for a medical device. The assembly can include a ferrule defining an aperture and a spacer ring disposed within the aperture. The assembly can also include an optical window coupled to the metal ferrule and the spacer ring. In an embodiment, the invention includes an implantable medical device including a housing and an optical window assembly coupled to the housing. In an embodiment, the invention can include a method of manufacturing a medical device. The method can include brazing a spacer ring to a metal ferrule, coupling an optical window to the spacer ring and the metal ferrule with a bonding glass material, depositing a chemical sensing element over the optical window, and coupling a porous cover layer to the spacer ring and the ferrule with an adhesive. Other embodiments are also included herein.

    摘要翻译： 本发明的实施例涉及用于可植入医疗装置的光学窗组件，其中包括。 在一个实施例中，本发明包括用于医疗装置的光学窗组件。 组件可以包括限定孔的套圈和设置在孔内的间隔环。 组件还可以包括耦合到金属套圈和间隔环的光学窗口。 在一个实施例中，本发明包括可植入医疗装置，其包括壳体和耦合到壳体的光学窗组件。 在一个实施例中，本发明可以包括制造医疗装置的方法。 该方法可以包括将间隔环钎焊到金属套箍上，用光学玻璃材料将光学窗口耦合到间隔环和金属套圈，在光学窗口上沉积化学感测元件，以及将多孔覆盖层耦合到间隔物 环和带有粘合剂的套圈。 本文还包括其它实施例。

    MRI OPERATION MODES FOR IMPLANTABLE MEDICAL DEVICES
    9.
    发明申请
    MRI OPERATION MODES FOR IMPLANTABLE MEDICAL DEVICES 有权
    可植入医疗器械的MRI手术模式

    公开(公告)号：US20090138058A1

    公开(公告)日：2009-05-28

    申请号：US11015807

    申请日：2004-12-17

    申请人： Daniel J. Cooke ,  Jeffrey A. Von Arx

    发明人： Daniel J. Cooke ,  Jeffrey A. Von Arx

    IPC分类号： A61N1/08 ,  A61N1/362 ,  A61N1/39

    CPC分类号： A61N1/3718 ,  A61N1/02 ,  A61N1/36092 ,  A61N1/3688 ,  A61N1/3931 ,  A61N1/3962 ,  Y10S128/901

    摘要： One embodiment of the present invention relates to an implantable medical device (“IMD”) that can be programmed from one operational mode to another operational mode when in the presence of electro-magnetic interference (“EMI”). In accordance with this particular embodiment, the IMD includes a communication interface for receiving communication signals from an external device, such as a command to switch the IMD from a first operation mode to a second operation mode. The IMD further includes a processor in electrical communication with the communication interface, which is operable to switch or reprogram the IMD from the first operation mode to the second operation mode upon receiving a command to do so. In addition, the IMD includes a timer operable to measure a time period from when the processor switches the IMD to the second operation mode. In accordance with this aspect of the invention, the processor is in electrical communication with the timer, and is further operable to switch the IMD from the second operation mode back to the first operation mode when the measured time period reaches a predetermined time period.

    摘要翻译： 本发明的一个实施例涉及当存在电磁干扰（“EMI”）时可从一个操作模式编程到另一个操作模式的可植入医疗装置（“IMD”）。 根据该特定实施例，IMD包括用于从外部设备接收通信信号的通信接口，诸如将IMD从第一操作模式切换到第二操作模式的命令。 IMD还包括与通信接口电通信的处理器，其可操作以在接收到这样做的命令时将IMD从第一操作模式切换或重新编程到第二操作模式。 另外，IMD包括一个定时器，可操作以测量从处理器将IMD切换到第二操作模式的时间段。 根据本发明的这个方面，处理器与定时器电通信，并且当测量的时间段达到预定的时间周期时，进一步可操作地将IMD从第二操作模式切换回第一操作模式。