-
公开(公告)号：US20060293342A1
公开(公告)日：2006-12-28
申请号：US10552424
申请日：2004-04-08
申请人： Jeff Chen , Lisa Dalrymple , Sergey Epshteyn , Timothy Forsyth , Tai Huynh , James Leahy , Brian Ridgway , Grace Mann , Larry Mann , Craig Takeuchi , Joan Sangalang
发明人： Jeff Chen , Lisa Dalrymple , Sergey Epshteyn , Timothy Forsyth , Tai Huynh , James Leahy , Brian Ridgway , Grace Mann , Larry Mann , Craig Takeuchi , Joan Sangalang
IPC分类号： A61K31/506 , A61K31/4439
CPC分类号： C07D401/04 , A61K31/4439 , A61K31/506
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. Compounds of the invention inhibit, regulate and/or modulate kinases, particularly Tie-2. Methods of using the compounds and pharmaceutical compositions thereof to treat kinase-dependent diseases and conditions are also an aspect of the invention.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 本发明的化合物抑制，调节和/或调节激酶，特别是Tie-2。 使用化合物及其药物组合物治疗激酶依赖性疾病和病症的方法也是本发明的一个方面。
-
公开(公告)号：US20060211709A1
公开(公告)日：2006-09-21
申请号：US10513081
申请日：2003-05-02
申请人： Chris Buhr , Tae-Gon Baik , Sunghoon Ma , Zerom Tesfai , Longcheng Wang , Erick Co , Sergey Epshteyn , Abigail Kennedy , Baili Chen , Larisa Dubenko , Neel Anand , Tsze Tsang , John Nuss , Csabaj Peto , Kenneth Rice , Mohamed Ibrahim , Xian Shi , James Leahy , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Grace Mann , Larry Mann , Craig Takeuchi
发明人： Chris Buhr , Tae-Gon Baik , Sunghoon Ma , Zerom Tesfai , Longcheng Wang , Erick Co , Sergey Epshteyn , Abigail Kennedy , Baili Chen , Larisa Dubenko , Neel Anand , Tsze Tsang , John Nuss , Csabaj Peto , Kenneth Rice , Mohamed Ibrahim , Xian Shi , James Leahy , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Grace Mann , Larry Mann , Craig Takeuchi
IPC分类号： A61K31/497 , C07D403/02
CPC分类号： C07D241/26 , C07D401/04 , C07D401/10 , C07D401/12 , C07D403/04 , C07D403/10 , C07D403/14 , C07D405/04 , C07D405/12 , C07D413/04 , C07D413/12
摘要： Substituted aryl 1,4-pyrazine derivatives and their use in treating anxiety disorders, depression and stress related disorders are disclosed.
摘要翻译： 公开了取代的芳基1,4-吡嗪衍生物及其在治疗焦虑症，抑郁症和应激相关疾病中的用途。
-
公开(公告)号：US20070225307A1
公开(公告)日：2007-09-27
申请号：US11753462
申请日：2007-05-24
申请人： Lynne Bannen , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wie Xu
发明人： Lynne Bannen , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wie Xu
IPC分类号： A61K31/517 , A61K31/4709 , A61K31/4704 , C07D401/02 , C07D403/02 , C07D417/02
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节与细胞活性变化相关的激酶受体，特别是c-Met，KDF，c-Kit，flt-3和flt-4信号转导途径的喹唑啉和喹啉 如上所述，含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。
-
公开(公告)号：US20070244116A1
公开(公告)日：2007-10-18
申请号：US11753503
申请日：2007-05-24
申请人： LYNNE BANNEN , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wei Xu
发明人： LYNNE BANNEN , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wei Xu
IPC分类号： A61K31/47 , A61K31/16 , A61K31/517 , C07C229/40 , C07D215/22 , C07D239/94 , C07D413/12 , C07D239/88 , C07C233/59 , A61K31/5355 , A61K31/196
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate, and/or modulate kinase receptor, particularly c-Met, KDF, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节与细胞活性变化相关的激酶受体，特别是c-Met，KDF，c-Kit，flt-3和flt-4信号转导途径的喹唑啉和喹啉 如上所述，含有这些化合物的组合物，及其用于治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。
-
公开(公告)号：US20070054928A1
公开(公告)日：2007-03-08
申请号：US11586751
申请日：2006-10-26
申请人： Lynne Bannen , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wei Xu
发明人： Lynne Bannen , Diva Chan , Jeff Chen , Lisa Dalrymple , Timothy Forsyth , Tai Huynh , Vasu Jammalamadaka , Richard Khoury , James Leahy , Morrison Mac , Grace Mann , Larry Mann , John Nuss , Jason Parks , Craig Takeuchi , Yong Wang , Wei Xu
IPC分类号： A61K31/517 , A61K31/4709 , C07D403/02 , C07D401/02
CPC分类号： C07D215/233 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/496 , A61K31/501 , A61K31/505 , A61K31/506 , A61K31/517 , A61K31/5377 , C07D215/22 , C07D215/36 , C07D215/38 , C07D215/46 , C07D239/88 , C07D239/94 , C07D295/15 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C12Q1/485 , G01N2500/04 , Y02A50/393
摘要： The present invention provides compounds for modulating protein kinase enzymatic activity for modulating cellular activities such as proliferation, differentiation, programmed cell death, migration and chemoinvasion. More specifically, the invention provides quinazolines and quinolines which inhibit, regulate and/or modulate kinase receptor, particularly c-Met, KDR, c-Kit, flt-3 and flt-4, signal transduction pathways related to the changes in cellular activities as mentioned above, compositions which contain these compounds, and methods of using them to treat kinase-dependent diseases and conditions. The present invention also provides methods for making compounds as mentioned above, and compositions which contain these compounds.
摘要翻译： 本发明提供调节蛋白激酶酶活性以调节细胞活性如增殖，分化，程序性细胞死亡，迁移和化学侵蚀的化合物。 更具体地，本发明提供抑制，调节和/或调节激酶受体，特别是c-Met，KDR，c-Kit，flt-3和flt-4，与细胞活性变化相关的信号转导途径的喹啉和喹啉 含有这些化合物的组合物，以及使用它们治疗激酶依赖性疾病和病症的方法。 本发明还提供了制备上述化合物的方法和含有这些化合物的组合物。
-
公开(公告)号：US08088767B2
公开(公告)日：2012-01-03
申请号：US12443103
申请日：2007-09-28
申请人： Adam Antoni Galan , Jeff Chen , Hongwang Du , Timothy Forsyth , Tai Phat Huynh , Henry William Beecroft Johnson , Patrick Kearney , James W. Leahy , Matthew Sangyup Lee , Grace Mann , Brian Hugh Ridgway , Craig Stacy Takeuchi , Peiwen Zhou
发明人： Adam Antoni Galan , Jeff Chen , Hongwang Du , Timothy Forsyth , Tai Phat Huynh , Henry William Beecroft Johnson , Patrick Kearney , James W. Leahy , Matthew Sangyup Lee , Grace Mann , Brian Hugh Ridgway , Craig Stacy Takeuchi , Peiwen Zhou
IPC分类号： A61K31/5377 , A61K31/4439 , A61K31/4184 , C07D413/14 , C07D401/14 , C07D403/12
CPC分类号： C07D405/14 , C07D233/90 , C07D401/14 , C07D403/12 , C07D403/14
摘要： This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention.
摘要翻译： 本发明涉及蛋白酪氨酸激酶及其抑制剂的领域。 特别地，本发明涉及JAK-2抑制剂，用于抑制JAK-2的化合物的药物组合物，抑制细胞中JAK-2的方法，包括使需要JAK-2抑制的细胞与化合物 或包含根据本发明的化合物的药物组合物。 还包括治疗涉及JAK-2的疾病或病症的方法，包括向患者施用包含本发明化合物的药物组合物。
-
公开(公告)号：US20100136136A1
公开(公告)日：2010-06-03
申请号：US12443103
申请日：2007-09-28
申请人： Adam Antoni Galan , Jeff Chen , Hongwang Du , Timothy Forsyth , Tai Phat Huynh , Henry William Beecroft Johnson , Patrick Kearney , James W. Leahy , Matthew Sangyup Lee , Grace Mann , Brian Hugh Ridgway , Craig Stacy Takeuchi , Peiwen Zhou
发明人： Adam Antoni Galan , Jeff Chen , Hongwang Du , Timothy Forsyth , Tai Phat Huynh , Henry William Beecroft Johnson , Patrick Kearney , James W. Leahy , Matthew Sangyup Lee , Grace Mann , Brian Hugh Ridgway , Craig Stacy Takeuchi , Peiwen Zhou
IPC分类号： A61K31/4178 , C07D403/12 , C07D401/14 , C07D403/14 , C07D413/14 , A61K31/4184 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , C12N5/00 , A61P35/00 , A61K31/7076 , A61K31/437 , A61K31/704 , A61K33/24
CPC分类号： C07D405/14 , C07D233/90 , C07D401/14 , C07D403/12 , C07D403/14
摘要： This invention relates to the field of protein tyrosine kinases and inhibitors thereof. In particular, the invention relates to inhibitors of JAK-2, pharmaceutical compositions of the compounds for inhibiting JAK-2, methods of inhibiting JAK-2 in a cell, comprising contacting a cell in which inhibition of JAK-2 is desired with a compound or pharmaceutical composition comprising a compound according to the invention. The also comprises methods of treating a disease or condition that involves JAK-2 comprising administering to a patient a pharmaceutical composition comprising a compound according to the invention.
摘要翻译： 本发明涉及蛋白酪氨酸激酶及其抑制剂的领域。 特别地，本发明涉及JAK-2抑制剂，用于抑制JAK-2的化合物的药物组合物，抑制细胞中JAK-2的方法，包括使需要JAK-2抑制的细胞与化合物 或包含根据本发明的化合物的药物组合物。 还包括治疗涉及JAK-2的疾病或病症的方法，包括向患者施用包含本发明化合物的药物组合物。
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.057 秒)
