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公开(公告)号:US20160082258A1
公开(公告)日:2016-03-24
申请号:US14954740
申请日:2015-11-30
申请人: Jeffery M. KRAMER , Daniel H. KIM , Mir A. IMRAN
发明人: Jeffery M. KRAMER , Daniel H. KIM , Mir A. IMRAN
CPC分类号: A61N1/36114 , A61N1/0551 , A61N1/36057 , A61N1/36071 , A61N1/36135
摘要: Systems, methods and devices are provided for the targeted treatment of a variety of medical conditions by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies. Typically, the target anatomy includes one or more dorsal root ganglia, dorsal roots, dorsal root entry zones, or portions thereof. Such target stimulation areas are utilized due in part to their effect on the sympathetic nervous system.
摘要翻译: 提供了系统,方法和装置,用于通过直接神经调节与条件相关联的目标解剖结构,同时最小化或排除其他解剖结构的不期望的神经调节来定向治疗各种医学状况。 通常,目标解剖结构包括一个或多个背根神经节,背根,背根进入区或其部分。 这些目标刺激区域部分地由于它们对交感神经系统的影响而被利用。
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公开(公告)号:US20170274212A1
公开(公告)日:2017-09-28
申请号:US15346587
申请日:2016-11-08
申请人: Jeffery M. KRAMER , Daniel H. KIM , Mir A. IMRAN
发明人: Jeffery M. KRAMER , Daniel H. KIM , Mir A. IMRAN
CPC分类号: A61N1/36114 , A61N1/0551 , A61N1/36057 , A61N1/36071 , A61N1/36135
摘要: Systems, methods and devices are provided for the targeted treatment of a variety of medical conditions by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies. Typically, the target anatomy includes one or more dorsal root ganglia, dorsal roots, dorsal root entry zones, or portions thereof. Such target stimulation areas are utilized due in part to their effect on the sympathetic nervous system.
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公开(公告)号:US20130165991A1
公开(公告)日:2013-06-27
申请号:US13706100
申请日:2012-12-05
申请人: Daniel H. KIM , Mir A. IMRAN , Jeffery M. KRAMER
发明人: Daniel H. KIM , Mir A. IMRAN , Jeffery M. KRAMER
IPC分类号: A61N1/36
CPC分类号: A61N1/36071 , A61B5/01 , A61B5/4836 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36164
摘要: Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.
摘要翻译: 本发明的一些实施例通过在背根神经节内或周围植入电极来提供用于选择性刺激和/或神经调节一个或多个背根神经节的刺激系统和组件。 本发明的一些其他实施方案提供了一种或多种背根神经节的选择性神经刺激的方法以及将神经刺激应用于脊髓的技术。 本发明的其它实施方案通过在背根神经节内或周围植入电极来选择性刺激和/或神经调节一个或多个背根神经节的刺激系统和组件,其与药理学组合。
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公开(公告)号:US20170128725A1
公开(公告)日:2017-05-11
申请号:US15406522
申请日:2017-01-13
申请人: Daniel H. KIM , Mir A. IMRAN , Jeffery M. KRAMER
发明人: Daniel H. KIM , Mir A. IMRAN , Jeffery M. KRAMER
CPC分类号: A61N1/36071 , A61B5/01 , A61B5/4836 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36164
摘要: Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.
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公开(公告)号:US20160250469A1
公开(公告)日:2016-09-01
申请号:US14960291
申请日:2015-12-04
申请人: Daniel H. KIM , Mir A. IMRAN , Jeffery M. KRAMER
发明人: Daniel H. KIM , Mir A. IMRAN , Jeffery M. KRAMER
CPC分类号: A61N1/36071 , A61B5/01 , A61B5/4836 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36164
摘要: Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.
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公开(公告)号:US20180126166A1
公开(公告)日:2018-05-10
申请号:US15861592
申请日:2018-01-03
申请人: Jeffery M. KRAMER , Daniel H. KIM , Mir A. IMRAN
发明人: Jeffery M. KRAMER , Daniel H. KIM , Mir A. IMRAN
CPC分类号: A61N1/36114 , A61N1/0551 , A61N1/36057 , A61N1/36071 , A61N1/36135
摘要: Systems, methods and devices are provided for the targeted treatment of a variety of medical conditions by directly neuromodulating a target anatomy associated with the condition while minimizing or excluding undesired neuromodulation of other anatomies. Typically, the target anatomy includes one or more dorsal root ganglia, dorsal roots, dorsal root entry zones, or portions thereof. Such target stimulation areas are utilized due in part to their effect on the sympathetic nervous system.
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公开(公告)号:US20160250468A1
公开(公告)日:2016-09-01
申请号:US14960280
申请日:2015-12-04
申请人: Daniel H. KIM , Mir A. IMRAN
发明人: Daniel H. KIM , Mir A. IMRAN
CPC分类号: A61N1/36071 , A61M5/142 , A61M25/06 , A61M2210/1003 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36067 , A61N1/36139 , A61N1/36171
摘要: Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.
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公开(公告)号:US20140200625A1
公开(公告)日:2014-07-17
申请号:US14216805
申请日:2014-03-17
申请人: Daniel H. KIM , Mir A. IMRAN
发明人: Daniel H. KIM , Mir A. IMRAN
IPC分类号: A61N1/36
CPC分类号: A61N1/36071 , A61M5/142 , A61M25/06 , A61M2210/1003 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36067 , A61N1/36139 , A61N1/36171
摘要: Some embodiments of the present invention provide neurostimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide neurostimulation systems adapted for selective neurostimulation of one or more nerve root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.
摘要翻译: 本发明的一些实施方案通过在背根神经节内或周围植入电极来提供用于选择性刺激和/或神经调节一个或多个背根神经节的神经刺激系统和组件。 本发明的一些其他实施方案提供了适用于一种或多种神经根神经节的选择性神经刺激的神经刺激系统以及将神经刺激应用于脊髓的技术。 本发明的其它实施方案通过在背根神经节内或周围植入电极来选择性刺激和/或神经调节一个或多个背根神经节的刺激系统和组件,其与药理学组合。
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公开(公告)号:US20170095666A1
公开(公告)日:2017-04-06
申请号:US15290953
申请日:2016-10-11
申请人: Daniel H. KIM , Mir A. IMRAN
发明人: Daniel H. KIM , Mir A. IMRAN
CPC分类号: A61N1/36071 , A61M5/142 , A61M25/06 , A61M2210/1003 , A61N1/0551 , A61N1/0558 , A61N1/0568 , A61N1/36017 , A61N1/36021 , A61N1/36067 , A61N1/36139 , A61N1/36171
摘要: Some embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia. Some other embodiments of the present invention provide methods for selective neurostimulation of one or more dorsal root ganglia as well as techniques for applying neurostimulation to the spinal cord. Still other embodiments of the present invention provide stimulation systems and components for selective stimulation and/or neuromodulation of one or more dorsal root ganglia through implantation of an electrode on, in or around a dorsal root ganglia in combination with a pharmacological agent.
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10.
公开(公告)号:US20100267809A1
公开(公告)日:2010-10-21
申请号:US12772652
申请日:2010-05-03
申请人: John J. ROSSI , Daniela CASTANOTTO , Gerd PFEIFER , Stella TOMMASI , Kevin V. MORRIS , Daniel H. KIM
发明人: John J. ROSSI , Daniela CASTANOTTO , Gerd PFEIFER , Stella TOMMASI , Kevin V. MORRIS , Daniel H. KIM
IPC分类号: A61K31/713 , C07H21/04 , A61P43/00
CPC分类号: C12N15/111 , C12N15/1135 , C12N15/63 , C12N2310/111 , C12N2310/14 , C12N2310/53
摘要: The present invention relates to transcriptional gene silencing (TGS) in mammalian, including human, cells that is mediated by small interfering RNA (siRNA) molecules. The present invention also relates to a double stranded nucleic acid that directs methylation of histones associated with target genes that produce low copy promoter-specific RNA. It has been found that siRNAs can be used to direct methylation of histones in mammalian, including human, cells.
摘要翻译: 本发明涉及哺乳动物(包括人)由小干扰RNA(siRNA)分子介导的细胞的转录基因沉默(TGS)。 本发明还涉及引导与产生低拷贝启动子特异性RNA的靶基因相关的组蛋白甲基化的双链核酸。 已经发现siRNA可以用于引导哺乳动物(包括人)细胞中组蛋白的甲基化。
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