-
1.发明授权Compounds and methods for increasing endogenous levels of corticotropin-releasing factor 失效增加促肾上腺皮质激素释放因子内源性水平的化合物和方法
公开(公告)号：US5959109A
公开(公告)日：1999-09-28
申请号：US645637
申请日：1996-05-15
申请人： Jeffrey P. Whitten , James R. McCarthy , Zhengyu Liu , Charles Q. Huang , Philip E. Erickson , Dominic P. Behan
发明人： Jeffrey P. Whitten , James R. McCarthy , Zhengyu Liu , Charles Q. Huang , Philip E. Erickson , Dominic P. Behan
IPC分类号： A61K31/00 , A61K31/35 , A61K31/352 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4168 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/433 , A61K31/505 , A61K31/513 , A61P5/00 , A61P43/00 , C07D239/62 , C07D239/66 , C07D311/56 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/08 , C07D487/04 , C07D239/02
CPC分类号： C07D409/14 , C07D239/62 , C07D239/66 , C07D311/56 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/08 , C07D487/04
摘要： Ligand inhibitors for increasing levels of free corticotropin-releasing factor (CRF) in the brain. Such ligand inhibitors cause release of CRF from the CRF/CRF-binding protein complex. Administration of the ligand inhibitors provide improvement in learning and memory, result in decreased food intake and/or provide treatment for diseases associated with low levels of CRF in the brain, notably Alzheimer's disease. The ligand inhibitor is represented by the formula: ##STR1##
摘要翻译： 增加脑中游离促皮质激素释放因子（CRF）水平的配体抑制剂。 这种配体抑制剂引起CRF / CRF结合蛋白复合物的CRF释放。 配体抑制剂的施用提供了学习和记忆的改善，导致食物摄取减少和/或提供与脑中低水平CRF相关疾病，特别是阿尔茨海默氏病的治疗。 配体抑制剂由下式表示：
-
2.发明授权Compounds and methods for increasing endogenous levels of corticotropin-releasing factor 失效增加促肾上腺皮质激素释放因子内源性水平的化合物和方法
公开(公告)号：US6133276A
公开(公告)日：2000-10-17
申请号：US222374
申请日：1998-12-29
申请人： Jeffrey P. Whitten , James R. McCarthy , Zhengyu Liu , Charles Q. Huang , Philip E. Erickson , Dominic P. Behan
发明人： Jeffrey P. Whitten , James R. McCarthy , Zhengyu Liu , Charles Q. Huang , Philip E. Erickson , Dominic P. Behan
IPC分类号： A61K31/00 , A61K31/35 , A61K31/352 , A61K31/41 , A61K31/415 , A61K31/4164 , A61K31/4168 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/428 , A61K31/433 , A61K31/505 , A61K31/513 , A61P5/00 , A61P43/00 , C07D239/62 , C07D239/66 , C07D311/56 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/08 , C07D487/04 , A61K31/515
CPC分类号： C07D409/14 , C07D239/62 , C07D239/66 , C07D311/56 , C07D401/12 , C07D403/06 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D417/14 , C07D471/04 , C07D473/08 , C07D487/04
摘要： Ligand inhibitors for increasing levels of free corticotropin-releasing factor (CRF) in the brain are disclosed. Such ligand inhibitors cause release of CRF from the CRF/CRF-bind protein complex. Administration of the ligand inhibitors provide improvement in learning and memory, result in decreased food intake and/or provide treatment for diseases associated with low levels of CRF in the brain, notably Alzheimer's disease.
摘要翻译： 公开了用于增加脑中游离促皮质激素释放因子（CRF）水平的配体抑制剂。 这种配体抑制剂引起CRF / CRF结合蛋白复合物的CRF释放。 配体抑制剂的施用提供了学习和记忆的改善，导致食物摄取减少和/或提供与脑中低水平CRF相关疾病，特别是阿尔茨海默氏病的治疗。
-
公开(公告)号：US5189052A
公开(公告)日：1993-02-23
申请号：US453648
申请日：1989-12-20
IPC分类号： C07D233/84 , C07D401/04 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/06
CPC分类号： C07D401/04 , C07D233/84 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/06
摘要： Imidazole-2-thione derivatives useful as antihypertensive agents are described herein. The compounds are obtained by cyclization of an appropriate open-chain compound such as an appropriately substituted thiourea.
摘要翻译： 本文描述了可用作抗高血压剂的咪唑-2-硫酮衍生物。 通过合适的开链化合物如适当取代的硫脲环化获得化合物。
-
公开(公告)号：US5795905A
公开(公告)日：1998-08-18
申请号：US468799
申请日：1995-06-06
申请人： James R. McCarthy , Yun Feng Xie , Jeffrey P. Whitten , Thomas R. Webb , Chen Chen , John Y. Ramphal
发明人： James R. McCarthy , Yun Feng Xie , Jeffrey P. Whitten , Thomas R. Webb , Chen Chen , John Y. Ramphal
IPC分类号： A61K31/41 , A61K31/433 , A61K31/505 , A61K31/53 , A61P1/12 , A61P3/04 , A61P5/38 , A61P9/00 , A61P11/00 , A61P25/08 , A61P25/18 , A61P25/20 , A61P25/30 , A61P29/00 , A61P37/00 , A61P43/00 , C07D239/42 , C07D239/46 , C07D239/48 , C07D249/14 , C07D251/14 , C07D251/16 , C07D251/18 , C07D251/22 , C07D285/08 , C07D491/052
CPC分类号： C07D239/42 , C07D239/47 , C07D239/48 , C07D249/14 , C07D251/16 , C07D251/18 , C07D251/22 , C07D285/08
摘要： CRF receptor antagonists are disclosed. Such receptor antagonists are thiadiazole-, pyrimidine-, triazine-, and triazole-containing compounds substituted with both a C3-C14 monocyclic or fused, homoaryl or heteroaryl group and a substituted amine group. The CFR receptor antagonists have utility in the treatment of a variety of disorders, including disorders associated with the hypersecretion of CRF.
摘要翻译： 公开了CRF受体拮抗剂。 这样的受体拮抗剂是被C3-C14单环或稠合，均芳基或杂芳基和取代胺基取代的噻二唑，嘧啶，三嗪和三唑化合物。 CFR受体拮抗剂可用于治疗多种疾病，包括与CRF过度分泌相关的疾病。
-
公开(公告)号：US4810800A
公开(公告)日：1989-03-07
申请号：US188661
申请日：1988-04-29
IPC分类号： C07D233/84 , C07D401/04 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/06 , C07D401/06
CPC分类号： C07D401/04 , C07D233/84 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/06
摘要： 1,2-Disubstituted imidazoles useful as antihypertensive agents are described herein. The compounds are obtained from the appropriate 1-substituted imidazole which can be reacted with methyl oxalyl chloride to give the oxalyl derivative or it can be reacted with cyanogen chloride to give the 2-carbonitrile which can then be converted to the other derivatives desired.
摘要翻译： 本文描述了可用作抗高血压剂的1,2-二取代的咪唑。 该化合物由合适的1-取代的咪唑得到，该咪唑可与甲基草酰氯反应得到草酰基衍生物，或者可与氯化氰反应得到2-甲腈，然后将其转化为所需的其它衍生物。
-
公开(公告)号：US5147863A
公开(公告)日：1992-09-15
申请号：US600295
申请日：1990-10-17
IPC分类号： C07D233/06 , C07D233/54 , C07D233/68 , C07D233/90 , C07D521/00 , C07F7/08
CPC分类号： C07D233/64 , C07D231/12 , C07D233/06 , C07D233/56 , C07D233/68 , C07D233/90 , C07D249/08 , C07F7/0812
摘要： This invention relates to novel derivatives of 2,2'-bi-1H-imidazoles, to the processes and intermediates used in their preparation, to their ability to exert the pharmacologic effects of lowering high blood pressure and of increasing heart contractile force and to their use as chemotherpauetic agents useful in treating cardiac insufficiency and hypertension.
摘要翻译： 本发明涉及2,2'-双-1H-咪唑的新型衍生物，其制备中使用的方法和中间体，其发挥降低高血压和增加心脏收缩力的药理作用及其增加心脏收缩力的能力 用作治疗心功能不全和高血压的化学疗法。
-
公开(公告)号：US5057613A
公开(公告)日：1991-10-15
申请号：US114168
申请日：1987-10-27
IPC分类号： C07D233/84 , C07D401/04 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/06
CPC分类号： C07D401/04 , C07D233/84 , C07D403/04 , C07D403/06 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/06 , C07D417/06
摘要： Imidazole-2-thione derivatives useful as antihypertensive agents are described herein. The compounds are obtained by cyclization of an appropriate open-chain compound such as an appropriately substituted thiourea.
摘要翻译： 本文描述了可用作抗高血压剂的咪唑-2-硫酮衍生物。 通过合适的开链化合物如适当取代的硫脲环化获得化合物。
-
8.发明授权
公开(公告)号：US4929744A
公开(公告)日：1990-05-29
申请号：US329148
申请日：1989-03-27
IPC分类号： C07D233/54 , C07D405/14 , C07D409/14 , C07D417/14
CPC分类号： C07D233/56 , C07D405/14 , C07D409/14 , C07D417/14
摘要： This invention relates to a process for preparing (aryl) or heteroaromatic methyl)-2,2'-1H-biimidazoles. Reacting an appropriate alpha-brominated or alpha-chlorinated, substituted or non-substituted, methylated monoaromatic ring compound with 2,2'-bi-1H-imidazole in a solvent such as ethanol in the presence of a base such as sodium hydroxide under reflux conditions; and to pharmaceutical compositions and methods of treating hypertension with such compounds.
摘要翻译： 本发明涉及一种制备（芳基）或杂芳族甲基）-2,2'-1H-联咪唑的方法。 在溶剂如乙醇中，在碱例如氢氧化钠的存在下，在回流下将2,2'-双-1H-咪唑的合适的α-溴代或α-氯代，取代或未取代的甲基化单芳环化合物反应 条件; 以及用这些化合物治疗高血压的药物组合物和方法。
-
9.发明授权(Aryl or heteroaromatic methyl)-2,2'-bi-1H-imidazoles and their use as anti-hypertensive agents 失效（芳基或杂芳族甲基）-2,2'-二-1H-咪唑及其作为抗高血压剂的用途
公开(公告)号：US4839375A
公开(公告)日：1989-06-13
申请号：US78352
申请日：1987-07-28
IPC分类号： A61K31/415 , A61K31/425 , A61P9/12 , C07D233/54 , C07D233/60 , C07D233/64 , C07D405/06 , C07D405/14 , C07D409/06 , C07D409/14 , C07D417/14
CPC分类号： C07D233/56 , C07D405/14 , C07D409/14 , C07D417/14
摘要： This invention relates to novel (aryl or heteroaromatic methyl)-2,2'-1H-biimidazoles; to a process for their production comprising of reacting an appropriate alpha-brominated or alpha-chlorinated, substituted or non-substituted, methylated monoaromatic ring compound with 2,2'-bi-1H-imidazole in a solvent such as ethanol in the presence of a base such as sodium hydroxide under reflux conditions; and to pharmaceutical compositions and methods of treating hypertension with such compounds.
-
公开(公告)号：US09079891B2
公开(公告)日：2015-07-14
申请号：US13219393
申请日：2011-08-26
申请人： Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
发明人： Jeffrey P. Whitten , Yazhong Pei , Jianguo Cao , Zhijun Wang , Evan Rogers , Brian Dyck , Jonathan Grey
IPC分类号： C07D277/34 , A61K31/426 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61K9/00 , A61K9/02 , A61K9/48 , C07D409/04 , C07D409/14
CPC分类号： C07D413/04 , A61K9/0014 , A61K9/0019 , A61K9/0031 , A61K9/0048 , A61K9/007 , A61K9/02 , A61K9/4866 , C07D409/04 , C07D409/14 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
-
-
-
-
-
-
-
-
-
搜索结果
89 条记录 (耗时 0.037 秒)
