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1.发明申请Stabilized Aptamers to Platelet Derived Growth Factor and their Use as Oncology Therapeutics 审中-公开稳定的血小板衍生生长因子及其作为肿瘤学治疗的用途公开(公告)号：US20090053138A1
公开(公告)日：2009-02-26
申请号：US11666954
申请日：2005-11-02
申请人： Jeffrey Preiss , Charles Wilson , Martin Stanton , John Diener , David Epstein , Dilara McCauley , Thomas McCauley
发明人： Jeffrey Preiss , Charles Wilson , Martin Stanton , John Diener , David Epstein , Dilara McCauley , Thomas McCauley
IPC分类号： A61K49/00 , C07H21/04 , A61P35/00 , A61K31/711
CPC分类号： C12N15/115 , A61K31/711 , A61K47/549 , A61K47/60 , C07H21/04 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/351 , C12N2310/3521
摘要： Materials and methods are provided for producing and using aptamers as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and/or VEGF receptor or any combination thereof with affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.
摘要翻译： 提供材料和方法用于生产和使用适配体作为能够以亲和力和特异性结合PDGF，PDGF同种型，PDGF受体，VEGF和/或VEGF受体或其任何组合的肿瘤学治疗剂。 本发明的组合物特别可用于实体瘤治疗，并且可以单独使用或与已知的细胞毒剂组合用于治疗实体瘤。 还公开了具有一个或多个CpG基序嵌入其中或附着于其上的适体。
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2.发明申请公开(公告)号：US20050124565A1
公开(公告)日：2005-06-09
申请号：US10873853
申请日：2004-06-21
申请人： John Diener , David Epstein , Alicia Ferguson , Dilara Grate , Anthony Keefe , Thomas McCauley , Jeffrey Preiss , Martin Stanton , Charles Wilson
发明人： John Diener , David Epstein , Alicia Ferguson , Dilara Grate , Anthony Keefe , Thomas McCauley , Jeffrey Preiss , Martin Stanton , Charles Wilson
摘要： Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.
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3.发明申请公开(公告)号：US20070048248A1
公开(公告)日：2007-03-01
申请号：US11354657
申请日：2006-02-14
申请人： Claude Benedict , David Epstein , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas McCauley , James Rottman , Charles Wilson
发明人： Claude Benedict , David Epstein , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas McCauley , James Rottman , Charles Wilson
IPC分类号： A61K48/00
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521
摘要： The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
摘要翻译： 本发明提供了使用这些核酸治疗剂治疗补体相关疾病的核酸治疗剂和方法。
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公开(公告)号：US20060018871A1
公开(公告)日：2006-01-26
申请号：US11058134
申请日：2005-02-14
申请人： Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Keene , Jeffrey Kurz , Markus Kurz , Thomas McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna Zoltoski
发明人： Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Keene , Jeffrey Kurz , Markus Kurz , Thomas McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna Zoltoski
CPC分类号： C12N15/115 , A61K47/60 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3533 , C12N2310/3521
摘要： The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
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公开(公告)号：US20060105980A1
公开(公告)日：2006-05-18
申请号：US11318227
申请日：2005-12-22
申请人： Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Keene , Jeffrey Kurz , Markus Kurz , Thomas McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna Zoltoski
发明人： Claude Benedict , John Diener , David Epstein , Dilara Grate , Sara Keene , Jeffrey Kurz , Markus Kurz , Thomas McCauley , James Rottman , Kristin Thompson , Charles Wilson , Anna Zoltoski
CPC分类号： C12N15/115 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/3521
摘要： The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
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6.发明授权公开(公告)号：US08236773B2
公开(公告)日：2012-08-07
申请号：US11884411
申请日：2006-02-14
申请人： Claude Benedict , David Epstein , Charles Wilson , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman
发明人： Claude Benedict , David Epstein , Charles Wilson , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman
IPC分类号： C12N15/11
CPC分类号： C12N15/115 , A61K47/60 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3533 , C12N2310/3521
摘要： The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
摘要翻译： 本发明提供了使用这些核酸治疗剂治疗补体相关疾病的核酸治疗剂和方法。
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公开(公告)号：US08436164B2
公开(公告)日：2013-05-07
申请号：US13525680
申请日：2012-06-18
申请人： Claude Benedict , David Epstein , Charles Wilson , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman
发明人： Claude Benedict , David Epstein , Charles Wilson , Dilara McCauley , Jeffrey Kurz , Markus Kurz , Thomas Greene McCauley , James Rottman
IPC分类号： C07H21/04
CPC分类号： C12N15/115 , A61K47/60 , C12N2310/16 , C12N2310/317 , C12N2310/321 , C12N2310/322 , C12N2310/344 , C12N2310/351 , C12N2310/3533 , C12N2310/3521
摘要： The invention provides nucleic acid therapeutics and methods for using these nucleic acid therapeutics in the treatment of complement-related disorders.
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公开(公告)号：US20060084109A1
公开(公告)日：2006-04-20
申请号：US11291610
申请日：2005-11-30
申请人： David Epstein , Charles Wilson , John Diener
发明人： David Epstein , Charles Wilson , John Diener
CPC分类号： C12Q1/6811 , A61K38/00 , C07H21/04 , C12N15/1048 , C12N15/115 , C12N2310/16 , C12N2310/3519 , C12N2320/50 , G01N33/66 , C12Q2541/101 , C12Q2563/131
摘要： Materials and methods of use thereof are presented for the treatment of diabetes and other diseases. Therapeutic compositions including regulated aptamer therapeutic compositions with specificity to components of diabetes disease are presented with methods of administering these therapeutic compositions.
摘要翻译： 介绍了其用途及其使用方法，用于治疗糖尿病和其他疾病。 呈现给予这些治疗组合物的方法的治疗组合物包括对糖尿病疾病组分具有特异性的调节适体治疗组合物。
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公开(公告)号：US10100316B2
公开(公告)日：2018-10-16
申请号：US10829504
申请日：2004-04-21
申请人： David Epstein , Dilara Grate , Martin Stanton , John L. Diener , Charles Wilson , Thomas Greene McCauley , Errol Desouza
发明人： David Epstein , Dilara Grate , Martin Stanton , John L. Diener , Charles Wilson , Thomas Greene McCauley , Errol Desouza
IPC分类号： C12N15/115 , C12N15/117
摘要： Materials and methods are provided for producing and using aptamers useful as oncology therapeutics capable of binding to PDGF, PDGF isoforms, PDGF receptor, VEGF, and VEGF receptor or any combination thereof with great affinity and specificity. The compositions of the present invention are particularly useful in solid tumor therapy and can be used alone or in combination with known cytotoxic agents for the treatment of solid tumors. Also disclosed are aptamers having one or more CpG motifs embedded therein or appended thereto.
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公开(公告)号：US07125660B2
公开(公告)日：2006-10-24
申请号：US10215982
申请日：2002-08-09
申请人： Martin Stanton , David Epstein , Nobuko Hamaguchi , Markus Kurz , Tony Keefe , Charles Wilson , Dilara Grate , Kristin A. Marshall , Thomas G. McCauley , Jeffrey C. Kurz
发明人： Martin Stanton , David Epstein , Nobuko Hamaguchi , Markus Kurz , Tony Keefe , Charles Wilson , Dilara Grate , Kristin A. Marshall , Thomas G. McCauley , Jeffrey C. Kurz
CPC分类号： B82Y30/00 , B01J2219/00385 , B01J2219/00479 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00626 , B01J2219/0063 , B01J2219/00637 , B01J2219/00653 , B01J2219/00662 , B01J2219/00691 , B01J2219/00722 , C07H21/02 , C07H21/04 , C12Q1/485 , C12Q1/6816 , C12Q1/6825 , C40B40/06 , C40B60/14 , C12Q2565/101 , C12Q2525/179 , C12Q2521/337 , C12Q2521/501
摘要： Methods for engineering a nucleic acid sensor molecule are provided. Biosensors comprise a plurality of nucleic acid sensor molecules labeled with a first signaling moiety and a second signaling moiety. The nucleic acid sensor molecules recognizes target molecules which do not naturally bind to DNA. Binding of a target molecule to the sensor molecules triggers a change in the proximity of the signaling moieties which leads to a change in the optical properties of the nucleic acid sensor molecules on the biosensor. Reagents and systems for performing the method are also provided. The method is useful in diagnostic applications and drug optimization.
摘要翻译： 提供了设计核酸传感器分子的方法。 生物传感器包含用第一信号传导部分和第二信号传导部分标记的多个核酸传感器分子。 核酸传感器分子识别不天然结合DNA的靶分子。 靶分子与传感器分子的结合触发信号部分的接近度的变化，导致生物传感器上的核酸传感器分子的光学性质的变化。 还提供了用于执行该方法的试剂和系统。 该方法可用于诊断应用和药物优化。
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