公开(公告)号：US08669488B2

公开(公告)日：2014-03-11

申请号：US13065778

申请日：2011-03-30

申请人： Jeffrey Squier ,  Dawn Vitek ,  Charles Durfee ,  Daniel Adams ,  David Kleinfeld

发明人： Jeffrey Squier ,  Dawn Vitek ,  Charles Durfee ,  Daniel Adams ,  David Kleinfeld

IPC分类号： G02B26/00 ,  B23K26/06 ,  B23K26/36

CPC分类号： B23K26/0624 ,  B23K26/36

摘要： Temporal focusing of spatially chirped femtosecond laser pulses overcomes previous limitations for ablating high aspect ratio features with low numerical aperture (NA) beams. Simultaneous spatial and temporal focusing reduces nonlinear interactions, such as self-focusing, prior to the focal plane so that deep (˜1 mm) features with parallel sidewalls are ablated at high material removal rates.

摘要翻译： 空间啁啾飞秒激光脉冲的时间聚焦克服了先前限制用低数值孔径（NA）光束消除高纵横比特征。 在焦平面之前，同时的空间和时间聚焦可减少诸如自聚焦之间的非线性相互作用，使得具有平行侧壁的深（〜1mm）特征在高材料去除速率下被消融。

公开(公告)号：US20110297651A1

公开(公告)日：2011-12-08

申请号：US13065778

申请日：2011-03-30

申请人： Jeffrey Squier ,  Dawn Vitek ,  David Kleinfeld ,  Daniel Adams ,  Charles Durfee

发明人： Jeffrey Squier ,  Dawn Vitek ,  David Kleinfeld ,  Daniel Adams ,  Charles Durfee

IPC分类号： B23K15/00 ,  G02B27/44 ,  G02B5/04

CPC分类号： B23K26/0624 ,  B23K26/36

摘要： Temporal focusing of spatially chirped femtosecond laser pulses overcomes previous limitations for ablating high aspect ratio features with low numerical aperture (NA) beams. Simultaneous spatial and temporal focusing reduces nonlinear interactions, such as self-focusing, prior to the focal plane so that deep (˜1 mm) features with parallel sidewalls are ablated at high material removal rates.

摘要翻译： 空间啁啾飞秒激光脉冲的时间聚焦克服了先前限制用低数值孔径（NA）光束消除高纵横比特征。 在焦平面之前，同时的空间和时间聚焦可以减少诸如自聚焦之间的非线性相互作用，使得具有平行侧壁的深（〜1mm）特征在高材料去除速率下被消融。

公开(公告)号：US20050035305A1

公开(公告)日：2005-02-17

申请号：US10886940

申请日：2004-07-08

申请人： David Kleinfeld ,  Jeffrey Squier ,  Philbert Tsai

发明人： David Kleinfeld ,  Jeffrey Squier ,  Philbert Tsai

IPC分类号： G01N1/04 ,  G01N1/06 ,  G01N33/483 ,  G01N1/00

CPC分类号： G01N1/06 ,  G01N2001/045 ,  G01N2001/2886

摘要： Femtosecond laser pulses are used to iteratively cut and image fixed as well as exsanguinated fresh tissue. Such images help to automate three-dimensional histological analysis of biological tissue. Cuts are accomplished with approximately 0.3 to 100 microJoule pulses to ablate tissue with one-micrometer precision. Permeability, immunoreactivity, and optical clarity of the remaining tissue is retained after pulsed laser cutting. Samples from transgenic mice that express fluorescent proteins retained their fluorescence to within micrometers of the cut surface.

摘要翻译： 飞秒激光脉冲用于迭代切割和图像固定以及放血的新鲜组织。 这样的图像有助于自动化生物组织的三维组织学分析。 用大约0.3至100微焦耳脉冲完成切割，以一微米精度烧蚀组织。 脉冲激光切割后，剩余组织的渗透性，免疫反应性和光学透明度得以保留。 来自表达荧光蛋白的转基因小鼠的样品将其荧光保留在切割表面的微米内。

公开(公告)号：US5235606A

公开(公告)日：1993-08-10

申请号：US784232

申请日：1991-10-29

申请人： Gerard A. Mourou ,  Jeffrey Squier ,  John S. Coe ,  Donald J. Harter

发明人： Gerard A. Mourou ,  Jeffrey Squier ,  John S. Coe ,  Donald J. Harter

IPC分类号： H01S3/00 ,  H01S3/094 ,  H01S3/23

CPC分类号： H01S3/2316 ,  H01S2301/04 ,  H01S3/0057 ,  H01S3/094 ,  H01S3/17

摘要： A system for producing ultra-high peak power pulses employs a plurality of solid state amplifying materials, such as Nd:glass, alexandrite, and Ti:sapphire, to achieve stretching of a pulse prior to amplification by a factor of approximately between 100 and 10,000. The time-stretched pulse is amplified by many orders of magnitude, illustratively 10.sup.9. After time-stretching and amplification, the pulse is then recompressed to its original duration. Pumping of the multiple solid-state elements is performed simultaneously using an alexandrite laser which is tunable between approximately 700 and 800 nm. The pumping energy has a pulse duration which is less than the fluorescence lifetime of the excited solid-state media.

摘要翻译： 用于产生超高峰值功率脉冲的系统采用多种固态放大材料，例如Nd：玻璃，亚历山大和Ti：蓝宝石，以实现扩增之前的脉冲拉伸约100至10,000倍 。 时间延伸的脉冲被放大许多数量级，示例性地为109.在时间拉伸和放大之后，脉冲被再压缩到其原始持续时间。 多个固态元件的泵送使用可调节在约700和800nm之间的白炽灯激光器同时进行。 泵浦能量的脉冲持续时间小于激发的固态介质的荧光寿命。