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公开(公告)号:US20120182609A1
公开(公告)日:2012-07-19
申请号:US13349830
申请日:2012-01-13
申请人: Jeffrey T. Borenstein , Joseph L. Charest , Joseph Cuiffi , Alla Epshteyn , Angela B. Holton , James Ching-Ming Hsiao
发明人: Jeffrey T. Borenstein , Joseph L. Charest , Joseph Cuiffi , Alla Epshteyn , Angela B. Holton , James Ching-Ming Hsiao
CPC分类号: B01L3/502707 , B01L2200/0689 , B01L2300/0816 , B01L2300/0887 , G02B21/33
摘要: The invention provides microfluidic devices, methods for imaging cells, and methods for preparing such microfluidic devices. The microfluidic devices are contemplated to provide advantages for use in imaging of cells and subcellular compartments in an environment that mimics in vivo conditions. The microfluidic devices can used with a microscope equipped with an oil emersion objective lens.
摘要翻译: 本发明提供了微流体装置,用于成像细胞的方法以及用于制备这种微流体装置的方法。 微流体装置被设想为在模拟体内条件的环境中用于细胞和亚细胞区室的成像中的优点。 微流体装置可以与装有油浸物镜的显微镜一起使用。
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公开(公告)号:US09844779B2
公开(公告)日:2017-12-19
申请号:US13349830
申请日:2012-01-13
申请人: Jeffrey T. Borenstein , Joseph L. Charest , Joseph Cuiffi , Alla Epshteyn , Angela B. Holton , James Ching-Ming Hsiao
发明人: Jeffrey T. Borenstein , Joseph L. Charest , Joseph Cuiffi , Alla Epshteyn , Angela B. Holton , James Ching-Ming Hsiao
CPC分类号: B01L3/502707 , B01L2200/0689 , B01L2300/0816 , B01L2300/0887 , G02B21/33
摘要: A microfluidic device is provided. The microfluidic device includes a first transparent, solid support layer. A first polymeric layer defining at least one chamber is attached to the first transparent, solid support layer. A semi-permeable membrane is attached to the first polymeric layer. A second polymeric layer is attached to the opposite side of the semi-permeable membrane from the first polymeric layer. The second polymeric layer has a thickness of less than 300 microns and defines at least one chamber positioned to overlap with at least one chamber in the first polymeric layer. A first manifold structure is attached to an input end of at least one chamber and a second manifold structure is attached to an output end of at least one chamber.
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公开(公告)号:US20180264687A1
公开(公告)日:2018-09-20
申请号:US15534918
申请日:2015-12-09
申请人: David J. CARTER , Tirunelveli S. SRIRAM , Parshant KUMAR , Clayton MORRIS , William W. MCFARLAND , Eugene H. COOK , John LE BLANC , Alla EPSHTEYN , W. Dennis SLAFER , B. Diane MARTIN , THE CHARLES STARK DRAPER LABORATORY, INC. , MICROCONTINUUM, INC.
发明人: David J. Carter , Tirunelveli S. Sriram , Parshant Kumar , Clayton Morris , William W. McFarland , Eugene H. Cook , John LeBlanc , Alla Epshteyn , W. Dennis Slafer , B. Diane Martin
CPC分类号: B29C33/307 , B23P15/00 , B23P15/24 , B29C33/3842 , B29C33/42 , B29C33/424 , B29C33/68 , B29C39/026 , B29K2905/00 , B81C99/0085 , C25D1/00 , C25D1/10 , C25D1/22 , C25D5/34
摘要: A method of forming a metal mold for casting a micro-scale dry adhesive structure includes securing a master patch of material including a micro-scale dry adhesive structure on a plating fixture, electroforming the metal mold on the patch of material, and removing the metal mold from the plating fixture and patch of material.
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