公开(公告)号：US20060247600A1

公开(公告)日：2006-11-02

申请号：US10555895

申请日：2004-05-07

申请人： Jeffrey Yeung ,  Teresa Yeung

发明人： Jeffrey Yeung ,  Teresa Yeung

IPC分类号： A61M31/00

CPC分类号： A61L27/3658 ,  A61B17/00 ,  A61B17/7061 ,  A61F2/94 ,  A61F2002/444 ,  A61L27/3604 ,  A61L27/3804 ,  A61L27/3856 ,  A61L2430/38

摘要： The intervertebral disc is avascular. With aging, endplates become occluded by calcified layers, and diffusion of nutrients and oxygen into the disc diminishes. The disc degenerates, and pain ensues. Conduits are delivered and deployed into the intervertebral disc to reestablish the exchange of nutrients and waste between the disc and bodily circulation to stop or reverse disc degeneration and relieve pain. The intervertebral disc installed with semi-permeable conduits may be used as an immuno-isolated capsule to encapsulate donor cells capable of biosynthesizing therapeutic molecules. The semi-permeable conduits establish the exchange of nutrients and therapeutic molecules between disc and bodily circulation to treat a disease without using immunosuppressive drugs.

摘要翻译： 椎间盘无血管。 随着老化，终板由钙化层堵塞，营养物质和氧气扩散到椎间盘中减少。 椎间盘退化，发生疼痛。 将管道输送并部署到椎间盘中，以重新建立椎间盘和身体循环之间的营养物质和废物的交换，以停止或逆转椎间盘退变并缓解疼痛。 安装有半渗透管道的椎间盘可以用作免疫分离的囊以封装能够生物合成治疗分子的供体细胞。 半透性管道建立盘与体循环之间的营养物质和治疗分子的交换，以治疗疾病而不使用免疫抑制药物。

公开(公告)号：US20060030884A1

公开(公告)日：2006-02-09

申请号：US10914059

申请日：2004-08-05

申请人： Jeffrey Yeung ,  Teresa Yeung

发明人： Jeffrey Yeung ,  Teresa Yeung

IPC分类号： A61B17/04

CPC分类号： A61B17/0401 ,  A61B17/0467 ,  A61B2017/00805 ,  A61B2017/0409 ,  A61B2017/0412 ,  A61B2017/0414 ,  A61B2017/0437 ,  A61B2017/0445 ,  A61B2017/0446 ,  A61B2017/045 ,  A61B2017/0458 ,  A61B2017/0464 ,  A61B2017/0496 ,  A61B2090/062

摘要： An elastically curved suture anchor is resiliently straightened and delivered into tissue by a needle. When the needle is withdrawn, resumption of the curvature provides leverage for anchor rotation as the attached suture is pulled to fasten the anchor within the tissue. A fin at the proximal end of the anchor further increases the rotational leverage and expedites anchor fastening. When two or more anchors with connecting suture are delivered in series on a needle, the tension of the suture helps to draw the anchors together and approximates the pierced tissue.

摘要翻译： 弹性弯曲的缝合锚固件被弹性地拉直并通过针递送到组织中。 当针被取出时，恢复曲率提供锚定旋转的杠杆作用，因为所附连接的缝合线被拉紧以将锚固件固定在组织内。 在锚的近端处的翅片进一步增加旋转杠杆并加快锚固。 当具有连接缝合线的两个或多个锚固件被串联地递送到针上时，缝合线的张力有助于将锚固件拉到一起并且近似穿刺的组织。

公开(公告)号：US08449490B2

公开(公告)日：2013-05-28

申请号：US13199906

申请日：2011-09-12

申请人： Jeffrey Yeung ,  Teresa Yeung ,  Andrew Yeung

发明人： Jeffrey Yeung ,  Teresa Yeung ,  Andrew Yeung

IPC分类号： A61M27/008

CPC分类号： A61B17/3468 ,  A61B17/7061

摘要： A solid stepped needle delivers a disc shunt bridging between muscle and a degenerated disc, drawing blood plasma from muscle into the degenerated disc to alleviate back pain and regenerate the disc. The device further includes pull lines attached to the ends of the disc shunt for withdrawing and repositioning the stepped needle during shunt delivery.

摘要翻译： 固定的步进式针头在肌肉和退化椎间盘之间提供桥接分离器，将血浆从肌肉吸入退化椎间盘以减轻背部疼痛并再生椎间盘。 该装置还包括附接到盘分路的端部的拉线，用于在分流输送期间抽出和重新定位阶梯式针。

公开(公告)号：US20070169911A1

公开(公告)日：2007-07-26

申请号：US11702267

申请日：2007-02-05

申请人： Jeffrey Yeung ,  Teresa Yeung

发明人： Jeffrey Yeung ,  Teresa Yeung

IPC分类号： B22D19/00

CPC分类号： A61B17/06066 ,  A61B17/062 ,  A61B17/1615 ,  A61B17/1671 ,  A61B17/7061 ,  A61B2017/061 ,  A61B2017/90 ,  A61F2002/444 ,  A61L27/28 ,  A61L2430/38

摘要： The intervertebral disc contains no blood vessels. Nutrients and waste are diffused mainly through adjacent vertebral bodies. As we age, calcified layers form between the disc and vertebral bodies, blocking diffusion. The disc begins to starve and flatten. The weight shifts abnormally from disc to the facet joints causing strain and back pain. Under anaerobic conditions, lactic acid is produced causing acidic irritation and unspecific pain. A U-shaped disc shunt is delivered into and sealed within the degenerated disc simply by needle puncturing and withdrawal, to draw nutrients from bodily circulation into the avascular disc. A continual supply of nutrients increases biosynthesis of the water-retaining sulfated glycosaminoglycans, hence swelling pressure within the disc. The weight is re-shifted from the facet joints to the regenerated disc, alleviating back pain. With oxygen transported through the shunt, anaerobic production of lactic acid is minimized. In addition, the residual lactic acid is expelled through the U-shaped shunt during disc compression into bodily circulation to alleviate unspecific pain.

公开(公告)号：US20070142791A1

公开(公告)日：2007-06-21

申请号：US11702279

申请日：2007-02-05

申请人： Jeffrey Yeung ,  Teresa Yeung

发明人： Jeffrey Yeung ,  Teresa Yeung

IPC分类号： A61M25/00

CPC分类号： A61B17/06066 ,  A61B17/062 ,  A61B17/1615 ,  A61B17/1671 ,  A61B17/7061 ,  A61B2017/061 ,  A61B2017/90 ,  A61F2002/444 ,  A61L27/28 ,  A61L2430/38

摘要： The intervertebral disc contains no blood vessels. Nutrients and waste are diffused mainly through adjacent vertebral bodies. As we age, calcified layers form between the disc and vertebral bodies, blocking diffusion. The disc begins to starve and flatten. The weight shifts abnormally from disc to the facet joints causing strain and back pain. Under anaerobic conditions, lactic acid is produced causing acidic irritation and unspecific pain. A U-shaped disc shunt is delivered into and sealed within the degenerated disc simply by needle puncturing and withdrawal, to draw nutrients from bodily circulation into the avascular disc. A continual supply of nutrients increases biosynthesis of the water-retaining sulfated glycosaminoglycans, hence swelling pressure within the disc. The weight is re-shifted from the facet joints to the regenerated disc, alleviating back pain. With oxygen transported through the shunt, anaerobic production of lactic acid is minimized. In addition, the residual lactic acid is expelled through the U-shaped shunt during disc compression into bodily circulation to alleviate unspecific pain.

摘要翻译： 椎间盘不含血管。 营养物和废物主要通过相邻的椎体扩散。 随着年龄的增长，钙化层形成在椎间盘和椎体之间，阻止扩散。 光盘开始变得饿死了。 重量从椎间盘异常移动到小关节，引起应变和背部疼痛。 在厌氧条件下，产生乳酸，引起酸性刺激和非特异性疼痛。 U形盘分流器简单地通过针穿刺和抽出而被输送并退化在退化的椎间盘中，以将营养物从身体循环中吸收到无血管盘中。 持续供应营养物质可增加保水性硫酸糖胺聚糖的生物合成，从而增加盘内的压力。 重量从小关节重新转移到再生椎间盘，减轻背痛。 通过分流运送的氧气，乳酸的厌氧生产被最小化。 另外，残留的乳酸通过U形分流在椎间盘压迫期间被排出到身体循环中以减轻非特异性疼痛。

公开(公告)号：US20050055027A1

公开(公告)日：2005-03-10

申请号：US10913041

申请日：2004-08-05

申请人： Jeffrey Yeung ,  Teresa Yeung

发明人： Jeffrey Yeung ,  Teresa Yeung

IPC分类号： A61B17/04 ,  A61B17/064 ,  A61B17/068 ,  A61B17/08 ,  A61B17/70 ,  A61B17/86 ,  A61F2/08

CPC分类号： A61B17/0642 ,  A61B17/0401 ,  A61B17/0643 ,  A61B17/0644 ,  A61B17/0682 ,  A61B17/86 ,  A61B2017/0409 ,  A61B2017/0412 ,  A61B2017/0414 ,  A61B2017/0427 ,  A61B2017/0438 ,  A61B2017/044 ,  A61B2017/0445 ,  A61B2017/0646 ,  A61B2017/0647 ,  A61B2017/0648 ,  A61F2/0805 ,  A61F2/0811 ,  A61F2002/0835 ,  A61F2002/0841 ,  A61F2002/0858 ,  A61F2002/4435

摘要： Anchoring elements of a fastener are made elastically curved. The curvatures of the elements are resiliently straightened by a trocar for tissue insertion. As the trocar is withdrawn, the anchoring elements resume the curved configuration, laterally pressing the elements against tissue to anchor the fastener.

摘要翻译： 紧固件的锚定元件被弹性弯曲。 元件的曲率由用于组织插入的套管针弹性地拉直。 当套管针撤出时，锚定元件恢复弯曲构造，将元件侧向地按压组织以锚固紧固件。

公开(公告)号：US20060206116A1

公开(公告)日：2006-09-14

申请号：US11418446

申请日：2006-05-03

申请人： Jeffrey Yeung

发明人： Jeffrey Yeung

IPC分类号： A61B17/00

CPC分类号： A61B17/3472 ,  A61B17/0057 ,  A61B17/7061 ,  A61B17/8811 ,  A61B2017/00637 ,  A61B2017/00654

摘要： The intervertebral disc is avascular. With aging, calcified layers occlude the cartilaginous endplates, blocking the diffusion of nutrients and oxygen into the avascular disc. Under anaerobic condition, excessive production of lactic acid irritates nerves and further hinders transport of sodium sulfate essential for biosynthesis of the water retaining and load sustaining sulfated glycosaminoglycans. As the result of acid irritation and load shifting to facet joints, pain ensues. Through the pedicle, calcified endplate is punctured by a well-supported and elastically curved needle, injecting antacid to neutralize the lactic acid and enhance transport of sodium sulfate into the shielded discs between ilia. Disc filler or nutrients can also be injected through the curved needle into the degenerated disc.

摘要翻译： 椎间盘无血管。 随着老化，钙化层阻塞软骨终板，阻止营养物质和氧气扩散到无血管盘中。 在厌氧条件下，过量的乳酸刺激神经，进一步阻碍了保持和负荷维持硫酸化糖胺聚糖生物合成所必需的硫酸钠的运输。 由于酸刺激和负荷转移到小关节，导致疼痛。 通过椎弓根，钙化终板被良好支撑和弹性弯曲的针刺穿，注射抗酸剂以中和乳酸并增强硫酸钠转运到髂骨之间的屏蔽盘中。 盘状填充物或营养物质也可以通过弯曲的针头注入退化的盘中。

公开(公告)号：US20050246023A1

公开(公告)日：2005-11-03

申请号：US11165076

申请日：2005-06-22

申请人： Jeffrey Yeung

发明人： Jeffrey Yeung

IPC分类号： A61B17/16 ,  A61B17/70 ,  A61B19/00 ,  A61F2/44

CPC分类号： A61B17/7061 ,  A61B17/1604 ,  A61B17/1615 ,  A61B17/162 ,  A61B17/1624 ,  A61B17/1637 ,  A61B17/1671 ,  A61B2090/033

摘要： The intervertebral disc is avascular. With aging, nutrients and oxygen transporting through the endplates diminish. The disc degenerates, and pain ensues. Conduits are delivered through a pedicle or vertebral body into the intervertebral disc to re-establish the exchange of nutrients and waste between the disc and bodily circulation to slow, stop or reverse disc degeneration and relieve pain. Endplate plugs may be deployed to seal gaps between the conduits and the endplates to prevent immune responses to the nucleus pulposus and to preserve the hydrostatic pressure within the disc.

摘要翻译： 椎间盘无血管。 随着老化，通过终板输送的营养物和氧气减少。 椎间盘退化，发生疼痛。 导管通过椎弓根或椎体输送到椎间盘中，以重新建立椎间盘和身体循环之间的营养物质和废物的交换以减缓，停止或逆转椎间盘退化并减轻疼痛。 可以部署端板塞以密封导管和端板之间的间隙，以防止对髓核的免疫应答并保持盘内的静水压力。

公开(公告)号：US20050240201A1

公开(公告)日：2005-10-27

申请号：US11159899

申请日：2005-06-22

申请人： Jeffrey Yeung

发明人： Jeffrey Yeung

IPC分类号： A61B17/16 ,  A61B17/70 ,  A61B19/00 ,  A61F2/44

CPC分类号： A61B17/7061 ,  A61B17/1604 ,  A61B17/1615 ,  A61B17/162 ,  A61B17/1624 ,  A61B17/1637 ,  A61B17/1671 ,  A61B2090/033

摘要： The intervertebral disc is avascular. With aging, nutrients and oxygen transporting through the endplates diminish. The disc degenerates, and pain ensues. Delivery devices are used to deliver a conduit through a pedicle or vertebral body into the intervertebral disc to re-establish the exchange of nutrients and waste between the disc and bodily circulation to slow, stop or reverse disc degeneration and relieve pain.

摘要翻译： 椎间盘无血管。 随着老化，通过终板输送的营养物和氧气减少。 椎间盘退化，发生疼痛。 输送装置用于将通过椎弓根或椎体的导管输送到椎间盘中，以重新建立椎间盘和身体循环之间的营养物和废物的交换以减缓，停止或逆转椎间盘变性并减轻疼痛。

公开(公告)号：US20070265561A1

公开(公告)日：2007-11-15

申请号：US11630706

申请日：2005-06-22

申请人： Jeffrey Yeung

发明人： Jeffrey Yeung

IPC分类号： A61M1/00 ,  A61F2/44

CPC分类号： A61B17/7061 ,  A61B17/1604 ,  A61B17/1615 ,  A61B17/162 ,  A61B17/1624 ,  A61B17/1637 ,  A61B17/1671 ,  A61B2090/033

摘要： The intervertebral disc is avascular. With aging, endplates become occluded by calcified layers, and diffusion of nutrients and oxygen into the disc diminishes. The disc degenerates, and pain ensues. Conduit is delivered and deployed into the vertebral body into the intervertebral disc to re-establish the exchange of nutrients and waste between the disc and bodily circulation to stop or reverse disc degeneration and relieve pain. The intervertebral disc installed with semi-permeable conduits may be used as an immuno-isolated capsule to encapsulate donor cells capable of biosynthesizing therapeutic molecules. The semi-permeable conduits establish the exchange of nutrients and therapeutic molecules between disc and bodily circulation to treat a disease without using immuno-suppressive drugs.

摘要翻译： 椎间盘无血管。 随着老化，终板由钙化层堵塞，营养物质和氧气扩散到椎间盘中减少。 椎间盘退化，发生疼痛。 将管道输送并插入椎体内进入椎间盘，以重新建立椎间盘和身体循环之间的营养物质和废物的交换，以阻止或逆转椎间盘退变并缓解疼痛。 安装有半渗透管道的椎间盘可以用作免疫分离的囊以封装能够生物合成治疗分子的供体细胞。 半透性管道建立了盘与体循环之间的营养物质和治疗分子的交换，以治疗疾病而不使用免疫抑制药物。