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公开(公告)号：US07776328B2
公开(公告)日：2010-08-17
申请号：US12495218
申请日：2009-06-30
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K16/30 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2866 , C07K2317/73 , C07K2317/77
摘要： Provided herein is disclosure about the development and characterization of an antibody that binds to antigen EphA2 which is present on a variety of human cancers from breast, lung, prostate, and colons. Methods of diagnosing and treating various cancers by using such antibodies directed against this antigen are also disclosed.
摘要翻译： 本文提供了关于与来自乳腺，肺，前列腺和冒号的各种人类癌症上存在的抗原EphA2结合的抗体的开发和表征的公开。 还公开了通过使用针对该抗原的这种抗体诊断和治疗各种癌症的方法。
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公开(公告)号：US20100086969A1
公开(公告)日：2010-04-08
申请号：US12627335
申请日：2009-11-30
CPC分类号： C07K16/30 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2866 , C07K2317/73 , C07K2317/77
摘要： Provided herein is disclosure about the development and characterization of an antibody that binds to antigen EphA2 which is present on a variety of human cancers from breast, lung, prostate, and colons. Methods of diagnosing and treating various cancers by using such antibodies directed against this antigen are also disclosed.
摘要翻译： 本文提供了关于与来自乳腺，肺，前列腺和冒号的各种人类癌症上存在的抗原EphA2结合的抗体的开发和表征的公开。 还公开了通过使用针对该抗原的这种抗体诊断和治疗各种癌症的方法。
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公开(公告)号：US07569672B2
公开(公告)日：2009-08-04
申请号：US11349327
申请日：2006-02-06
IPC分类号： C07K16/00 , C12N5/12 , A61K39/395
CPC分类号： C07K16/30 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2866 , C07K2317/73 , C07K2317/77
摘要： Provided herein is disclosure about the development and characterization of an antibody that binds to antigen EphA2 which is present on a variety of human cancers from breast, lung, prostate, and colons. Methods of diagnosing and treating various cancers by using such antibodies directed against this antigen are also disclosed.
摘要翻译： 本文提供了关于与来自乳腺，肺，前列腺和冒号的各种人类癌症上存在的抗原EphA2结合的抗体的开发和表征的公开。 还公开了通过使用针对该抗原的这种抗体诊断和治疗各种癌症的方法。
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公开(公告)号：US20140328857A1
公开(公告)日：2014-11-06
申请号：US14294935
申请日：2014-06-03
IPC分类号： C07K16/30 , A61N5/10 , A61K47/48 , A61K39/395 , A61K45/06
CPC分类号： C07K16/30 , A61K38/00 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K2039/505 , A61N5/10 , C07K14/70532 , C07K16/2827 , C07K2317/77 , G01N33/57492 , G01N2333/70503
摘要： The invention provides the identification and characterization of disease and cancer-associated antigen, RAAG10. The invention also provides a family of monoclonal antibodies that bind to antigen RAAG10, methods of diagnosing and treating various human cancers and diseases that express RAAG10.
摘要翻译： 本发明提供疾病和癌症相关抗原RAAG10的鉴定和表征。 本发明还提供了与抗原RAAG10结合的单克隆抗体家族，诊断和治疗表达RAAG10的各种人类癌症和疾病的方法。
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5.发明授权RAAG10 cell surface target and a family of antibodies recognizing that target 有权RAAG10细胞表面靶标和识别该靶标的一系列抗体公开(公告)号：US07527969B2
公开(公告)日：2009-05-05
申请号：US10600802
申请日：2003-06-19
IPC分类号： C12N1/20
CPC分类号： C07K16/30 , A61K38/00 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K2039/505 , A61N5/10 , C07K14/70532 , C07K16/2827 , C07K2317/77 , G01N33/57492 , G01N2333/70503
摘要： The invention provides the identification and characterization of disease and cancer-associated antigen, RAAG10. The invention also provides a family of monoclonal antibodies that bind to antigen RAAG10, methods of diagnosing and treating various human cancers and diseases that express RAAG10.
摘要翻译： 本发明提供疾病和癌症相关抗原RAAG10的鉴定和表征。 本发明还提供了与抗原RAAG10结合的单克隆抗体家族，诊断和治疗表达RAAG10的各种人类癌症和疾病的方法。
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6.发明授权
公开(公告)号：US5736345A
公开(公告)日：1998-04-07
申请号：US455755
申请日：1995-05-31
IPC分类号： C07K14/475 , C07K14/785 , C12N5/071 , C12N15/85 , C12N15/01 , C12Q1/68 , G01N33/483
CPC分类号： C12N5/0688 , C07K14/475 , C07K14/785 , C12N15/85 , C12N2500/25 , C12N2500/84 , C12N2501/01 , C12N2501/11 , C12N2501/385 , C12N2501/39 , C12N2501/392 , C12N2501/395 , C12N2503/02
摘要： A novel bronchial or bronchiolar epithelial cell from normal neonatal mammalian lung has been isolated, established and maintained for multiple passages in the absence of serum, without undergoing crisis or senescence. By careful manipulation of the nutritional/hormonal microenvironment we have been able to select, from a heterogeneous population, a single epithelial cell type which can maintain highly differentiated features in vitro. This cell type has characteristics of bronchiolar epithelial cells. A clonal line, RL-65, has been selected and observed for more than 3 years in continuous culture. It has been characterized by ultrastructural, morphological and biochemical criteria.
摘要翻译： 已经分离出来自正常新生儿哺乳动物肺的新型支气管或细支气管上皮细胞，在没有血清的情况下建立和维持多次传代，而不经历危机或衰老。 通过仔细操纵营养/激素微环境，我们已经能够从异质群体中选择能在体外保持高度分化特征的单一上皮细胞类型。 该细胞类型具有细支气管上皮细胞的特征。 克隆系RL-65在连续培养中被选择并观察3年以上。 其特征在于超微结构，形态和生化标准。
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公开(公告)号：US08779098B2
公开(公告)日：2014-07-15
申请号：US12413483
申请日：2009-03-27
IPC分类号： C07K16/00
CPC分类号： C07K16/30 , A61K38/00 , A61K39/39558 , A61K45/06 , A61K47/6851 , A61K2039/505 , A61N5/10 , C07K14/70532 , C07K16/2827 , C07K2317/77 , G01N33/57492 , G01N2333/70503
摘要： The invention provides the identification and characterization of disease and cancer-associated antigen, RAAG10. The invention also provides a family of monoclonal antibodies that bind to antigen RAAG10, methods of diagnosing and treating various human cancers and diseases that express RAAG10.
摘要翻译： 本发明提供疾病和癌症相关抗原RAAG10的鉴定和表征。 本发明还提供了与抗原RAAG10结合的单克隆抗体家族，诊断和治疗表达RAAG10的各种人类癌症和疾病的方法。
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公开(公告)号：US08187594B2
公开(公告)日：2012-05-29
申请号：US12483774
申请日：2009-06-12
IPC分类号： A61K39/395 , A61K39/00 , C07K16/00 , C12P21/08
CPC分类号： C07K16/2881 , A61K39/39533 , A61K2039/505 , C07K16/2863 , C07K2317/77 , Y10S530/808 , Y10S530/809 , A61K2300/00
摘要： The invention provides further characterization of the disease and cancer-associated antigen, transferrin receptor. The invention also provides a novel family of antibodies that bind to the transferrin receptor, methods of diagnosing and treating various human cancers and diseases that express transferrin receptor.
摘要翻译： 本发明提供了疾病和癌症相关抗原转铁蛋白受体的进一步表征。 本发明还提供了结合转铁蛋白受体的新型抗体家族，诊断和治疗表达转铁蛋白受体的各种人类癌症和疾病的方法。
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公开(公告)号：US20090263391A1
公开(公告)日：2009-10-22
申请号：US12495218
申请日：2009-06-30
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2866 , C07K2317/73 , C07K2317/77
摘要： Provided herein is disclosure about the development and characterization of an antibody that binds to antigen EphA2 which is present on a variety of human cancers from breast, lung, prostate, and colons. Methods of diagnosing and treating various cancers by using such antibodies directed against this antigen are also disclosed.
摘要翻译： 本文提供了关于与来自乳腺，肺，前列腺和冒号的各种人类癌症上存在的抗原EphA2结合的抗体的开发和表征的公开。 还公开了通过使用针对该抗原的这种抗体诊断和治疗各种癌症的方法。
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公开(公告)号：US5830685A
公开(公告)日：1998-11-03
申请号：US910260
申请日：1992-07-16
IPC分类号： C07K14/475 , C07K14/785 , C12N5/071 , C12N15/85 , C12N15/63 , C07K1/00 , C12N5/06 , C12P21/00
CPC分类号： C12N5/0688 , C07K14/475 , C07K14/785 , C12N15/85 , C12N2500/25 , C12N2500/84 , C12N2501/01 , C12N2501/11 , C12N2501/385 , C12N2501/39 , C12N2501/392 , C12N2501/395 , C12N2503/02
摘要： A novel bronchial or bronchiolar epithelial cell from normal neonatal mammalian lung has been isolated, established and maintained for multiple passages in the absence of serum, without undergoing crisis or senescence. By careful manipulation of the nutritional/hormonal microenvironment we have been able to select, from a heterogeneous population, a single epithelial cell type which can maintain highly differentiated features in vitro. This cell type has characteristics of bronchiolar epithelial cells. A clonal line, RL-65, has been selected and observed for more than 3 years in continuous culture. It has been characterized by ultrastructural, morphological and biochemical criteria.
摘要翻译： PCT No.PCT / US91 / 00878 Sec。 371日期：1992年7月16日 102（e）日期1992年7月16日PCT 1991年2月8日PCT公布。 公开号WO91 / 12317 日期1991年8月22日已经分离了来自正常新生儿哺乳动物肺的新型支气管或细支气管上皮细胞，在不存在血清的情况下建立并维持多次传代，而不经历危机或衰老。 通过仔细操纵营养/激素微环境，我们已经能够从异质群体中选择能在体外保持高度分化特征的单一上皮细胞类型。 该细胞类型具有细支气管上皮细胞的特征。 克隆系RL-65在连续培养中被选择并观察3年以上。 其特征在于超微结构，形态和生化标准。
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