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    Eosinophil degranulating conditions
    1.
    发明授权
    Eosinophil degranulating conditions 有权
    嗜酸粒细胞脱颗粒状况

    公开(公告)号：US06416955B1

    公开(公告)日：2002-07-09

    申请号：US09553790

    申请日：2000-04-21

    申请人： David Sherris ,  Eugene Kern ,  Jens Ponikau ,  Hirohito Kita

    发明人： David Sherris ,  Eugene Kern ,  Jens Ponikau ,  Hirohito Kita

    IPC分类号： G01N3353

    CPC分类号： G01N33/5094 ,  G01N33/6893

    摘要： The invention provides methods and materials related to the diagnosis of eosinophil degranulating conditions. Specifically, the invention provides methods and materials that involve visual types of analysis (e.g., microscopic analysis) that are used to determine the presence or absence of a horseshoe-shaped eosinophil granule structure within a mucus sample collected from a mammal. The presence of a horseshoe-shaped eosinophil granule structure within a patient's mucus indicates that the patient has an eosinophil degranulating condition. In addition, the invention provides methods and materials that involve immunological types of analysis (e.g., immunoassays) that are used to determine if a patient's mucus contains a tissue-damaging amount of eosinophil granule content that is outside the eosinophil granule and within the mucus. Like the presence of a horseshoe-shaped eosinophil granule structure, the presence of a tissue-damaging amount of eosinophil granule content outside the eosinophil granule and within the mucus indicates that the patient has an eosinophil degranulating condition. Further, the invention provides diagnostic kits that can be used to determine whether or not a patient has an eosinophil degranulating condition.

    摘要翻译： 本发明提供了与嗜酸性粒细胞脱粒条件的诊断相关的方法和材料。 具体地说，本发明提供了涉及用于确定从哺乳动物收集的粘液样品内是否存在马蹄形嗜酸性粒细胞结构的分析的视觉类型（例如，微观分析）的方法和材料。 患者粘液中马蹄形嗜酸粒细胞颗粒结构的存在表明患者具有嗜酸性粒细胞脱颗粒状态。 此外，本发明提供了涉及用于确定患者的粘液是否包含嗜酸性粒细胞颗粒外部和粘液内的组织损伤量的嗜酸性粒细胞颗粒含量的分析免疫学类型（例如免疫测定）的方法和材料。 像马蹄形嗜酸粒细胞颗粒结构的存在一样，嗜酸性粒细胞颗粒内部和粘液内存在组织损伤量的嗜酸性粒细胞颗粒含量表示患者具有嗜酸性粒细胞脱颗粒状态。 此外，本发明提供可用于确定患者是否具有嗜酸性粒细胞脱颗粒状况的诊断试剂盒。

    Detecting a bacterial process in chronic rhinosinusitis
    2.
    发明申请
    Detecting a bacterial process in chronic rhinosinusitis 失效
    检测慢性鼻鼻窦炎中的细菌过程

    公开(公告)号：US20080090252A1

    公开(公告)日：2008-04-17

    申请号：US11897494

    申请日：2007-08-30

    申请人： Jens Ponikau ,  David Sherris ,  Hirohito Kita

    发明人： Jens Ponikau ,  David Sherris ,  Hirohito Kita

    IPC分类号： C12Q1/02 ,  C12Q1/37 ,  G01N33/53

    CPC分类号： G01N33/56972 ,  G01N33/5091 ,  G01N2333/908 ,  G01N2333/966 ,  G01N2800/26

    摘要： The present invention provides a method for identifying bacterial induced rhinosinusitis. The method comprises obtaining a nasal or paranasal mucus sample and detecting the presence of neutrophil degranulation in the mucus sample. Degranulation of neutrophils can be determined by morphological analysis of the cells in the mucus or by detection of released (i.e., “free”) granule content markers such as neutrophil elastase or myeloperoxidase. Based on an accurate determination of the cause of sinusitis as described herein, an appropriate treatment can be instituted.

    摘要翻译： 本发明提供了鉴定细菌诱导的鼻鼻窦炎的方法。 该方法包括获得鼻或鼻旁粘液样品并检测粘液样品中嗜中性粒细胞脱粒的存在。 嗜中性粒细胞的脱颗粒可以通过粘液中的细胞的形态学分析或通过检测释放的（即游离的）颗粒含量标记如嗜中性粒细胞弹性蛋白酶或髓过氧化物酶来确定。 基于如本文所述的正确确定鼻窦炎的原因，可以进行适当的治疗。

    Detecting a Bacterial Process in Chronic Rhinosinusitis
    3.
    发明申请
    Detecting a Bacterial Process in Chronic Rhinosinusitis 审中-公开
    检测慢性鼻鼻窦炎中的细菌过程

    公开(公告)号：US20100099119A1

    公开(公告)日：2010-04-22

    申请号：US12641868

    申请日：2009-12-18

    申请人： Jens Ponikau ,  David Sherris ,  Hirohito Kita

    发明人： Jens Ponikau ,  David Sherris ,  Hirohito Kita

    IPC分类号： G01N33/573 ,  C12Q1/44 ,  C12Q1/28

    CPC分类号： G01N33/56972 ,  G01N33/5091 ,  G01N2333/908 ,  G01N2333/966 ,  G01N2800/26

    摘要： The present invention provides a method for identifying bacterial induced rhinosinusitis. The method comprises obtaining a nasal or paranasal mucus sample and detecting the presence of neutrophil degranulation in the mucus sample. Degranulation of neutrophils can be determined by morphological analysis of the cells in the mucus or by detection of released (i.e., “free”) granule content markers such as neutrophil elastase or myeloperoxidase. Based on an accurate determination of the cause of sinusitis as described herein, an appropriate treatment can be instituted.

    摘要翻译： 本发明提供了鉴定细菌诱导的鼻鼻窦炎的方法。 该方法包括获得鼻或鼻旁粘液样品并检测粘液样品中嗜中性粒细胞脱粒的存在。 嗜中性粒细胞的脱颗粒可以通过粘液中的细胞的形态学分析或通过检测释放的（即游离的）颗粒含量标记如嗜中性粒细胞弹性蛋白酶或髓过氧化物酶来确定。 基于如本文所述的正确确定鼻窦炎的原因，可以进行适当的治疗。

    Detecting a bacterial process in chronic rhinosinusitis
    4.
    发明授权
    Detecting a bacterial process in chronic rhinosinusitis 失效
    检测慢性鼻鼻窦炎中的细菌过程

    公开(公告)号：US07659080B2

    公开(公告)日：2010-02-09

    申请号：US11897494

    申请日：2007-08-30

    申请人： Jens Ponikau ,  David Sherris ,  Hirohito Kita

    发明人： Jens Ponikau ,  David Sherris ,  Hirohito Kita

    IPC分类号： G01N33/53 ,  G01N33/567 ,  G01N33/00 ,  G01N33/573 ,  C12N9/66

    CPC分类号： G01N33/56972 ,  G01N33/5091 ,  G01N2333/908 ,  G01N2333/966 ,  G01N2800/26

    摘要： The present invention provides a method for identifying bacterial induced rhinosinusitis. The method comprises obtaining a nasal or paranasal mucus sample and detecting the presence of neutrophil degranulation in the mucus sample. Degranulation of neutrophils can be determined by morphological analysis of the cells in the mucus or by detection of released (i.e., “free”) granule content markers such as neutrophil elastase or myeloperoxidase. Based on an accurate determination of the cause of sinusitis as described herein, an appropriate treatment can be instituted.

    摘要翻译： 本发明提供了鉴定细菌诱导的鼻鼻窦炎的方法。 该方法包括获得鼻或鼻旁粘液样品并检测粘液样品中嗜中性粒细胞脱粒的存在。 嗜中性粒细胞的脱颗粒可以通过粘液中的细胞的形态学分析或通过检测释放的（即游离的）颗粒含量标记如嗜中性粒细胞弹性蛋白酶或髓过氧化物酶来确定。 基于如本文所述的正确确定鼻窦炎的原因，可以进行适当的治疗。

    Fungus-induced inflammation and eosinophil degranulation
    9.
    发明授权
    Fungus-induced inflammation and eosinophil degranulation 有权
    真菌引起的炎症和嗜酸性粒细胞脱粒

    公开(公告)号：US07815919B2

    公开(公告)日：2010-10-19

    申请号：US12629638

    申请日：2009-12-02

    申请人： Hirohito Kita ,  Jens Ponikau ,  Christopher B. Lawrence

    发明人： Hirohito Kita ,  Jens Ponikau ,  Christopher B. Lawrence

    IPC分类号： A61K39/00

    CPC分类号： C12N9/58

    摘要： This document relates to methods and materials involved in fungus-induced inflammation and eosinophil degranulation. For example, isolated nucleic acids encoding fungal polypeptides, fungal polypeptides, methods for assessing fungus-induced inflammation, methods for assessing eosinophil degranulation, and methods for identifying inhibitors of fungus-induced inflammation and/or eosinophil degranulation are provided.

    摘要翻译： 本文件涉及真菌诱导的炎症和嗜酸性粒细胞脱粒所涉及的方法和材料。 例如，提供了编码真菌多肽的分离的核酸，用于评估真菌诱发的炎症的方法，用于评估嗜酸性粒细胞脱粒的方法，以及用于鉴定真菌诱导的炎症和/或嗜酸性粒细胞脱粒的抑制剂的方法。

    Fungus-induced inflammation and eosinophil degranulation
    10.
    发明授权
    Fungus-induced inflammation and eosinophil degranulation 有权
    真菌引起的炎症和嗜酸性粒细胞脱粒

    公开(公告)号：US07972611B2

    公开(公告)日：2011-07-05

    申请号：US12973100

    申请日：2010-12-20

    申请人： Hirohito Kita ,  Jens Ponikau ,  Christopher Lawrence

    发明人： Hirohito Kita ,  Jens Ponikau ,  Christopher Lawrence

    IPC分类号： A61K39/00

    CPC分类号： C12N9/58

    摘要： This document relates to methods and materials involved in fungus-induced inflammation and eosinophil degranulation. For example, isolated nucleic acids encoding fungal polypeptides, fungal polypeptides, methods for assessing fungus-induced inflammation, methods for assessing eosinophil degranulation, and methods for identifying inhibitors of fungus-induced inflammation and/or eosinophil degranulation are provided.

    摘要翻译： 本文件涉及真菌诱导的炎症和嗜酸性粒细胞脱粒所涉及的方法和材料。 例如，提供了编码真菌多肽的分离的核酸，用于评估真菌诱发的炎症的方法，用于评估嗜酸性粒细胞脱粒的方法，以及用于鉴定真菌诱导的炎症和/或嗜酸性粒细胞脱粒的抑制剂的方法。