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10 条记录 (耗时 0.037 秒)

    Leukotriene antagonist
    4.
    发明授权
    Leukotriene antagonist 失效

    公开(公告)号：US4730005A

    公开(公告)日：1988-03-08

    申请号：US864562

    申请日：1986-05-16

    申请人： John G. Gleason ,  Carl D. Perchonock

    发明人： John G. Gleason ,  Carl D. Perchonock

    IPC分类号： A61K31/19 ,  A61K31/38 ,  C07C45/29 ,  C07C45/44 ,  C07C45/56 ,  C07C45/62 ,  C07C45/67 ,  C07C45/68 ,  C07C45/71 ,  C07C45/72 ,  C07C47/542 ,  C07C47/546 ,  C07C47/548 ,  C07C47/55 ,  C07C47/575 ,  C07C49/86 ,  C07D333/18 ,  C07D333/36 ,  C07D333/32 ,  C07D333/24

    CPC分类号： C07D333/18 ,  A61K31/19 ,  C07C317/00 ,  C07C321/00 ,  C07C45/298 ,  C07C45/44 ,  C07C45/56 ,  C07C45/62 ,  C07C45/673 ,  C07C45/68 ,  C07C45/71 ,  C07C45/72 ,  C07C47/542 ,  C07C47/546 ,  C07C47/548 ,  C07C47/55 ,  C07C47/575 ,  C07C49/86

    摘要： The compounds represented by the following structural formula (I) ##STR1## wherein m is 1 or 2; n is 1, 2 or 3; R' is hydrogen or methyl; R is a radical selected from the group consisting of: ##STR2## wherein R.sub.1 is C.sub.8 to C.sub.13 alkyl, C.sub.7 to C.sub.12 alkoxy, C.sub.7 to C.sub.12 thioalkyl, C.sub.10 to C.sub.12 1-alkynyl, 11-dodecynyl, 1-trans-dodecenyl, 5-(4-acetyl-3-hydroxy-2-propylphenoxypentoxy, 2(Z), 5(Z)-undecadienyloxy, phenyl-C.sub.4 to C.sub.10 alkyl with the phenyl optionally mono substituted with bromo, chloro, trifluoromethyl, methoxy, methylthio or trifluoromethylthio, phenylthio-C.sub.3 to C.sub.9 alkyl with the phenyl optionally mono substituted with bromo, chloro, trifluoromethyl, methoxy, methylthio or trifluoromethylthio, phenyl-CH.dbd.CH--(CH.sub.2).sub.2-8, phenyl-C.sub.3 to C.sub.9 alkoxy, trifluoromethyl-C.sub.7 to C.sub.12 alkyl, cyclohexyl- C.sub.4 to C.sub.10 alkyl or ##STR3## wherein each q is 0, 1, 2 or 3 but the sum of both q's does not exceed 3, and R.sub.2 is hydrogen, bromo, chloro, methyl, trifluoromethyl, hydroxy, methoxy or nitro; or R.sub.1 is hydrogen and R.sub.2 is C.sub.8 to C.sub.13 alkyl, C.sub.7 to C.sub.12 alkoxy, C.sub.7 to C.sub.12 thioalkyl, C.sub.10 to C.sub.12 1-alkynyl, 11-dodecynyl, 1-trans-dodecenyl, 5-(4-acetyl-3-hydroxy-2-propylphenoxy(pentoxy, 2(Z), 5(Z)-undecadienyloxy, phenyl-C.sub.4 to C.sub.10 alkyl with the phenyl optionally mono substituted with bromo, chloro, trifluoromethyl, methoxy, methylthio or trifluoromethylthio, phenylthio-C.sub.3 to C.sub.9 alkyl with the phenyl optionally mono substituted with bromo, chloro, trifluoromethyl, methoxy, methylthio or trifluoromethylthio, phenyl-CH.dbd.CH--(CH.sub.2).sub.2-8, phenyl-C.sub.3 to C.sub.9 alkoxy, trifluoromethyl-C.sub.7 to C.sub.12 alkyl, cyclohexyl-C.sub.4 to C.sub.10 alkyl or ##STR4## wherein each q is 0, 1, 2 or 3 but the sum of both q's does not exceed 3, and p is 0 or 1, with the proviso that R is not a thiophene radical and any of R.sub.1 and R.sub.2 above are not thioalkyl or phenylthioalkyl when p is 1; and pharmaceutically acceptable salts thereof have been found to be leukotriene antagonists and useful in the treatment of diseases in which leukotrienes are a factor, such as asthma.

    Tricyclic (azeto-isoquinoline) .beta.-lactams
    8.
    发明授权
    Tricyclic (azeto-isoquinoline) .beta.-lactams 失效
    三环（α-异喹啉）{62-内酰胺

    公开(公告)号：US4140688A

    公开(公告)日：1979-02-20

    申请号：US892531

    申请日：1978-04-03

    申请人： Carl D. Perchonock

    发明人： Carl D. Perchonock

    IPC分类号： C07D317/26 ,  C07D463/00 ,  C07D451/02

    CPC分类号： C07D317/26 ,  C07D463/20

    摘要： A new compound with a nucleus containing a benzo-fused carbocyclic .beta.-lactam system is disclosed. The compound has antibacterial activity against B. subtilis.

    摘要翻译： {PG，1一种具有含有苯并稠合的碳环（62-内酰胺）体系的核的新化合物。 该化合物对抗枯草芽孢杆菌具有抗菌活性。