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1.发明申请METHOD AND COMPOSITIONS FOR DETECTING RESPIRATORY DISEASE-CAUSING BACTERIAL SPECIES 有权用于检测呼吸道疾病细菌物种的方法和组合物公开(公告)号：US20080081770A1
公开(公告)日：2008-04-03
申请号：US11862758
申请日：2007-09-27
申请人： Ji-young OH , Sang-hyun PAEK , Kyung-hee PARK , Jung-nam LEE , Jong-suk CHUNG , Ah-gi KIM
发明人： Ji-young OH , Sang-hyun PAEK , Kyung-hee PARK , Jung-nam LEE , Jong-suk CHUNG , Ah-gi KIM
IPC分类号： C40B40/08
CPC分类号： C12Q1/689 , C12Q2600/16 , Y02A50/451
摘要： Provided are a primer set for specifically amplifying target sequence(s) of twelve respiratory disease-causing bacterial species, a probe set specifically hybridizing with target sequence(s) of twelve respiratory disease-causing bacterial species, a microarray comprising the probe set, and a method of detecting a respiratory disease-causing bacterial species using the probe set.
摘要翻译： 提供了用于特异性扩增十二种呼吸道性疾病的细菌种类的靶序列的引物组，与12种呼吸道性疾病致细菌物种的靶序列特异性杂交的探针组，包含探针组的微阵列和 使用探针组检测呼吸系统疾病的细菌物种的方法。
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2.发明申请METHOD OF DESIGNING PROBES FOR DETECTING TARGET SEQUENCE AND METHOD OF DETECTING TARGET SEQUENCE USING THE PROBES 有权设计用于检测目标序列的探针的方法和使用探测器检测目标序列的方法公开(公告)号：US20080139398A1
公开(公告)日：2008-06-12
申请号：US11739354
申请日：2007-04-24
申请人： Tae-jin AHN , Ji-young OH , Jung-nam LEE , Jong-suk CHUNG
发明人： Tae-jin AHN , Ji-young OH , Jung-nam LEE , Jong-suk CHUNG
CPC分类号： C12Q1/6827 , C12Q1/6837 , C12Q1/689 , Y10T436/145555 , C12Q2521/501 , C12Q2525/161 , C12Q2525/185
摘要： A method of designing probes for detecting a target sequence and a method of detecting target sequence using the probes are provided. The method of designing probes for detecting target sequence includes: selecting an anchoring location in the target sequence, wherein the anchoring location is a location in the target sequence at which a first non-target sequence in a plurality of non-target sequences is different from the target sequence, wherein the first non-target sequence has a sequence similarity to the target sequence that is identical to or higher than the sequence similarity of other non-target sequences in the plurality of non-target sequences; selecting a first probe designing region, wherein the first probe designing region is a fixed region in the target sequence comprising the anchoring location; selecting a probe selection location, wherein the probe selection location is a location in the target sequence at which a second non-target sequence in the plurality of non-target sequences is different from the target sequence; selecting a matched probe, wherein the matched probe comprises a sequence complementary to the target sequence, wherein the probe selecting location is at the center of the sequence of the matched probe; and selecting a mismatched probe, wherein the mismatched probe is longer than the matched probe, wherein the mismatched probe comprises a sequence complementary to the target sequence at all locations except at a mismatched location, wherein the probe selection location is at a first location in the sequence of the mismatched probe and the mismatched location is at a second location in the sequence of the mismatched probe.
摘要翻译： 提供了一种设计用于检测靶序列的探针的方法和使用探针检测靶序列的方法。 设计用于检测目标序列的探针的方法包括：在目标序列中选择锚定位置，其中锚定位置是目标序列中多个非靶序列中的第一非靶序列不同于 所述靶序列，其中所述第一非靶序列与所述靶序列具有与所述多个非靶序列中的其他非靶序列的序列相似性相同或更高的序列相似性; 选择第一探针设计区域，其中所述第一探针设计区域是包括所述锚定位置的所述目标序列中的固定区域; 选择探针选择位置，其中所述探针选择位置是所述多个非靶序列中的第二非靶序列与所述靶序列不同的所述靶序列中的位置; 选择匹配的探针，其中所述匹配的探针包含与所述靶序列互补的序列，其中所述探针选择位置位于所述匹配探针的序列的中心; 以及选择不匹配的探针，其中所述不匹配的探针长于所述匹配的探针，其中所述不匹配的探针包括除所述不匹配位置之外的所有位置处与所述靶序列互补的序列，其中所述探针选择位置位于所述匹配探针的第一位置 不匹配探针和不匹配位置的序列位于错配探针序列中的第二个位置。
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3.发明申请PRIMERS, PROBES, MICROARRAY, AND METHOD FOR SPECIFIC DETECTION OF NINE RESPIRATORY DISEASE-ASSOCIATED BACTERIAL SPECIES 审中-公开PRIMERS，PROBES，MICROARRAY和方法，用于特异性检测九种呼吸系统疾病相关物种公开(公告)号：US20100279884A1
公开(公告)日：2010-11-04
申请号：US11616516
申请日：2006-12-27
申请人： Ji-young OH , Nam HUH , Sang-hyun PEAK , Jong-Suk CHUNG , Soon-min MA
发明人： Ji-young OH , Nam HUH , Sang-hyun PEAK , Jong-Suk CHUNG , Soon-min MA
CPC分类号： C12Q1/689 , C12Q2600/16 , Y02A50/451
摘要： Provided herein are a primer set capable of amplifying target sequence(s) of nine respiratory disease-associated bacterial species, a probe set specifically hybridizing with the target sequence(s), a microarray comprising the probe set, and a method of detecting one or more of the nine respiratory disease-associated bacterial species using the probe set.
摘要翻译： 本文提供能够扩增九种呼吸系统疾病相关细菌种类的靶序列的引物组，与靶序列特异性杂交的探针组，包含探针组的微阵列，以及检测一种或多种 更多的9种呼吸系统疾病相关细菌物种使用探针组。
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公开(公告)号：US20080076127A1
公开(公告)日：2008-03-27
申请号：US11742111
申请日：2007-04-30
申请人： Ji-young OH , Jung-nam LEE
发明人： Ji-young OH , Jung-nam LEE
CPC分类号： C12Q1/689 , C12Q2563/107 , C12Q2531/113
摘要： Provided are an oligonucleotide primer set for amplifying at least one target sequence of the cagA gene of Helicobacter pylori, a method of detecting Helicobacter pylori using the primer set, and a kit for detecting Helicobacter pylori, including the primer set.
摘要翻译： 提供了用于扩增幽门螺杆菌的cagA基因的至少一个靶序列的寡核苷酸引物组，使用引物组检测幽门螺杆菌的方法和用于检测幽门螺杆菌的试剂盒，包括引物组。
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公开(公告)号：US20070225920A1
公开(公告)日：2007-09-27
申请号：US11610185
申请日：2006-12-13
申请人： Kie-eun KIM , Ji-young OH
发明人： Kie-eun KIM , Ji-young OH
IPC分类号： G06F19/00
摘要： Provided are a method and apparatus for determining specificity of a candidate probe.
摘要翻译： 提供了一种用于确定候选探针的特异性的方法和装置。
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6.发明申请Oligonucleotide Primer Set For Amplifying Target Sequence(S) Of Norovirus, Oligonucleotide Probe Or Probe Set Specifically Hybridizing With Target Sequence(S) Of Norovirus, Microarray Immobilized With The Probe Or Probe Set, And Method Of Detecting Norovirus Using The Probe Or Probe Set 有权用于扩增诺如病毒的目标序列（S）的寡核苷酸引物组，用与探针或探针组固定的微阵列的Norovirus靶序列（S）特异性杂交的寡核苷酸探针或探针，以及使用探针或探针组检测诺如病毒的方法公开(公告)号：US20100152061A1
公开(公告)日：2010-06-17
申请号：US12709744
申请日：2010-02-22
申请人： Ji-young OH , Sook-young KIM
发明人： Ji-young OH , Sook-young KIM
摘要： Provided are an oligonucleotide primer set for amplifying at least one target sequence of the genomic RNA of norovirus, an oligonucleotide probe or probe set specifically hybridizing with at least one target sequence of the genomic RNA of norovirus, a microarray immobilized with the probe or probe set, and a method of detecting norovirus using the probe or probe set.
摘要翻译： 提供了用于扩增诺如病毒的基因组RNA的至少一个靶序列的寡核苷酸引物组，与Norovirus的基因组RNA的至少一个目标序列特异性杂交的寡核苷酸探针或探针组，固定有探针或探针组的微阵列 以及使用探针或探针组检测诺如病毒的方法。
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7.发明申请OLIGONUCLEOTIDE PRIMER SET FOR AMPLIFYING TARGET SEQUENCE(S) OF NOROVIRUS, OLIGONUCLEOTIDE PROBE OR PROBE SET SPECIFICALLY HYBRIDIZING WITH TARGET SEQUENCE(S) OF NOROVIRUS, MICROARRAY IMMOBILIZED WITH THE PROBE OR PROBE SET, AND METHOD OF DETECTING NOROVIRUS USING THE PROBE OR PROBE SET 有权用于放大针对NOROVIRUS目标序列的寡核苷酸引物组，寡核苷酸探针或探针与特异性杂交与NOROVIRUS的目标序列（用探针或探针组确定的微阵列）以及使用探针或探针组检测NOROVIRUS的方法公开(公告)号：US20080119369A1
公开(公告)日：2008-05-22
申请号：US11830132
申请日：2007-07-30
申请人： Ji-young OH , Sook-young KIM
发明人： Ji-young OH , Sook-young KIM
摘要： Provided are an oligonucleotide primer set for amplifying at least one target sequence of the genomic RNA of norovirus, an oligonucleotide probe or probe set specifically hybridizing with at least one target sequence of the genomic RNA of norovirus, a microarray immobilized with the probe or probe set, and a method of detecting norovirus using the probe or probe set.
摘要翻译： 提供了用于扩增诺如病毒的基因组RNA的至少一个靶序列的寡核苷酸引物组，与Norovirus的基因组RNA的至少一个目标序列特异性杂交的寡核苷酸探针或探针组，固定有探针或探针组的微阵列 以及使用探针或探针组检测诺如病毒的方法。
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