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公开(公告)号：US20120322114A1
公开(公告)日：2012-12-20
申请号：US13417641
申请日：2012-03-12
申请人： Jian Liu , Robert J. Linhardt , Fikri Y. Avci , Eva M. Munoz , Jinghua Chen
发明人： Jian Liu , Robert J. Linhardt , Fikri Y. Avci , Eva M. Munoz , Jinghua Chen
CPC分类号： C12P19/64
摘要： Heparosan is sulfated at the iduronic acid residue by providing a reaction mixture comprising C5 epimerase to convert glucuronic acid to iduronic acid, and at least one O-sulfotransferase (OST) enzyme and 3′-phosphoadenosine 5′-phosphosulfate (PAPS).
摘要翻译： 通过提供包含C5差向异构酶以将葡萄糖醛酸转化为艾杜糖醛酸的反应混合物和至少一种O-磺基转移酶（OST）酶和3'-磷酸腺苷5'-磷酸硫酸酯（PAPS），将Heparosan硫酸化在艾杜糖醛酸残基上。
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公开(公告)号：US20090197308A1
公开(公告)日：2009-08-06
申请号：US11920319
申请日：2006-05-12
申请人： Jian Liu , Robert J. Linhardt , Fikri Y. Avci , Eva M. Munoz , Jinghua Chen
发明人： Jian Liu , Robert J. Linhardt , Fikri Y. Avci , Eva M. Munoz , Jinghua Chen
CPC分类号： C12P19/64
摘要： A method of sulfating a polysaccharide is provided. The method can include providing a reaction mixture comprising at least one O-sulfotransferase (OST) enzyme and 3′-phosphoadenosine 5′-phosphosulfate (PAPS); incubating a polysaccharide substrate with the reaction mixture, wherein production of the sulfated polysaccharide from the polysaccharide substrate is catalyzed by the OST enzyme with a conversion of the PAPS to adenosine 3′,5′-diphosphate (PAP); and providing a reaction condition which modifies PAP to reduce an inhibitory effect of PAP on the polysaccharide sulfation.
摘要翻译： 提供了一种硫酸化多糖的方法。 该方法可以包括提供包含至少一种O-磺基转移酶（OST）酶和3'-磷酸腺苷5'-磷酸硫酸酯（PAPS）的反应混合物; 将多糖底物与反应混合物一起孵育，其中由多糖底物生产硫酸化多糖由OST酶催化，PAPS转化为腺苷3'，5'-二磷酸（PAP）; 提供修饰PAP以降低PAP对多糖硫酸化的抑制作用的反应条件。
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公开(公告)号：US08771995B2
公开(公告)日：2014-07-08
申请号：US13417641
申请日：2012-03-12
申请人： Jian Liu , Robert J. Linhardt , Fikri Y. Avci , Ava M. Munoz , Jinghua Chen
发明人： Jian Liu , Robert J. Linhardt , Fikri Y. Avci , Ava M. Munoz , Jinghua Chen
CPC分类号： C12P19/64
摘要： Heparin is synthesized from a polysaccharide comprised of a 1-4 glycosidically linked alternating polymer of uronic acid and glucosamine residues, wherein the uronic acid is selected from iduronic and glucuronic acid, wherein the glucosamine is partially N-sulfated; by a series of selective reactions catalyzed by recombinant enzymes.
摘要翻译： 肝素由包含1-4糖苷键的糖醛酸交替聚合物和葡糖胺残基的多糖合成，其中糖醛酸选自艾杜糖醛酸和葡糖醛酸，其中葡糖胺部分为N-硫酸化; 通过重组酶催化的一系列选择性反应。
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4.发明授权Purified and isolated heparan sulfate 3-O-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same 有权纯化和分离的硫酸乙酰肝素3-O-磺基转移酶同工型5核酸和多肽以及使用其的治疗和筛选方法公开(公告)号：US07531338B2
公开(公告)日：2009-05-12
申请号：US10520341
申请日：2003-07-07
申请人： Jian Liu , Guoqing Xia , Jinghua Chen , Michael B. Duncan , Deepak Shukla , Vaibhav Tiwari , Anders Malmstrom
发明人： Jian Liu , Guoqing Xia , Jinghua Chen , Michael B. Duncan , Deepak Shukla , Vaibhav Tiwari , Anders Malmstrom
CPC分类号： C12N9/13 , A01K2217/05 , A61K38/00 , A61K2039/505 , C12N2799/026 , C12N2799/028
摘要： 3-OST-5 proteins, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to 3-OST-5 homologs, and methods of producing the same, are also disclosed. 3OST-5 gene products have biological activity in specific heparan sulfate 3-O-sulfotransferase reactions. These reactions provide unique modified heparan sulfate. Thus, therapeutic methods involving this activity are also disclosed.
摘要翻译： 3-OST-5蛋白和编码它们的核酸分子。 还公开了重组宿主细胞，重组核酸和重组蛋白，以及各自产生的方法。 还公开了对3-OST-5同系物的分离和纯化的抗体及其制备方法。 3OST-5基因产物在特异性硫酸乙酰肝素3-O-磺基转移酶反应中具有生物活性。 这些反应提供了独特的改性硫酸乙酰肝素。 因此，还公开了涉及该活性的治疗方法。
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5.发明申请Purified and isolated heparan sulfate 3-o-sulfotransferase isoform 5 nucleic acids and polypeptides and therapeutic and screening methods using same 有权纯化和分离的硫酸乙酰肝素3-o-磺基转移酶同工型5核酸和多肽以及使用其的治疗和筛选方法公开(公告)号：US20060165673A1
公开(公告)日：2006-07-27
申请号：US10520341
申请日：2003-07-07
申请人： Jian Liu , Guoqing Xia , Jinghua Chen , Michael Duncan , Deepark Shuka , Vaibhav Tiwari , Anders Malmstrom
发明人： Jian Liu , Guoqing Xia , Jinghua Chen , Michael Duncan , Deepark Shuka , Vaibhav Tiwari , Anders Malmstrom
CPC分类号： C12N9/13 , A01K2217/05 , A61K38/00 , A61K2039/505 , C12N2799/026 , C12N2799/028
摘要： 3-OST-5 proteins, and nucleic acid molecules encoding the same. Recombinant host cells, recombinant nucleic acids and recombinant proteins are also disclosed, along with methods of producing each. Isolated and purified antibodies to 3-OST-5 homologs, and methods of producing the same, are also disclosed. 3OST-5 gene products have biological activity in specific heparan sulfate 3-O-sulfotransferase reactions. These reactions provide unique modified heparan sulfate. Thus, therapeutic methods involving this activity are also disclosed.
摘要翻译： 3-OST-5蛋白和编码它们的核酸分子。 还公开了重组宿主细胞，重组核酸和重组蛋白，以及各自产生的方法。 还公开了对3-OST-5同系物的分离和纯化的抗体及其制备方法。 3OST-5基因产物在特异性硫酸乙酰肝素3-O-磺基转移酶反应中具有生物活性。 这些反应提供了独特的改性硫酸乙酰肝素。 因此，还公开了涉及该活性的治疗方法。
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6.发明申请公开(公告)号：US20090035787A1
公开(公告)日：2009-02-05
申请号：US12178434
申请日：2008-07-23
申请人： Jian Liu , Courtney Jones , Jinghua Chen , Yongmei Xu
发明人： Jian Liu , Courtney Jones , Jinghua Chen , Yongmei Xu
CPC分类号： C08B37/0075 , C12P19/64
摘要： Iduronic acid (IdoUA)-free heparan sulfate (HS)-like compounds are provided. Also provided are methods of synthesizing IdoUA-free HS-like compounds. The methods can include providing at least one O-sulfotransferase (OST) enzyme and a reaction mixture comprising 3′-phosphoadenosine 5′-phosphosulfate (PAPS); and incubating a polysaccharide substrate with the at least one OST and the reaction mixture, whereby the HS-like compounds are synthesized. Also disclosed are methods of synthesizing a library of HS-like compounds and methods of determining the mechanism of activity of HS-like compounds.
摘要翻译： 提供了鸢尾酸（IdoUA） - 无硫酸乙酰肝素（HS）样化合物。 还提供了合成不含IdoUA的HS样化合物的方法。 所述方法可以包括提供至少一种O-磺基转移酶（OST）酶和包含3'-磷酸腺苷5'-磷酸硫酸酯（PAPS）的反应混合物; 并将多糖底物与至少一种OST和反应混合物一起孵育，由此合成HS样化合物。 还公开了合成HS样化合物的文库的方法和确定HS样化合物的活性机理的方法。
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公开(公告)号：US20090240083A1
公开(公告)日：2009-09-24
申请号：US12408899
申请日：2009-03-23
申请人： Huiyue Li , Jinghua Chen , Jiangwei Wu , Guirong Huang , Xinping Zhao , Kaiquan Wang
发明人： Huiyue Li , Jinghua Chen , Jiangwei Wu , Guirong Huang , Xinping Zhao , Kaiquan Wang
IPC分类号： C07C209/10
CPC分类号： C07C209/10 , C07C211/52
摘要： This invention is involved with a preparation method of 2,6-dichlor-4-trifluoromethyl aniline. With this process, 4-chlorotrifluoromethyl benzene is used as the starting material and subjected to halogenation reaction and ammoniation reaction and through separation of reaction products the desired 2,6-dichlor-4-trifluoromethyl aniline is obtained. In addition, ammonia is recovered from the surplus ammonia water in ammoniation reaction. This applied invention in characterized by simple process, cheap and easy-available raw materials, high reaction yield and friendly environment.
摘要翻译： 本发明涉及2,6-二氯-4-三氟甲基苯胺的制备方法。 通过该方法，使用4-氯三氟甲基苯作为原料，进行卤化反应和氨化反应，通过分离反应产物，得到所需的2,6-二氯-4-三氟甲基苯胺。 此外，在氨化反应中从多余的氨水中回收氨。 本发明的特点是工艺简单，原料价格便宜，反应产率高，环境友好。
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公开(公告)号：US20070134555A1
公开(公告)日：2007-06-14
申请号：US11595561
申请日：2006-11-09
申请人： Zhifeng Ren , Jian Wen , Jinghua Chen , Zhongping Huang , Dezhi Wang
发明人： Zhifeng Ren , Jian Wen , Jinghua Chen , Zhongping Huang , Dezhi Wang
CPC分类号： H01G9/155 , B82Y10/00 , B82Y30/00 , H01L51/0048 , H01L51/0052 , H01M4/133 , H01M4/137 , H01M4/366 , H01M4/583 , H01M4/602 , H01M4/663 , H01M4/96 , Y02E60/13 , Y10S977/742 , Y10S977/857 , Y10S977/948
摘要： The present invention provides conductive carbon nanotube (CNT) electrode materials comprising aligned CNT substrates coated with an electrically conducting polymer, and the fabrication of electrodes for use in high performance electrical energy storage devices. In particular, the present invention provides conductive CNTs electrode material whose electrical properties render them especially suitable for use in high efficiency rechargeable batteries. The present invention also provides methods for obtaining surface modified conductive CNT electrode materials comprising an array of individual linear, aligned CNTs having a uniform surface coating of an electrically conductive polymer such as polypyrrole, and their use in electrical energy storage devices.
摘要翻译： 本发明提供了导电碳纳米管（CNT）电极材料，其包括涂覆有导电聚合物的对准的CNT基片，以及用于高性能电能存储装置的电极的制造。 特别地，本发明提供导电CNT电极材料，其电性能使它们特别适用于高效率可再充电电池。 本发明还提供了用于获得表面改性的导电CNT电极材料的方法，其包括具有导电聚合物如聚吡咯的均匀表面涂层的各种线性排列的CNT阵列，以及它们在电能存储装置中的用途。
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公开(公告)号：US07777079B2
公开(公告)日：2010-08-17
申请号：US12408899
申请日：2009-03-23
申请人： Huiyue Li , Jinghua Chen , Jiangwei Wu , Guirong Huang , Xinping Zhao , Kaiquan Wang
发明人： Huiyue Li , Jinghua Chen , Jiangwei Wu , Guirong Huang , Xinping Zhao , Kaiquan Wang
IPC分类号： C07C209/10
CPC分类号： C07C209/10 , C07C211/52
摘要： This invention is involved with a preparation method of 2,6-dichloro-4-trifluoromethyl-aniline. With this process, p-Chlorobenzotrifluoride is used as the starting material and subjected to halogenation reaction and ammoniation reaction and through separation of reaction products the desired 2,6-dichloro-4-trifluoromethyl-aniline is obtained. In addition, ammonia is recovered from the surplus ammonia water in ammoniation reaction. This applied invention in characterized by simple process, cheap and easy-available raw materials, high reaction yield and friendly environment.
摘要翻译： 本发明涉及2,6-二氯-4-三氟甲基 - 苯胺的制备方法。 通过该方法，使用对氯三氟甲苯作为原料，进行卤化反应和氨化反应，通过反应产物的分离，得到所需的2,6-二氯-4-三氟甲基 - 苯胺。 此外，在氨化反应中从多余的氨水中回收氨。 本发明的特点是工艺简单，原料价格便宜，反应产率高，环境友好。
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公开(公告)号：US07442284B2
公开(公告)日：2008-10-28
申请号：US11595561
申请日：2006-11-09
申请人： Zhifeng Ren , Jian Wen , Jinghua Chen , Zhongping Huang , Dezhi Wang
发明人： Zhifeng Ren , Jian Wen , Jinghua Chen , Zhongping Huang , Dezhi Wang
IPC分类号： H01M4/66
CPC分类号： H01G9/155 , B82Y10/00 , B82Y30/00 , H01L51/0048 , H01L51/0052 , H01M4/133 , H01M4/137 , H01M4/366 , H01M4/583 , H01M4/602 , H01M4/663 , H01M4/96 , Y02E60/13 , Y10S977/742 , Y10S977/857 , Y10S977/948
摘要： The present invention provides conductive carbon nanotube (CNT) electrode materials comprising aligned CNT substrates coated with an electrically conducting polymer, and the fabrication of electrodes for use in high performance electrical energy storage devices. In particular, the present invention provides conductive CNTs electrode material whose electrical properties render them especially suitable for use in high efficiency rechargeable batteries. The present invention also provides methods for obtaining surface modified conductive CNT electrode materials comprising an array of individual linear, aligned CNTs having a uniform surface coating of an electrically conductive polymer such as polypyrrole, and their use in electrical energy storage devices.
摘要翻译： 本发明提供了导电碳纳米管（CNT）电极材料，其包括涂覆有导电聚合物的对准的CNT基片，以及用于高性能电能存储装置的电极的制造。 特别地，本发明提供导电CNT电极材料，其电性能使它们特别适用于高效率可再充电电池。 本发明还提供了用于获得表面改性的导电CNT电极材料的方法，其包括具有导电聚合物如聚吡咯的均匀表面涂层的各种线性排列的CNT阵列，以及它们在电能存储装置中的用途。
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