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    Polynucleotides encoding a human chemotactic cytokine I
    1.
    发明授权
    Polynucleotides encoding a human chemotactic cytokine I 失效
    编码人趋化因子I的多核苷酸

    公开(公告)号：US07393943B1

    公开(公告)日：2008-07-01

    申请号：US08761289

    申请日：1996-12-06

    申请人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner Gentz ,  Jeffrey Y. Su

    发明人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner Gentz ,  Jeffrey Y. Su

    IPC分类号： C07H21/04 ,  C12P21/06 ,  C12N1/20 ,  C12N15/00 ,  C12N5/00 ,  C12N5/02 ,  C12N15/74

    CPC分类号： C07K14/52 ,  C07H21/04

    摘要： Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫，慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

    Human chemotactic cytokine I polypeptides
    2.
    发明申请
    Human chemotactic cytokine I polypeptides 审中-公开
    人类趋化性细胞因子I多肽

    公开(公告)号：US20050069945A1

    公开(公告)日：2005-03-31

    申请号：US10994821

    申请日：2004-11-23

    申请人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner Gentz ,  Jeffrey Su

    发明人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner Gentz ,  Jeffrey Su

    IPC分类号： C07H21/04 ,  C07K14/52 ,  C12P21/02 ,  C12Q1/68

    CPC分类号： C07K14/52 ,  C07H21/04

    摘要： Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫，慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

    Human Chemotactic Cytokine I Polypeptides
    3.
    发明申请
    Human Chemotactic Cytokine I Polypeptides 审中-公开
    人类趋化细胞因子I多肽

    公开(公告)号：US20090062510A1

    公开(公告)日：2009-03-05

    申请号：US11737622

    申请日：2007-04-19

    申请人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner L. Gentz ,  Jeffrey Y. Su

    发明人： Jian Ni ,  Guo-Liang Yu ,  Pedro Alfonso ,  Reiner L. Gentz ,  Jeffrey Y. Su

    IPC分类号： C07K14/52

    CPC分类号： C07K14/52 ,  C07H21/04

    摘要： Human chemotactic cytokine I polypeptides and DNA (RNA) encoding such chemotactic cytokines and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such chemotactic cytokines for the treatment of leukemia, tumors, chronic infections, auto-immune disease, fibrotic disorders, wound healing and psoriasis. Antagonists against such chemotactic cytokines and their use as a therapeutic to treat rheumatoid arthritis, auto-immune and chronic and acute inflammatory and infective diseases, allergic reactions, prostaglandin-independent fever and bone marrow failure are also disclosed. Also disclosed are diagnostic assays for detecting diseases related to mutations in the nucleic acid sequences and altered concentrations of the polypeptides. Also disclosed are diagnostic assays for detecting mutations in the polynucleotides encoding the chemotactic cytokines and for detecting altered levels of the polypeptide in a host.

    摘要翻译： 公开了人类趋化性细胞因子I多肽和编码这种趋化性细胞因子的DNA（RNA）以及通过重组技术产生此类多肽的方法。 还公开了利用这种趋化性细胞因子治疗白血病，肿瘤，慢性感染，自身免疫疾病，纤维化病症，伤口愈合和牛皮癣的方法。 还公开了抗这种趋化性细胞因子的拮抗剂及其作为治疗类风湿性关节炎，自身免疫，慢性和急性炎性和感染性疾病，过敏反应，前列腺素不依赖性发烧和骨髓衰竭的治疗剂的用途。 还公开了用于检测与核酸序列中的突变和多肽的改变的浓度相关的疾病的诊断测定。 还公开了用于检测编码趋化性细胞因子的多核苷酸中的突变并用于检测宿主中多肽的改变水平的诊断测定。

    Computer system including a hanging support bracket
    7.
    发明授权
    Computer system including a hanging support bracket 有权
    计算机系统包括悬挂支架

    公开(公告)号：US6102218A

    公开(公告)日：2000-08-15

    申请号：US193696

    申请日：1998-11-17

    申请人： Pedro Alfonso ,  Benjamin Trapp

    发明人： Pedro Alfonso ,  Benjamin Trapp

    IPC分类号： A47B96/06 ,  A47G29/087

    CPC分类号： A47B96/061

    摘要： A computer system according to which a bracket supports a computer chassis on a structure having an accessible upper edge. The bracket is formed by a plurality of support members for receiving the chassis and for engaging the chassis in a manner to prevent movement of the chassis relative to the bracket. At least one hook is connected to the support member for extending over the edge to support the support member, and therefore the chassis, relative to the structure.

    摘要翻译： 一种计算机系统，根据该计算机系统，支架在具有可接近的上边缘的结构上支撑计算机机架。 支架由多个支撑构件形成，用于接收底盘并以防止底盘相对于支架移动的方式与底盘接合。 至少一个钩连​​接到支撑构件，用于在边缘上延伸以支撑支撑构件，并且因此相对于结构支撑底盘。