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公开(公告)号：US07528158B2
公开(公告)日：2009-05-05
申请号：US11235375
申请日：2005-09-26
申请人： Kurt Amrein , Jianping Cai , Robert Alan Goodnow, Jr. , Daniel Hunziker , Bernd Kuhn , Alexander Mayweg , Werner Neidhart
发明人： Kurt Amrein , Jianping Cai , Robert Alan Goodnow, Jr. , Daniel Hunziker , Bernd Kuhn , Alexander Mayweg , Werner Neidhart
IPC分类号： A61K31/44 , C07D231/56
CPC分类号： C07D231/56 , C07D401/06 , C07D405/12 , C07D413/12
摘要： Compounds of formula (I) as well as pharmaceutically acceptable salts and esters thereof, wherein R1 to R7 have the significances given in the description and claims can be used in the form of pharmaceutical compositions.
摘要翻译： 式（I）化合物及其药学上可接受的盐和酯，其中R 1至R 7具有在说明书和权利要求中给出的含义，可以以药物组合物的形式使用。
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公开(公告)号：US07396940B2
公开(公告)日：2008-07-08
申请号：US10957159
申请日：2004-10-01
IPC分类号： C07D209/42
CPC分类号： C07D209/42 , C07B2200/11 , C40B40/04
摘要： Combinatorial libraries that contains various different 4, 5 fused 3-substituted-2-pyrrolocarboxylic acids for screening pharmacological activity and methods of synthesizing said libraries.
摘要翻译： 包含各种不同的4,5-稠合的3-取代-2-吡咯羧酸用于筛选药理活性的组合文库和合成所述文库的方法。
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公开(公告)号：US07504513B2
公开(公告)日：2009-03-17
申请号：US11703306
申请日：2007-02-07
申请人： John Frederick Boylan , Jianping Cai , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Kang Le , Christophe Michoud
发明人： John Frederick Boylan , Jianping Cai , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Kang Le , Christophe Michoud
IPC分类号： A61K31/427 , C07D417/04 , C07D417/14
CPC分类号： C07D417/04
摘要： The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.
摘要翻译： 本发明涉及式（1）的化合物及其药学上可接受的盐，其制备方法及其使用方法。
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公开(公告)号：US08044213B2
公开(公告)日：2011-10-25
申请号：US12634771
申请日：2009-12-10
申请人： Jianping Cai , Shaoqing Chen , Yi Chen , Xin-Jie Chu , Robert Alan Goodnow, Jr. , Kang Le , Kin-Chun Luk , Steven Gregory Mischke , Peter Michael Wovkulich
发明人： Jianping Cai , Shaoqing Chen , Yi Chen , Xin-Jie Chu , Robert Alan Goodnow, Jr. , Kang Le , Kin-Chun Luk , Steven Gregory Mischke , Peter Michael Wovkulich
IPC分类号： A61K31/427 , C07D417/04 , C07D417/14
CPC分类号： C07D417/04 , C07D417/14
摘要： The invention is directed to compounds of formula (1) and pharmaceutically acceptable salts thereof, methods for the preparation thereof, and methods of use thereof.
摘要翻译： 本发明涉及式（1）的化合物及其药学上可接受的盐，其制备方法及其使用方法。
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公开(公告)号：US08088936B2
公开(公告)日：2012-01-03
申请号：US12720822
申请日：2010-03-10
申请人： Romyr Dominique , Robert Alan Goodnow, Jr. , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri , Jefferson Wright Tilley
发明人： Romyr Dominique , Robert Alan Goodnow, Jr. , Agnieszka Kowalczyk , Qi Qiao , Achyutharao Sidduri , Jefferson Wright Tilley
IPC分类号： C07D317/44 , A61K31/405
CPC分类号： C07C59/68 , C07C59/90 , C07D209/08 , C07D213/38 , C07D213/61 , C07D239/26 , C07D277/24 , C07D317/54 , C07D317/58 , C07D319/18 , C07D333/16 , C07D333/20 , C07D333/24
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, COPD.
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公开(公告)号：US07625895B2
公开(公告)日：2009-12-01
申请号：US12050235
申请日：2008-03-18
IPC分类号： A61K31/437 , C07D471/04 , A61K31/5377 , A61P35/00 , C07D413/14
CPC分类号： C07D471/04
摘要： and the pharmaceutically acceptable salts and esters thereof, X, R1, R2, Y1 and Y2 are described herein inhibit the interaction of MDM2 protein with a p53-like peptide and hence have anti proliferative activity.
摘要翻译： 其药学上可接受的盐和酯，X，R 1，R 2，Y 1和Y 2如本文所述抑制MDM2蛋白与p53样肽的相互作用，因此具有抗增殖活性。
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公开(公告)号：US07622492B2
公开(公告)日：2009-11-24
申请号：US11507080
申请日：2006-08-18
申请人： Bruce Lester Banner , Joseph Anthony Bilotta , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Matthew Michael Hamilton , Nancy-Ellen Haynes , Agnieszka Kowalczyk , Alexander Mayweg , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Kevin Richard Guertin
发明人： Bruce Lester Banner , Joseph Anthony Bilotta , Nader Fotouhi , Paul Gillespie , Robert Alan Goodnow, Jr. , Matthew Michael Hamilton , Nancy-Ellen Haynes , Agnieszka Kowalczyk , Alexander Mayweg , Michael Paul Myers , Sherrie Lynn Pietranico-Cole , Nathan Robert Scott , Kshitij Chhabilbhai Thakkar , Jefferson Wright Tilley , Kevin Richard Guertin
IPC分类号： A61K31/416 , C07D231/54
CPC分类号： C07D231/54
摘要： Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
摘要翻译： 本文提供式（I）的化合物及其药学上可接受的盐，其中取代基如说明书中公开的那些。 这些化合物和含有它们的药物组合物可用于治疗疾病，例如II型糖尿病和代谢综合征。
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公开(公告)号：US07371869B2
公开(公告)日：2008-05-13
申请号：US11225950
申请日：2005-09-14
申请人： Robert Alan Goodnow, Jr. , Nicholas J. S. Huby , Norman Kong , Lee Apostle McDermott , John Anthony Moliterni , Zhuming Zhang
发明人： Robert Alan Goodnow, Jr. , Nicholas J. S. Huby , Norman Kong , Lee Apostle McDermott , John Anthony Moliterni , Zhuming Zhang
IPC分类号： A61K31/427 , C07D409/12
CPC分类号： C07D417/14 , C07D417/12
摘要： The present invention relates to compounds of the formula which are useful in treating diseases characterized by the hyperactivity of MEK. Accordingly the compounds are useful in the treatment of diseases, such as, cancer, cognative and CNS disorders and inflammatory/autoimmune diseases.
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公开(公告)号：US08263656B2
公开(公告)日：2012-09-11
申请号：US12540839
申请日：2009-08-13
申请人： Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, Jr. , Tai-An Lin , Achyutharao Sidduri , Sung-Sau So , Jenny Tan
发明人： Fariborz Firooznia , Paul Gillespie , Robert Alan Goodnow, Jr. , Tai-An Lin , Achyutharao Sidduri , Sung-Sau So , Jenny Tan
IPC分类号： A61K31/195 , C07C317/12
CPC分类号： C07C311/29 , C07C311/20 , C07C317/14 , C07C2602/10 , C07D213/34
摘要： The invention is concerned with the compounds of formula I: and pharmaceutically acceptable salts and esters thereof, wherein R1-R4 are defined in the detailed description and claims. In addition, the present invention relates to methods of manufacturing and using the compounds of formula I as well as pharmaceutical compositions containing such compounds. The compounds of formula I are antagonists at the CRTH2 receptor and may be useful in treating diseases and disorders associated with that receptor such as asthma.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐和酯，其中R 1 -R 4在详细描述和权利要求书中定义。 此外，本发明涉及制备和使用式I化合物的方法以及含有这些化合物的药物组合物。 式I化合物是CRTH2受体的拮抗剂，可用于治疗与该受体相关的疾病和病症如哮喘。
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10.发明授权公开(公告)号：US07524870B2
公开(公告)日：2009-04-28
申请号：US11283925
申请日：2005-11-21
IPC分类号： C07D401/02 , A61K31/44
CPC分类号： C07C65/24 , C07C51/09 , C07D213/30 , C07D213/61 , C07D213/64 , C07D213/79 , C07D215/06 , C07D215/14 , C07D231/12 , C07D261/08 , C07D277/56 , C07D307/42 , C07D317/54 , C07D319/08 , C07D333/16 , C07D401/12 , C07D409/12 , C07D417/12 , C07C59/66
摘要： The present invention relates to compounds of formula (I) wherein Ar, Ar2, R2, R3, R4, m, p and s are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases that are associated with the activation of the glycogen synthase enzyme, such as diabetes.
摘要翻译： 本发明涉及其中Ar，Ar 2，R 2，R 3，R 4，m，p和s如说明书和权利要求书中所定义的式（I）化合物及其药学上可接受的盐。 该化合物可用于治疗和/或预防与糖原合成酶如糖尿病的活化相关的疾病。
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